Background
Methods
Participants
HCs (n = 20) | Patients with CM (n = 20) | |
---|---|---|
Women (n) | 13 | 14 |
Age (years) | 28.5 ± 4.1 | 31.3 ± 10.2 |
Disease duration (years) | 15.0 ± 13.1 | |
Days with headache/month (n) | 23.0 ± 6.8 | |
Severity of headache attacks (0–10) | 7.6 ± 1.6 | |
Duration of the chronic headache (months) | 17.1 ± 29.3 | |
Tablet intake/month (n) | 2.8 ± 3.1 |
Imaging protocols
Data processing and analysis
Statistical analysis
Results
Anatomical regions | Brodmann area | Cluster extent (mm3) | Montreal Neurological Institute coordinates (x, y, z) | Peak Z Score | T value |
P value (cluster level p uncorrected) |
---|---|---|---|---|---|---|
Cluster 1
| 390 | 0.0224 | ||||
L Amygdala | −20, 3, −15 | 4.34 | 5.04 | |||
L Temporal pole | −26, 9, −26 | 3.23 | 3.52 | |||
L Hippocampus | −31, −5, −15 | 3.20 | 3.47 |
Anatomical regions | Brodmann area | Cluster extent (mm3) | Montreal Neurological Institute coordinates (x, y, z) | Peak Z Score | T value |
P value (cluster level p uncorrected) |
---|---|---|---|---|---|---|
Cluster 1
| 1624 | 0.0085 | ||||
R Cerebellum (lobule VIIIa) | 27, −48, −48 | 4.01 | 4.53 | |||
R Cerebellum (Crus II) | 45, −64, −48 | 3.01 | 3.22 | |||
Cluster 2
| 1707 | 0.0073 | ||||
L Middle temporal gyrus | BA21 | −58, −32, 0 | 3.75 | 4.17 | ||
Cluster 3
| 1620 | 0.009 | ||||
L Amygdala | −20, 2, −19 | 3.67 | 4.06 | |||
L Temporal pole | BA38 | −27, 7, −25 | 3.62 | 4.0 | ||
L Pallidum | −18, 0, 3 | 3.48 | 3.81 | |||
L Orbitofrontal cortex | BA11 | −10, 30, −18 | 2.73 | 2.94 | ||
Cluster 4
| 582 | 0.037 | ||||
L Primary occipital cortex | BA17 | −9, −74, 10 | 3.83 | 3.25 | ||
L visual association area | BA18 | −14, −90, 16 | 3.64 | 3.5 |
Anatomical regions | Cluster extent (mm3) | Montreal Neurological Institute coordinates (x, y, z) | T value |
P value (cluster level p uncorrected) | Clinical feature |
---|---|---|---|---|---|
711 | 0.0014 | Tablet intake/month (n) | |||
R Cerebellum (lobule VIIIa) | 39, −41, −48 | 5.71 | |||
R Cerebellum (Crus II) | 50, −48, −47 | 5.05 | |||
685 | 0.0017 | ||||
L Cerebellum (lobule VI) | −17, −68, −17 | 6.03 | |||
L Cerebellum (Crus I) | −15, −78, −21 | 4.33 | |||
625 | 0.028 | Disease duration (years) | |||
R Cerebellum (Crus II) | 24, −68, −39 | 4.95 |