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Erschienen in: Critical Care 6/2005

Open Access 01.12.2005 | Research

Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]

verfasst von: Rupert Pearse, Deborah Dawson, Jayne Fawcett, Andrew Rhodes, R Michael Grounds, E David Bennett

Erschienen in: Critical Care | Ausgabe 6/2005

Abstract

Introduction

Goal-directed therapy (GDT) has been shown to improve outcome when commenced before surgery. This requires pre-operative admission to the intensive care unit (ICU). In cardiac surgery, GDT has proved effective when commenced after surgery. The aim of this study was to evaluate the effect of post-operative GDT on the incidence of complications and duration of hospital stay in patients undergoing general surgery.

Methods

This was a randomised controlled trial with concealed allocation. High-risk general surgical patients were allocated to post-operative GDT to attain an oxygen delivery index of 600 ml min-1 m-2 or to conventional management. Cardiac output was measured by lithium indicator dilution and pulse power analysis. Patients were followed up for 60 days.

Results

Sixty-two patients were randomised to GDT and 60 patients to control treatment. The GDT group received more intravenous colloid (1,907 SD ± 878 ml versus 1,204 SD ± 898 ml; p < 0.0001) and dopexamine (55 patients (89%) versus 1 patient (2%); p < 0.0001). Fewer GDT patients developed complications (27 patients (44%) versus 41 patients (68%); p = 0.003, relative risk 0.63; 95% confidence intervals 0.46 to 0.87). The number of complications per patient was also reduced (0.7 SD ± 0.9 per patient versus 1.5 SD ± 1.5 per patient; p = 0.002). The median duration of hospital stay in the GDT group was significantly reduced (11 days (IQR 7 to 15) versus 14 days (IQR 11 to 27); p = 0.001). There was no significant difference in mortality (seven patients (11.3%) versus nine patients (15%); p = 0.59).

Conclusion

Post-operative GDT is associated with reductions in post-operative complications and duration of hospital stay. The beneficial effects of GDT may be achieved while avoiding the difficulties of pre-operative ICU admission.
Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​cc3887) contains supplementary material, which is available to authorized users.

Competing interests

RP received a travel grant from LiDCO Ltd. to present this data at an international meeting. JF has previously performed consultancy work for LiDCO Ltd. DB currently performs consultancy work for LiDCO Ltd. and has previously performed consultancy work for Deltex Ltd. No other competing interests are declared.

Authors' contributions

RP, DD, AR, MG and DB were responsible for study design. RP, DD and JF were responsible for administering the protocol. All authors were involved in data analysis and drafting the manuscript and approved the final version. All authors had full access to data and take responsibility for the integrity of the data and the accuracy of the analysis.
Abkürzungen
CVP
central venous pressure
DO
oxygen delivery index
GDT
goal-directed therapy
ICU
intensive care unit
IQR
Interquartile range
PO
partial pressure of oxygen
P-POSSUM
Portsmouth Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity.

Introduction

Goal-directed therapy (GDT) is a term used to describe the use of cardiac output or similar parameters to guide intravenous fluid and inotropic therapy. When commenced in the pre-operative period, this technique has been shown to improve outcome after major general surgery [13]. Although the number of post-operative deaths has changed little in recent years [4, 5], pre-operative GDT has not been introduced into routine practice. The principal reason for this is likely to be the limited availability of intensive care unit (ICU) facilities, but there are also safety concerns regarding the use of the pulmonary artery catheter to measure cardiac output [6].
In cardiac surgery, these problems have been addressed successfully by commencing GDT in the immediate post-operative period [7, 8] and by using the oesophageal Doppler probe in place of the pulmonary artery catheter to measure cardiac output [8]. Use of the oesophageal Doppler probe to guide fluid administration during surgery is also associated with improved outcome [913] Unfortunately the Doppler probe is not readily tolerated by conscious patients, restricting use to patients who are ventilated following surgery.
There is a need to establish whether GDT is effective when commenced after major general surgery. This study was undertaken to assess the effect of post-operative GDT on complication rates and duration of hospital stay in high-risk general surgical patients.

Materials and methods

Participants

Adult patients scheduled for major general surgery and deemed to be at a high risk of post-operative complications were enrolled in accordance with criteria similar to those used in previous trials (see Additional file 1) [1, 2]. Patients were screened for eligibility by a member of the research team, who obtained written informed consent before surgery. This study was approved by the Local Research Ethics Committee of St George's Healthcare National Health Service Trust.

