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Arthritis Research & Therapy

Erschienen in:

01.12.2011 | Review

Cytokine disturbances in systemic lupus erythematosus

verfasst von: Noam Jacob, William Stohl

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2011

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Abstract

The pathogenesis of systemic lupus erythematosus (SLE) is complex, and the resulting disease manifestations are heterogeneous. Cytokine dysregulation is pervasive, and their protein and gene expression profiles may serve as markers of disease activity and severity. Importantly, biologic agents that target specific cytokines may represent novel therapies for SLE. Four cytokines (IL-6, TNFα, IFNα, and BLyS) are being evaluated as therapeutic targets in SLE. The present review will examine the roles of each of these cytokines in murine and human SLE, and will summarize results from clinical trials of agents that target these cytokines.

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Titel: Cytokine disturbances in systemic lupus erythematosus
verfasst von: Noam Jacob
William Stohl
Publikationsdatum: 01.12.2011
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 4/2011
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3349

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