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Breast Cancer Research

Erschienen in:

01.04.2011 | Review

Stress and breast cancer: from epidemiology to molecular biology

verfasst von: Lilia Antonova, Kristan Aronson, Christopher R Mueller

Erschienen in: Breast Cancer Research | Ausgabe 2/2011

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Abstract

Stress exposure has been proposed to contribute to the etiology of breast cancer. However, the validity of this assertion and the possible mechanisms involved are not well established. Epidemiologic studies differ in their assessment of the relative contribution of stress to breast cancer risk, while physiological studies propose a clear connection but lack the knowledge of intracellular pathways involved. The present review aims to consolidate the findings from different fields of research (including epidemiology, physiology, and molecular biology) in order to present a comprehensive picture of what we know to date about the role of stress in breast cancer development.

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Madigan M, Ziegler R, Benichou J, Byrne C, Hoover R: Proportion of breast cancer cases in the United States explained by well-established risk factors. J Natl Cancer Inst. 1995, 87: 1681-1685. 10.1093/jnci/87.22.1681.PubMedCrossRef

Tonin P: Genes implicated in hereditary breast cancer syndromes. Semin Surg Oncol. 2000, 18: 281-286. 10.1002/(SICI)1098-2388(200006)18:4<281::AID-SSU2>3.0.CO;2-Q.PubMedCrossRef

Hankiston S, Colditz G, Willett W: Towards an integrated model for breast cancer etiology. The lifelong interplay of genes, lifestyle, and hormones. Breast Cancer Res. 2004, 6: 213-218. 10.1186/bcr921.CrossRef

Gerber B, Muller H, Reimer T, Krause A, Friese K: Nutrition and lifestyle factors on the risk of developing breast cancer. Breast Cancer Res Treat. 2003, 79: 265-276. 10.1023/A:1023959818513.PubMedCrossRef

Bleiker E, van der Ploeg H: Psychosocial factors in the etiology of breast cancer: review of a popular link. Patient Educ Couns. 1999, 37: 201-214. 10.1016/S0738-3991(99)00027-0.PubMedCrossRef

Schwarz R, Geyer S: Social and psychological differences between cancer and noncancer patients: cause or consequence of the disease?. Psychother Psychosom. 1984, 41: 195-199. 10.1159/000287809.PubMedCrossRef

Petticrew M, Fraser J, Regan M: Adverse life-events and risk of breast cancer: a meta-analysis. Br J Health Psychol. 1999, 4: 1-17. 10.1348/135910799168434.CrossRef

Duijts S, Zeegers M, Vd Borne B: The association between stressful life events and breast cancer risk: a meta-analysis. Int J Cancer. 2003, 107: 1023-1029. 10.1002/ijc.11504.PubMedCrossRef

Nielsen N, Gronbaek M: Stress and breast cancer: a systemic update on the current knowledge. Nat Clin Pract Oncol. 2006, 3: 612-620. 10.1038/ncponc0652.PubMedCrossRef

10.

Michael Y, Carlson N, Chlebowski R, Aickin M, Weihs K, Ockene J, Bowen D, Ritenbaugh C: Influence of stressors on breast cancer incidence in the Women's Health Initiative. Health Psychol. 2009, 28: 137-146. 10.1037/a0012982.PubMedPubMedCentralCrossRef

11.

Helgesson O, Cabrera C, Lapidus L, Bengtsson C, Lissner L: Self-reported stress levels predict subsequent breast cancer in a cohort of Swedish women. Eur J Cancer Prev. 2003, 12: 377-381. 10.1097/00008469-200310000-00006.PubMedCrossRef

12.

Matthews K, Gallo L, Taylor S: Are psychosocial factors mediators of socioeconomic status and health connections?. Ann NY Acad Sci. 2010, 1186: 146-173. 10.1111/j.1749-6632.2009.05332.x.PubMedCrossRef

13.

Chida Y, Hamer M: Chronic psychosocial factors and actute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations. Psychol Bull. 2008, 134: 829-885. 10.1037/a0013342.PubMedCrossRef

14.

Chrousos G: Stress and disorders of the stress system. Nat Rev Endocrinol. 2009, 5: 374-381. 10.1038/nrendo.2009.106.PubMedCrossRef

15.

Kuper H, Yang L, Theorell T, Weiderpass E: Job strain and risk of breast cancer. Epidemiology. 2007, 18: 764-768. 10.1097/EDE.0b013e318142c534.PubMedCrossRef

16.