Protocol

This was a randomised controlled, partly blind, single-centre study conducted in the adult ICU at St George's Hospital, London. The primary outcome measure was the incidence of post-operative complications. Secondary outcome measures were the duration of hospital stay and mortality. Patients were assigned to GDT or control groups by computer-generated random sequence. Study group assignments were placed in serially numbered opaque envelopes. Randomisation was performed by a member of the research team when surgery was complete. Data were analysed on an intention-to-treat basis, including all patients who were randomised (Figure 1).
Protocols for haemodynamic management during the first 8 hours after surgery are summarised in Figure 2. Patients in the control group were administered 250 ml boluses of intravenous colloid solution (Gelofusine; B Braun Medical Ltd., Sheffield, UK) to achieve a sustained increase in central venous pressure (CVP) of at least 2 mmHg for 20 minutes. GDT patients received 250 ml boluses of intravenous colloid solution to achieve a sustained rise in stroke volume of at least 10% for 20 minutes. Fluid challenges were repeated if the target parameter subsequently decreased or if there was strong clinical suspicion of persistent hypovolaemia. The GDT group also received dopexamine up to a maximum of 1 μg kg-1 min-1 if oxygen delivery index (DO2I) did not reach 600 ml min-1 m-2 with intravenous fluid alone. The dose of dopexamine was reduced or discontinued in patients who became tachycardic (heart rate above 100 beats min-1 or an increase greater than 20% above baseline) or developed myocardial ischaemia (clinical symptoms or electrocardiograph criteria). These treatments were administered by a member of the research team who was the only individual aware of study group allocation. All other aspects of patient care were handled by clinical staff. Dopexamine was prepared in a masked syringe for each patient in the GDT group, while a dummy infusion (normal saline) was prepared in a similarly masked syringe for all patients in the control group. Cardiac output data were concealed from non-research staff unless predefined criteria were satisfied allowing the use of cardiac output data in deteriorating patients (Figure 2).

Assessments

The following parameters were monitored continuously during the study period: electrocardiograph, pulse oximetry, invasive arterial pressure, CVP and cardiac output. Lithium indicator dilution and pulse power analysis was used to measure cardiac output and to calculate DO2I (LiDCO plus system; LiDCO Ltd., Cambridge, UK). This technique is minimally invasive and well validated [14]. Arterial blood gas measurements were performed hourly during the study period. P-POSSUM (Portsmouth Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity) and APACHE II (Acute Physiology and Chronic Health Evaluation II) scores were calculated after admission to the ICU [15, 16]. Patients were followed up for 60 days. Diagnosis and management of complications were undertaken by non-research staff. These were verified, in accordance with predefined criteria, by a member of the research team unaware of study group allocation. This process involved inspection of notes, radiological investigations, laboratory data and clinical assessment.

Statistical analysis

Assuming a two-sided type I error rate of 5% and a power of 80%, we calculated that a sample size of 300 patients would be required to detect a reduction in the proportion of patients developing complications from 50% in the control group to 34% in the GDT group. These values were based on the observed incidence of complications in the control groups of previous similar trials [1, 3]. Arrangements were made prospectively for interim analyses after the recruitment of 100 and 200 patients. To minimise the possibility of type I error at interim analysis, a more stringent level of significance was required (p < 0.01) for the trial to be stopped after interim analysis than that used for the initial power analysis (p < 0.05).
Data are presented as means (standard deviation) where normally distributed, and as median (interquartile range) where not normally distributed. Relative risk is presented with 95% confidence intervals. Categorical data were tested with Fisher's exact test. Continuous data were tested with the t test where normally distributed, and with the Mann–Whitney U test where not normally distributed. Confidence intervals were constructed for the difference in mean duration of stay between the two groups by bootstrapping within treatment groups [17]. Analysis was performed with GraphPad Prism version 4.0. Significance was set at p < 0.05.

