Tension-type headache (TTH) represents the most common type of headache among the general population. Although such headaches are usually mild in severity, some individuals with TTH experience severe symptoms and psychiatric comorbidities. Such patients may also experience sleep disturbances, which have been associated with headache exacerbation. Nevertheless, information regarding the prevalence and impact of insomnia among individuals with TTH in a population-based setting is limited. Therefore, the aim of the present study was to evaluate the prevalence and impact of insomnia among individuals with TTH using data from the Korean Headache-Sleep Study (KHSS).
Methods
We analysed data from the KHSS—a nation-wide, cross-sectional, population-based survey on headache and sleep involving Korean adults aged 19 to 69 years. Insomnia was defined as an Insomnia Severity Index score ≥ 10.
Results
Among 2695 participants, 570 (21.2%) and 290 (10.8%) were classified as having TTH and insomnia, respectively. Among individuals with TTH, 113 (19.8%) met the criteria for probable migraine (PM). The prevalence of insomnia among individuals with TTH was significantly higher than that among individuals without headache (13.2% vs. 5.8%, p < 0.001). However, among the TTH group, the prevalence of insomnia did not significantly differ between participants fulfilling PM criteria and those not fulfilling PM criteria (14.2% vs. 12.9%, p = 0.725). Among individuals with TTH, headache frequency [median and interquartile range (IQR): 1.0 (0.3–3.0) vs. 0.4 (0.2–1.0), p = 0.002], visual analogue scale scores for headache intensity [median and IQR: 5.0 (4.0–7.0) vs. 4.0 (3.0–6.0), p < 0.001], Headache Impact Test-6 scores [median and IQR: 46.0 (40.0–52.0) vs. 42.0 (38.0–46.0), p < 0.001], anxiety prevalence (28.0% vs. 6.7%, p < 0.001), and depression prevalence (21.3% vs. 1.6%, p < 0.001) were significantly higher in those with insomnia than in those without insomnia.
Conclusions
Our findings indicate that insomnia is prevalent among individuals with TTH. Moreover, insomnia was associated with exacerbation of headache symptoms and psychiatric comorbidities. Therefore, identification of insomnia among individuals with TTH is required to improve the management of headache symptoms in such patients.
International Classification of Headache Disorders
KHSS
Korean Headache-Sleep Study
OR
Odds ratio
PHQ-9
Patient Health Questionnaire-9
PM
Probable migraine
PSG
Polysomnography
PSQI
Pittsburgh Sleep Quality Index score
RR
Relative risk
TTH
Tension-type headache
VAS
Visual analogue scale
Background
Tension-type headache (TTH) is the most common form of primary headache among the general population, with a lifetime prevalence ranging from 20 to 87% [1]. TTH is usually associated with mild symptoms, and has been regarded as relatively non-severe since the condition is not life-threatening. However, some individuals with TTH experience frequent and severe headaches, which can decrease the ability to function at work, school, or home. Due to its high prevalence, the Global Campaign against Headache—a collaborative effort among the World Health Organization and three non-governmental organisations—has reported that the rate of disability due to TTH is greater than that due to migraine [1]. Therefore, the identification of factors associated with TTH represents an important public health issue.
Individuals who experience frequent headaches, including those with TTH, often report experiencing insomnia as well. Research has demonstrated that both lack of sleep and excessive sleep can trigger TTH [2, 3], and that sleep disturbances are associated with an increased risk of chronic tension-type headache (CTTH) among individuals with frequent episodic tension-type headaches (ETTH) [4].
