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Arthritis Research & Therapy
Erschienen in: Arthritis Research & Therapy 3/2012

01.06.2012 | Review

Energy metabolism and rheumatic diseases: from cell to organism

verfasst von: Cornelia M Spies, Rainer H Straub, Frank Buttgereit

Erschienen in: Arthritis Research & Therapy | Ausgabe 3/2012

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Abstract

In rheumatic and other chronic inflammatory diseases, high amounts of energy for the activated immune system have to be provided and allocated by energy metabolism. In recent time many new insights have been gained into the control of the immune response through metabolic signals. Activation of immune cells as well as reduced nutrient supply and hypoxia in inflamed tissues cause stimulation of glycolysis and other cellular metabolic pathways. However, persistent cellular metabolic signals can promote ongoing chronic inflammation and loss of immune tolerance. On the organism level, the neuroendocrine immune response of the hypothalamic-pituitary adrenal axis and sympathetic nervous system, which is meant to overcome a transient inflammatory episode, can lead to metabolic disease sequelae if chronically activated. We conclude that, on cellular and organism levels, a prolonged energy appeal reaction is an important factor of chronic inflammatory disease etiology.
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Metadaten
Titel
Energy metabolism and rheumatic diseases: from cell to organism
verfasst von
Cornelia M Spies
Rainer H Straub
Frank Buttgereit
Publikationsdatum
01.06.2012
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 3/2012
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3885

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