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Erschienen in: Arthritis Research & Therapy 4/2007

01.08.2007 | Review

B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue

verfasst von: Arne Hansen, Peter E Lipsky, Thomas Dörner

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2007

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Abstract

Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathological features. A hallmark of pSS is B-cell hyperactivity as manifested by the production of autoantibodies, hypergammaglobulinemia, formation of ectopic lymphoid structures within the inflamed tissues, and enhanced risk of B-cell lymphoma. Changes in the distribution of peripheral B-cell subsets and differences in post-recombination processes of immunoglobulin variable region (IgV) gene usage are also characteristic features of pSS. Comparison of B cells from the peripheral blood and salivary glands of patients with pSS with regard to their expression of the chemokine receptors CXCR4 and CXCR5, and their migratory capacity towards the corresponding ligands, CXCL12 and CXCL13, provide a mechanism for the prominent accumulation of CXCR4+CXCR5+ memory B cells in the inflamed glands. Glandular B cells expressing distinct features of IgV light and heavy chain rearrangements, (re)circulating B cells with increased mutations of cμ transcripts in both CD27- and CD27+ memory B-cell subsets, and enhanced frequencies of individual peripheral B cells containing IgV heavy chain transcripts of multiple isotypes indicate disordered selection and incomplete differentiation processes of B cells in the inflamed tissues in pSS. This may possibly be related to a lack of appropriate censoring mechanisms or different B-cell activation pathways within the ectopic lymphoid structures of the inflamed tissues. These findings add to our understanding of the pathogenesis of this autoimmune inflammatory disorder and may result in new therapeutic approaches.
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Literatur
1.
Zurück zum Zitat Fox RI: Sjögren's syndrome. Lancet. 2005, 366: 321-331. 10.1016/S0140-6736(05)66990-5.PubMed Fox RI: Sjögren's syndrome. Lancet. 2005, 366: 321-331. 10.1016/S0140-6736(05)66990-5.PubMed
2.
Zurück zum Zitat Kassan SS, Moutsopoulos HM: Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004, 164: 1275-1284. 10.1001/archinte.164.12.1275.PubMed Kassan SS, Moutsopoulos HM: Clinical manifestations and early diagnosis of Sjögren syndrome. Arch Intern Med. 2004, 164: 1275-1284. 10.1001/archinte.164.12.1275.PubMed
3.
Zurück zum Zitat Hansen A, Lipsky PE, Dörner T: Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy. Curr Opin Rheum. 2005, 17: 558-565. 10.1097/01.bor.0000172801.56744.c3. Hansen A, Lipsky PE, Dörner T: Immunopathogenesis of primary Sjögren's syndrome: implications for disease management and therapy. Curr Opin Rheum. 2005, 17: 558-565. 10.1097/01.bor.0000172801.56744.c3.
4.
Zurück zum Zitat Mitsias DI, Kapsogeorgou EK, Moutsopoulos HM: The role of epithelial cells in the initiation and perpetuation of autoimmune lesions: lessons from Sjögren's syndrome (autoimmune epithelitis). Lupus. 2006, 15: 255-261. 10.1191/0961203306lu2290rr.PubMed Mitsias DI, Kapsogeorgou EK, Moutsopoulos HM: The role of epithelial cells in the initiation and perpetuation of autoimmune lesions: lessons from Sjögren's syndrome (autoimmune epithelitis). Lupus. 2006, 15: 255-261. 10.1191/0961203306lu2290rr.PubMed
5.
Zurück zum Zitat Cisholm DM, Mason DK: Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968, 21: 656-660. 10.1136/jcp.21.5.656. Cisholm DM, Mason DK: Labial salivary gland biopsy in Sjögren's disease. J Clin Pathol. 1968, 21: 656-660. 10.1136/jcp.21.5.656.
6.
Zurück zum Zitat Daniels TE: Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum. 1984, 27: 147-156. 10.1002/art.1780270205.PubMed Daniels TE: Labial salivary gland biopsy in Sjögren's syndrome. Assessment as a diagnostic criterion in 362 suspected cases. Arthritis Rheum. 1984, 27: 147-156. 10.1002/art.1780270205.PubMed
7.
Zurück zum Zitat Adamson TC, Fox RI, Frisman DM, Howell FV: Immmunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal antibodies. J Immunol. 1983, 130: 203-208.PubMed Adamson TC, Fox RI, Frisman DM, Howell FV: Immmunohistologic analysis of lymphoid infiltrates in primary Sjögren's syndrome using monoclonal antibodies. J Immunol. 1983, 130: 203-208.PubMed
8.
Zurück zum Zitat Larsson A, Bredberg A, Henriksson G, Manthorpe R, Sallmyr A: Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjögren's syndrome and healthy subjects. Scand J Immunol. 2005, 61: 98-107. 10.1111/j.0300-9475.2005.01540.x.PubMed Larsson A, Bredberg A, Henriksson G, Manthorpe R, Sallmyr A: Immunohistochemistry of the B-cell component in lower lip salivary glands of Sjögren's syndrome and healthy subjects. Scand J Immunol. 2005, 61: 98-107. 10.1111/j.0300-9475.2005.01540.x.PubMed
9.
Zurück zum Zitat Xanthou G, Tapinos NI, Polihronis M, Nezis IP, Margaritis LH, Moutsopoulos HM: CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjögren's syndrome. Clin Exp Immunol. 1999, 118: 154-163. 10.1046/j.1365-2249.1999.01037.x.PubMedCentralPubMed Xanthou G, Tapinos NI, Polihronis M, Nezis IP, Margaritis LH, Moutsopoulos HM: CD4 cytotoxic and dendritic cells in the immunopathologic lesion of Sjögren's syndrome. Clin Exp Immunol. 1999, 118: 154-163. 10.1046/j.1365-2249.1999.01037.x.PubMedCentralPubMed
10.
Zurück zum Zitat Zeher M, Adany R, Nagy G, Gomez R, Szegedi G: Macrophage containing factor XIII subunit a in salivary glands of patients with Sjögren's syndrome. J Investig Allergol Clin Immunol. 1991, 1: 261-265.PubMed Zeher M, Adany R, Nagy G, Gomez R, Szegedi G: Macrophage containing factor XIII subunit a in salivary glands of patients with Sjögren's syndrome. J Investig Allergol Clin Immunol. 1991, 1: 261-265.PubMed
11.
Zurück zum Zitat James JA, Harley JB, Scofield RH: Role of viruses in systemic lupus erythematosus and Sjögren's syndrome. Curr Opin Rheumatol. 2001, 13: 370-376. 10.1097/00002281-200109000-00005.PubMed James JA, Harley JB, Scofield RH: Role of viruses in systemic lupus erythematosus and Sjögren's syndrome. Curr Opin Rheumatol. 2001, 13: 370-376. 10.1097/00002281-200109000-00005.PubMed
12.
Zurück zum Zitat Fox RI, Pearson G, Vaughan JH: Detection of Epstein–Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J Immunol. 1986, 137: 3162-3168.PubMed Fox RI, Pearson G, Vaughan JH: Detection of Epstein–Barr virus-associated antigens and DNA in salivary gland biopsies from patients with Sjögren's syndrome. J Immunol. 1986, 137: 3162-3168.PubMed
13.
Zurück zum Zitat Nakamura H, Kawakami A, Tominaga M, Hida A, Yamasaki S, Migita K, Kawabe Y, Nakamura T, Eguchi K: Relationship between Sjögren's syndrome and human T-lymphotropic virus type I infection: follow-up study of 83 patients. J Lab Clin Med. 2000, 135: 139-144. 10.1067/mlc.2000.103429.PubMed Nakamura H, Kawakami A, Tominaga M, Hida A, Yamasaki S, Migita K, Kawabe Y, Nakamura T, Eguchi K: Relationship between Sjögren's syndrome and human T-lymphotropic virus type I infection: follow-up study of 83 patients. J Lab Clin Med. 2000, 135: 139-144. 10.1067/mlc.2000.103429.PubMed
14.
