Background
Methods
Study population and data collection
Treatment for ECRC
Histopathological evaluation
ESD-related complications
Follow-up
Statistical analysis
Results
Baseline characteristics of patients and tumors
Variables | Total |
---|---|
Patients | 51 |
Age | |
Average ± s.d.(median, range),years | 63.0 ± 9.5(63,38–80) |
≤ 60 years | 22(43.1%) |
> 60 years | 29(56.9%) |
Sex | |
Male | 31(60.8%) |
Female | 20(39.2%) |
Tumors | 51 |
Tumor size | |
Average ± s.d.(median, range),cm | 2.6 ± 0.9(2.0,1.5–5.0) |
< 40 mm | 42(82.4%) |
≥ 40 mm | 9(17.6%) |
Tumor location | |
Right side of colon | 7(13.7%) |
Left side of colon | 14(27.4%) |
Rectum | 30(58.9%) |
Growth type | |
Laterally spreading tumor | 20(39.2%) |
Polypoid | 31(60.8%) |
Outcomes of ESD for ECRCs
Variables | Total |
---|---|
Number of tumors | 51 |
Resection Method | |
ESD | 41(80.4%) |
Hybrid ESD | 10(19.6%) |
Resection status | |
En bloc | 46(90.2%) |
Piecemeal | 5(9.8%) |
Histological complete resection | |
Complete | 34(66.7%) |
Incomplete | 17(33.3%) |
Histology | |
T1 cancer (<1000 μm) | 15(29.4%) |
T1 cancer (≥1000 μm) | 36(70.6%) |
Differentiation | |
Well and moderate | 49(96.1%) |
Poor | 2(3.9%) |
Lymphovascular infiltration | |
Absence | 46(90.2%) |
Presence | 5(9.8%) |
Complications | |
Perforation | 1(2.0%) |
Delayed bleeding | 0(0.0%) |
Outcomes of additional surgery after colorectal ESD
Variables | Total |
---|---|
Number of patients | 51 |
Postoperative hospital stay | |
Average ± s.d.(median, range), day | 7.4 ± 3.1(6,4–21) |
Complications | 3(5.9%) |
Postoperative heart failure | 1(2.0%) |
Anemia | 1(2.0%) |
Urinary tract infection | 1(2.0%) |
Pathological examination | |
Lymph node metastasis | 5(9.8%) |
Follow up | |
Lost to follow up | 2(3.9%) |
Average(median, range), month | 63.9(59, 30–115) |
Recurrence | 0(0.0%) |
Metastasis | 0(0.0%) |
Overall survival | 48/51(94.1%) |
Association of the clinicopathological characteristics of ECRCs with regional LNM
Variables | Total |
---|---|
Number of tumors | 51 |
Piecemeal resection | 5(9.8%) |
Positive margin | 13(25.5%) |
Vertical | 11(21.6%) |
Circumferential | 2(3.9%) |
T1 cancer (≥1000 μm) | 34(66.7%) |
Poor differentiation | 2(3.9%) |
Lymphovascular infiltration | 5(9.8%) |
Factors | Lymph node metastasis |
P value |
---|---|---|
Age | ||
≤ 60 years | 3/22 (13.6%) | 0.638 |
> 60 years | 2/29(6.9%) | |
Sex | ||
Male | 3/31(9.7%) | 1.000 |
Female | 2/20(10.0%) | |
Tumor size | ||
< 40 mm | 5/42(11.9%) | 0.571 |
≥ 40 mm | 0/9(0.0%) | |
Tumor location | ||
Rectum | 4/30(13.3%) | 0.391 |
Colon | 1/21(4.8%) | |
Growth type | ||
Polypoid | 4/31(12.9%) | 1.000 |
LST | 1/20(5.0%) | |
Resection Method | ||
ESD | 5/41(12.2%) | 0.569 |
Hybrid ESD | 0/10(0.0%) | |
Resection status | ||
En bloc | 5/46(10.9%) | 1.000 |
Piecemeal | 0/5(0.0%) | |
Histological complete resection | ||
Complete | 4/34(11.8%) | 0.654 |
Incomplete | 1/17(5.9%) | |
Histology | ||
T1 cancer (<1000 μm) | 1/15(6.7%) | 1.000 |
T1 cancer (≥1000 μm) | 4/36(11.1%) | |
Differentiation | ||
Well and moderate | 1/49(2.0%) | 0.078 |
Poor | 1/2(50%) | |
Lymphovascular infiltration | ||
Absence | 2/46(4.3%) | 0.005 |
Presence | 3/5(60.0%) |