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Arthritis Research & Therapy

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01.10.2006 | Review

The role of leptin in innate and adaptive immune responses

verfasst von: Eiva Bernotiene, Gaby Palmer, Cem Gabay

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2006

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Abstract

Leptin is produced primarily by adipocytes and functions in a feedback loop regulating body weight. Leptin deficiency results in severe obesity and a variety of endocrine abnormalities in animals and humans. Several studies indicated that leptin plays an important role in immune responses. It exerts protective anti-inflammatory effects in models of acute inflammation and during activation of innate immune responses. In contrast, leptin stimulates T lymphocyte responses, thus having rather a proinflammatory role in experimental models of autoimmune diseases. Clinical studies have so far yielded inconsistent results, suggesting a rather complex role for leptin in immune-mediated inflammatory conditions in humans.

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Titel: The role of leptin in innate and adaptive immune responses
verfasst von: Eiva Bernotiene
Gaby Palmer
Cem Gabay
Publikationsdatum: 01.10.2006
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 5/2006
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2004

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The role of leptin in innate and adaptive immune responses

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