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Insomnia is a relatively common condition, affecting 10–30% of the general population [5]. Individuals with insomnia tend to exhibit limited functional capacity and decreased quality of life due to a variety of symptoms, including headaches [6, 7]. Cross-sectional studies have revealed that individuals with headaches exhibit increased odds ratios (ORs) for insomnia relative to those for individuals without headache [8, 9]. Additional research has indicated that the prevalence of insomnia is higher in patients with TTH than in individuals without headache [10]. Longitudinal studies have demonstrated that patients with migraine (OR =1.7) and non-migraineous headache (OR =1.4) are at increased risk for insomnia at the 11-year follow-up. Furthermore, individuals with insomnia exhibited an increased risk for TTH (relative risk [RR] = 1.4) and migraine (RR =1.4) at the 11-year follow-up [11, 12]. Several clinical studies have demonstrated an association between insomnia and exacerbation of TTH symptoms [13, 14]. Nevertheless, information regarding the impact of insomnia on the clinical presentation of TTH in a population-based setting is limited. We hypothesised that, among individuals with TTH, those with insomnia experience more severe symptoms than those without insomnia. Therefore, the objectives of the present study were as follows: 1) to evaluate the prevalence of insomnia and TTH in a general population-based sample, 2) to assess clinical characteristics and comorbidities of TTH according to the presence of insomnia, and 3) to investigate the association between TTH and insomnia including covariates such as sociodemographic factors, sleep time, sleep quality, and psychiatric comorbidities.
Methods
Survey
The present study utilised data from the Korean Headache-Sleep Study (KHSS), the design and methods of which have been described in detail in a previous report [15]. Briefly, a two-stage clustered random-sampling method was adopted for all Korean territories except Jeju-do, proportional to population distribution. The survey was performed via door-to-door visits and face-to-face interviews. The questionnaire utilised during these interviews exhibited sensitivity and specificity values of 86.2 and 75.5% for TTH diagnosis, respectively [16]. All interviewers were non-medical employees of Gallup Korea. The study protocol was approved by the Institutional Review Board and Ethics Committee of Hallym University Sacred Heart Hospital (Approval No. 2011-I077). Informed consent was obtained from each participant prior to each interview.
Assessment of TTH
Diagnoses of TTH were based on criteria B to D for infrequent TTH (code 2.1) as listed in the third edition of the International Classification of Headache Disorders, beta version (ICHD-3 beta) (B: attack duration ranging from 30 min to 7 days; C: any two of four typical headache characteristics [i.e., bilateral location, non-pulsating quality, mild-to-moderate pain intensity, and no aggravation with movement]; D: attacks associated with both of the following: no nausea or vomiting and no more than either photophobia or phonophobia). Participants fulfilling all criteria were classified as having TTH. In accordance with ICHD-3 beta criteria, participants meeting criteria for both TTH and probable migraine (PM) were considered to have TTH.
Assessment of insomnia
The self-reported Insomnia Severity Index (ISI) was used to evaluate the presence and severity of insomnia [17]. Participants with ISI scores of 10 or more were classified as having insomnia [18].
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Assessment of sleep time and sleep quality
Data regarding typical sleep times on workdays and free days during the previous month were collected and analysed. Average sleep time was defined as follows: [(workday sleep time × 5) + (free-day sleep time × 2)] / 7. Short sleep time was defined as an average sleep time ≤ 6 h per day. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the quality of sleep in the present study. The PSQI is a self-administered questionnaire composed of 19 questions designed to assess seven components of perceived sleep status, including subjective sleep quality, sleep latency, sleep duration, habitual sleep insufficiency, sleep disturbance, use of sleep medications, and daytime dysfunction. Poor sleep quality was defined as a global PSQI score of 6 or more [19].
Assessment of anxiety and depression
The Goldberg Anxiety Scale (GAS) was used to assess the prevalence of anxiety among participants. The GAS comprises four screening items and five supplementary items [20]. Participants who responded positively to two or more screening items and five or more total items were considered to have anxiety. The present study utilised the Korean version of the GAS, which has a sensitivity of 82.0% and a specificity of 94.4% for the diagnosis of anxiety [21]. The Korean version of the Patient Health Questionnaire-9 (PHQ-9), which has a sensitivity of 81.1% and specificity of 89.9% for the diagnosis of depression, was used to screen for depression in the present study [22, 23]. PHQ-9 scores of 10 or more were considered indicative of depression.