Zurück zum Zitat Triantafyllopoulou A, Tapinos N, Moutsopoulos HM: Evidence for Coxsackievirus infection in primary Sjögren's syndrome. Arthritis Rheum. 2004, 50: 2897-2902. 10.1002/art.20463.PubMed Triantafyllopoulou A, Tapinos N, Moutsopoulos HM: Evidence for Coxsackievirus infection in primary Sjögren's syndrome. Arthritis Rheum. 2004, 50: 2897-2902. 10.1002/art.20463.PubMed
15.
16.
Zurück zum Zitat Saegusa K, Ishimaru N, Yanagi K, Mishima K, Arakaki R, Suda T, Saito I, Hayashi Y: Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjögren's syndrome. J Immunol. 2002, 169: 1050-1057.PubMed Saegusa K, Ishimaru N, Yanagi K, Mishima K, Arakaki R, Suda T, Saito I, Hayashi Y: Prevention and induction of autoimmune exocrinopathy is dependent on pathogenic autoantigen cleavage in murine Sjögren's syndrome. J Immunol. 2002, 169: 1050-1057.PubMed
17.
Zurück zum Zitat Nordmark G, Alm GV, Ronnblom L: Mechanisms of disease: primary Sjögren's syndrome and the type I interferon system. Nat Clin Pract Rheumatol. 2006, 2: 262-269. 10.1038/ncprheum0173.PubMed Nordmark G, Alm GV, Ronnblom L: Mechanisms of disease: primary Sjögren's syndrome and the type I interferon system. Nat Clin Pract Rheumatol. 2006, 2: 262-269. 10.1038/ncprheum0173.PubMed
18.
Zurück zum Zitat Nagata Y, Inoue H, Yamada K, Higashiyama H, Mishima K, Kizu Y, Takeda I, Mizuno F, Hayashi Y, Saito I: Activation of Epstein–Barr virus by saliva from Sjögren's syndrome patients. Immunology. 2004, 111: 223-229. 10.1111/j.0019-2805.2003.01795.x.PubMedCentralPubMed Nagata Y, Inoue H, Yamada K, Higashiyama H, Mishima K, Kizu Y, Takeda I, Mizuno F, Hayashi Y, Saito I: Activation of Epstein–Barr virus by saliva from Sjögren's syndrome patients. Immunology. 2004, 111: 223-229. 10.1111/j.0019-2805.2003.01795.x.PubMedCentralPubMed
19.
Zurück zum Zitat Hagiwara E, Pando J, Ishigatsubo Y, Klinman DM: Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol. 1998, 25: 89-93.PubMed Hagiwara E, Pando J, Ishigatsubo Y, Klinman DM: Altered frequency of type 1 cytokine secreting cells in the peripheral blood of patients with primary Sjögren's syndrome. J Rheumatol. 1998, 25: 89-93.PubMed
20.
Zurück zum Zitat Mitsias DI, Tzioufas AG, Veiopoulou C, Zintzaras E, Tassios IK, Kogopoulou O, Moutsopoulos HM, Thyphronitis G: The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome. Clin Exp Immunol. 2002, 128: 562-568. 10.1046/j.1365-2249.2002.01869.x.PubMedCentralPubMed Mitsias DI, Tzioufas AG, Veiopoulou C, Zintzaras E, Tassios IK, Kogopoulou O, Moutsopoulos HM, Thyphronitis G: The Th1/Th2 cytokine balance changes with the progress of the immunopathological lesion of Sjögren's syndrome. Clin Exp Immunol. 2002, 128: 562-568. 10.1046/j.1365-2249.2002.01869.x.PubMedCentralPubMed
21.
Zurück zum Zitat Zintsaras E, Voulgarelis M, Moutsopoulos HM: The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med. 2005, 165: 2337-2344. 10.1001/archinte.165.20.2337. Zintsaras E, Voulgarelis M, Moutsopoulos HM: The risk of lymphoma development in autoimmune diseases: a meta-analysis. Arch Intern Med. 2005, 165: 2337-2344. 10.1001/archinte.165.20.2337.
22.
Zurück zum Zitat Bohnhorst J, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM: Bm1-bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J Immunol. 2001, 167: 3610-3618.PubMed Bohnhorst J, Bjorgan MB, Thoen JE, Natvig JB, Thompson KM: Bm1-bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J Immunol. 2001, 167: 3610-3618.PubMed
23.
Zurück zum Zitat Bohnhorst JO, Bjorgan MB, Thoen JE, Jonsson R, Natvig JB, Thompson KM: Abnormal B cell differentiation in primary Sjögren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with serum IgG concentration. Clin Immunol. 2002, 103: 79-88. 10.1006/clim.2002.5199.PubMed Bohnhorst JO, Bjorgan MB, Thoen JE, Jonsson R, Natvig JB, Thompson KM: Abnormal B cell differentiation in primary Sjögren's syndrome results in a depressed percentage of circulating memory B cells and elevated levels of soluble CD27 that correlate with serum IgG concentration. Clin Immunol. 2002, 103: 79-88. 10.1006/clim.2002.5199.PubMed
24.
Zurück zum Zitat Hansen A, Odendahl M, Reiter K, Jacobi AM, Feist E, Scholze J, Burmester GR, Lipsky PE, Dörner T: Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 2002, 46: 2160-2167. 10.1002/art.10445.PubMed Hansen A, Odendahl M, Reiter K, Jacobi AM, Feist E, Scholze J, Burmester GR, Lipsky PE, Dörner T: Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 2002, 46: 2160-2167. 10.1002/art.10445.PubMed
25.
Zurück zum Zitat Hansen A, Gosemann M, Pruss A, Reiter K, Ruzickova S, Lipsky PE, Dörner T: Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndrome. Arthritis Rheum. 2004, 50: 1897-1908. 10.1002/art.20276.PubMed Hansen A, Gosemann M, Pruss A, Reiter K, Ruzickova S, Lipsky PE, Dörner T: Abnormalities in peripheral B cell memory of patients with primary Sjögren's syndrome. Arthritis Rheum. 2004, 50: 1897-1908. 10.1002/art.20276.PubMed
26.
Zurück zum Zitat Hansen A, Reiter K, Ziprian T, Jacobi A, Hoffmann A, Gosemann M, Scholze J, Lipsky PE, Dörner T: Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome. Arthritis Rheum. 2005, 52: 2109-2119. 10.1002/art.21129.PubMed Hansen A, Reiter K, Ziprian T, Jacobi A, Hoffmann A, Gosemann M, Scholze J, Lipsky PE, Dörner T: Dysregulation of chemokine receptor expression and function by B cells of patients with primary Sjögren's syndrome. Arthritis Rheum. 2005, 52: 2109-2119. 10.1002/art.21129.PubMed
27.
Zurück zum Zitat Stott DI, Hiepe F, Hummel M, Steinhauser G, Berek C: Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome. J Clin Invest. 1998, 102: 938-946.PubMedCentralPubMed Stott DI, Hiepe F, Hummel M, Steinhauser G, Berek C: Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome. J Clin Invest. 1998, 102: 938-946.PubMedCentralPubMed
28.
Zurück zum Zitat Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, Crocker J, Hamburger J, Ainsworth J, Mathews J, Salmon M, et al: Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum. 2001, 44: 2633-2641. 10.1002/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9.PubMed Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, Crocker J, Hamburger J, Ainsworth J, Mathews J, Salmon M, et al: Ectopic expression of the B cell-attracting chemokine BCA-1 (CXCL13) on endothelial cells and within lymphoid follicles contributes to the establishment of germinal center-like structures in Sjögren's syndrome. Arthritis Rheum. 2001, 44: 2633-2641. 10.1002/1529-0131(200111)44:11<2633::AID-ART443>3.0.CO;2-9.PubMed
29.
