nach oben

Breast Cancer Research

Erschienen in:

01.10.2001 | Review

Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways

verfasst von: Christopher W Pugh, Jonathan Gleadle, Patrick H Maxwell

Erschienen in: Breast Cancer Research | Ausgabe 5/2001

Einloggen, um Zugang zu erhalten

Abstract

Hypoxia-inducible factor-1 (HIF), which is centrally involved in physiological oxygen homeostasis, is also activated in the majority of tumours. Activation of HIF can occur through genetic mechanisms or as a result of hypoxia within the tumour microenvironment. In some cases HIF activation appears to be intimately linked to the proliferative stimulus itself. HIF affects patterns of gene expression and tumour growth, although precise effects vary between tumour types. Modulation of HIF activity, if correctly applied, may be therapeutically beneficial in tumour therapy.

Maxwell PH, Pugh CW, Ratcliffe PJ: Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen sensing mechanism. Proc Natl Acad Sci USA. 1993, 90: 2423-2427.CrossRefPubMedPubMedCentral

Wang GL, Semenza GL: General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA. 1993, 90: 4304-4308.CrossRefPubMedPubMedCentral

Wang GL, Jiang B-H, Rue EA, Semenza GL: Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O₂ tension. Proc Natl Acad Sci USA. 1995, 92: 5510-5514.CrossRefPubMedPubMedCentral

Ratcliffe PJ, Ebert BL, Firth JD, Gleadle JM, Maxwell PH, Nagao M, O'Rourke JF, Pugh CW, Wood SM: Oxygen regulated gene expression: erythropoietin as a model system. Kidney Int. 1997, 51: 514-526.CrossRefPubMed

Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ: Isoenzyme specific regulation of genes involved in energy metabolism by hypoxia, cobalt and desferrioxamine: similarities with the regulation of erythropoietin. Biochem J. 1995, 313: 809-814.CrossRef

O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ: Identification of hypoxically inducible mRNAs in Hela cells using differential display PCR. Eur J Biochem. 1996, 241: 403-410.CrossRefPubMed

Wykoff CC, Pugh CW, Maxwell PH, Harris AL, Ratcliffe PJ: Identification of novel hypoxia-dependent and independent target genes of the von Hippel–Lindau (VHL) tumor suppressor by mRNA differential expression profiling. Oncogene. 2000, 19: 6297-6305. 10.1038/sj.onc.1204012.CrossRefPubMed

Arany Z, Huang LE, Eckner R, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, Livingston DM: An essential role for p300/CBP in the cellular response to hypoxia. Proc Natl Acad Sci USA. 1996, 93: 12969-12973. 10.1073/pnas.93.23.12969.CrossRefPubMedPubMedCentral

Salceda S, Caro J: Hypoxia-inducible factor 1α (HIF-1 α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J Biol Chem. 1997, 272: 22642-22647. 10.1074/jbc.272.36.22642.CrossRefPubMed

10.

Huang LE, Gu J, Schau M, Bunn HF: Regulation of hypoxia-inducible factor 1a is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 1998, 95: 7987-7992. 10.1073/pnas.95.14.7987.CrossRefPubMedPubMedCentral

11.

Maxwell PH, Wiesener MS, Chang G-W, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ: The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999, 399: 271-275. 10.1038/20459.CrossRefPubMed

12.

Cockman ME, Masson N, Mole DR, Jaakkola P, Chang GW, Clifford SC, Maher ER, Pugh CW, Ratcliffe PJ, Maxwell PH: Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel–Lindau tumor suppressor protein. J Biol Chem. 2000, 275: 25733-25741. 10.1074/jbc.M002740200.CrossRefPubMed

13.

Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, Salic A, Asara JM, Lane WS, Kaelin WG: HIF α targeted for VHL-mediated destruction by proline hydroxylation: implications for O₂ sensing. Science. 2001, 292: 464-468.CrossRefPubMed

14.

Jaakkola P, Mole DR, Tian Y-M, Wilson MI, Gielbert J, Gaskell SJ, von Kriegsheim K, Hebestreit HF, Mukherji M, Schofield CJ, Maxwell PH, Pugh CW, Ratcliffe PJ: Targeting of HIF-α to the von Hippel–Lindau ubiquitylation complex by O₂ -regulated prolyl hydroxylation. Science. 2001, 292: 468-472.CrossRefPubMed

15.

Maxwell PH, Dachs GU, Gleadle JM, Nicholls LG, Harris AL, Stratford IJ, Hankinson O, Pugh CW, Ratcliffe PJ: Hypoxia inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA. 1997, 94: 8104-8109. 10.1073/pnas.94.15.8104.CrossRefPubMedPubMedCentral

16.

Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KMS, Stratford IJ, Harris AL: Targeting gene expression to hypoxic tumour cells. Nat Med. 1997, 3: 515-520.CrossRefPubMed

17.

Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL, Simons JW: Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 1999, 59: 5830-5835.PubMed

18.

Talks K, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL: The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol. 2000, 157: 411-421.CrossRefPubMedPubMedCentral

19.

Richard DE, Berra E, Pouyssegur J: Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1α) in vascular smooth muscle cells. J Biol Chem. 2000, 275: 26765-26771.PubMed

20.

Semenza GL: Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit Rev Biochem Mol Biol. 2000, 35: 71-103.CrossRefPubMed

21.

Jiang BH, Agani F, Passaniti A, Semenza GL: V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res. 1997, 57: 5328-5335.PubMed

22.

Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ: Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 2000, 14: 391-396.PubMedPubMedCentral

23.

Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu M-M, Simons JW, Semenza GL: Modulation of hypoxia-inducible factor la expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/ FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000, 60: 1541-1545.PubMed

24.

Mazure NM, Chen EY, Laderoute KR, Giaccia AJ: Induction of a vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha- ras -transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 1997, 90: 3322-3331.PubMed

25.

Chen C, Pore N, Behrooz A, Ismail-Beigi F, Maity A: Regulation of glut1 mRNA by hypoxia inducible factor-1: interaction between H- ras and hypoxia. J Biol Chem. 2001, 276: 9519-9525. 10.1074/jbc.M010144200.CrossRefPubMed

26.

Richard DE, Berra E, Gothie E, Roux D, Pouysségur J: p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1. J Biol Chem. 1999, 274: 32631-32637. 10.1074/jbc.274.46.32631.CrossRefPubMed

27.

Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng Q, Dillehay LE, Madan A, Semenza GL, Bedi A: Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1α. Genes Dev. 2000, 14: 34-44.PubMedPubMedCentral

28.

Shim H, Dolde C, Lewis BC, Wu C-S, Dang G, Jungmann RA, Dalla-Favera R, Dang CV: c-Myc transactivation of LDH-A : implications for tumor metabolism and growth. Proc Natl Acad Sci USA. 1997, 94: 6658-6663. 10.1073/pnas.94.13.6658.CrossRefPubMedPubMedCentral

29.

Ryan HE, Lo J, Johnson RS: HIF-1a is required for solid tumor formation and embryonic vascularization. EMBO J. 1998, 17: 3005-3015. 10.1093/emboj/17.11.3005.CrossRefPubMedPubMedCentral

30.

Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, Neeman M, Bono F, Abramovitch R, Maxwell P, Koch CJ, Ratcliffe P, Moons L, Jain RK, Collen D, Keshet E: Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998, 394: 485-490. 10.1038/28867.CrossRefPubMed

31.

Ryan HE, Poloni M, McNulty W, Elson D, Gassmann M, Arbeit JM, Johnson RS: Hypoxia-inducible factor-lα is a positive factor in solid tumor growth. Cancer Res. 2000, 60: 4010-4015.PubMed

32.

Hockel M, Knoop C, Schlenger K, Vorndran B, Baussmann E, Mitze M, Knapstein PG, Vaupel P: Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix. Radiother Oncol. 1993, 26: 45-50.CrossRefPubMed

33.

Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G: Overexpression of hypoxia-inducible factor lα is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000, 60: 4693-4696.PubMed

34.

Volm M, Koomagi R: Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res. 2000, 20: 1527-1533.PubMed

35.

Kung AL, Wang S, Klco JM, Kaelin WG, Livingston DM: Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat Med. 2000, 6: 1335-1340. 10.1038/82146.CrossRefPubMed

Titel: Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways
verfasst von: Christopher W Pugh
Jonathan Gleadle
Patrick H Maxwell
Publikationsdatum: 01.10.2001
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 5/2001
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr313

Neu im Fachgebiet Onkologie

24.04.2024 | DGIM 2024 | Nachrichten

Springer Medizin

Hypoxia and oxidative stress in breast cancer Hypoxia signalling pathways

Abstract

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2001

Phosphoinositide 3-kinase signalling in breast cancer: how big a role might it play?

Hypoxia and oxidative stress in breast cancer Oxidative stress - its effects on the growth, metastatic potential and response to therapy of breast cancer

The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression

BRCA2 and homologous recombination

Hormone replacement therapy use dramatically increases breast oestrogen receptor expression in obese postmenopausal women

Highlights from the 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, USA, 12-15 May 2001

Neu im Fachgebiet Onkologie

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Update Onkologie