Data analyses
The Kolmogorov–Smirnov test was used to evaluate the normality of the distribution. After confirming the normality of the distribution, Student’s t-tests and Chi-square tests were utilised to compare prevalence rates where appropriate. If the normality of the distribution was not confirmed, Mann-Whitney U tests were used to compare data between two groups. All statistical analyses were performed using Statistical Package for Social Sciences version 22.0 (SPSS 22.0; IBM, Armonk, NY, USA). The significance level was set at p < 0.05 for all analyses.
Univariable and multivariable analyses were performed to determine factors contributing to insomnia among individuals with TTH. Among individuals with TTH, factors exhibiting significant differences between those with insomnia and those without insomnia were considered for univariable analyses. For multivariable analyses, three models were developed to examine the association between insomnia and TTH. Model 1—which included sociodemographic variables (age, sex, size of residential area, and educational level), anxiety, and depression—was used to investigate the association between insomnia and psychiatric conditions. Model 2—which included sociodemographic variables, short sleep time, and poor sleep quality as covariates—was used to investigate the association between insomnia and sleep-related parameters. Finally, Model 3—which included sociodemographic variables, anxiety, depression, short sleep time, and poor sleep quality as covariates—was used to investigate the association among insomnia, psychiatric conditions, and sleep-related parameters. Missing data occurred only with regard to educational level. All reported results are based on available data. Imputation techniques were not used to minimise non-response effects [24].
Results
Survey
Among 7430 individuals contacted by our interviewer, a total of 3114 provided consent for the survey, including the 2695 individuals who had completed the survey (cooperation rate: 36.2%, Fig. 1). No significant differences in the distributions of age, sex, size of residential area, or level of education were observed between the study population and the general population in Korea (Table 1).
Fig. 1
Patient flow chart in the Korean Headache-Sleep Study. TTH: Tension-type headache
Table 1
Sociodemographic characteristics of survey participants and total Korean population and cases identified as having TTH or insomnia
Survey participants
Total population
P
Tension-type headache
P
Insomnia
P
N (%)
N (%)
N, % (95% CI)
N, % (95% CI)
Sex
Men
1345 (49.3)
17,584,365 (50.6)
0.854a
268, 19.9 (17.8–22.0)
0.120b
117, 8.7 (7.2–1.2)
0.001c
Women
1350 (50.7)
17,198,350 (49.4)
302, 22.3 (20.1–24.6)
173, 12.4 (11.0–14.6)
Age
19–29
542 (20.5)
7,717,947 (22.2)
0.917a
119, 22.0 (18.5–25.5)
0.971b
59, 10.9 (8.3–13.5)
0.427c
30–39
604 (21.9)
8,349,487 (24.0)
127, 21.0(17.8–24.3)
53, 8.8 (6.5–11.0)
40–49
611 (23.1)
8,613,110 (24.8)
131, 21.4 (18.2–24.7)
66, 10.8 (8.3–13.3)
50–59
529 (18.9)
6,167,505 (17.7)
107, 20.2 (16.8–23.7)
63, 11.9 (9.1–14.7)
60–69
409 (15.6)
3,934,666 (11.3)
86, 21.0 (17.1–25.0)
49, 12.0 (8.8–15.1)
Size of residential area
Large city
1248 (46.3)
16,776,771 (48.2)
0.921a
251, 20.1 (17.9–22.4)
0.004b
136, 10.9 (9.2–12.6)
0.943c
Medium-to-small city
1186 (44.0)
15,164,345 (43.6)
243, 20.5 (18.2–22.8)
125, 10.5 (8.8–12.2)
Rural area
261 (9.7)
2,841,599 (8.2)
76, 29.1 (23.6–34.7)
29, 11.1 (7.3–14.9)
Education level
Middle school or less
393 (14.9)
6,608,716 (19.0)
0.752a
96, 24.5 (20.1–28.7)
0.327b
62, 15.8 (12.1–19.4)
0.006c
High school
1208 (44.5)
15,234,829 (43.8)
247, 20.5 (18.2–22.7)
116, 9.6 (7.9–11.3)
College or more
1068 (39.6)
12,939,170 (37.2)
223, 20.9 (18.4–23.3)
109, 10.2 (8.4–12.0)
Not responded
26 (1.0)
4, 15.4 (0.5–30.2)
3, 11.5 (0.0–24.7)
Total
2695 (100.0)
34,782,715 (100.0)
570, 21.2 (19.6–22.7)
290, 10.8 (9.6–11.9)
N number, CI confidence interval, TTH tension-type headache
