Background
Methods
Registers
Definition of retinal vascular occlusion, comorbidities and outcome
Study population and outcomes
Statistical analysis
Ethics
Results
Overall | Retinal arterial and vein occlusion | |||||
---|---|---|---|---|---|---|
With retinal vascular occlusion | Controls | p-value | Arterial | Vein | p-value for difference between retinal artery and vein occlusion | |
n | 1368 | 6840 | 706 | 529 | ||
Median age, years (IQR) | 71.4 (61.2–79.8) | 71.4 (61.2–79.8) | * | 70.7 (61.2–78.7) | 73.4 (62.3–81.3) | < 0.01 |
Male | 648 (47.3%) | 3240 (47.3%) | * | 351 (49.7%) | 241 (45.6%) | 0.150 |
Diabetes | 115 (8.4%) | 368 (5.4%) | < 0.01 | 59 (8.4%) | 50 (9.5%) | 0.502 |
Heart failure | 67 (4.9%) | 168 (2.5%) | < 0.01 | 34 (4.8%) | 29 (5.5%) | 0.599 |
Hypertension | 391 (28.6%) | 1188 (17.4%) | < 0.01 | 183 (25.9%) | 160 (30.2%) | 0.093 |
Stroke/TE/TIA | 257 (18.8%) | 395 (5.8%) | < 0.01 | 161 (22.8%) | 62 (11.7%) | < 0.01 |
Vascular disease | 148 (10.8%) | 416 (6.1%) | < 0.01 | 92 (13%) | 45 (8.5%) | 0.012 |
Acetylsalicylic acid | 514 (37.6%) | 1236 (18.1%) | < 0.01 | 277 (39.2%) | 190 (35.9%) | 0.234 |
Antiadrenergic | 24 (1.8%) | 61 (0.9%) | < 0.01 | 10 (1.4%) | 13 (2.5%) | 0.181 |
Beta blockers | 234 (17.1%) | 753 (11%) | < 0.01 | 113 (16%) | 94 (17.8%) | 0.412 |
Calcium channel blockers | 279 (20.4%) | 831 (12.1%) | < 0.01 | 138 (19.5%) | 107 (20.2%) | 0.767 |
Clopidogrel | 22 (1.6%) | 55 (0.8%) | < 0.01 | 18 (2.5%) | 3 (0.6%) | < 0.01 |
Loop diuretics | 185 (13.5%) | 590 (8.6%) | < 0.01 | 97 (13.7%) | 77 (14.6%) | 0.683 |
NSAID | 235 (17.2%) | 915 (13.4%) | < 0.01 | 125 (17.7%) | 84 (15.9%) | 0.397 |
Non-loop diuretics | 405 (29.6%) | 1347 (19.7%) | < 0.01 | 182 (25.8%) | 170 (32.1%) | 0.014 |
Dipyridamole | 79 (5.8%) | 108 (1.6%) | < 0.01 | 54 (7.6%) | 16 (3%) | < 0.01 |
With retinal vascular occlusion | |||
---|---|---|---|
No of patients | No of events | Rate of AF (95% confidence interval) | |
Any retinal vascular occlusion | 1368 | 135 | 1.74 (1.47–2.06) |
No retinal vascular occlusion (total matched control population) | 6840 | 537 | 1.22 (1.12–1.33) |
RAO | 706 | 74 | 2.01 (1.6–2.52) |
RVO | 529 | 49 | 1.52 (1.15–2.01) |
Unspecified retinal vascular occlusion | 133 | 12 | 1.45 (0.82–2.55) |