Nielsen N, Stahlberg C, Strandberg-Larsen K, Kristensen T, Zhang Z, Hundrup Y, Gronbaek M: Are work-related stressors associated with diagnosis of more advanced stages of incident breast cancers?. Cancer Causes Control. 2008, 19: 297-303. 10.1007/s10552-007-9092-7.PubMedCrossRef

17.

Schernhammer E, Hankinson S, Rosner B, Kroenke C, Willett W, Colditz G, Kawachi I: Job stress and breast cancer risk: the Nurses' Health Study. Am J Epidemiol. 2004, 160: 1079-1086. 10.1093/aje/kwh327.PubMedCrossRef

18.

Kroenke C, Hankinson S, Schernhammer E, Colditz G, Kawachi I, Holmes M: Caregiving stress, endogenous sex steroid hormone levels, and breast cancer incidence. Am J Epidemiol. 2004, 159: 1019-1027. 10.1093/aje/kwh148.PubMedCrossRef

19.

Nielsen NR, Zhang ZF, Kristensen TS, Netterstrom B, Schnohr P, Gronbaek M: Self reported stress and risk of breast cancer: prospective cohort study. BMJ. 2005, 331: 548-10.1136/bmj.38547.638183.06.PubMedPubMedCentralCrossRef

20.

Surtees P, Wainwright N, Luben R, Khaw K, Bingham S: No evidence that social stress is associated with breast cancer incidence. Breast Cancer Res Treat. 2010, 120: 169-174. 10.1007/s10549-009-0454-6.PubMedCrossRef

21.

Metcalfe C, Davey Smith G, Macleod J, Hart C: The role of self-reported stress in the development of breast cancer and prostate cancer: a prospective cohort study of employed males and females with 30 years of follow-up. Eur J Cancer. 2007, 43: 1060-1065. 10.1016/j.ejca.2007.01.027.PubMedCrossRef

22.

Lillberg K, Verkasalo PK, Kaprio J, Teppo L, Helenius H, Koskenvuo M: Stressful life events and risk of breast cancer in 10,808 women: a cohort study. Am J Epidemiol. 2003, 157: 415-423. 10.1093/aje/kwg002.PubMedCrossRef

23.

Lambe M, Cerrato R, Askling J, Hsieh C: Maternal breast cancer risk after death of a child. Int J Cancer. 2004, 110: 763-766. 10.1002/ijc.20181.PubMedCrossRef

24.

Ollonen P, Lehtonen J, Eskelinen M: Stressful and adverse life experiences in patients with breast symptoms; a prospective case-control study in Kuopio, Finland. Anticancer Res. 2005, 25: 531-536.PubMed

25.

Land C, Tokunaga M, Koyama K, Soda M, Preston D, Nishimori I, Tokuoka S: Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res. 2003, 160: 707-717. 10.1667/RR3082.PubMedCrossRef

26.

Tokunaga M, Norman JJ, Asano M, Tokuoka S, Ezaki H, Nishimori I, Tsuji Y: Malignant breast tumors among atomic bomb survivors, Hiroshima and Nagasaki, 1950-74. J Natl Cancer Inst. 1979, 62: 1347-1359.PubMed

27.

28.

Eskelinen M, Ollonen P: Life stress due to losses and deficit in childhood and adolescence as breast cancer risk factor: a prospective case-control study in Kuopio, Finland. Anticancer Res. 2010, 30: 4303-4308.PubMed

29.

Jacobs J, Bovasso G: Early and chronic stress and their relation to breast cancer. Psychol Med. 2000, 30: 669-678. 10.1017/S0033291799002020.PubMedCrossRef

30.

Keinan-Boker L, Vin-Raviv N, Liphshitz I, Linn S, Barchana M: Cancer incidence in Israeli Jewish survivors of World War II. J Natl Cancer Inst. 2009, 101: 1489-1500. 10.1093/jnci/djp327.PubMedCrossRef

31.

Koupil I, Plavinskaja S, Parfenova N, Shestov D, Danziger P, Vågerö D: Cancer mortality in women and men who survived the siege of Leningrad (1941-1944). Int J Cancer. 2009, 124: 1416-1421. 10.1002/ijc.24093.PubMedCrossRef

32.

Mason JW: A historical view of the stress field. J Human Stress. 1975, 1: 6-12. contdPubMedCrossRef

33.

