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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2001

01.03.2001 | Commentary

The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity

verfasst von: Argyrios N Theofilopoulos, Stefanos Koundouris, Dwight H Kono, Brian R Lawson

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2001

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Abstract

The classification of T helper cells into type 1 (Th1) and type 2 (Th2) led to the hypothesis that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-γ) are involved in cell-mediated autoimmune diseases, and that Th2 cells and their cytokines (IL-4, IL-5, IL-10, IL-13) are involved in autoantibody(humoral)-mediated autoimmune diseases. However, this paradigm has been refuted by recent studies in several induced and spontaneous mouse models of systemic lupus erythematosus, which showed that IFN-γ is a major effector molecule in this disease. These and additional findings, reviewed here, suggest that these two cross-talking classes of cytokines can exert autoimmune disease-promoting or disease-inhibiting effects without predictability or strict adherence to the Th1-versus-Th2 dualism.
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Metadaten
Titel
The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
verfasst von
Argyrios N Theofilopoulos
Stefanos Koundouris
Dwight H Kono
Brian R Lawson
Publikationsdatum
01.03.2001
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2001
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar290

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