Zurück zum Zitat Xanthou G, Polihronis M, Tzioufas AG, Paikos S, Sideras P, Moutsopoulos HM: 'Lymphoid' chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjögren's syndrome patients. Possible participation in lymphoid structure formation. Arthritis Rheum. 2001, 44: 408-418. 10.1002/1529-0131(200102)44:2<408::AID-ANR60>3.0.CO;2-0.PubMed Xanthou G, Polihronis M, Tzioufas AG, Paikos S, Sideras P, Moutsopoulos HM: 'Lymphoid' chemokine messenger RNA expression by epithelial cells in the chronic inflammatory lesion of the salivary glands of Sjögren's syndrome patients. Possible participation in lymphoid structure formation. Arthritis Rheum. 2001, 44: 408-418. 10.1002/1529-0131(200102)44:2<408::AID-ANR60>3.0.CO;2-0.PubMed
30.
Zurück zum Zitat Salomonsson S, Larsson P, Tengnér P, Mellquist E, Hjelmström P, Wahren-Herlenius M: Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndrome. Scand J Immunol. 2002, 55: 336-342. 10.1046/j.1365-3083.2002.01058.x.PubMed Salomonsson S, Larsson P, Tengnér P, Mellquist E, Hjelmström P, Wahren-Herlenius M: Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndrome. Scand J Immunol. 2002, 55: 336-342. 10.1046/j.1365-3083.2002.01058.x.PubMed
31.
Zurück zum Zitat Barone F, Bombardieri M, Manzo A, Blades MC, Morgan PR, Challacombe SJ, Valesini G, Pitzalis C: Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome. Arthritis Rheum. 2005, 52: 1773-1784. 10.1002/art.21062.PubMed Barone F, Bombardieri M, Manzo A, Blades MC, Morgan PR, Challacombe SJ, Valesini G, Pitzalis C: Association of CXCL13 and CCL21 expression with the progressive organization of lymphoid-like structures in Sjögren's syndrome. Arthritis Rheum. 2005, 52: 1773-1784. 10.1002/art.21062.PubMed
32.
Zurück zum Zitat Salomonsson S, Jonsson MV, Skarstein K, Brokstad KA, Hjelmström P, Wahren-Herlenius M, Jonsson R: Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. Arthritis Rheum. 2003, 48: 3187-3201. 10.1002/art.11311.PubMed Salomonsson S, Jonsson MV, Skarstein K, Brokstad KA, Hjelmström P, Wahren-Herlenius M, Jonsson R: Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome. Arthritis Rheum. 2003, 48: 3187-3201. 10.1002/art.11311.PubMed
33.
Zurück zum Zitat Jonsson MV, Szodoray P, Jellestad S, Jonsson R, Skarstein K: Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome. J Clin Immunol. 2005, 25: 189-201. 10.1007/s10875-005-4091-5.PubMed Jonsson MV, Szodoray P, Jellestad S, Jonsson R, Skarstein K: Association between circulating levels of the novel TNF family members APRIL and BAFF and lymphoid organization in primary Sjögren's syndrome. J Clin Immunol. 2005, 25: 189-201. 10.1007/s10875-005-4091-5.PubMed
34.
Zurück zum Zitat Szodoray P, Alex P, Jonsson MV, Knowlton N, Dozmorov I, Nakken B, Delaleu N, Jonsson R, Centola M: Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin Immunol. 2005, 117: 168-176. 10.1016/j.clim.2005.06.016.PubMed Szodoray P, Alex P, Jonsson MV, Knowlton N, Dozmorov I, Nakken B, Delaleu N, Jonsson R, Centola M: Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF. Clin Immunol. 2005, 117: 168-176. 10.1016/j.clim.2005.06.016.PubMed
35.
Zurück zum Zitat Daridon C, Pers JO, Devauchelle V, Martins-Cavalho C, Hutin P, Pennec YL, Saraux A, Youinouh P: Identification of transitional type II B cells in the salivary glands of patients with primary Sjögren's syndrome. Arthritis Rheum. 2006, 54: 2280-2288. 10.1002/art.21936.PubMed Daridon C, Pers JO, Devauchelle V, Martins-Cavalho C, Hutin P, Pennec YL, Saraux A, Youinouh P: Identification of transitional type II B cells in the salivary glands of patients with primary Sjögren's syndrome. Arthritis Rheum. 2006, 54: 2280-2288. 10.1002/art.21936.PubMed
36.
Zurück zum Zitat Schröder AE, Greiner A, Seyfert C, Berek C: Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA. 1996, 93: 221-225. 10.1073/pnas.93.1.221.PubMedCentralPubMed Schröder AE, Greiner A, Seyfert C, Berek C: Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritis. Proc Natl Acad Sci USA. 1996, 93: 221-225. 10.1073/pnas.93.1.221.PubMedCentralPubMed
37.
Zurück zum Zitat Hutloff A, Buchner K, Reiter K, Baelde HJ, Odendahl M, Jacobi A, Dörner T, Kroczek RA: Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum. 2004, 50: 3211-3220. 10.1002/art.20519.PubMed Hutloff A, Buchner K, Reiter K, Baelde HJ, Odendahl M, Jacobi A, Dörner T, Kroczek RA: Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum. 2004, 50: 3211-3220. 10.1002/art.20519.PubMed
38.
Zurück zum Zitat Hsi ED, Singleton TP, Svoboda SM, Schnitzer B, Ross CW: Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain rearrangement. Am J Clin Pathol. 1998, 110: 327-333.PubMed Hsi ED, Singleton TP, Svoboda SM, Schnitzer B, Ross CW: Characterization of the lymphoid infiltrate in Hashimoto thyroiditis by immunohistochemistry and polymerase chain reaction for immunoglobulin heavy chain rearrangement. Am J Clin Pathol. 1998, 110: 327-333.PubMed
39.
Zurück zum Zitat Ansell SM, Grant CS, Habermann TM: Primary thyroid lymphoma. Semin Oncol. 1999, 26: 316-323.PubMed Ansell SM, Grant CS, Habermann TM: Primary thyroid lymphoma. Semin Oncol. 1999, 26: 316-323.PubMed
40.
Zurück zum Zitat Kordossis T, Paikos S, Aroni K, Kitsanta P, Dimitrakopoulos A, Kavouklis E, Alevizou V, Kyriaki P, Skopouli FN, Moutsopoulos HM: Prevalence of Sjögren's-like syndrome in a cohort of HIV-1-positive patients: descriptive pathology and immunopathology. Br J Rheumatol. 1998, 37: 691-695. 10.1093/rheumatology/37.6.691.PubMed Kordossis T, Paikos S, Aroni K, Kitsanta P, Dimitrakopoulos A, Kavouklis E, Alevizou V, Kyriaki P, Skopouli FN, Moutsopoulos HM: Prevalence of Sjögren's-like syndrome in a cohort of HIV-1-positive patients: descriptive pathology and immunopathology. Br J Rheumatol. 1998, 37: 691-695. 10.1093/rheumatology/37.6.691.PubMed
41.
Zurück zum Zitat Widney D, Gundapp G, Said JW, van der Meijden M, Bonavida B, Demidem A, Trevisan C, Taylor J, Detels R, Martinez-Maza O: Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma. Clin Immunol. 1999, 93: 114-123. 10.1006/clim.1999.4782.PubMed Widney D, Gundapp G, Said JW, van der Meijden M, Bonavida B, Demidem A, Trevisan C, Taylor J, Detels R, Martinez-Maza O: Aberrant expression of CD27 and soluble CD27 (sCD27) in HIV infection and in AIDS-associated lymphoma. Clin Immunol. 1999, 93: 114-123. 10.1006/clim.1999.4782.PubMed
42.
Zurück zum Zitat Scott CA, Avellini C, Desinan L, Pirisi M, Ferraccioli GF, Bardus P, Fabris C, Casatta L, Bartoli E, Beltrami CA: Chronic lymphocytic sialoadenitis in HCV-related chronic liver disease: comparison of Sjögren's syndrome. Histopathology. 1997, 30: 41-48. 10.1046/j.1365-2559.1997.d01-561.x.PubMed Scott CA, Avellini C, Desinan L, Pirisi M, Ferraccioli GF, Bardus P, Fabris C, Casatta L, Bartoli E, Beltrami CA: Chronic lymphocytic sialoadenitis in HCV-related chronic liver disease: comparison of Sjögren's syndrome. Histopathology. 1997, 30: 41-48. 10.1046/j.1365-2559.1997.d01-561.x.PubMed
43.