aComparison of sex, age group, size of residential area, and educational level distributions between the sample in the present study and the total population of Korea
bComparison of sex, age group, size of residential area, and educational level distributions among survey participants
cComparison of sex, age group, size of residential area, and educational level distributions among survey participants
×
Prevalence of TTH, non-headache controls, and insomnia
Among the 2695 participants, 570 (21.2%) experienced TTH during the previous year, while 1422 (52.8%) did not. Among individuals with TTH, 113 (19.8%) also met the criteria for PM. The prevalence of TTH was not significantly affected by age, sex, or educational level. However, the prevalence of TTH was higher in rural areas than in large or small-to-medium cities (Table 1). A total of 290 (10.8%) participants were classified as having insomnia. Insomnia was more prevalent among women than men, and among those with lower levels of education (middle school or less) than those with higher levels of education. The prevalence of insomnia tended to increase with increasing age (Table 1). Sociodemographic characteristics of individuals with TTH and those without headache are summarised in Additional file 1: Table S1.
Prevalence of anxiety, depression, short sleep time and poor sleep quality
A total of 268 (9.9%) participants exhibited symptoms of anxiety, while 116 (4.3%) exhibited symptoms of depression. The prevalence of anxiety (9.5% vs. 5.3%, p = 0.001) and depression (4.2% vs. 1.8%, p = 0.001) was significantly higher among individuals with TTH than among individuals without headache. A total of 469 (17.4%) participants reported an average sleep duration ≤6 h, and were thus classified as having short sleep time. Poor sleep quality was noted in 715 (26.5%) participants.
Prevalence of insomnia among individuals with TTH
Among the 570 participants with TTH, 75 (13.2%) were classified as having insomnia. The prevalence of insomnia among participants with TTH was significantly higher than that among participants without headache (13.2% vs. 5.8%, p < 0.001).
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Previous studies have demonstrated a significant association between insomnia and migraine [12, 25]. Therefore, migrainous features may affect the prevalence of insomnia. We assessed the prevalence of insomnia among participants with TTH according to fulfillment of PM criteria. Among participants with TTH, the prevalence of insomnia did not significantly differ between those fulfilling PM criteria and those not fulfilling PM criteria (14.2% vs. 12.9%, p = 0.725). The prevalence of insomnia was significantly higher among participants with TTH not fulfilling PM criteria than among individuals without headache (12.9% vs. 5.8%, p < 0.001) (Fig. 2). We then analysed the prevalence of insomnia according to headache frequency. The prevalence of insomnia was significantly higher among participants with 1–10 TTH attacks per month than among those with < 1 TTH attack per month (17.1% vs. 10.4%, p = 0.022). However, the prevalence of insomnia did not significantly differ between participants with > 10 TTH attacks per month and those with < 1 TTH attack per month (14.3% vs. 10.4%, p = 0.575).
Fig. 2
Prevalence of insomnia among individuals without headache, those with TTH fulfilling PM criteria, and those with TTH not fulfilling PM criteria. PM, probable igraine; TTH, tension-type headache
×
Demographic characteristics and clinical presentation of TTH according to the presence of insomnia
Among individuals with TTH, those with insomnia exhibited significantly higher headache frequency per month, visual analogue scale (VAS) scores for headache intensity, and Headache Impact Test-6 scores than those without insomnia. Anxiety and depression were more prevalent among individuals with TTH and insomnia than among those without insomnia (Table 2).