Selye H: Confusion and controversy in the stress field. J Human Stress. 1975, 1: 37-44.PubMedCrossRef

34.

Harbuz M, Lightman S: Stress and the hypothalamo-pituitary-adrenal axis: acute, chronic and immunological activation. J Endocrinol. 1992, 134: 327-339. 10.1677/joe.0.1340327.PubMedCrossRef

35.

Keller S, Weiss J, S. S, Miller N, Stein M: Stress-induced suppression of immunity in adrenalectomized rats. Science. 1983, 221: 1301-1304. 10.1126/science.6612346.PubMedCrossRef

36.

Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez E, Bach J, Dardenne M: Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol. 1991, 40: 619-637. 10.1016/0960-0760(91)90285-D.PubMedCrossRef

37.

VanItallie T: Stress: a risk factor for serious illness. Metabolism. 2002, 51: 40-45. 10.1053/meta.2002.33191.PubMedCrossRef

38.

Holden R, Pakula I, Mooney P: An immunological model connecting the pathogenesis of stress, depression and carcinoma. Med Hypotheses. 1998, 51: 309-314. 10.1016/S0306-9877(98)90054-8.PubMedCrossRef

39.

Strange K, Kerr L, Andrews H, Emerman J, Weiberg J: Psychosocial stressors and mammary tumour growth: an animal model. Neurotoxicol Teratol. 2000, 22: 89-102. 10.1016/S0892-0362(99)00049-5.PubMedCrossRef

40.

Hennighausen L, Robinson G: Signaling pathways in mammary gland development. Dev Cell. 2001, 1: 467-475. 10.1016/S1534-5807(01)00064-8.PubMedCrossRef

41.

Robinson G, Smith G, Gallahan D, Zimmerm A, Furth P, Hennighausen L: Understanding mammary gland development through the imbalanced expression of growth regulators. Dev Dyn. 1996, 206: 159-168. 10.1002/(SICI)1097-0177(199606)206:2<159::AID-AJA5>3.0.CO;2-H.PubMedCrossRef

42.

Gilbert S: Developmental Biology. 2006, Sunderland, MA: Sinauer Associates, 8

43.

Majumder P, Joshi J, Banerjee M: Correlation between nuclear glucocorticoid receptor levels and casein gene expression in murine mammary gland in vitro. J Biol Chem. 1983, 258: 6793-6798.PubMed

44.

Reichardt H, Horsch K, Grone H, Kolbus A, Beug H, Hynes N, Schutz G: Mammary gland development and lactation are controlled by different glucocorticoid receptor activities. Eur J Endocrinol. 2001, 145: 519-527. 10.1530/eje.0.1450519.PubMedCrossRef

45.

Wintermantel T, Bock D, Fleig V, Greiner E, Schutz G: The epithelial glucocorticoid receptor is required for the normal timing of cell proliferation during mammary lobuloalveolar development but is dispensable for milk production. Mol Endocrinol. 2005, 19: 340-349. 10.1210/me.2004-0068.PubMedCrossRef

46.

Maina G, Bovenzi M, Palmas A, Larese Filon F: Associations between two job stress models and measures of salivary cortisol. Int Arch Occup Environ Health. 2009, 82: 1141-1150. 10.1007/s00420-009-0439-0.PubMedCrossRef

47.

Chida Y, Steptoe A: Cortisol awakening response and psychosocial factors: a systematic review and meta-analysis. Biol Psychol. 2009, 80: 265-278. 10.1016/j.biopsycho.2008.10.004.PubMedCrossRef

48.

Gonzalez A, Jenkins J, Steiner M, Fleming A: The relation between early life adversity, cortisol awakening response and diurnal salivary cortisol levels in postpartum women. Psychoneuroendocrinology. 2009, 34: 76-86. 10.1016/j.psyneuen.2008.08.012.PubMedCrossRef

49.

Elzinga B, Roelofs K, Tollenaar M, Bakvis P, van Pelt J, Spinhoven P: Diminished cortisol responses to psychosocial stress associated with lifetime adverse events: a study among healthy young subjects. Psychoneuroendocrinology. 2008, 33: 227-237. 10.1016/j.psyneuen.2007.11.004.PubMedCrossRef

50.

