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Arthritis Research & Therapy

Erschienen in:

01.10.2009 | Review

B cells in autoimmunity

verfasst von: Thomas Dörner, Annett M Jacobi, Peter E Lipsky

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2009

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Abstract

B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functions of B cells as well as their roles in human autoimmune diseases. The current review addresses the role of certain stages of B-cell development as well as plasmablasts/plasma cells in immune regulation under normal and autoimmune conditions with particular emphasis on systemic lupus erythematosus. Based on preclinical and clinical data, B cells have emerged increasingly as both effector cells as well as cells with immunoregulatory potential.

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Titel: B cells in autoimmunity
verfasst von: Thomas Dörner
Annett M Jacobi
Peter E Lipsky
Publikationsdatum: 01.10.2009
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 5/2009
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2780

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