Table 2
Demographics and clinical presentation of individuals with TTH according to the presence of insomnia
TTH with insomnia, N = 75
TTH without insomnia, N = 495
P
Demographics
Age, Mean ± SD (years)
44.5 ± 13.7
42.5 ± 13.7
0.236
Women, N (%)
43 (57.3)
259 (52.3)
0.418
Headache characteristics
Bilateral pain, N (%)
45 (60.0)
329 (66.5)
0.272
Non-pulsating quality, N (%)
29 (38.7)
198 (40.0)
0.824
Mild-to-moderate severity, N (%)
73 (97.3)
490 (99.0)
0.225
Non-aggravation by movement, N(%)
58 (77.3)
393 (79.4)
0.682
Associated symptoms
Photophobia, N (%)
6 (8.0)
40 (8.1)
0.981
Phonophobia, N (%)
31 (41.3)
150 (30.3)
0.056
Headache frequency, Median (IQR)
1.0 (0.3–3.0)
0.4 (0.2–1.0)
0.002a
VAS score, Median (IQR)
5.0 (4.0–7.0)
4.0 (3.0–6.0)
< 0.001a
HIT-6 score, Median (IQR)
46.0 (40.0–52.0)
42.0 (38.0–46.0)
< 0.001a
Anxiety, N (%)
21 (28.0)
33 (6.7)
< 0.001
Depression, N (%)
16 (21.3)
8 (1.6)
< 0.001
N number, SD standard deviation, IQR interquartile range
aMann-Whitney U test
Univariable and multivariable analyses for factors contributing to insomnia among individuals with TTH
Univariable analyses revealed that anxiety [OR = 5.4, 95% Confidence interval (CI): 2.9–10.0], depression (OR = 16.5, 95% CI: 6.8–40.2), short sleep time (OR = 3.1, 95% CI: 1.9–5.3), and poor sleep quality (OR = 12.8, 95% CI: 7.1–23.0) were associated with an increased risk of insomnia among individuals with TTH. Multivariate analyses including sociodemographic variables, anxiety and depression (Model 1) indicated that patients with anxiety (OR = 3.9, 95% CI: 2.0–8.0) and depression (OR = 14.8, 95% CI: 5.5–39.7) exhibited increased ORs for insomnia. In Model 2 (including sociodemographic variables, short sleep time, and poor sleep quality), poor sleep quality (OR = 13.4, 95% CI: 7.1–25.3) was significantly associated with insomnia status. In Model 3 (including sociodemographic variables, anxiety, depression, short sleep time, and poor sleep quality), anxiety (OR = 3.0, 95% CI: 1.4–6.7), depression (OR = 5.8, 95% CI: 2.0–16.3), and poor sleep quality (OR = 9.9, 95% CI: 5.1–19.2) were significantly associated with insomnia status (Table 3).
Table 3
Univariable and multivariable logistic regression analyses for contributing factors of insomnia among individuals with tension-type headache (N = 570)
Univariable analysis
Multivariable analysis
Multivariable analysis
Multivariable analysis
OR, 95% CI, P-value
Model 1
Model 2
Model 3
Sex
1.2 (0.8–2.0), p = 0418
1.2 (0.7–2.0), p = 0.609
1.3 (0.8–2.4), p = 0.305
1.2 (0.7–2.2), p = 0.528
Age
20s
Reference
30s
0.8 (0.3–1.8), p = 0.556
0.7 (0.2–1.6), p = 0.360
0.6 (0.2–1.5), p = 0.256
0.5 (0.2–1.4), p = 0.220
40s
1.1 (0.5–2.4), p = 0.772
1.1 (0.5–2.5), p = 0.833
1.1 (0.5–2.6), p = 0.836
1.1 (0.4–2.6), p = 0.910
50s
1.6 (0.8–3.4), p = 0.206
1.7 (0.7–4.2), p = 0.246
0.8 (0.3–2.1), p = 0.704
1.0 (0.4–2.8), p = 0.931
60s
1.3 (0.6–3.0), p = 0.485
1.2 (0.4–3.5), p = 0.689
0.9 (0.3–2.6), p = 0.789
0.9 (0.3–3.0), p = 0.928
Size of residential area
Large city
Reference
Medium-to-small city
1.2(0.7–2.0), p = 0.508
1.2 (0.7–2.1), p = 0.566
1.4(0.8–2.4), p = 0.295
1.3(0.7–2.4), p = 0.395
Rural area
0.5(0.2–1.2), p = 0.125
0.5 (0.2–1.5), p = 0.244
0.5(0.2–1.6), p = 0.268
0.6(0.2–1.8), P = 0.340
Education level
Middle school or less
Reference
High school
0.9(0.5–1.7), p = 0.732
0.9(0.4–2.0), p = 0.716
0.6(0.2–1.5), p = 0.260
0.6(0.2–1.4), p = 0.215
College or more
0.7(0.3–1.3), p = 0.226
0.8(0.3–2.1), p = 0.622
0.5(0.2–1.4), p = 0.190
0.5(0.2–1.6), p = 0.250
Not responded
1.8(0.2–18.5), p = 0.621
2.1(0.2–22.2), p = 0.543