Zurück zum Zitat Arcaini L, Burcheri S, Rossi A, Paulli M, Bruno R, Passamonti F, Brusamolino E, Molteni A, Pulsoni A, Cox MC, et al: Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT. Ann Oncol. 2007, 18: 346-350. 10.1093/annonc/mdl388.PubMed Arcaini L, Burcheri S, Rossi A, Paulli M, Bruno R, Passamonti F, Brusamolino E, Molteni A, Pulsoni A, Cox MC, et al: Prevalence of HCV infection in nongastric marginal zone B-cell lymphoma of MALT. Ann Oncol. 2007, 18: 346-350. 10.1093/annonc/mdl388.PubMed
44.
Zurück zum Zitat Maszzuccheli L, Blaser A, Kappeler A, Scharli P, Laissue JA, Baggiolini M, Uguccioni M: BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J Clin Invest. 1999, 104: R49-R54. Maszzuccheli L, Blaser A, Kappeler A, Scharli P, Laissue JA, Baggiolini M, Uguccioni M: BCA-1 is highly expressed in Helicobacter pylori-induced mucosa-associated lymphoid tissue and gastric lymphoma. J Clin Invest. 1999, 104: R49-R54.
45.
Zurück zum Zitat Fox RI, Saito I: Criteria for diagnosis of Sjögren's syndrome. Rheum Dis Clin North Am. 1994, 20: 391-407.PubMed Fox RI, Saito I: Criteria for diagnosis of Sjögren's syndrome. Rheum Dis Clin North Am. 1994, 20: 391-407.PubMed
46.
Zurück zum Zitat Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, the European Study Group on Classification Criteria for Sjögren's Syndrome, et al: Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American–European consensus group. Ann Rheum Dis. 2002, 61: 554-558. 10.1136/ard.61.6.554.PubMedCentralPubMed Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS, the European Study Group on Classification Criteria for Sjögren's Syndrome, et al: Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American–European consensus group. Ann Rheum Dis. 2002, 61: 554-558. 10.1136/ard.61.6.554.PubMedCentralPubMed
47.
Zurück zum Zitat Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN, Smith PM: Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum. 2006, 54: 1165-1173. 10.1002/art.21764.PubMed Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers SN, Smith PM: Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum. 2006, 54: 1165-1173. 10.1002/art.21764.PubMed
48.
Zurück zum Zitat Jonsson MV, Delaleu N, Brokstad KA, Berggreen E, Skarstein K: Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis Rheum. 2006, 54: 2300-2305. 10.1002/art.21945.PubMed Jonsson MV, Delaleu N, Brokstad KA, Berggreen E, Skarstein K: Impaired salivary gland function in NOD mice: association with changes in cytokine profile but not with histopathologic changes in the salivary gland. Arthritis Rheum. 2006, 54: 2300-2305. 10.1002/art.21945.PubMed
49.
Zurück zum Zitat Tsunawaki S, Nakamura S, Ohyama Y, Sasaki M, Ikebe-Hiroki A, Hiraki A, Kadena T, Kawamura W, Shinohara M, Shirasuna K: Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren's syndrome. J Rheumatol. 2002, 29: 1884-1896.PubMed Tsunawaki S, Nakamura S, Ohyama Y, Sasaki M, Ikebe-Hiroki A, Hiraki A, Kadena T, Kawamura W, Shinohara M, Shirasuna K: Possible function of salivary gland epithelial cells as nonprofessional antigen-presenting cells in the development of Sjögren's syndrome. J Rheumatol. 2002, 29: 1884-1896.PubMed
50.
Zurück zum Zitat Vogelsang P, Jonsson MV, Dalvin ST, Appel S: Role of dendritic cells in Sjögren's syndrome. Scand J Immunol. 2006, 64: 219-226. 10.1111/j.1365-3083.2006.01811.x.PubMed Vogelsang P, Jonsson MV, Dalvin ST, Appel S: Role of dendritic cells in Sjögren's syndrome. Scand J Immunol. 2006, 64: 219-226. 10.1111/j.1365-3083.2006.01811.x.PubMed
51.
Zurück zum Zitat Dimitrou ID, Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN: CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjögren's syndrome patients indicating their intrinsic activation. Clin Exp Immunol. 2002, 127: 386-392. 10.1046/j.1365-2249.2002.01752.x. Dimitrou ID, Kapsogeorgou EK, Moutsopoulos HM, Manoussakis MN: CD40 on salivary gland epithelial cells: high constitutive expression by cultured cells from Sjögren's syndrome patients indicating their intrinsic activation. Clin Exp Immunol. 2002, 127: 386-392. 10.1046/j.1365-2249.2002.01752.x.
52.
Zurück zum Zitat Ohlsson M, Szodoray P, Loro LL, Johanessen AC, Jonsson R: CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Scand J Immunol. 2002, 56: 561-571. 10.1046/j.1365-3083.2002.01168.x.PubMed Ohlsson M, Szodoray P, Loro LL, Johanessen AC, Jonsson R: CD40, CD154, Bax and Bcl-2 expression in Sjögren's syndrome salivary glands: a putative anti-apoptotic role during its effector phases. Scand J Immunol. 2002, 56: 561-571. 10.1046/j.1365-3083.2002.01168.x.PubMed
53.
Zurück zum Zitat Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, et al: Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest. 2002, 109: 59-68. 10.1172/JCI200214121.PubMedCentralPubMed Groom J, Kalled SL, Cutler AH, Olson C, Woodcock SA, Schneider P, Tschopp J, Cachero TG, Batten M, Wheway J, et al: Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome. J Clin Invest. 2002, 109: 59-68. 10.1172/JCI200214121.PubMedCentralPubMed
54.
Zurück zum Zitat Ittah M, Miceli-Richard C, Gottenberg JE, Lavie F, Lazure T, Ba N, Sellam J, Lepajolec C, Mariette X: B-cell activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome. Arthritis Res Ther. 2006, 8: R51-10.1186/ar1912.PubMedCentralPubMed Ittah M, Miceli-Richard C, Gottenberg JE, Lavie F, Lazure T, Ba N, Sellam J, Lepajolec C, Mariette X: B-cell activating factor of the tumor necrosis factor family (BAFF) is expressed under stimulation by interferon in salivary gland epithelial cells in primary Sjögren's syndrome. Arthritis Res Ther. 2006, 8: R51-10.1186/ar1912.PubMedCentralPubMed
55.
Zurück zum Zitat Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X: Expression of BAFF (BLys) in T cell infiltrating labial salivary glands from patients with Sjögren's syndrome. J Pathol. 2004, 202: 496-502. 10.1002/path.1533.PubMed Lavie F, Miceli-Richard C, Quillard J, Roux S, Leclerc P, Mariette X: Expression of BAFF (BLys) in T cell infiltrating labial salivary glands from patients with Sjögren's syndrome. J Pathol. 2004, 202: 496-502. 10.1002/path.1533.PubMed
56.
Zurück zum Zitat Kelsoe G: Life and death in germinal centers (Redux). Immunity. 1996, 4: 107-111. 10.1016/S1074-7613(00)80675-5.PubMed Kelsoe G: Life and death in germinal centers (Redux). Immunity. 1996, 4: 107-111. 10.1016/S1074-7613(00)80675-5.PubMed
57.
Zurück zum Zitat Nanki T, Hayashida K, El-Gabalawy HS, Suson S, Shi K, Girschick HJ, Yavuz S, Lipsky PE: Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol. 2000, 165: 6590-6598.PubMed Nanki T, Hayashida K, El-Gabalawy HS, Suson S, Shi K, Girschick HJ, Yavuz S, Lipsky PE: Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium. J Immunol. 2000, 165: 6590-6598.PubMed
58.