Heim C, Newport D, Wagner D, Wilcox M, Miller A, Nemeroff C: The role of early adverse experience and adulthood stress in the prediction of neuroendocrine stress reactivity in women: a multiple regression analysis. Depress Anxiety. 2002, 15: 117-125. 10.1002/da.10015.PubMedCrossRef

51.

Henderson B, Ross R, Bernstein L: Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res. 1988, 48: 246-253.PubMed

52.

Russo J, Hasan Lareef M, Balogh G, Guo S, Russo I: Estrogen and its metabolites are carcinogenic agents in human breast epithelial cells. J Steroid Biochem Mol Biol. 2003, 87: 1-25. 10.1016/S0960-0760(03)00390-X.PubMedCrossRef

53.

Simpson E: Sources of estrogen and their importance. J Steroid Biochem Mol Biol. 2003, 86: 225-230. 10.1016/S0960-0760(03)00360-1.PubMedCrossRef

54.

Simpson E: Biology of aromatase in the mammary gland. J Mammary Gland Biol Neoplasia. 2000, 5: 251-258. 10.1023/A:1009590626450.PubMedCrossRef

55.

O'Neill JS, Elton RA, Miller WR: Aromatase activity in adipose tissue from breast quadrants: a link with tumour site. Br Med J (Clin Res Ed). 1988, 296: 741-743.CrossRef

56.

Bulun S, Price T, Aitken J, Mahendroo M, Simpson E: A link between breast cancer and local estrogen biosynthesis suggested by quantification of breast adipose tissue aromatase cytochrome P450 transcripts using competitive polymerase chain reaction after reverse transcription. J Clin Endocrinol Metab. 1993, 77: 1622-1628. 10.1210/jc.77.6.1622.PubMed

57.

Brodie A, Lu Q, Nakamura J: Aromatase in the normal breast and breast cancer. J Steroid Biochem Mol Biol. 1997, 61: 281-286. 10.1016/S0960-0760(97)80024-6.PubMedCrossRef

58.

Simpson E, Ackerman G, Smith M, Mendelson C: Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids. Proc Natl Acad Sci USA. 1981, 78: 5690-5694. 10.1073/pnas.78.9.5690.PubMedPubMedCentralCrossRef

59.

Schmidt M, Loffler G: Induction of aromatase in stromal vascular cells from human breast adipose tissue depends on cortisol and growth factors. FEBS Lett. 1994, 341: 177-181. 10.1016/0014-5793(94)80452-4.PubMedCrossRef

60.

Schmidt M, Loffler G: RU486 is a potent inhibitor of aromatase induction in human breast adipose tissue stromal cells. J Steroid Biochem Mol Biol. 1997, 60: 197-204. 10.1016/S0960-0760(96)00178-1.PubMedCrossRef

61.

Romagnolo D, Annab L, Thompson T, Risinger J, Terry L, Barrett J, Afshari C: Estrogen upregulation of BRCA1 expression with no effect on localization. Mol Carcinog. 1998, 22: 102-109. 10.1002/(SICI)1098-2744(199806)22:2<102::AID-MC5>3.0.CO;2-O.PubMedCrossRef

62.

Razandi M, Pedram A, Rosen E, Levin E: BRCA1 inhibits membrane estrogen and growth factor receptor signaling to cell proliferation in breast cancer. Mol Cell Biol. 2004, 24: 5900-5913. 10.1128/MCB.24.13.5900-5913.2004.PubMedPubMedCentralCrossRef

63.

Antonova L, Mueller C: Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes, Chromosomes Cancer. 2008, 47: 341-352. 10.1002/gcc.20538.PubMedCrossRef

64.

Huizenga N, Koper J, de Lange P, Pols H, Stolk R, Burger H, Grobbee D, Brinkmann A, de Jong F, Lamberts S: A polymorphism in the glucocoritcoid receptor gene may be associated with an increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab. 1998, 83: 144-151. 10.1210/jc.83.1.144.PubMed

65.

Di Blasio AM, van Rossum EF, Maestrini S, Berselli ME, Tagliaferri M, Podesta F, Koper JW, Liuzzi A, Lamberts SW: The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients. Clin Endocrinol (Oxf). 2003, 59: 68-74. 10.1046/j.1365-2265.2003.01798.x.CrossRef

66.

Lin R, Wang W, Morris B: High penetrance, overweight, and glucocorticoid receptor variant: case-control study. Br Med J. 1999, 319: 1337-1338.CrossRef

67.

