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Erschienen in: Critical Care 4/2002

01.08.2002 | Review

Bench-to-bedside review: Glucose production from the kidney

verfasst von: Noël Cano

Erschienen in: Critical Care | Ausgabe 4/2002

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Abstract

Data obtained from net organ balance studies of glucose production lead to the classic view according to which glucose homeostasis is mainly ensured by the liver, and renal glucose production only plays a significant role during acidosis and prolonged starvation. Renal glucose release and uptake, as well as the participation of gluconeogenic substrates in renal gluconeogenesis, were recently re-evaluated using systemic and renal arteriovenous balance of substrates in combination with deuterated glucose dilution. Data obtained using these methods lead one to reconsider the magnitude of renal glucose production as well as its role in various physiological and pathological circumstances. These findings now conduce one to consider that renal gluconeogenesis substantially participates in postabsorptive glucose production, and that its role in glucose homeostasis is of first importance.
Literatur
1.
Zurück zum Zitat Gerich JE, Meyer C, Woerle HJ, Stumvoll M: Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care 2001, 24: 382-391.CrossRefPubMed Gerich JE, Meyer C, Woerle HJ, Stumvoll M: Renal gluconeogenesis: its importance in human glucose homeostasis. Diabetes Care 2001, 24: 382-391.CrossRefPubMed
2.
Zurück zum Zitat Fischer KF, Lees JA, Newman JH: Hypoglycemia in hospitalized patients: causes and outcome. N Engl J Med 1986, 315: 1245-1250.CrossRefPubMed Fischer KF, Lees JA, Newman JH: Hypoglycemia in hospitalized patients: causes and outcome. N Engl J Med 1986, 315: 1245-1250.CrossRefPubMed
3.
Zurück zum Zitat Cano N: Inter-relationships between renal metabolism (both in physiology and renal dysfunction) and the liver. Curr Opin Clin Nutr Metab Care 2001, 4: 279-285. 10.1097/00075197-200107000-00006CrossRefPubMed Cano N: Inter-relationships between renal metabolism (both in physiology and renal dysfunction) and the liver. Curr Opin Clin Nutr Metab Care 2001, 4: 279-285. 10.1097/00075197-200107000-00006CrossRefPubMed
4.
Zurück zum Zitat Bjorkman O, Gunnarsson R, Hagstrom E, Felig P, Wahren J: Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls. J Clin Invest 1989, 83: 52-59.PubMedCentralCrossRefPubMed Bjorkman O, Gunnarsson R, Hagstrom E, Felig P, Wahren J: Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls. J Clin Invest 1989, 83: 52-59.PubMedCentralCrossRefPubMed
5.
Zurück zum Zitat Ahlborg G, Weitzberg E, Sollevi A, Lundberg JM: Splanchnic and renal vasoconstrictor and metabolic responses to neuropeptide Y in resting and exercising man. Acta Physiol Scand 1992, 145: 139-149.CrossRefPubMed Ahlborg G, Weitzberg E, Sollevi A, Lundberg JM: Splanchnic and renal vasoconstrictor and metabolic responses to neuropeptide Y in resting and exercising man. Acta Physiol Scand 1992, 145: 139-149.CrossRefPubMed
6.
Zurück zum Zitat Brundin T, Wahren J: Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man. Am J Physiol 1994, 267: E648-E655.PubMed Brundin T, Wahren J: Renal oxygen consumption, thermogenesis, and amino acid utilization during i.v. infusion of amino acids in man. Am J Physiol 1994, 267: E648-E655.PubMed
7.
Zurück zum Zitat Gerich JE, Campbell PJ: Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions. Diab Metab Rev 1988, 4: 93-111.CrossRef Gerich JE, Campbell PJ: Overview of counterregulation and its abnormalities in diabetes mellitus and other conditions. Diab Metab Rev 1988, 4: 93-111.CrossRef
8.
Zurück zum Zitat Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI: Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol 1996, 270: E186-E191.PubMed Petersen KF, Price T, Cline GW, Rothman DL, Shulman GI: Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol 1996, 270: E186-E191.PubMed
9.
