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Breast Cancer Research

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01.02.2003 | Commentary

Akt2: a role in breast cancer metastasis

verfasst von: Noan-Minh Chau, Margaret Ashcroft

Erschienen in: Breast Cancer Research | Ausgabe 1/2003

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Abstract

Metastasis in breast cancer significantly increases morbidity and mortality. The 5-year survival rate reduces from 90% for localised disease to about 20% once metastasis has taken place. The phosphoinositide 3-kinase/Akt signalling pathway has an important role in cell motility, invasion and metastasis. However, the precise contribution of the Akt kinase family members, Akt1, Akt2 and Akt3, in mediating these processes is unclear. The possibility that they have distinct functions in tumour progression is particularly interesting.

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Titel: Akt2: a role in breast cancer metastasis
verfasst von: Noan-Minh Chau
Margaret Ashcroft
Publikationsdatum: 01.02.2003
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 1/2003
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr739

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