Lin R, Wang W, Morris B: Association of coronary artery disease with glucocorticoid receptor N363S variant. Hypertension. 2003, 41: 404-407. 10.1161/01.HYP.0000055342.40301.DC.PubMedCrossRef

68.

Lin R, Wang W, Dalziel B, Caterson I, Morris B: Association of obesity, but not diabetes or hypertension, with glucocorticoid receptor N363S variant. Obes Res. 2003, 11: 802-808. 10.1038/oby.2003.111.PubMedCrossRef

69.

Curran JE, Lea RA, Rutherford S, Weinstein SR, Griffiths LR: Association of estrogen receptor and glucocorticoid receptor gene polymorphisms with sporadic breast cancer. Int J Cancer. 2001, 95: 271-275. 10.1002/1097-0215(20010720)95:4<271::AID-IJC1046>3.0.CO;2-D.PubMedCrossRef

70.

Grippo A, Gerena D, Huang J, Kumar N, Shah M, Ughreja R, Sue Carter C: Social isolation induces behavioral and neuroendocrine disturbances relevant to depression in female and male prairie voles. Psychoneuroendocrinology. 2007, 32: 966-980. 10.1016/j.psyneuen.2007.07.004.PubMedPubMedCentralCrossRef

71.

Dechambre R, Gosse C: Individual versus group caging of mice with grafted tumors. Cancer Res. 1973, 33: 140-144.PubMed

72.

Sklar L, Anisman H: Social stress influences tumor growth. Psychosom Med. 1980, 42: 347-365.PubMedCrossRef

73.

Weinberg J, Emerman J: Effects of psychosocial stressors on mouse mammary tumor growth. Brain Behav Immun. 1989, 3: 234-246. 10.1016/0889-1591(89)90039-1.PubMedCrossRef

74.

Grimm M, Emerman J, Weinberg J: Effects of social housing condition and behavior on growth of the Shionogi mouse mammary carcinoma. Physiol Behav. 1996, 59: 633-642. 10.1016/0031-9384(95)02126-4.PubMedCrossRef

75.

Hermes G, Delgado B, Tretiakova M, Cavigelli S, Krausz T, Conzen S, McClintock M: Social isolation dysregulates endocrine and behavioral stress while increasing malignant burden of spontaneous mammary tumors. Proc Natl Acad Sci USA. 2009, 106: 22393-22398. 10.1073/pnas.0910753106.PubMedPubMedCentralCrossRef

76.

Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock M, Conzen S: A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev Res (Philia). 2009, 2: 850-861. 10.1158/1940-6207.CAPR-08-0238.CrossRef

77.

Rao U, Hammen C, Ortiz L, Chen L, Poland R: Effects of early and recent adverse experiences on adrenal response to psychosocial stress in depressed adolescents. Biol Psychiatry. 2008, 64: 521-526. 10.1016/j.biopsych.2008.05.012.PubMedPubMedCentralCrossRef

78.

Faravelli C, Amedei S, Rotella F, Faravelli L, Palla A, Consoli G, Ricca V, Batini S, Sauro C, Spiti A, Dell'osso M: Childhood trauma, dexamethasone suppression test and psychiatric symptoms: a trans-diagnostic approach. Psychol Med. 2010, 40: 2037-2048. 10.1017/S0033291710000115.PubMedCrossRef

79.

Gerritsen L, Geerlings M, Beekman A, Deeg D, Penninx B, Comijs H: Early and late life events and salivary cortisol in older persons. Psychol Med. 2010, 40: 1569-1578. 10.1017/S0033291709991863.PubMedCrossRef

80.

Uchida S, Hara K, Kobayashi A, Funato H, Hobara T, Otsuki K, Yamagata H, McEwen B, Watanabe Y: Early life stress enhances behavioral vulnerability to stress through the activation of REST4-mediated gene transcription in the medial prefrontal cortex of rodents. J Neurosci. 2010, 30: 15007-15018. 10.1523/JNEUROSCI.1436-10.2010.PubMedCrossRef

81.

Enthoven L, de Kloet E, Oitzl M: Differential development of stress system (re)activity at weaning dependent on time of disruption of maternal care. Brain Res. 2008, 1217: 62-69. 10.1016/j.brainres.2008.04.009.PubMedCrossRef

82.

Weaver I, Cervoni N, Champagne F, D'Alessio A, Sharma S, Seckl J, Dymov S, Szyf M, Meaney M: Epigenetic programming by maternal behavior. Nat Neurosci. 2004, 7: 847-854. 10.1038/nn1276.PubMedCrossRef

83.

Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky P, Meaney M: Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science. 1997, 277: 1659-1662. 10.1126/science.277.5332.1659.PubMedCrossRef

84.

Maina G, Palmas A, Bovenzi M, Larese Filonm F: Salivary cortisol and psychosocial hazards at work. Am J Ind Med. 2009, 52: 251-260. 10.1002/ajim.20659.PubMedCrossRef

85.

Borders AE, Grobman WA, Amsden LB, McDade TW, Sharp LK, Holl JL: The relationship between self-report and biomarkers of stress in low-income reproductiveage women. Am J Obstet Gynecol. 2010, 203: 1-8. 10.1016/j.ajog.2009.12.002.CrossRef

86.

Glaser R, Pearson G, Jones J, Hillhouse J, Kennedy S, Mao H, Kiecolt-Glaser J: Stress-related activation of Epstein-Barr virus. Brain Behav Immun. 1991, 5: 219-232. 10.1016/0889-1591(91)90018-6.PubMedCrossRef

87.

Palanza P: Animal models of anxiety and depression: how are females different?. Neurosci Biobehav Rev. 2001, 25: 219-233. 10.1016/S0149-7634(01)00010-0.PubMedCrossRef

88.

Hasen NS, O'Leary KA, Auger AP, Schuler LA: Social isolation reduces mammary development, tumor incidence, and expression of epigenetic regulators in wild-type and p53-heterozygotic mice. Cancer Prev Res (Phila). 2010, 3: 620-629. 10.1158/1940-6207.CAPR-09-0225.CrossRef

89.

Amsterdam A, Tajima K, Sasson R: Cell-specific regulation of apoptosis by glucocorticoids. Biochem Pharmacol. 2002, 64: 843-850. 10.1016/S0006-2952(02)01147-4.PubMedCrossRef

90.

Feng Z, Marti A, Jehn B, Altermatt H, Chicaiza G, Jaggi R: Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary gland. J Cell Biol. 1995, 131: 1095-1103. 10.1083/jcb.131.4.1095.PubMedCrossRef

91.

Moran T, Gray S, Mikosz C, Conzen S: The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res. 2000, 60: 867-872.PubMed

92.

Wu W, Pew T, Zou M, Pang D, Conzen S: Glucocorticoid receptor-induced MAPK phosphatase-1 (MPK-1) expression inhibits paclitaxel-associated MAPK activation and contributes to breast cancer cell survival. J Biol Chem. 2005, 280: 4117-4124. 10.1074/jbc.M411200200.PubMedCrossRef

93.

Filderman A, Bruckner A, Kacinski B, Deng N, Remold H: Macrophage colonystimulating factor (CSF-1) enhances invasiveness in CSF-1 receptorpositive carcinoma cell lines. Cancer Res. 1992, 52: 3661-3666.PubMed

94.

Tangir J, Bonafe N, Gilmore-Hebert M, Henegariu O: SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004, 21: 477-483. 10.1007/s10585-004-4226-8.PubMedCrossRef

95.

Lien H, Lu Y, Cheng A, Chang W, Jeng Y, Kuo Y, Huang C, Chang K, Yao Y: Differential expression of glucocorticoid receptor in human breast tissues and related neoplasms. J Pathol. 2006, 209: 317-327. 10.1002/path.1982.PubMedCrossRef

96.

Lippman M, Bolan G, Huff K: The effects of glucocorticoids and progesterone on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 1976, 36: 4602-4609.PubMed

97.

Goya L, Maiyar A, Ge Y, Firestone G: Glucocorticoids induce a G1/G0 cell cycle arrest of Con8 rat mammary tumor cells that is synchronously reversed by steroid withdrawal or addition of transforming growth factoralpha. Mol Endocrinol. 1993, 7: 1121-1132. 10.1210/me.7.9.1121.PubMed

98.

Rocha Viegas L, Hoijman E, Beato M, Pecci A: Mechanisms involved in tissuespecific apoptosis regulated by glucocorticoids. J Steroid Biochem Mol Biol. 2008, 109: 273-278. 10.1016/j.jsbmb.2008.03.007.CrossRef

99.

Moutsatsou P, Papavassiliou A: The glucocorticoid receptor signalling in breast cancer. J Cell Mol Med. 2008, 12: 145-163. 10.1111/j.1582-4934.2007.00177.x.PubMedCrossRef

100.