Results

A total of 122 patients were recruited between November 2002 and August 2004 (Figure 1). The study was stopped early on the advice of the external safety assessor, after assessment of data from the first 100 patients, because the primary end-point had been achieved. By this time 62 patients had been randomised to the GDT group and 60 patients to the control group. The groups were well matched for age, sex, blood loss, type of surgery and anaesthetic technique (Table 1).
Table 1
Baseline characteristics of patients in the goal-directed therapy (GDT) and control groups
Characteristics
Control group
GDT group
Number in group
60
62
Age (years)
68 ± 11.6
66 ± 11.4
Male
39 (65%)
42 (68%)
P-POSSUM operative score
17.1 ± 4.9
17.8 ± 4.9
P-POSSUM physiology score
19.8 ± 5.5
21.9 ± 6.7
APACHE II score
9.6 ± 4.3
9.4 ± 3.9
ASA status 3 and above
43 (72%)
50 (81%)
Aged over 70 years with limited physiological reserve
20 (33%)
13 (21%)
Known history of severe cardiac or respiratory illness
22 (37%)
19 (31%)
Extensive surgery planned for carcinoma involving bowel anastomosis
21 (35%)
27 (44%)
Late-stage vascular disease involving the aorta
15 (25%)
11 (18%)
Elective surgery
54 (90%)
55 (88%)
Type of surgery
  
   Vascular
16 (27%)
12 (19%)
   Upper gastro-intestinal
8 (13%)
16 (26%)
   Hepato-biliary
4 (7%)
8 (13%)
   Lower gastro-intestinal
14 (23%)
10 (16%)
   Urology
15 (25%)
11 (18%)
   Other
3 (5%)
5 (8%)
Values are absolute (%) or mean ± SD. APACHE, Acute Physiology and Chronic Health Evaluation; ASA, American Society of Anesthesiologists; P-POSSUM, Portsmouth Physiologic and Operative Severity Score for the enUmeration of Mortality and morbidity.
The goal for DO2I was achieved by most patients in the GDT group and spontaneously by a smaller proportion of the control group (49 patients (79%) versus 27 patients (45%); p = 0.0002; Figure 3). Patients in the GDT group received a greater volume of colloid solution but a similar volume of blood (Table 2). Dopexamine was administered to 55 patients in the GDT group and, on the instruction of clinical staff, to one patient in the control group. Despite receiving the maximum therapy allowed by the protocol, 13 patients in the GDT group did not achieve the goal for DO2I. In seven of these patients the dose of dopexamine was reduced either because of tachycardia (six patients) or myocardial ischaemia (one patient).
Table 2
Therapeutic interventions and changes in physiological parameters during the 8-hour study period
Parameter
Control group
GDT group
p
Intervention
   
   Crystalloid (ml)
960 ± 335
930 ± 221
0.39
   Colloid (ml)
1,204 ± 898
1,907 ± 878
<0.0001
   Blood (ml)
0 (0–485)
125 (0–734)
0.10
   Dopexamine (μg kg-1 min-1)
0.0 (0.0–0.0)
0.75 (0.5–1.0)
<0.0001
Change in variable
   
   DO2I (ml min-1 m-2)
-10 ± 190
+163 ± 249
0.0001
   Stroke volume (ml)
-7.2 ± 28.7
+6.7 ± 26.1
0.01
   CVP (mmHg)
-1.6 ± 6.8
-2.1 ± 5.4
0.69
   Serum lactate (mmol l-1)
-0.6 ± 1.1
-0.3 ± 0.8
0.11
Data are presented as mean ± SD or median (interquartile range). CVP, central venous pressure; DO2I, oxygen delivery index. GDT, goal-directed therapy.
Fewer patients developed complications in the GDT group (27 patients (44%) versus 41 patients (68%); relative risk 0.63; 95% confidence interval 0.46 to 0.87; p = 0.003). The total number of complications per patient was also lower in the GDT group (0.7 per patient (SD 0.9) versus 1.5 per patient (SD 1.5); p = 0.002; Tables 3 and 4). The reduction in the number of post-operative complications in the GDT group was associated with a reduction in both mean duration of hospital stay (17.5 days versus 29.5 days, 41% reduction (95% confidence intervals 0 to 81); p = 0.001) and median duration of stay (11 days (7 to 15) versus 14 days (11 to 27); p = 0.001). There was no difference in duration of ICU stay (43 hours (24 to 102) versus 45 hours (25 to 99); p = 0.82). There were no delays in discharge as a result of problems in organising nursing home placement or other social care. There were no significant differences in 28-day or 60-day mortality (Table 3). The 28-day mortality predicted with the P-POSSUM score was higher for the GDT than for the control group (18.5% versus 13.7%; p = 0.09).
Table 3
Summary of outcomes after 8-hour intervention period
Outcome measure
Control group
GDT group
p
Number of patients with complications
41 (68%)
27 (44%)
0.007
Median duration of hospital stay (days)
14 (11–27)
11 (7–15)
0.001
Mean duration of hospital stay (days)
29.5 (34.8)
17.5 (20.8)
0.001
Duration of ICU stay (hours)
45 (25–99)
43 (24–102)
0.82
28-day mortality
7 (11.7%)
6 (9.7%)
0.78
60-day mortality
9 (15%)
7 (11.3%)
0.59
Data are presented as median (interquartile range) or absolute value (%). ICU, intensive care unit. GDT, goal-directed therapy.
Table 4
Post-operative complications in goal-directed therapy (GDT) and control groups
Complication
Control group
GDT group
Infection
  