Zurück zum Zitat Shi K, Hayashida K, Kaneko M, Hashimoto J, Tomita T, Lipsky PE, Yoshikawa H, Ochi T: Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol. 2001, 166: 650-655.PubMed Shi K, Hayashida K, Kaneko M, Hashimoto J, Tomita T, Lipsky PE, Yoshikawa H, Ochi T: Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patients. J Immunol. 2001, 166: 650-655.PubMed
59.
Zurück zum Zitat Weyand CM, Kurtin PJ, Goronzy JJ: Ectopic lymphoid organogenesis. A fast track for autoimmunity. Am J Pathol. 2001, 159: 787-793.PubMedCentralPubMed Weyand CM, Kurtin PJ, Goronzy JJ: Ectopic lymphoid organogenesis. A fast track for autoimmunity. Am J Pathol. 2001, 159: 787-793.PubMedCentralPubMed
60.
Zurück zum Zitat Cupedo T, Mebius RE: Role of chemokines in the development of secondary and tertiary lymphoid tissues. Semin Immunol. 2003, 15: 243-248. 10.1016/j.smim.2003.08.002.PubMed Cupedo T, Mebius RE: Role of chemokines in the development of secondary and tertiary lymphoid tissues. Semin Immunol. 2003, 15: 243-248. 10.1016/j.smim.2003.08.002.PubMed
61.
Zurück zum Zitat Manthorpe R, Benoni C, Jacobsson L, Kirtava Z, Larsson A, Riedholm R, Nyhagen C, Tabery H, Theander E: Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjögren's syndrome?. Ann Rheum Dis. 2000, 59: 54-60. 10.1136/ard.59.1.54.PubMedCentralPubMed Manthorpe R, Benoni C, Jacobsson L, Kirtava Z, Larsson A, Riedholm R, Nyhagen C, Tabery H, Theander E: Lower frequency of focal lip sialadenitis (focus score) in smoking patients. Can tobacco diminish the salivary gland involvement as judged by histological examination and anti-SSA/Ro and anti-SSB/La antibodies in Sjögren's syndrome?. Ann Rheum Dis. 2000, 59: 54-60. 10.1136/ard.59.1.54.PubMedCentralPubMed
62.
Zurück zum Zitat Wise CM, Woodruff RD: Minor salivary gland biopsies in patients investigated for primary Sjögren's syndrome. A review of 187 patients. J Rheumatol. 1993, 20: 1515-1518.PubMed Wise CM, Woodruff RD: Minor salivary gland biopsies in patients investigated for primary Sjögren's syndrome. A review of 187 patients. J Rheumatol. 1993, 20: 1515-1518.PubMed
63.
Zurück zum Zitat Hyjek E, Smith WJ, Isaacson PG: Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988, 19: 766-776. 10.1016/S0046-8177(88)80259-4.PubMed Hyjek E, Smith WJ, Isaacson PG: Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988, 19: 766-776. 10.1016/S0046-8177(88)80259-4.PubMed
64.
Zurück zum Zitat Jaffe ES: Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002, 15: 255-263. 10.1038/modpathol.3880521.PubMed Jaffe ES: Lymphoid lesions of the head and neck: a model of lymphocyte homing and lymphomagenesis. Mod Pathol. 2002, 15: 255-263. 10.1038/modpathol.3880521.PubMed
65.
Zurück zum Zitat Ioannidis JP, Vassiliou VA, Moutsopoulos HM: Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome. Arthritis Rheum. 2002, 46: 741-747. 10.1002/art.10221.PubMed Ioannidis JP, Vassiliou VA, Moutsopoulos HM: Long-term risk of mortality and lymphoproliferative disease and predictive classification of primary Sjögren's syndrome. Arthritis Rheum. 2002, 46: 741-747. 10.1002/art.10221.PubMed
66.
Zurück zum Zitat Xu KP, Katagiri S, Takeuchi T, Tsubota K: Biopsy of labial salivary glands and lacrimal glands in the diagnosis of Sjögren's syndrome. J Rheumatol. 1997, 23: 76-82. Xu KP, Katagiri S, Takeuchi T, Tsubota K: Biopsy of labial salivary glands and lacrimal glands in the diagnosis of Sjögren's syndrome. J Rheumatol. 1997, 23: 76-82.
67.
Zurück zum Zitat Pijpe J, Kalk WW, van der Wal JE, Vissink A, Kluin PM, Roodenburg JL, Bootsma H, Kallenberg CG, Spijkervert FK: Parotid gland biopsy compared to labial biopsy in the diagnosis of patients with primary Sjögren's syndrome. Rheumatology. Pijpe J, Kalk WW, van der Wal JE, Vissink A, Kluin PM, Roodenburg JL, Bootsma H, Kallenberg CG, Spijkervert FK: Parotid gland biopsy compared to labial biopsy in the diagnosis of patients with primary Sjögren's syndrome. Rheumatology.
68.
Zurück zum Zitat Dörner T, Lipsky PE: Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome. Arthritis Res. 2002, 4: 360-371. 10.1186/ar603.PubMedCentralPubMed Dörner T, Lipsky PE: Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome. Arthritis Res. 2002, 4: 360-371. 10.1186/ar603.PubMedCentralPubMed
69.
Zurück zum Zitat Potter KN, Mockridge CI, Rahman A, Buchan S, Hamblin T, Davidson B, Isenberg DA, Stevenson FK: Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus. 2002, 11: 872-877. 10.1191/0961203302lu309oa.PubMed Potter KN, Mockridge CI, Rahman A, Buchan S, Hamblin T, Davidson B, Isenberg DA, Stevenson FK: Disturbances in peripheral blood B cell subpopulations in autoimmune patients. Lupus. 2002, 11: 872-877. 10.1191/0961203302lu309oa.PubMed
70.
Zurück zum Zitat Klein U, Rajewsky K, Küppers R: Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med. 1998, 188: 1679-1689. 10.1084/jem.188.9.1679.PubMedCentralPubMed Klein U, Rajewsky K, Küppers R: Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J Exp Med. 1998, 188: 1679-1689. 10.1084/jem.188.9.1679.PubMedCentralPubMed
71.
Zurück zum Zitat Agematsu K, Nagumo H, Yang FC, Nakazawa T, Fukushima K, Ito S, Sugita K, Mori T, Kobata T, Morimoto C: B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol. 1997, 27: 2073-2079. 10.1002/eji.1830270835.PubMed Agematsu K, Nagumo H, Yang FC, Nakazawa T, Fukushima K, Ito S, Sugita K, Mori T, Kobata T, Morimoto C: B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol. 1997, 27: 2073-2079. 10.1002/eji.1830270835.PubMed
72.
Zurück zum Zitat Shinozaki K, Yasui K, Agematsu K: Direct B/B-cell interactions in immunoglobulin synthesis. Clin Exp Immunol. 2001, 124: 386-391. 10.1046/j.1365-2249.2001.01518.x.PubMedCentralPubMed Shinozaki K, Yasui K, Agematsu K: Direct B/B-cell interactions in immunoglobulin synthesis. Clin Exp Immunol. 2001, 124: 386-391. 10.1046/j.1365-2249.2001.01518.x.PubMedCentralPubMed
73.
Zurück zum Zitat Nagumo H, Agematsu K, Kobayashi N, Shinozaki K, Hokibara S, Nagase H, Takamoto M, Yasui K, Sugane K, Komiyama A: The different process of class switching and somatic hypermutation; a novel analysis by CD27- naive B cells. Blood. 2002, 99: 567-575. 10.1182/blood.V99.2.567.PubMed Nagumo H, Agematsu K, Kobayashi N, Shinozaki K, Hokibara S, Nagase H, Takamoto M, Yasui K, Sugane K, Komiyama A: The different process of class switching and somatic hypermutation; a novel analysis by CD27- naive B cells. Blood. 2002, 99: 567-575. 10.1182/blood.V99.2.567.PubMed
74.
Zurück zum Zitat Odendahl M, Mei H, Hoyer BF, Jacobi AM, Hansen A, Radbruch A, Dörner T: Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood. 2005, 105: 1614-1621. 10.1182/blood-2004-07-2507.PubMed Odendahl M, Mei H, Hoyer BF, Jacobi AM, Hansen A, Radbruch A, Dörner T: Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response. Blood. 2005, 105: 1614-1621. 10.1182/blood-2004-07-2507.PubMed
75.