1.9(0.1–28.8), p = 0.626
2.3(0.2–32.9), p = 0.539
Anxiety
5.4 (2.9–10.0), p < 0.001
3.9(2.0–8.0), p < 0.001
3.0 (1.4–6.7), p = 0.006
Depression
16.5 (6.8–40.2), p < 0.001
14.8(5.5–39.7), p < 0.001
5.8 (2.0–16.3), p = 0.001
Short sleep time
3.1 (1.9–5.3), p < 0.001
1.2(0.7–2.3), p = 0.538
1.2 (0.6–2.4), p = 0.570
Poor sleep quality
12.8 (7.1–23.0), p < 0.001
13.4(7.1–25.3), p < 0.001
9.9 (5.1–19.2), p < 0.001
Model 1 included sociodemographic variables (sex, age, size of residential area, level of education), anxiety, and depression
Model 2 included sociodemographic variables, short sleep time (≤6 h), and poor sleep quality (PSQI ≥ 6)
Model 3 included sociodemographic variables, anxiety, depression, short sleep time, and poor sleep quality
Discussion
The main findings of the present study were as follows: 1) The prevalence of insomnia was significantly higher among individuals with TTH than among individuals without headache; 2) headache frequency, headache intensity, and impact of headache on functioning were significantly greater among participants with TTH and insomnia than among those without insomnia; and 3) anxiety, depression, and poor sleep quality were significant risk factors for insomnia among participants with TTH.
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Previous studies have demonstrated a significant association between insomnia and TTH. For example, a community-based study in Hong Kong revealed that individuals with TTH exhibit increased ORs for insomnia relative to those for individuals without headache (OR = 2.2) [26]. A population-based study conducted in Norway further reported that the prevalence of insomnia is 1.8 times higher in individuals with TTH than in those without headache [10]. The findings of the present study are in agreement with the results of these previous studies, as our analyses indicated that the prevalence of insomnia was approximately two times higher among individuals with TTH than among those without headache. Therefore, our findings support the association between TTH and insomnia, and the similarity between our data and values reported in previous studies suggests that the methods of the present study were appropriate for evaluating this association.
One possible explanation for the observed association between insomnia and TTH involves the shared comorbidities of anxiety and depression. Indeed, anxiety and depression are common among patients with insomnia, and previous studies have indicated that both anxiety and depression are closely associated with the clinical presentation of insomnia [27]. Furthermore, insomnia symptoms tend to worsen as the severity of anxiety and/or depression [28]. Anxiety and depression are common among patients with headache [29, 30]. Although the prevalence of anxiety and depression among patients with TTH is lower than among patients with migraine, a significant proportion of individuals with TTH experience anxiety and depression [31]. In the present study, anxiety and depression were identified as significant risk factors for insomnia among individuals with TTH, even after adjusting for potential covariates. Alternatively, insomnia may trigger TTH [32]. Taken together, these findings indicate that the prevalence of TTH may be higher among individuals with insomnia than among those without insomnia. However, previous studies have reported that sleep deprivation and interruption of slow wave sleep can reduce pain threshold and cause hyperalgesia [33, 34]. Thus, insomnia may induce frequent headaches (including TTH) by decreasing the pain threshold.
