Skip to main content
Erschienen in: Arthritis Research & Therapy 5/2010

01.10.2010 | Editorial

Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?

verfasst von: Steven R Goldring, Mary B Goldring

Erschienen in: Arthritis Research & Therapy | Ausgabe 5/2010

Einloggen, um Zugang zu erhalten

Abstract

The interest in the relationship between articular cartilage and the structural and functional properties of peri-articular bone relates to the intimate contact that exists between these tissues in joints that are susceptible to the development of osteoarthritis (OA). The demonstration in several animal models that osteoporosis and decreased bone tissue modulus leads to an increased propensity for the development of post-traumatic OA is paradoxical in light of the extensive epidemiological literature indicating that individuals with high systemic bone mass, assessed by bone mineral density, are at increased risk for OA. These observations underscore the need for further studies to define the pathophysiological mechanisms involved in the interaction between subchondral bone and articular cartilage and for applying this information to the development of therapeutic interventions to improve the outcomes in patients with OA.
Literatur
1.
Zurück zum Zitat Bellido M, Lugo L, Roman-Blas JA, Castaneda S, Caeiro JR, Dapia S, Calvo E, Largo R, Herrero-Beaumont G: Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Arthritis Res Ther. 2010, 12: R152-10.1186/ar3103.CrossRef Bellido M, Lugo L, Roman-Blas JA, Castaneda S, Caeiro JR, Dapia S, Calvo E, Largo R, Herrero-Beaumont G: Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Arthritis Res Ther. 2010, 12: R152-10.1186/ar3103.CrossRef
2.
Zurück zum Zitat Radin EL, Rose RM: Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. 1986, 213: 34-40. Radin EL, Rose RM: Role of subchondral bone in the initiation and progression of cartilage damage. Clin Orthop Relat Res. 1986, 213: 34-40.
3.
Zurück zum Zitat Goldring MB, Goldring SR: Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci. 2010, 1192: 230-237. 10.1111/j.1749-6632.2009.05240.x.CrossRef Goldring MB, Goldring SR: Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci. 2010, 1192: 230-237. 10.1111/j.1749-6632.2009.05240.x.CrossRef
4.
Zurück zum Zitat Goldring SR: Role of bone in osteoarthritis pathogenesis. Med Clin North Am. 2009, 93: 25-35xv. 10.1016/j.mcna.2008.09.006.CrossRef Goldring SR: Role of bone in osteoarthritis pathogenesis. Med Clin North Am. 2009, 93: 25-35xv. 10.1016/j.mcna.2008.09.006.CrossRef
5.
Zurück zum Zitat Burr DB: Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis. Osteoarthritis Cartilage. 2004, 12 (Suppl A): S20-S30. 10.1016/j.joca.2003.09.016.CrossRef Burr DB: Anatomy and physiology of the mineralized tissues: role in the pathogenesis of osteoarthrosis. Osteoarthritis Cartilage. 2004, 12 (Suppl A): S20-S30. 10.1016/j.joca.2003.09.016.CrossRef
6.
Zurück zum Zitat Karvonen RL, Miller PR, Nelson DA, Granda JL, Fernandez-Madrid F: Periarticular osteoporosis in osteoarthritis of the knee. J Rheumatol. 1998, 25: 2187-2194.PubMed Karvonen RL, Miller PR, Nelson DA, Granda JL, Fernandez-Madrid F: Periarticular osteoporosis in osteoarthritis of the knee. J Rheumatol. 1998, 25: 2187-2194.PubMed
7.
Zurück zum Zitat Buckland-Wright C: Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage. 2004, 12 (Suppl A): S10-S19. 10.1016/j.joca.2003.09.007.CrossRef Buckland-Wright C: Subchondral bone changes in hand and knee osteoarthritis detected by radiography. Osteoarthritis Cartilage. 2004, 12 (Suppl A): S10-S19. 10.1016/j.joca.2003.09.007.CrossRef
8.
Zurück zum Zitat Day JS, Ding M, van der Linden JC, Hvid I, Sumner DR, Weinans H: A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res. 2001, 19: 914-918. 10.1016/S0736-0266(01)00012-2.CrossRef Day JS, Ding M, van der Linden JC, Hvid I, Sumner DR, Weinans H: A decreased subchondral trabecular bone tissue elastic modulus is associated with pre-arthritic cartilage damage. J Orthop Res. 2001, 19: 914-918. 10.1016/S0736-0266(01)00012-2.CrossRef
9.
Zurück zum Zitat Sniekers YH, Intema F, Lafeber FP, van Osch GJ, van Leeuwen JP, Weinans H, Mastbergen SC: A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models. BMC Musculoskelet Disord. 2008, 9: 20-10.1186/1471-2474-9-20.CrossRef Sniekers YH, Intema F, Lafeber FP, van Osch GJ, van Leeuwen JP, Weinans H, Mastbergen SC: A role for subchondral bone changes in the process of osteoarthritis; a micro-CT study of two canine models. BMC Musculoskelet Disord. 2008, 9: 20-10.1186/1471-2474-9-20.CrossRef
10.
Zurück zum Zitat Ham KD, Carlson CS: Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res. 2004, 19: 823-829. 10.1359/jbmr.040309.CrossRef Ham KD, Carlson CS: Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res. 2004, 19: 823-829. 10.1359/jbmr.040309.CrossRef
Metadaten
Titel
Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?
verfasst von
Steven R Goldring
Mary B Goldring
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 5/2010
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3135

Weitere Artikel der Ausgabe 5/2010

Arthritis Research & Therapy 5/2010 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.