Zurück zum Zitat Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dörner T: Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol. 2000, 165: 5970-5979.PubMed Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dörner T: Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol. 2000, 165: 5970-5979.PubMed
76.
Zurück zum Zitat Jacobi AM, Odendahl M, Reiter K, Bruns A, Burmester GR, Radbruch A, Valet G, Lipsky PE, Dörner T: Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2003, 48: 1332-1342. 10.1002/art.10949.PubMed Jacobi AM, Odendahl M, Reiter K, Bruns A, Burmester GR, Radbruch A, Valet G, Lipsky PE, Dörner T: Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2003, 48: 1332-1342. 10.1002/art.10949.PubMed
77.
Zurück zum Zitat Mandl T, Bredberg A, Jacobsson LT, Manthorpe R, Henriksson G: CD4+ lymphopenia – a frequent finding in anti-SSA antibody seropositive patients with primary Sjögren's syndrome. J Rheumatol. 2004, 31: 726-728.PubMed Mandl T, Bredberg A, Jacobsson LT, Manthorpe R, Henriksson G: CD4+ lymphopenia – a frequent finding in anti-SSA antibody seropositive patients with primary Sjögren's syndrome. J Rheumatol. 2004, 31: 726-728.PubMed
78.
Zurück zum Zitat Gellrich S, Rutz S, Borkowski A, Golembowski S, Gromnica-Ihle E, Sterry W, Jahn S: Analysis of VH-D-JH gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sjögren's syndrome. Arthritis Rheum. 1999, 42: 240-247. 10.1002/1529-0131(199902)42:2<240::AID-ANR5>3.0.CO;2-I.PubMed Gellrich S, Rutz S, Borkowski A, Golembowski S, Gromnica-Ihle E, Sterry W, Jahn S: Analysis of VH-D-JH gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sjögren's syndrome. Arthritis Rheum. 1999, 42: 240-247. 10.1002/1529-0131(199902)42:2<240::AID-ANR5>3.0.CO;2-I.PubMed
79.
Zurück zum Zitat Hansen A, Jacobi A, Pruss A, Kaufmann O, Scholze J, Lipsky PE, Dörner T: Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjögren's syndrome. Scand J Immunol. 2003, 57: 470-479. 10.1046/j.1365-3083.2003.01226.x.PubMed Hansen A, Jacobi A, Pruss A, Kaufmann O, Scholze J, Lipsky PE, Dörner T: Comparison of immunoglobulin heavy chain rearrangements between peripheral and glandular B cells in a patient with primary Sjögren's syndrome. Scand J Immunol. 2003, 57: 470-479. 10.1046/j.1365-3083.2003.01226.x.PubMed
80.
Zurück zum Zitat Jacobi AM, Hansen A, Kaufmann O, Burmester GR, Lipsky PE, Dörner T: Analysis of immunglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome. Arthritis Res. 2002, 4: R4-10.1186/ar423.PubMedCentralPubMed Jacobi AM, Hansen A, Kaufmann O, Burmester GR, Lipsky PE, Dörner T: Analysis of immunglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome. Arthritis Res. 2002, 4: R4-10.1186/ar423.PubMedCentralPubMed
81.
Zurück zum Zitat Ansel KM, Ngo VN, Hyman PL, Luther SA, Forster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG: A chemokine-driven feedback loop organizes lymphoid follicles. Nature. 2000, 406: 309-314. 10.1038/35018581.PubMed Ansel KM, Ngo VN, Hyman PL, Luther SA, Forster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG: A chemokine-driven feedback loop organizes lymphoid follicles. Nature. 2000, 406: 309-314. 10.1038/35018581.PubMed
82.
Zurück zum Zitat Dörner T, Lipsky PE: Signalling pathways in B cells: implications for autoimmunity. Curr Top Microbiol Immunol. 2006, 305: 213-240.PubMed Dörner T, Lipsky PE: Signalling pathways in B cells: implications for autoimmunity. Curr Top Microbiol Immunol. 2006, 305: 213-240.PubMed
83.
Zurück zum Zitat Horsfall AC, Rose LM, Maini RN: Autoantibodiy synthesis in salivary glands of Sjögren's syndrome patients. J Autoimmun. 1989, 2: 554-568. 10.1016/0896-8411(89)90189-3. Horsfall AC, Rose LM, Maini RN: Autoantibodiy synthesis in salivary glands of Sjögren's syndrome patients. J Autoimmun. 1989, 2: 554-568. 10.1016/0896-8411(89)90189-3.
84.
Zurück zum Zitat Berra A, Sterin-Borda L, Bacman S, Borda E: Role of salivary IgA in the pathogenesis of Sjögren syndrome. Clin Immunol. 2002, 104: 49-57. 10.1006/clim.2002.5228.PubMed Berra A, Sterin-Borda L, Bacman S, Borda E: Role of salivary IgA in the pathogenesis of Sjögren syndrome. Clin Immunol. 2002, 104: 49-57. 10.1006/clim.2002.5228.PubMed
85.
Zurück zum Zitat Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Purin GJM: The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death Differ. 1999, 6: 976-986. 10.1038/sj.cdd.4400571.PubMed Rutjes SA, Utz PJ, van der Heijden A, Broekhuis C, van Venrooij WJ, Purin GJM: The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis. Cell Death Differ. 1999, 6: 976-986. 10.1038/sj.cdd.4400571.PubMed
86.
Zurück zum Zitat Ohlsson M, Jonsson R, Brokstad KA: Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigens during apoptosis in human ductal epithelial cells: a possible mechanism in the pathogenesis of Sjögren's syndrome. Scand J Immunol. 2002, 56: 456-469. 10.1046/j.1365-3083.2002.01072_79.x.PubMed Ohlsson M, Jonsson R, Brokstad KA: Subcellular redistribution and surface exposure of the Ro52, Ro60 and La48 autoantigens during apoptosis in human ductal epithelial cells: a possible mechanism in the pathogenesis of Sjögren's syndrome. Scand J Immunol. 2002, 56: 456-469. 10.1046/j.1365-3083.2002.01072_79.x.PubMed
87.
Zurück zum Zitat Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Mohamed O, Nyberg F, et al: The Sjögren's syndrome-associated autoantigen Ro 52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006, 176: 6277-6285.PubMed Espinosa A, Zhou W, Ek M, Hedlund M, Brauner S, Popovic K, Horvath L, Wallerskog T, Mohamed O, Nyberg F, et al: The Sjögren's syndrome-associated autoantigen Ro 52 is an E3 ligase that regulates proliferation and cell death. J Immunol. 2006, 176: 6277-6285.PubMed
88.
Zurück zum Zitat Namekawa T, Kuroda K, Kato T, Yamamoto K, Murata H, Sakamaki T, Nishioka K, Iwamoto I, Saitoh Y, Sumida T: Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol. 1995, 22: 2092-2099.PubMed Namekawa T, Kuroda K, Kato T, Yamamoto K, Murata H, Sakamaki T, Nishioka K, Iwamoto I, Saitoh Y, Sumida T: Identification of Ro(SSA) 52 kDa reactive T cells in labial salivary glands from patients with Sjögren's syndrome. J Rheumatol. 1995, 22: 2092-2099.PubMed
89.
Zurück zum Zitat Tengnér P, Halse AK, Haga HJ, Jonsson R, Wahren-Herlenius M: Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum. 1998, 41: 2238-2248. 10.1002/1529-0131(199812)41:12<2238::AID-ART20>3.0.CO;2-V.PubMed Tengnér P, Halse AK, Haga HJ, Jonsson R, Wahren-Herlenius M: Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome. Arthritis Rheum. 1998, 41: 2238-2248. 10.1002/1529-0131(199812)41:12<2238::AID-ART20>3.0.CO;2-V.PubMed
90.
