Introduction
Methods
German Consortium for Hereditary Breast and Ovarian Cancer
Statistical analysis
Results
Characteristics of the study population
Relatives of index patients | Index patients | |
---|---|---|
Number of patients | 6,235 | 6,230 |
Mutation status, number of patients | ||
BRCA1 pathogenic mutation | 213 | 1,154 |
BRCA2 pathogenic mutation | 106 | 575 |
BRCA negative | 4,326 | 4,501 |
not tested, BRCA1 family | 1,046 | - |
not tested, BRCA2 family | 544 | - |
Patients with contralateral breast cancer | ||
patients from BRCA1 families | 193 | 304 |
patients from BRCA2 families | 56 | 84 |
patients from BRCA negative families | 253 | 349 |
Median year of birth (IQR) | ||
patients from BRCA1 families | 1,943 (1933-1955) | 1,960 (1952-1968) |
patients from BRCA2 families | 1,939 (1928-1952) | 1,957 (1945-1965) |
patients from BRCA negative families | 1,936 (1926-1946) | 1,955 (1944-1964) |
Median age at first breast cancer (IQR) | ||
patients from BRCA1 families | 43.5 (37.5-51.5) | 38.2 (32.8-44.4) |
patients from BRCA2 families | 48.1 (40.4-58.5) | 42.5 (36.4-49.4) |
patients from BRCA negative families | 53.6 (45.3-63.9) | 44.9 (37.9-51.4) |
Median age at contralateral breast cancer (IQR) | ||
patients from BRCA1 families | 47.7 (40.1-55.5) | 43.5 (37.7-50.5) |
patients from BRCA2 families | 53.1 (44.7-62.6) | 47.9 (42.7-55.7) |
patients from BRCA negative families | 56.0 (48.5-66.6) | 51.6 (45.3-59.0) |
Risk of contralateral breast cancer depending on mutation status
Risk of contralateral breast cancer depending on age at first breast cancer
BRCA1
|
BRCA2
| BRCA negative | |
---|---|---|---|
Age at first breast cancer < 40 years | |||
5 years after first breast cancer | 14.1 (10.1-18.0) | 2.9 (0.0-6.3) | 4.8 (2.6-6.9) |
10 years after first breast cancer | 30.1 (24.0-36.2) | 18.2 (7.9-28.5) | 10.6 (6.8-14.4) |
15 years after first breast cancer | 40.8 (33.2-48.3) | 20.9 (9.7-32.1) | 15.3 (10.4-20.3) |
25 years after first breast cancer | 55.1 (45.4-64.9) | 38.4 (18.5-58.2) | 28.4 (20.5-36.3) |
Age at first breast cancer 40-49 years | |||
5 years after first breast cancer | 9.2 (5.8-12.5) | 6.9 (2.7-11.1) | 4.2 (2.9-5.5) |
10 years after first breast cancer | 16.7 (11.7-21.7) | 13.4 (7.0-19.8) | 8.4 (6.3-10.5) |
15 years after first breast cancer | 23.2 (16.9-29.6) | 22.0 (12.1-31.9) | 10.7 (8.1-13.3) |
25 years after first breast cancer | 44.5 (33.2-55.7) | 40.5 (22.4-58.6) | 18.1 (13.9-22.3) |
Age at first breast cancer ≥ 50 years | |||
5 years after first breast cancer | 7.1 (3.8-10.5) | 3.5 (0.9-6.1) | 3.6 (2.7-4.5) |
10 years after first breast cancer | 11.4 (6.5-16.3) | 10.4 (4.9-16.0) | 5.5 (4.3-6.7) |
15 years after first breast cancer | 18.7 (11.0-26.3) | 15.5 (7.8-23.3) | 8.1 (6.3-9.9) |
25 years after first breast cancer | 21.6 (12.3-30.8) | 15.5 (7.8-23.3) | 12.9 (8.9-17.0) |
Total | |||
5 years after first breast cancer | 10.4 (8.3-12.5) | 4.5 (2.5-6.5) | 3.9 (3.2-4.6) |
10 years after first breast cancer | 20.4 (17.1-23.7) | 13.2 (9.2-17.2) | 7.1 (6.0-8.2) |
15 years after first breast cancer | 28.7 (24.4-32.9) | 19.0 (13.5-24.4) | 9.9 (8.5-11.4) |
25 years after first breast cancer | 44.1 (37.6-50.6) | 33.5 (22.4-44.7) | 17.2 (14.5-19.9) |