Wu W, Zou M, Brickley D, Pew T, Conzen S: Glucocorticoid receptor activation signals through Forkhead Transcription Factor 3a in breast cancer cells. Mol Endocrinol. 2006, 20: 2304-2314. 10.1210/me.2006-0131.PubMedCrossRef

101.

Messmer U, Pereda-Fernandez C, Manderscheid M, Pfeilschifter J: Dexamethasone inhibits TNFa-induced apoptosis and IAP protein downregulation in MCF-7 cells. Br J Pharmacol. 2001, 133: 467-476. 10.1038/sj.bjp.0704093.PubMedPubMedCentralCrossRef

102.

Webster Marketon J, Glaser R: Stress hormones and immune function. Cell Immunol. 2008, 252: 16-26. 10.1016/j.cellimm.2007.09.006.PubMedCrossRef

103.

Yang E, Glaser R: Stress-induced immunomodulation: implications for tumorigenesis. Brain Behav Immun. 2003, 17: S37-S40. 10.1016/S0889-1591(02)00064-8.PubMedCrossRef

104.

Kiecolt-Glaser J, Stephens R, Lipetz P, Speicher C, Glaser R: Distress and DNA repair in human lymphocytes. J Behav Med. 1985, 8: 311-320. 10.1007/BF00848366.PubMedCrossRef

105.

Glaser R, Kiecolt-Glaser J, Stout J, Tarr K, Speicher C, Holliday J: Stress-related impairments in cellular immunity. Psychiatry Res. 1985, 16: 233-239. 10.1016/0165-1781(85)90111-8.PubMedCrossRef

106.

Cohen L, Marshall GJ, Cheng L, Sandeep A, Wei Q: DNA repair capacity in healthy medical students during and after exam stress. J Behav Med. 2000, 23: 531-544. 10.1023/A:1005503502992.PubMedCrossRef

107.

Fischman H, Pero R, Kelly D: Psychogenic stress induces chromosomal and DNA damage. Int J Neurosci. 1996, 84: 219-227. 10.3109/00207459608987267.PubMedCrossRef

108.

Sacharczuk M, Jaszczak K, Sadowski B: Cytogenetic comparison of the sensitivity to mutagens in mice selected for high (HA) and low (LA) swim stress-induced analgesia. Mutat Res. 2003, 535: 95-102. 10.1016/S1383-5718(02)00290-5.PubMedCrossRef

109.

Adachi S, Kawamura K, Takemoto K: Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress. Cancer Res. 1993, 53: 4153-4155.PubMed

110.

Flint M, Baum A, Chambers W, Jenkins F: Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones. Psychoneuroendocrinology. 2007, 32: 470-479. 10.1016/j.psyneuen.2007.02.013.PubMedCrossRef

111.

Miki Y, Swensen J, Shattuck-Eidens D, Futreal P, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al: A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. 1994, 266: 66-71. 10.1126/science.7545954.PubMedCrossRef

112.

Easton D, Ford D, Bishop D: Breast and ovarian cancer incidence in BRCA1-mutation carriers. Breast Cancer Linkage Consortium. Am J Hum Genet. 1995, 56: 265-271.PubMedPubMedCentralCrossRef

113.

Thompson M, Jensen R, Obermiller P, Page D, Holt J: Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression. Nat Genet. 1995, 9: 444-450. 10.1038/ng0495-444.PubMedCrossRef

114.

Bellacosa A, Godwin AK, Peri S, Devarajan K, Caretti E, Vanderveer L, Bove B, Slater C, Zhou Y, Daly M, Howard S, Campbell KS, Nicolas E, Yeung AT, Clapper ML, Crowell JA, Lynch HT, Ross E, Kopelovich L, Knudson AG: Altered gene expression in morphologically normal epithelial cells from heterozygous carriers of BRCA1 or BRCA2 mutations. Cancer Prev Res (Phila). 2010, 3: 48-61. 10.1158/1940-6207.CAPR-09-0078.CrossRef

Titel: Stress and breast cancer: from epidemiology to molecular biology
verfasst von: Lilia Antonova
Kristan Aronson
Christopher R Mueller
Publikationsdatum: 01.04.2011
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 2/2011
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr2836

Neu im Fachgebiet Onkologie

25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Stress and breast cancer: from epidemiology to molecular biology

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

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