Zurück zum Zitat Chandramouli V, Ekberg K, Schumann W, Kalhan S, Wahren J, Landau B: Quantifying gluconeogenesis during fasting. Am J Physiol 1997, 273: E1209-E1215.PubMed Chandramouli V, Ekberg K, Schumann W, Kalhan S, Wahren J, Landau B: Quantifying gluconeogenesis during fasting. Am J Physiol 1997, 273: E1209-E1215.PubMed
10.
Zurück zum Zitat Newsholme EA, Leech AR: Biochemistry for the Medical Sciences. Chichester: John Wiley and Sons; 1990. Newsholme EA, Leech AR: Biochemistry for the Medical Sciences. Chichester: John Wiley and Sons; 1990.
11.
Zurück zum Zitat Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J: Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest 1995, 96: 2528-2533.PubMedCentralCrossRefPubMed Stumvoll M, Chintalapudi U, Perriello G, Welle S, Gutierrez O, Gerich J: Uptake and release of glucose by the human kidney. Postabsorptive rates and responses to epinephrine. J Clin Invest 1995, 96: 2528-2533.PubMedCentralCrossRefPubMed
12.
Zurück zum Zitat Meyer C, Nadkarni V, Stumvoll M, Gerich J: Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. Am J Physiol 1997, 273: E650-E654.PubMed Meyer C, Nadkarni V, Stumvoll M, Gerich J: Human kidney free fatty acid and glucose uptake: evidence for a renal glucose-fatty acid cycle. Am J Physiol 1997, 273: E650-E654.PubMed
13.
Zurück zum Zitat Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J: Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 1998, 102: 619-624.PubMedCentralCrossRefPubMed Meyer C, Stumvoll M, Nadkarni V, Dostou J, Mitrakou A, Gerich J: Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 1998, 102: 619-624.PubMedCentralCrossRefPubMed
14.
Zurück zum Zitat Meyer C, Dostou J, Nadkarni V, Gerich J: Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism. Am J Physiol 1998, 275: F915-F921.PubMed Meyer C, Dostou J, Nadkarni V, Gerich J: Effects of physiological hyperinsulinemia on systemic, renal, and hepatic substrate metabolism. Am J Physiol 1998, 275: F915-F921.PubMed
15.
Zurück zum Zitat Stumvoll M, Meyer C, Perriello G, Kreider M, Welle S, Gerich J: Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity. Am J Physiol 1998, 274: E817-E826.PubMed Stumvoll M, Meyer C, Perriello G, Kreider M, Welle S, Gerich J: Human kidney and liver gluconeogenesis: evidence for organ substrate selectivity. Am J Physiol 1998, 274: E817-E826.PubMed
16.
Zurück zum Zitat Stumvoll M, Meyer C, Kreider M, Perriello G, Gerich J: Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans. Metabolism 1998, 47: 1227-1232.CrossRefPubMed Stumvoll M, Meyer C, Kreider M, Perriello G, Gerich J: Effects of glucagon on renal and hepatic glutamine gluconeogenesis in normal postabsorptive humans. Metabolism 1998, 47: 1227-1232.CrossRefPubMed
17.
Zurück zum Zitat Ekberg K, Landau BR, Wajngot A, Chandramouli V, Efendic S, Brunengraber H, Wahren J: Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. Diabetes 1999, 48: 292-298.CrossRefPubMed Ekberg K, Landau BR, Wajngot A, Chandramouli V, Efendic S, Brunengraber H, Wahren J: Contributions by kidney and liver to glucose production in the postabsorptive state and after 60 h of fasting. Diabetes 1999, 48: 292-298.CrossRefPubMed
18.
Zurück zum Zitat Cersosimo E, Garlick P, Ferretti J: Insulin regulation of renal glucose metabolism in humans. Am J Physiol 1999, 276: E78-E84.PubMed Cersosimo E, Garlick P, Ferretti J: Insulin regulation of renal glucose metabolism in humans. Am J Physiol 1999, 276: E78-E84.PubMed
19.
Zurück zum Zitat Cersosimo E, Garlick P, Ferretti J: Renal glucose production during insulin-induced hypoglycemia in humans. Diabetes 1999, 48: 261-266.CrossRefPubMed Cersosimo E, Garlick P, Ferretti J: Renal glucose production during insulin-induced hypoglycemia in humans. Diabetes 1999, 48: 261-266.CrossRefPubMed
20.
Zurück zum Zitat Cersosimo E, Garlick P, Ferretti J: Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans. Diabetes 2000, 49: 1186-1193.CrossRefPubMed Cersosimo E, Garlick P, Ferretti J: Renal substrate metabolism and gluconeogenesis during hypoglycemia in humans. Diabetes 2000, 49: 1186-1193.CrossRefPubMed
21.
