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Breast Cancer Research

Erschienen in:

01.04.2003 | Commentary

Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1

verfasst von: Mina J Bissell, David Bilder

Erschienen in: Breast Cancer Research | Ausgabe 2/2003

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Abstract

In all epithelial organs, apicobasal polarity determines functional integrity and contributes to the maintenance of tissue and organ specificity. In the breast, the functional unit is a polar double-layered tube consisting of luminal epithelial cells surrounded by myoepithelial cells and a basement membrane. It is far from clear how this double-layered structure is established and how polarity is maintained. Two recent papers have shed some light onto this intriguing problem in mammary gland biology. The results point to desmosomes and laminin 1 as having crucial roles. However, some questions remain.

Bilder D: PDZ proteins and polarity: functions from the fly. Trends Genet. 2001, 17: 511-519. 10.1016/S0168-9525(01)02407-6.CrossRefPubMed

Knust E: Regulation of epithelial cell shape and polarity by cell-cell adhesion. Mol Membr Biol. 2002, 19: 113-120. 10.1080/09687680210137219.CrossRefPubMed

Yeaman C, Grindstaff KK, Nelson WJ: New perspectives on mechanisms involved in generating epithelial cell polarity. Physiol Rev. 1999, 79: 73-98.PubMed

Knust E: Control of epithelial cell shape and polarity. Curr Opin Genet Dev. 2000, 10: 471-475. 10.1016/S0959-437X(00)00115-5.CrossRefPubMed

Tsukita S, Furuse M, Itoh M: Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol. 2001, 2: 285-293. 10.1038/35067088.CrossRefPubMed

O'Brien LE, Zegers MM, Mostov KE: Opinion. Building epithelial architecture: insights from three-dimensional culture models. Nat Rev Mol Cell Biol. 2002, 3: 531-537. 10.1038/nrm859.CrossRefPubMed

Nelson WJ, Yeaman C: Protein trafficking in the exocytic pathway of polarized epithelial cells. Trends Cell Biol. 2001, 11: 483-486. 10.1016/S0962-8924(01)02145-6.CrossRefPubMed

Bissell MJ: The differentiated state of normal and malignant cells or how to define a 'normal' cell in culture. Int Rev Cytol. 1981, 70: 27-100.CrossRefPubMed

Walpita D, Hay E: Studying actin-dependent processes in tissue culture. Nat Rev Mol Cell Biol. 2002, 3: 137-141. 10.1038/nrm727.CrossRefPubMed

10.

Jacks T, Weinberg RA: Taking the study of cancer cell survival to a new dimension. Cell. 2002, 111: 923-925. 10.1016/S0092-8674(02)01229-1.CrossRefPubMed

11.

Barcellos-Hoff MH, Aggeler J, Ram TG, Bissell MJ: Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Development. 1989, 105: 223-235.PubMedPubMedCentral

12.

Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ: Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA. 1992, 89: 9064-9068.CrossRefPubMedPubMedCentral

13.

Bissell MJ, Weaver VM, Lelievre SA, Wang F, Petersen OW, Schmeichel KL: Tissue structure, nuclear organization, and gene expression in normal and malignant breast. Cancer Res. 1999, 59: 1757s-1763s.

14.

Streuli CH, Bissell MJ: Expression of extracellular matrix components is regulated by substratum. J Cell Biol. 1990, 110: 1405-1415.CrossRefPubMed

15.

Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR: Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol. 2001, 3: 823-830. 10.1038/ncb0901-823.CrossRefPubMed

16.

Gudjonsson T, Ronnov-Jessen L, Villadsen R, Rank F, Bissell MJ, Petersen OW: Normal and tumor-derived myoepithelial cells differ in their ability to interact with luminal breast epithelial cells for polarity and basement membrane deposition. J Cell Sci. 2002, 115: 39-50.PubMedPubMedCentral

17.

Page MJ, Amess B, Townsend RR, Parekh R, Herath A, Brusten L, Zvelebil MJ, Stein RC, Waterfield MD, Davies SC, O'Hare MJ: Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Proc Natl Acad Sci USA. 1999, 96: 12589-12594. 10.1073/pnas.96.22.12589.CrossRefPubMedPubMedCentral

18.

Pechoux C, Gudjonsson T, Ronnov-Jessen L, Bissell MJ, Petersen OW: Human mammary luminal epithelial cells contain progenitors to myoepithelial cells. Dev Biol. 1999, 206: 88-99. 10.1006/dbio.1998.9133.CrossRefPubMed

19.

Weaver V, Lelievre S, Lakins J, Chrenek M, Jones J, Giancotti F, Werb Z, Bissell M: 4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002, 2: 205-216. 10.1016/S1535-6108(02)00125-3.CrossRefPubMedPubMedCentral

20.

Howlett AR, Bailey N, Damsky C, Petersen OW, Bissell MJ: Cellular growth and survival are mediated by beta 1 integrins in normal human breast epithelium but not in breast carcinoma. J Cell Sci. 1995, 108: 1945-1957.PubMed

21.

Lelievre SA, Weaver VM, Nickerson JA, Larabell CA, Bhaumik A, Petersen OW, Bissell MJ: Tissue phenotype depends on reciprocal interactions between the extracellular matrix and the structural organization of the nucleus. Proc Natl Acad Sci USA. 1998, 95: 14711-14716. 10.1073/pnas.95.25.14711.CrossRefPubMedPubMedCentral

22.

Gateff E: Malignant neoplasms of genetic origin in Drosophila melanogaster. Science. 1978, 200: 1448-1459.CrossRefPubMed

23.

Brown NH: Cell-cell adhesion via the ECM: integrin genetics in fly and worm. Matrix Biol. 2000, 19: 191-201. 10.1016/S0945-053X(00)00064-0.CrossRefPubMed

Titel: Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1
verfasst von: Mina J Bissell
David Bilder
Publikationsdatum: 01.04.2003
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 2/2003
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr579

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Polarity determination in breast tissue: desmosomal adhesion, myoepithelial cells, and laminin 1

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