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Erschienen in: Critical Care 6/2006

01.12.2006 | Commentary

Seleno-enzymes and seleno-compounds: the two faces of selenium

verfasst von: Xavier Forceville

Erschienen in: Critical Care | Ausgabe 6/2006

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Abstract

Selenium protects cells and inhibits many inflammatory cell mechanisms through antioxidant seleno-enzymes. Immunity improvement is illustrated by the study of Berger and colleagues, with reduction of nosocomial pneumonia in burnt patients under multi-trace-element supplementation. As seleno-compounds (especially sodium selenite) are pro-oxidant, however, administration above 800 μg/day may be dangerous in septic shock. Paradoxically, direct reversible pro-oxidative effects of seleno-compounds may also be beneficial for reduction of inflammation (genomic action, apoptosis), and may even be bactericidal or virucidal. These facts need to be further examined, as well as the possible dramatic drop of plasma selenoprotein P in septic shock and its role in endothelium protection.
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Metadaten
Titel
Seleno-enzymes and seleno-compounds: the two faces of selenium
verfasst von
Xavier Forceville
Publikationsdatum
01.12.2006
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 6/2006
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc5109

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