Previous studies regarding the association between insomnia and TTH have not examined the impact of insomnia on the clinical presentation of TTH. In the present study, we observed that, among individuals with TTH, those with insomnia exhibited a higher frequency of headache and increased impact of headache on daily function than those without insomnia. In accordance with our findings, previous studies have indicated that individuals with a high frequency of TTH may experience increased disability, decreased quality of life, and a higher rate of comorbidities than those with low frequency of TTH [13]. Therefore, proper identification and management of insomnia may reduce the impact of headache among individuals with TTH. While pharmacological treatments for insomnia have demonstrated efficacy in randomised controlled trials, research has indicated that non-pharmacological alternatives such as cognitive behavioral therapy (CBT) are also effective [35].
In the present study, anxiety and depression were more common among individuals with TTH and insomnia than among those with TTH only (Table 2). Multivariable regression analyses revealed that anxiety and depression were significant contributing factors for insomnia among individuals with TTH (Table 3). Anxiety and depression often co-occur and have been closely associated with insomnia in previous studies [28, 36, 37]. Therefore, anxiety and depression may underlie the association between insomnia and TTH. However, further studies are required in order to clarify the associations among anxiety, depression, insomnia, and TTH.
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Although there was no significant difference in the prevalence of insomnia between individuals with TTH fulfilling PM criteria and those not fulfilling PM criteria, the prevalence of insomnia among those fulfilling PM criteria was numerically higher than that among those not fulfilling PM criteria (Fig. 2). Considering that the prevalence of insomnia among individuals with migraine is much higher than that among those with TTH, our findings indicate that migrainous features may be substrates for the development of insomnia among individuals with TTH [9, 10, 25]. Further studies involving larger sample sizes are required to more fully elucidate the association between migrainous features and insomnia among individuals with TTH.
The present study possesses some limitations of note. First, polysomnography (PSG) was not performed to evaluate for sleep disorders such as sleep-disordered breathing. Some patients with sleep-disordered breathing present with symptoms of chronic insomnia [38]. Second, our study did not investigate the rate of chronic pain disorders such as fibromyalgia among participants. Since chronic pain disorders are also associated with psychiatric co-morbidities, future studies should investigate the association between chronic pain disorders and anxiety/depression in patients with headaches. Third, we did not evaluate the use of antidepressants, hypnotics, anxiolytics, or preventive medications for TTH, and were thus unable to examine the effects of such agents on TTH and insomnia. Fourth, although our study utilised a large sample size, the statistical power for executing some subgroup analyses was limited. That is, the lack of significant findings in certain subgroup analyses may have been due to the limited sample size.
Despite these limitations, our study possesses several strengths. First, the distributions of sex, age, size of residential area, and level of education for the study population reflected those observed in the general population, indicating that our findings may be applicable to the general population. Second, the characteristics of headache and psychiatric comorbidities were compared according to the presence of insomnia in patients with TTH. Third, we examined the association among TTH, insomnia, and closely related psychiatric comorbidities (i.e., anxiety and depression).
Conclusion
Our findings indicate that insomnia is more prevalent among individuals with TTH than among those without headache. Moreover, among individuals with TTH, those with insomnia experienced more frequent headaches, increased rates of psychiatric comorbities, and more severe disability due to headache. Our findings suggest that insomnia represents an important comorbidity among individuals with TTH. Therefore, proper identification and management of insomnia may reduce the impact of headache among individuals with TTH.
Acknowledgements
The authors would like to thank Gallup Korea for providing technical support for the Korean Headache-Sleep Study.
Funding
This Study was Supported by a 2011-Grant from Korean Academy of Medical Sciences.
Competing interests
The authors declare that they have no competing interests.
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