Background
Case presentation
Clinical presentation and laboratory findings
Test | Unit/Reference | Index case (NIV151175) | Case A (NIV151149) | Case B (NIV151162) | Case C (NIV151165) |
---|---|---|---|---|---|
WBCs | 4000–10000/CMM | 12100 | 13600 | 5300 | 2430 |
Hb | 12–16 | 15.5 | 9.1 | 14.3 | 14.5 |
Platelet count | 150000–500000/CMM | 26000 | 8000 | 60000 | 21000 |
Lymphocytes | 20–45 % | ND | 16 % | 55 % | 60 % |
Alanine transaminase [ALT) | 9–52 U/L | 162 | 102 | 166 | 1146 |
BUN/Urea | 14–36 mg/dl | 137/48 | 120 | *NA | *NA |
Serum Creatinine | 0.7 to 1.3 mg/dL | 4.98 | 4.13 | 0.6 | 0.9 |
Aspartate transaminase [AST) | 14–36 U/L | 114 | 95 | 285 | 2638 |
Serum bilirubin [Total) | 0.2–1.3 mg/dl | 3.80 | 1.88 | 0.32 | 1.87 |
Serum billirubin [Direct) | 0–0.3 mg/dl | 2.87 | 0.95 | *NA | *NA |
Serum alkaline phosphatase | 38–120 | 553 | 89 | *NA | *NA |
PT | 12–13 Sec | 23 | 18 | *NA | *NA |
Total protein | 6–8.3 gm/dL | 6.31 | 6.92 | *NA | *NA |
Sr.No. | NIV No. | Case detail | Age/Gender | Location/Hospital | State | Ct value of CCHFV Real-time RT- PCR | CCHFV IgM ELISA | Recovery status | GenBank Accession numbers of the sequences for S, L, M gene |
---|---|---|---|---|---|---|---|---|---|
1 | NIV 151175 | Index case (Nursing staff: contact of suspected CCHF case) | 21 year/Male | Private hospital, Jodhpur | Rajasthan | 26 | Positive | Died | S (KT384396), L (KT384386), M (KT384394) |
2 | NIV 151149 | Case A (Nursing staff: contact of suspected CCHF case) | 30 year/Male | Admitted to AIIMS hospital, Delhi from Jodhpur | Delhi | 25 | Positive | Died | S (KT384401), L (KT384384), M (KT384403) |
3 | NIV 151162 | Case B (Nursing staff: contact of suspected CCHF case) | 29 years/Male | Admitted to Apollo hospital Gandhi Nagar | Gujarat | 36 | Positive | Survived | NA |
4 | NIV 151165 | Case C (Nursing staff: contact of suspected CCHF case) | 25 years/Male | Admitted to Apollo hospital Gandhi Nagar | Gujarat | 31 | Positive | Survived | L (KT384385) |
5 | NIV 1510241 | Case D (Contact of suspected CCHF case at residence) | -/Male | Pokhran, Jaisalmer | Rajasthan | 37 | Positive | Survived | NA |
Phylogenetic analysis of CCHF confirmed cases from Jodhpur, Rajasthan State
NIV151175_Jodhpur 2015 [GeneBank Accession no. S (KT384396), M (KT384394), L (KT384386)] | |||||||
---|---|---|---|---|---|---|---|
CCHF virus strains | GenBank Accession no. | S gene | M gene | L gene | |||
% NT | % AA | % NT | % AA | % NT | % AA | ||
NIV1312492_Amreli_2013 | S (KT384399), M (KT384392), L (KT384390) | 9.2 | 2.7 | 7.3 | 3.7 | 2.8 | 2.2 |
NIV1312358_Surendranagar_2013 | S (KT384398), M (KT384391), L (KT384389) | 9.1 | 2.3 | 7.1 | 3.2 | 1.6 | 0.3 |
NIV149210_Kutch_2014 | S (KT724950), M (KT384393), L (KT384383) | 10.0 | 1.7 | 7.7 | 4.0 | 1.4 | 0.5 |
NIV155249_Kutch_2015 | S (KT384402), M (KT384395), L (KT384387) | 10.4 | 1.9 | 6.9 | 2.8 | 1.5 | 0.5 |
Tajikistan_1990 | S (AY049083), M (AY179962), L (AY720893) | 8.8 | 2.3 | 11.8 | 8.7 | 11.4 | 2.6 |
Afghanistan_2009 | S (HM452305), M (HM452306), L (HM452307) | 0.6 | 0.4 | 1.4 | 0.9 | 1.8 | 0.7 |