Zurück zum Zitat Cersosimo E, Garlick P, Ferretti J: Regulation of splanchnic and renal substrate supply by insulin in humans. Metabolism 2000, 49: 676-683.CrossRefPubMed Cersosimo E, Garlick P, Ferretti J: Regulation of splanchnic and renal substrate supply by insulin in humans. Metabolism 2000, 49: 676-683.CrossRefPubMed
22.
Zurück zum Zitat Joseph SE, Heaton N, Potter D, Pernet A, Umpleby MA, Amiel SA: Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation. Diabetes 2000, 49: 450-456.CrossRefPubMed Joseph SE, Heaton N, Potter D, Pernet A, Umpleby MA, Amiel SA: Renal glucose production compensates for the liver during the anhepatic phase of liver transplantation. Diabetes 2000, 49: 450-456.CrossRefPubMed
23.
Zurück zum Zitat Tizianello A, De Ferrari G, Garibotto G, Gurreri G, Robaudo C: Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980, 65: 1162-1173.PubMedCentralCrossRefPubMed Tizianello A, De Ferrari G, Garibotto G, Gurreri G, Robaudo C: Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. J Clin Invest 1980, 65: 1162-1173.PubMedCentralCrossRefPubMed
24.
Zurück zum Zitat Tessari P, Garibotto G: Interorgan amino acid exchange. Curr Opin Clin Nutr Metab Care 2000, 3: 51-57. 10.1097/00075197-200001000-00009CrossRefPubMed Tessari P, Garibotto G: Interorgan amino acid exchange. Curr Opin Clin Nutr Metab Care 2000, 3: 51-57. 10.1097/00075197-200001000-00009CrossRefPubMed
25.
Zurück zum Zitat Fafournoux P, Demigné C, Rémésy C, Le Cam A: Bidirectional transport of glutamine across the cell membrane in rat liver. Biochem J 1983, 216: 401-408.PubMedCentralCrossRefPubMed Fafournoux P, Demigné C, Rémésy C, Le Cam A: Bidirectional transport of glutamine across the cell membrane in rat liver. Biochem J 1983, 216: 401-408.PubMedCentralCrossRefPubMed
27.
Zurück zum Zitat Rajas F, Bruni N, Montano S, Zitoun C, Mithieux G: The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology 1999, 117: 132-139.CrossRefPubMed Rajas F, Bruni N, Montano S, Zitoun C, Mithieux G: The glucose-6 phosphatase gene is expressed in human and rat small intestine: regulation of expression in fasted and diabetic rats. Gastroenterology 1999, 117: 132-139.CrossRefPubMed
28.
Zurück zum Zitat Rajas F, Croset M, Zitoun C, Montano S, Mithieux G: Induction of PEPCK gene expression in insulinopenia in rat small intestine. Diabetes 2000, 49: 1165-1168.CrossRefPubMed Rajas F, Croset M, Zitoun C, Montano S, Mithieux G: Induction of PEPCK gene expression in insulinopenia in rat small intestine. Diabetes 2000, 49: 1165-1168.CrossRefPubMed
29.
Zurück zum Zitat Cano N, Catelloni F, Fontaine E, Novaretti R, Reynier JP, Leverve XM: Isolated rat hepatocyte metabolism is affected by chronic renal failure. Kidney Int 1995, 47: 1522-1527.CrossRefPubMed Cano N, Catelloni F, Fontaine E, Novaretti R, Reynier JP, Leverve XM: Isolated rat hepatocyte metabolism is affected by chronic renal failure. Kidney Int 1995, 47: 1522-1527.CrossRefPubMed
30.
Zurück zum Zitat Vinay P, Lemieux G, Gougoux A, Halperin M: Regulation of glutamine metabolism in dog kidney in vivo. Kidney Int 1986, 29: 68-79.CrossRefPubMed Vinay P, Lemieux G, Gougoux A, Halperin M: Regulation of glutamine metabolism in dog kidney in vivo. Kidney Int 1986, 29: 68-79.CrossRefPubMed
31.
Zurück zum Zitat Boon L, Blommart PJE, Meijer AJ, Lamers WH, Schoolwerth AC: Effect of chronic acidosis on hepatic amino acid uptake and gene regulation: implications for control of acid–base balance. In Renal Ammoniagenesis and Interorgan Cooperation in Acid–Base Homeostasis. (Edited by: Tizianello A, Baverel G, Endou H). Basel: Karger 1994, 138-143. Boon L, Blommart PJE, Meijer AJ, Lamers WH, Schoolwerth AC: Effect of chronic acidosis on hepatic amino acid uptake and gene regulation: implications for control of acid–base balance. In Renal Ammoniagenesis and Interorgan Cooperation in Acid–Base Homeostasis. (Edited by: Tizianello A, Baverel G, Endou H). Basel: Karger 1994, 138-143.
Metadaten
Titel
Bench-to-bedside review: Glucose production from the kidney
verfasst von
Noël Cano
Publikationsdatum
01.08.2002
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 4/2002
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc1517

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