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Arthritis Research & Therapy

Erschienen in:

01.08.2011 | Review

T-helper cells as new players in ANCA-associated vasculitides

verfasst von: Wayel H Abdulahad, Peter Lamprecht, Cees GM Kallenberg

Erschienen in: Arthritis Research & Therapy | Ausgabe 4/2011

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Abstract

In anti-neutrophil cytoplasmic autoantibody-associated vasculitides (AAV), several observations support a key role of T-helper cells (CD4⁺ T cells) in disease pathophysiology. An expanded population of effector memory CD4⁺ T cells in AAV patients may contribute to tissue injury and disease progression. In addition, functional impairment of regulatory T cells (T_Regs) is reported in AAV patients. A fraction of T_Regs have the capacity to differentiate into Th17 cells in the context of a proinflammatory environment. Therefore, nonfunctionality of T_Regs described in AAV patients may be caused by their conversion into IL-17-producing cells that may contribute to granulomatous vasculitis. Further investigations directed at the plasticity of T_Regs in AAV patients are warranted.

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Titel: T-helper cells as new players in ANCA-associated vasculitides
verfasst von: Wayel H Abdulahad
Peter Lamprecht
Cees GM Kallenberg
Publikationsdatum: 01.08.2011
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 4/2011
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3362

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T-helper cells as new players in ANCA-associated vasculitides

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