Zurück zum Zitat Weller S, Faili A, Garcia C, Braun MC, Le Deist FF, de Saint Basile GG, Hermine O, Fischer A, Reynaud CA, Weill JC: CD40–CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci USA. 2001, 98: 1166-1170. 10.1073/pnas.98.3.1166.PubMedCentralPubMed Weller S, Faili A, Garcia C, Braun MC, Le Deist FF, de Saint Basile GG, Hermine O, Fischer A, Reynaud CA, Weill JC: CD40–CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans. Proc Natl Acad Sci USA. 2001, 98: 1166-1170. 10.1073/pnas.98.3.1166.PubMedCentralPubMed
91.
Zurück zum Zitat Obukhanych TV, Nussenzweig MC: T-independent type II immune responses generate memory B cells. J Exp Med. 2006, 203: 305-310. 10.1084/jem.20052036.PubMedCentralPubMed Obukhanych TV, Nussenzweig MC: T-independent type II immune responses generate memory B cells. J Exp Med. 2006, 203: 305-310. 10.1084/jem.20052036.PubMedCentralPubMed
92.
Zurück zum Zitat Ng LG, Ng CH, Woehl B, Sutherland AP, Huo J, Xu S, Mackay F, Lam KP: BAFF costimulation of Toll-like receptor-activated B1 cells. Eur J Immunol. 2006, 36: 1837-1846. 10.1002/eji.200635956.PubMed Ng LG, Ng CH, Woehl B, Sutherland AP, Huo J, Xu S, Mackay F, Lam KP: BAFF costimulation of Toll-like receptor-activated B1 cells. Eur J Immunol. 2006, 36: 1837-1846. 10.1002/eji.200635956.PubMed
93.
Zurück zum Zitat Dörner T, Egerer K, Feist E, Burmester GR: Rheumatoid factor revisited. Curr Opin Rheumatol. 2004, 16: 246-253. 10.1097/00002281-200405000-00013.PubMed Dörner T, Egerer K, Feist E, Burmester GR: Rheumatoid factor revisited. Curr Opin Rheumatol. 2004, 16: 246-253. 10.1097/00002281-200405000-00013.PubMed
94.
Zurück zum Zitat Deacon EM, Matthews JB, Potts AJ, Hamburger J, Mageed RA, Jefferis R: Expression of rheumatoid factor associated cross-reactive idiotypes by glandular B cells in Sjögren's syndrome. Clin Exp Immunol. 1991, 83: 280-285.PubMedCentralPubMed Deacon EM, Matthews JB, Potts AJ, Hamburger J, Mageed RA, Jefferis R: Expression of rheumatoid factor associated cross-reactive idiotypes by glandular B cells in Sjögren's syndrome. Clin Exp Immunol. 1991, 83: 280-285.PubMedCentralPubMed
95.
Zurück zum Zitat Kipps TJ, Tomhave E, Chen PP, Fox RI: Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjögren's syndrome. J Immunol. 1989, 142: 4261-4268.PubMed Kipps TJ, Tomhave E, Chen PP, Fox RI: Molecular characterization of a major autoantibody-associated cross-reactive idiotype in Sjögren's syndrome. J Immunol. 1989, 142: 4261-4268.PubMed
96.
Zurück zum Zitat Miklos JA, Swerdlow SH, Bahler DW: Salivary gland mucosa associated lymphoid tissue lymphoma immunoglobulin VH genes show frequent use of V1-69 with distinctive CDR3 features. Blood. 2000, 95: 3878-3884.PubMed Miklos JA, Swerdlow SH, Bahler DW: Salivary gland mucosa associated lymphoid tissue lymphoma immunoglobulin VH genes show frequent use of V1-69 with distinctive CDR3 features. Blood. 2000, 95: 3878-3884.PubMed
97.
Zurück zum Zitat Martin T, Weber JC, Levallois H, Labouret N, Soley A, Koenig S, Korganow AS, Pasquali JC: Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. Arthritis Rheum. 2000, 43: 908-916. 10.1002/1529-0131(200004)43:4<908::AID-ANR24>3.0.CO;2-K.PubMed Martin T, Weber JC, Levallois H, Labouret N, Soley A, Koenig S, Korganow AS, Pasquali JC: Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells. Arthritis Rheum. 2000, 43: 908-916. 10.1002/1529-0131(200004)43:4<908::AID-ANR24>3.0.CO;2-K.PubMed
98.
Zurück zum Zitat Hansen A, Reiter K, Pruss A, Loddenkemper C, Kaufmann O, Jacobi AM, Scholze J, Lipsky PE, Dörner T: Dissemination of a Sjögren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutational pattern of nodal Ig heavy and light chain variable-region gene rearrangements. Arthritis Rheum. 2006, 54: 127-137. 10.1002/art.21558.PubMed Hansen A, Reiter K, Pruss A, Loddenkemper C, Kaufmann O, Jacobi AM, Scholze J, Lipsky PE, Dörner T: Dissemination of a Sjögren's syndrome-associated extranodal marginal-zone B cell lymphoma: circulating lymphoma cells and invariant mutational pattern of nodal Ig heavy and light chain variable-region gene rearrangements. Arthritis Rheum. 2006, 54: 127-137. 10.1002/art.21558.PubMed
99.
Zurück zum Zitat Tzioufas AG, Boumba DS, Skopouli FN, Moutsopoulos HM: Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjögren's syndrome. Arthritis Rheum. 1996, 39: 767-772. 10.1002/art.1780390508.PubMed Tzioufas AG, Boumba DS, Skopouli FN, Moutsopoulos HM: Mixed monoclonal cryoglobulinemia and monoclonal rheumatoid factor cross-reactive idiotypes as predictive factors for the development of lymphoma in primary Sjögren's syndrome. Arthritis Rheum. 1996, 39: 767-772. 10.1002/art.1780390508.PubMed
100.
Zurück zum Zitat Voulgarelis M, Dafni UG, Isenberg DA, Moutsopoulos HM, the members of the European Concerted Action on Sjögren's syndrome: Malignant lymphoma in primary Sjögren's syndrome. A multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's syndrome. Arthritis Rheum. 1999, 42: 1765-1772. 10.1002/1529-0131(199908)42:8<1765::AID-ANR28>3.0.CO;2-V.PubMed Voulgarelis M, Dafni UG, Isenberg DA, Moutsopoulos HM, the members of the European Concerted Action on Sjögren's syndrome: Malignant lymphoma in primary Sjögren's syndrome. A multicenter, retrospective, clinical study by the European Concerted Action on Sjögren's syndrome. Arthritis Rheum. 1999, 42: 1765-1772. 10.1002/1529-0131(199908)42:8<1765::AID-ANR28>3.0.CO;2-V.PubMed
101.
Zurück zum Zitat Theander E, Manthorpe R, Jacobsson LTH: Mortality and causes of death in primary Sjögren's syndrome. A prospective cohort study. Arthritis Rheum. 2004, 50: 1262-1269. 10.1002/art.20176.PubMed Theander E, Manthorpe R, Jacobsson LTH: Mortality and causes of death in primary Sjögren's syndrome. A prospective cohort study. Arthritis Rheum. 2004, 50: 1262-1269. 10.1002/art.20176.PubMed
102.
Zurück zum Zitat Tsuiji M, Yurasov S, Velinzon K, Thomas S, Nussenzweig MC, Wardemann H: A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med. 2006, 203: 293-400. 10.1084/jem.20052033. Tsuiji M, Yurasov S, Velinzon K, Thomas S, Nussenzweig MC, Wardemann H: A checkpoint for autoreactivity in human IgM+ memory B cell development. J Exp Med. 2006, 203: 293-400. 10.1084/jem.20052033.
103.
Zurück zum Zitat Sutherland AP, Mackay F, Mackay CR: Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. Pharmacol Ther. 2006, 112: 774-786. 10.1016/j.pharmthera.2006.06.002.PubMed Sutherland AP, Mackay F, Mackay CR: Targeting BAFF: immunomodulation for autoimmune diseases and lymphomas. Pharmacol Ther. 2006, 112: 774-786. 10.1016/j.pharmthera.2006.06.002.PubMed
104.