   Pneumonia
20
11
   Abdominal
5
4
   Urinary tract
3
1
   Central venous catheter
6
2
   Wound
20
4
Respiratory
  
   Pleural effusion
4
1
   Pneumothorax
1
0
   Pulmonary embolism
1
0
   Acute respiratory distress syndrome
2
2
Cardiovascular
  
   Arrhythmia
9
5
   Acute pulmonary oedema
4
3
   Acute myocardial infarction
3
0
   Stroke
1
2
Abdominal
  
   Clostridium difficile diarrhoea
1
0
   Acute bowel obstruction
1
1
   Upper gastro-intestinal bleed
4
2
   Prolonged paralytic ileus
3
2
   Anastomotic leak
1
1
   Intra-abdominal hypertension
1
0
Post-operative massive haemorrhage
1
1
Total
90
43

Discussion

This is the first study to investigate the effects of post-operative GDT in high-risk patients undergoing major general surgery. The effect of the GDT protocol was to reduce the number of patients developing complications and shorten their hospital stay in comparison with a protocol designed to reflect standard care. Thus, some of the beneficial effects of GDT might still be achieved when pre-operative ICU admission is not possible. In addition, the use of lithium indicator dilution and pulse power analysis to measure cardiac output obviates the need for insertion of a pulmonary artery catheter. The GDT protocol used in this study is therefore a practical and effective intervention.
The mortality in both groups was lower than had been predicted by the P-POSSUM score, suggesting that all patients received a high standard of care. All patients in the control group were admitted to the ICU and received intravenous fluid resuscitation guided by CVP measurements. Rather than apply an absolute target for CVP, a dynamic fluid response target of at least 2 mmHg was used. This provides a more reliable guide to fluid requirements and avoids discrepancies arising from differences in intrathoracic pressures between patients who are ventilated and those who are not. In addition, cardiac output was measured in all patients and was revealed to clinical staff according to predefined criteria. It is difficult to design a simple protocol that will account for all eventualities. Allowance was therefore made for the administration of a fluid challenge where there was strong clinical suspicion of hypovolaemia, but a fluid challenge was not mandated by the protocol.
In several studies, GDT has been shown to improve outcome when commenced before surgery [13]. However, a recent multi-centre trial that randomised surgical patients to pulmonary artery catheterisation or conventional management failed to show a difference in outcome [18]. These findings might have occurred as a result of several important methodological flaws, which have been discussed elsewhere [19]. The important differences between the present study and previous work in general surgical patients are that the protocol was commenced after surgery, was only 8 hours in duration and did not require the use of a pulmonary artery catheter. This design is similar to two successful trials of post-operative GDT in cardiac surgical patients [7, 8]. A recent retrospective study illustrates the continued interest in the use of peri-operative β-blockade in high-risk surgical patients [20], although the results of a multi-centre trial are still awaited [21]. The apparent efficacy of GDT and β-blockade relates to effects on different pathophysiological processes. Both treatments are likely to have a role in the management of the high-risk surgical patient.
The mechanism of the therapeutic effect of GDT remains unclear. It may be that increased global oxygen delivery results in increased tissue partial pressure of oxygen (PO2), with improved tissue healing and reduced infection rates. There is some evidence that additional intravenous fluid use improves tissue PO2 during surgery [22] and that decreases in global oxygen delivery and regional oxygen tension are associated with poor tissue healing and infection [23, 24]. The use of GDT may also have financial implications. Previous studies have shown peri-operative GDT to be associated with an overall cost reduction [25, 26]. In the present study, GDT was associated with a 41% reduction in mean duration of hospital stay. This suggests that the use of GDT might reduce the overall cost of surgical care.
There are some potential weaknesses in the design of this study. It was a small single-centre study that was stopped early after interim analysis of a composite end-point. These factors limit the applicability of the findings. Recruitment was possible only when a member of the research team was available to take informed consent before surgery and administer the 8-hour study protocol. During the trial period, 979 surgical patients were admitted to ICU, with a hospital mortality of 12.1%. Not all of these patients would have been eligible for recruitment. Studies of any interventional protocol will require at least one individual to be aware of study group allocation. Although this does increase the possibility of bias, we took several measures to conceal allocation from everyone except the member of the research team delivering the protocol. Masked infusions and identical monitoring equipment were used for all patients. It would not have been possible for non-research staff to identify study group allocation.

