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Arthritis Research & Therapy

Erschienen in:

01.04.2008 | Review

Recent developments in the immunobiology of rheumatoid arthritis

verfasst von: Anna K Andersson, Ching Li, Fionula M Brennan

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2008

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Abstract

Progress into the understanding of immunopathology in rheumatoid arthritis is reviewed in the present article with regard to pro-inflammatory cytokine production, cell activation and recruitment, and osteoclastogenesis. Studies highlight the potential importance of T helper 17 cells and regulatory T cells in driving and suppressing inflammation in rheumatoid arthritis, respectively, and highlight other potential T-cell therapeutic targets. The genetic associations of the HLA shared epitope alleles with antibodies to citrullinated peptides in rheumatoid arthritis patients indicate that T cells are providing help to B cells to produce autoantibodies, and there is increasing evidence that these autoantibodies are pathogenic in rheumatoid arthritis.

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Titel: Recent developments in the immunobiology of rheumatoid arthritis
verfasst von: Anna K Andersson
Ching Li
Fionula M Brennan
Publikationsdatum: 01.04.2008
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2008
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2370

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