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Erschienen in: Critical Care 5/2010

01.10.2010 | Letter

Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury

verfasst von: Barry Dixon, Marcus J Schultz, Jorrit J Hofstra, Duncan J Campbell, John D Santamaria

Erschienen in: Critical Care | Ausgabe 5/2010

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Excerpt

Previously in this journal, we published a phase 1 study of nebulized heparin in patients with acute lung injury [1]. Patients were administered heparin at doses of 50,000, 100,000, 200,000, or 400,000 U/day for 2 days, and bronchoalveolar lavage (BAL) fluid samples were taken at baseline and after the last heparin dose. The study demonstrated a trend to reduced coagulation activation (prothrombin fragments) in BAL fluid after the last dose of nebulized heparin [1]. …
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Literatur
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2.
Zurück zum Zitat Dixon B: The role of microvascular thrombosis in sepsis. Anaesth Intensive Care. 2004, 32: 619-629.PubMed Dixon B: The role of microvascular thrombosis in sepsis. Anaesth Intensive Care. 2004, 32: 619-629.PubMed
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Zurück zum Zitat Blaisdell FW: Pathophysiology of the respiratory distress syndrome. Arch Surg. 1974, 108: 44-49.CrossRefPubMed Blaisdell FW: Pathophysiology of the respiratory distress syndrome. Arch Surg. 1974, 108: 44-49.CrossRefPubMed
Metadaten
Titel
Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury
verfasst von
Barry Dixon
Marcus J Schultz
Jorrit J Hofstra
Duncan J Campbell
John D Santamaria
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 5/2010
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9269

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