Conclusion

The use of post-operative GDT is associated with reductions in complications and duration of hospital stay but avoids the problems associated with pre-operative ICU admission and pulmonary artery catheterisation. A large multi-centre trial should be performed to validate the applicability of these findings to a wider population.

Key messages

  • Goal Directed Therapy has been shown to improve outcome when commenced before surgery, but this approach has proved impractical.
  • This study suggests that post-operative Goal Directed Therapy is also effective, but does not require pre-operative ICU admission.

Competing interests

RP received a travel grant from LiDCO Ltd. to present this data at an international meeting. JF has previously performed consultancy work for LiDCO Ltd. DB currently performs consultancy work for LiDCO Ltd. and has previously performed consultancy work for Deltex Ltd. No other competing interests are declared.

Authors' contributions

RP, DD, AR, MG and DB were responsible for study design. RP, DD and JF were responsible for administering the protocol. All authors were involved in data analysis and drafting the manuscript and approved the final version. All authors had full access to data and take responsibility for the integrity of the data and the accuracy of the analysis.
Anhänge

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Literatur
1.
Zurück zum Zitat Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993, 270: 2699-2707. 10.1001/jama.270.22.2699CrossRefPubMed Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993, 270: 2699-2707. 10.1001/jama.270.22.2699CrossRefPubMed
2.
Zurück zum Zitat Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS: Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988, 94: 1176-1186.CrossRefPubMed Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS: Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 1988, 94: 1176-1186.CrossRefPubMed
3.
Zurück zum Zitat Wilson J, Woods I, Fawcett J, Whall R, Dibb W, Morris C, McManus E: Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery. BMJ 1999, 318: 1099-1103.PubMedCentralCrossRefPubMed Wilson J, Woods I, Fawcett J, Whall R, Dibb W, Morris C, McManus E: Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery. BMJ 1999, 318: 1099-1103.PubMedCentralCrossRefPubMed
4.
Zurück zum Zitat Cullinane M, Gray AJ, Hargraves CM, Lansdown M, Martin IC, Schubert M: The 2003 Report of the National Confidential Enquiry into Peri-Operative Deaths. London: NCEPOD; 2003. Cullinane M, Gray AJ, Hargraves CM, Lansdown M, Martin IC, Schubert M: The 2003 Report of the National Confidential Enquiry into Peri-Operative Deaths. London: NCEPOD; 2003.
5.
Zurück zum Zitat Campling EA, Devlin HB, Lunn JN: Report of the National Confidential Enquiry into Peri-Operative Deaths. London: NCEPOD; 1990. Campling EA, Devlin HB, Lunn JN: Report of the National Confidential Enquiry into Peri-Operative Deaths. London: NCEPOD; 1990.
7.
Zurück zum Zitat Polonen P, Ruokonen E, Hippelainen M, Poyhonen M, Takala J: A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg 2000, 90: 1052-1059.CrossRefPubMed Polonen P, Ruokonen E, Hippelainen M, Poyhonen M, Takala J: A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg 2000, 90: 1052-1059.CrossRefPubMed
8.
Zurück zum Zitat McKendry M, McGloin H, Saberi D, Caudwell L, Brady AR, Singer M: Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery. BMJ 2004, 329: 258. 10.1136/bmj.38156.767118.7CPubMedCentralCrossRefPubMed McKendry M, McGloin H, Saberi D, Caudwell L, Brady AR, Singer M: Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery. BMJ 2004, 329: 258. 10.1136/bmj.38156.767118.7CPubMedCentralCrossRefPubMed
9.
