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Breast Cancer Research

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01.06.2000 | Review

Homeobox genes in mammary gland development and neoplasia

verfasst von: Michael T Lewis

Erschienen in: Breast Cancer Research | Ausgabe 3/2000

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Abstract

Both normal development and neoplastic progression involve cellular transitions from one physiological state to another. Whereas much is being discovered about signal transduction networks involved in regulating these transitions, little progress has been made in identifying the higher order genetic determinants that establish and maintain mammary cell identity and dictate cell type-specific responses to mammotropic signals. Homeobox genes are a large superfamily of genes whose members function in establishing and maintaining cell fate and cell identity throughout embryonic development. Recent genetic and expression analyses strongly suggest that homeobox genes may perform similar functions at specific developmental transition points in the mammary gland. These analyses also suggest that homeobox genes may play a contributory or causal role in breast cancer.

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Titel: Homeobox genes in mammary gland development and neoplasia
verfasst von: Michael T Lewis
Publikationsdatum: 01.06.2000
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 3/2000
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr49

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Springer Medizin

Homeobox genes in mammary gland development and neoplasia

Abstract

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ICI-Therapie in der Schwangerschaft wird gut toleriert

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Springer Medizin

Abstract

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