Erschienen in:
01.10.2010 | Letter
Nebulized heparin reduces levels of pulmonary coagulation activation in acute lung injury
verfasst von:
Barry Dixon, Marcus J Schultz, Jorrit J Hofstra, Duncan J Campbell, John D Santamaria
Erschienen in:
Critical Care
|
Ausgabe 5/2010
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Excerpt
Previously in this journal, we published a phase 1 study of nebulized heparin in patients with acute lung injury [
1]. Patients were administered heparin at doses of 50,000, 100,000, 200,000, or 400,000 U/day for 2 days, and bronchoalveolar lavage (BAL) fluid samples were taken at baseline and after the last heparin dose. The study demonstrated a trend to reduced coagulation activation (prothrombin fragments) in BAL fluid after the last dose of nebulized heparin [
1]. …