Zurück zum Zitat Gan TJ, Soppitt A, Maroof M, el-Moalem H, Robertson KM, Moretti E, Dwane P, Glass PS: Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 2002, 97: 820-826. 10.1097/00000542-200210000-00012CrossRefPubMed Gan TJ, Soppitt A, Maroof M, el-Moalem H, Robertson KM, Moretti E, Dwane P, Glass PS: Goal-directed intraoperative fluid administration reduces length of hospital stay after major surgery. Anesthesiology 2002, 97: 820-826. 10.1097/00000542-200210000-00012CrossRefPubMed
10.
Zurück zum Zitat Mythen MG, Webb AR: Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 1995, 130: 423-429.CrossRefPubMed Mythen MG, Webb AR: Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 1995, 130: 423-429.CrossRefPubMed
11.
Zurück zum Zitat Sinclair S, James S, Singer M: Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ 1997, 315: 909-912.PubMedCentralCrossRefPubMed Sinclair S, James S, Singer M: Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. BMJ 1997, 315: 909-912.PubMedCentralCrossRefPubMed
12.
Zurück zum Zitat Venn R, Steele A, Richardson P, Poloniecki J, Grounds M, Newman P: Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures. Br J Anaesth 2002, 88: 65-71. 10.1093/bja/88.1.65CrossRefPubMed Venn R, Steele A, Richardson P, Poloniecki J, Grounds M, Newman P: Randomized controlled trial to investigate influence of the fluid challenge on duration of hospital stay and perioperative morbidity in patients with hip fractures. Br J Anaesth 2002, 88: 65-71. 10.1093/bja/88.1.65CrossRefPubMed
13.
Zurück zum Zitat Wakeling HG, McFall MR, Jenkins CS, Woods WG, Miles WF, Barclay GR, Fleming SC: Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth 2005, 95: 634-642. 10.1093/bja/aei223CrossRefPubMed Wakeling HG, McFall MR, Jenkins CS, Woods WG, Miles WF, Barclay GR, Fleming SC: Intraoperative oesophageal Doppler guided fluid management shortens postoperative hospital stay after major bowel surgery. Br J Anaesth 2005, 95: 634-642. 10.1093/bja/aei223CrossRefPubMed
14.
Zurück zum Zitat Pearse RM, Ikram K, Barry J: Equipment review: an appraisal of the LiDCO plus method of measuring cardiac output. Crit Care 2004, 8: 190-195. 10.1186/cc2852PubMedCentralCrossRefPubMed Pearse RM, Ikram K, Barry J: Equipment review: an appraisal of the LiDCO plus method of measuring cardiac output. Crit Care 2004, 8: 190-195. 10.1186/cc2852PubMedCentralCrossRefPubMed
15.
Zurück zum Zitat Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med 1985, 13: 818-829.CrossRefPubMed Knaus WA, Draper EA, Wagner DP, Zimmerman JE: APACHE II: a severity of disease classification system. Crit Care Med 1985, 13: 818-829.CrossRefPubMed
16.
Zurück zum Zitat Prytherch DR, Whiteley MS, Higgins B, Weaver PC, Prout WG, Powell SJ: POSSUM and Portsmouth POSSUM for predicting mortality. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity. Br J Surg 1998, 85: 1217-1220. 10.1046/j.1365-2168.1998.00840.xCrossRefPubMed Prytherch DR, Whiteley MS, Higgins B, Weaver PC, Prout WG, Powell SJ: POSSUM and Portsmouth POSSUM for predicting mortality. Physiological and Operative Severity Score for the enUmeration of Mortality and morbidity. Br J Surg 1998, 85: 1217-1220. 10.1046/j.1365-2168.1998.00840.xCrossRefPubMed
17.
18.
Zurück zum Zitat Sandham JD, Hull RD, Brant RF, Knox L, Pineo GF, Doig CJ, Laporta DP, Viner S, Passerini L, Devitt H, et al.: A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 2003, 348: 5-14. 10.1056/NEJMoa021108CrossRefPubMed Sandham JD, Hull RD, Brant RF, Knox L, Pineo GF, Doig CJ, Laporta DP, Viner S, Passerini L, Devitt H, et al.: A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 2003, 348: 5-14. 10.1056/NEJMoa021108CrossRefPubMed
19.
Zurück zum Zitat De Backer D, Creteur J, Vincent JL: Perioperative optimization and right heart catheterization: what technique in which patient? Crit Care 2003, 7: 201-202. 10.1186/cc2177PubMedCentralCrossRefPubMed De Backer D, Creteur J, Vincent JL: Perioperative optimization and right heart catheterization: what technique in which patient? Crit Care 2003, 7: 201-202. 10.1186/cc2177PubMedCentralCrossRefPubMed
