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Breast Cancer Research

Erschienen in:

01.06.2009 | Editorial

The transition from ductal carcinoma in situto invasive breast cancer: the other side of the coin

verfasst von: Stuart J Schnitt

Erschienen in: Breast Cancer Research | Ausgabe 1/2009

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Abstract

The factors associated with the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer are poorly understood. Many studies of this subject focus on the role of molecular and genetic alterations in the neoplastic epithelial cells. However, emerging evidence suggests that transition from DCIS to invasive cancer is strongly dependent upon alterations in the microenvironment. The potential roles of myoepithelial cells and of stromal-epithelial interaction are of particular interest in this regard.

Castro NP, Osório CABT, Torres C, Bastos EP, Mourão-Neto M, Soares FA, Brentani HP, Carraro DM: Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma. Breast Cancer Res. 2008, 10: R87-10.1186/bcr2157.CrossRefPubMedPubMedCentral

Porter D, Lahti-Domenici J, Keshaviah A, Bae YK, Argani P, Marks J, Richardson A, Cooper A, Strausberg R, Riggins GJ, Schnitt S, Gabrielson E, Gelman R, Polyak K: Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003, 1: 362-375.PubMed

Ma XJ, Salunga R, Tuggle JT, Gaudet J, Enright E, McQuary P, Payette T, Pistone M, Stecker K, Zhang BM, Zhou YX, Varnholt H, Smith B, Gadd M, Chatfield E, Kessler J, Baer TM, Erlander MG, Sgroi DC: Gene expression profiles of human breast cancer progression. Proc Natl Acad Sci USA. 2003, 100: 5974-5979. 10.1073/pnas.0931261100.CrossRefPubMedPubMedCentral

Lakhani SR, O'Hare MJ: The mammary myoepithelial cell – Cinderella or ugly sister?. Breast Cancer Res. 2001, 3: 1-4. 10.1186/bcr260.CrossRefPubMed

Barsky SH, Karlin NJ: Mechanisms of disease: breast tumor pathogenesis and the role of the myoepithelial cell. Nat Clin Pract Oncol. 2006, 3: 138-151. 10.1038/ncponc0450.CrossRefPubMed

Polyak K, Hu M: Do myoepithelial cells hold the key for breast tumor progression?. J Mammary Gland Biol Neoplasia. 2005, 10: 231-247. 10.1007/s10911-005-9584-6.CrossRefPubMed

Allinen M, Beroukhim R, Cai L, Brennan C, Lahti-Domenici J, Huang H, Porter D, Hu M, Chin L, Richardson A, Schnitt S, Sellers WR, Polyak K: Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell. 2004, 6: 17-32. 10.1016/j.ccr.2004.06.010.CrossRefPubMed

Adriance MC, Inman JL, Petersen OW, Bissell MJ: Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. 2005, 7: 190-197. 10.1186/bcr1286.CrossRefPubMedPubMedCentral

Hu M, Yao J, Cai L, Bachman KE, Brûle van den F, Velculescu V, Polyak K: Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet. 2005, 37: 899-905. 10.1038/ng1596.CrossRefPubMed

10.

Hilson JB, Schnitt SJ, Collins LC: Phenotypic alterations in ductal carcinoma in situ-associated myoepithelial cells: biological and diagnostic implications. Am J Surg Pathol. 2009, 33: 227-232. 10.1097/PAS.0b013e318180431d.CrossRefPubMed

11.

Kim JB, Stein R, O'Hare MJ: Tumour-stromal interactions in breast cancer: the role of stroma in tumourigenesis. Tumour Biol. 2005, 26: 173-185. 10.1159/000086950.CrossRefPubMed

12.

Guidi AJ, Fischer L, Harris JR, Schnitt SJ: Microvessel density and distribution in ductal carcinoma in situ of the breast. J Natl Cancer Inst. 1994, 86: 614-619. 10.1093/jnci/86.8.614.CrossRefPubMed

13.

Brown LF, Guidi AJ, Schnitt SJ, Water Van De L, Iruela-Arispe ML, Yeo TK, Tognazzi K, Dvorak HF: Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res. 1999, 5: 1041-1056.PubMed

14.

Kleer CG, Bloushtain-Qimron N, Chen YH, Carrasco D, Hu M, Yao J, Kraeft SK, Collins LC, Sabel MS, Argani P, Gelman R, Schnitt SJ, Krop IE, Polyak K: Epithelial and stromal cathepsin K and CXCL14 expression in breast tumor progression. Clin Cancer Res. 2008, 14: 5357-5367. 10.1158/1078-0432.CCR-08-0732.CrossRefPubMedPubMedCentral

Titel: The transition from ductal carcinoma in situto invasive breast cancer: the other side of the coin
verfasst von: Stuart J Schnitt
Publikationsdatum: 01.06.2009
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 1/2009
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2228

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The transition from ductal carcinoma in situto invasive breast cancer: the other side of the coin

Abstract

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Abstract

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