Zurück zum Zitat Martin F, Dixit VM: Unraveling TACIt functions. Nat Genet. 2005, 37: 793-794. 10.1038/ng0805-793.PubMed Martin F, Dixit VM: Unraveling TACIt functions. Nat Genet. 2005, 37: 793-794. 10.1038/ng0805-793.PubMed
105.
Zurück zum Zitat Szodoray P, Jellestad S, Alex P, Zhou T, Wilson PC, Centola M, Brun JG, Jonsson R: Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjögren's syndrome with special emphasis on BAFF. J Clin Immunol. 2004, 24: 600-611. 10.1007/s10875-004-6240-7.PubMed Szodoray P, Jellestad S, Alex P, Zhou T, Wilson PC, Centola M, Brun JG, Jonsson R: Programmed cell death of peripheral blood B cells determined by laser scanning cytometry in Sjögren's syndrome with special emphasis on BAFF. J Clin Immunol. 2004, 24: 600-611. 10.1007/s10875-004-6240-7.PubMed
106.
Zurück zum Zitat Mariette X, Roux S, Zhang J, Bengoufa D, Lavie F, Zhou T, Kimberly R: The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome. Ann Rheum Dis. 2003, 62: 168-171. 10.1136/ard.62.2.168.PubMedCentralPubMed Mariette X, Roux S, Zhang J, Bengoufa D, Lavie F, Zhou T, Kimberly R: The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome. Ann Rheum Dis. 2003, 62: 168-171. 10.1136/ard.62.2.168.PubMedCentralPubMed
107.
Zurück zum Zitat Batten M, Fletcher C, Ng LG, Groom J, Wheway J, Laabi Y, Xin X, Schneider P, Tschopp J, Mackay GR, et al: TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol. 2004, 172: 812-822.PubMed Batten M, Fletcher C, Ng LG, Groom J, Wheway J, Laabi Y, Xin X, Schneider P, Tschopp J, Mackay GR, et al: TNF deficiency fails to protect BAFF transgenic mice against autoimmunity and reveals a predisposition to B cell lymphoma. J Immunol. 2004, 172: 812-822.PubMed
108.
Zurück zum Zitat Manoussakis MN, Tzioufas AG, Pange PJE, Moutsopoulos HM: Serologic profiles in subgroups of patients with Sjögren's syndrome. Scand J Rheumatol. 1986, 61: 89-92. Manoussakis MN, Tzioufas AG, Pange PJE, Moutsopoulos HM: Serologic profiles in subgroups of patients with Sjögren's syndrome. Scand J Rheumatol. 1986, 61: 89-92.
109.
Zurück zum Zitat Radbruch A, Muehlinghaus G, Luger EO, Inamine A, Smith KG, Dörner T, Hiepe F: Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol. 2006, 6: 741-750. 10.1038/nri1886.PubMed Radbruch A, Muehlinghaus G, Luger EO, Inamine A, Smith KG, Dörner T, Hiepe F: Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol. 2006, 6: 741-750. 10.1038/nri1886.PubMed
110.
Zurück zum Zitat Wahren M, Skarstein K, Blange I, Petterson I, Jonsson R: MRL/lpr mice produce anti-Ro 52,000 MW antibodies: detection, analysis of specificity and site of production. Immunology. 1994, 83: 9-15.PubMedCentralPubMed Wahren M, Skarstein K, Blange I, Petterson I, Jonsson R: MRL/lpr mice produce anti-Ro 52,000 MW antibodies: detection, analysis of specificity and site of production. Immunology. 1994, 83: 9-15.PubMedCentralPubMed
111.
Zurück zum Zitat Heimbächer C, Hansen A, Pruss A, Jacobi A, Reiter K, Lipsky PE, Dörner T: Immunoglobulin Vκ light chain analysis in patients with Sjögren's syndrome. Arthritis Rheum. 2001, 44: 626-637. 10.1002/1529-0131(200103)44:3<626::AID-ANR111>3.0.CO;2-T.PubMed Heimbächer C, Hansen A, Pruss A, Jacobi A, Reiter K, Lipsky PE, Dörner T: Immunoglobulin Vκ light chain analysis in patients with Sjögren's syndrome. Arthritis Rheum. 2001, 44: 626-637. 10.1002/1529-0131(200103)44:3<626::AID-ANR111>3.0.CO;2-T.PubMed
112.
Zurück zum Zitat Kaschner S, Hansen A, Jacobi A, Reiter K, Monson NL, Odendahl M, Burmester GR, Lipsky PE, Dörner T: Immunoglobulin Vλ light chain gene usage in patients with Sjögren's syndrome. Arthritis Rheum. 2001, 44: 2620-2632. 10.1002/1529-0131(200111)44:11<2620::AID-ART442>3.0.CO;2-M.PubMed Kaschner S, Hansen A, Jacobi A, Reiter K, Monson NL, Odendahl M, Burmester GR, Lipsky PE, Dörner T: Immunoglobulin Vλ light chain gene usage in patients with Sjögren's syndrome. Arthritis Rheum. 2001, 44: 2620-2632. 10.1002/1529-0131(200111)44:11<2620::AID-ART442>3.0.CO;2-M.PubMed
113.
Zurück zum Zitat Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L: Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in clonal expansion. Leukemia. 1996, 10: 1190-1197.PubMed Du M, Diss TC, Xu C, Peng H, Isaacson PG, Pan L: Ongoing mutation in MALT lymphoma immunoglobulin gene suggests that antigen stimulation plays a role in clonal expansion. Leukemia. 1996, 10: 1190-1197.PubMed
114.
Zurück zum Zitat Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T: Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000, 102: 553-563. 10.1016/S0092-8674(00)00078-7.PubMed Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T: Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell. 2000, 102: 553-563. 10.1016/S0092-8674(00)00078-7.PubMed
115.
Zurück zum Zitat Bertorello R, Cordone MP, Contini P, Rossi P, Indiveri F, Puppo F, Cordone G: Increased levels of interleukin-10 in saliva of Sjögren's syndrome patients. Correlation with disease activity. Clin Exp Med. 2004, 4: 148-151. 10.1007/s10238-004-0049-9.PubMed Bertorello R, Cordone MP, Contini P, Rossi P, Indiveri F, Puppo F, Cordone G: Increased levels of interleukin-10 in saliva of Sjögren's syndrome patients. Correlation with disease activity. Clin Exp Med. 2004, 4: 148-151. 10.1007/s10238-004-0049-9.PubMed
116.
Zurück zum Zitat Steinfeld SD, Tant L, Burmester GR, Teoh NK, Wegener WA, Goldenberg DM, Pradier O: Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase I/II study. Arthritis Res Ther. 2006, 8: R129-10.1186/ar2018.PubMedCentralPubMed Steinfeld SD, Tant L, Burmester GR, Teoh NK, Wegener WA, Goldenberg DM, Pradier O: Epratuzumab (humanised anti-CD22 antibody) in primary Sjögren's syndrome: an open-label phase I/II study. Arthritis Res Ther. 2006, 8: R129-10.1186/ar2018.PubMedCentralPubMed
117.
Zurück zum Zitat Pijpe J, van Imhoff GW, Spijkervet FK, Roodenburg JL, Wolbink GJ, Mansour K, Vissink A, Kallenberg CG, Bootsma H: Rituximab treatment in patients with Sjögren's syndrome: an open-label phase II study. Arthritis Rheum. 2005, 52: 2740-2750. 10.1002/art.21260.PubMed Pijpe J, van Imhoff GW, Spijkervet FK, Roodenburg JL, Wolbink GJ, Mansour K, Vissink A, Kallenberg CG, Bootsma H: Rituximab treatment in patients with Sjögren's syndrome: an open-label phase II study. Arthritis Rheum. 2005, 52: 2740-2750. 10.1002/art.21260.PubMed
Metadaten
Titel
B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue
verfasst von
Arne Hansen
Peter E Lipsky
Thomas Dörner
Publikationsdatum
01.08.2007
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 4/2007
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar2210

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