20.
Zurück zum Zitat Lindenauer PK, Pekow P, Wang K, Mamidi DK, Gutierrez B, Benjamin EM: Perioperative beta-blocker therapy and mortality after major noncardiac surgery. N Engl J Med 2005, 353: 349-361. 10.1056/NEJMoa041895CrossRefPubMed Lindenauer PK, Pekow P, Wang K, Mamidi DK, Gutierrez B, Benjamin EM: Perioperative beta-blocker therapy and mortality after major noncardiac surgery. N Engl J Med 2005, 353: 349-361. 10.1056/NEJMoa041895CrossRefPubMed
21.
Zurück zum Zitat Devereaux PJ, Yusuf S, Yang H, Choi PT, Guyatt GH: Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence? CMAJ 2004, 171: 245-247.PubMedCentralCrossRefPubMed Devereaux PJ, Yusuf S, Yang H, Choi PT, Guyatt GH: Are the recommendations to use perioperative beta-blocker therapy in patients undergoing noncardiac surgery based on reliable evidence? CMAJ 2004, 171: 245-247.PubMedCentralCrossRefPubMed
22.
Zurück zum Zitat Arkilic CF, Taguchi A, Sharma N, Ratnaraj J, Sessler DI, Read TE, Fleshman JW, Kurz A: Supplemental perioperative fluid administration increases tissue oxygen pressure. Surgery 2003, 133: 49-55. 10.1067/msy.2003.80CrossRefPubMed Arkilic CF, Taguchi A, Sharma N, Ratnaraj J, Sessler DI, Read TE, Fleshman JW, Kurz A: Supplemental perioperative fluid administration increases tissue oxygen pressure. Surgery 2003, 133: 49-55. 10.1067/msy.2003.80CrossRefPubMed
23.
Zurück zum Zitat Kusano C, Baba M, Takao S, Sane S, Shimada M, Shirao K, Natsugoe S, Fukumoto T, Aikou T: Oxygen delivery as a factor in the development of fatal postoperative complications after oesophagectomy. Br J Surg 1997, 84: 252-257. 10.1046/j.1365-2168.1997.02542.xCrossRefPubMed Kusano C, Baba M, Takao S, Sane S, Shimada M, Shirao K, Natsugoe S, Fukumoto T, Aikou T: Oxygen delivery as a factor in the development of fatal postoperative complications after oesophagectomy. Br J Surg 1997, 84: 252-257. 10.1046/j.1365-2168.1997.02542.xCrossRefPubMed
24.
Zurück zum Zitat Sheridan WG, Lowndes RH, Young HL: Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis Colon Rectum 1987, 30: 867-871.CrossRefPubMed Sheridan WG, Lowndes RH, Young HL: Tissue oxygen tension as a predictor of colonic anastomotic healing. Dis Colon Rectum 1987, 30: 867-871.CrossRefPubMed
25.
Zurück zum Zitat Guest JF, Boyd O, Hart WM, Grounds RM, Bennett ED: A cost analysis of a treatment policy of a deliberate perioperative increase in oxygen delivery in high risk surgical patients. Intensive Care Med 1997, 23: 85-90. 10.1007/s001340050295CrossRefPubMed Guest JF, Boyd O, Hart WM, Grounds RM, Bennett ED: A cost analysis of a treatment policy of a deliberate perioperative increase in oxygen delivery in high risk surgical patients. Intensive Care Med 1997, 23: 85-90. 10.1007/s001340050295CrossRefPubMed
26.
Zurück zum Zitat Fenwick E, Wilson J, Sculpher M, Claxton K: Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis. Intensive Care Med 2002, 28: 599-608. 10.1007/s00134-002-1257-yCrossRefPubMed Fenwick E, Wilson J, Sculpher M, Claxton K: Pre-operative optimisation employing dopexamine or adrenaline for patients undergoing major elective surgery: a cost-effectiveness analysis. Intensive Care Med 2002, 28: 599-608. 10.1007/s00134-002-1257-yCrossRefPubMed
Metadaten
Titel
Early goal-directed therapy after major surgery reduces complications and duration of hospital stay. A randomised, controlled trial [ISRCTN38797445]
verfasst von
Rupert Pearse
Deborah Dawson
Jayne Fawcett
Andrew Rhodes
R Michael Grounds
E David Bennett
Publikationsdatum
01.12.2005
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 6/2005
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc3887

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