Background
Methods
Study sample
Body composition and exposure assessment
Genotyping
Statistical analyses
Results
Trait | Total sample (N = 16,157) | Controls (N = 8232) | Cases (N = 7925) |
---|---|---|---|
Sex (male/female) % | 82/18 | 80/20 | 84/16 |
BMI (kg/m2) | 25.8 ± 4.1 | 25.9 ± 4.3 | 25.8 ± 3.9 |
Age (years) | 53.8 ± 9.6 | 54.1 ± 8.9 | 53.6 ± 10.3 |
Genetic risk score | 87 ± 6 | 87 ± 6 | 87 ± 6 |
aSmoking – N (%) | |||
Never | 8045 (50) | 4810 (58) | 3235 (41) |
Ex-smokers | 1495 (9) | 819 (10) | 676 (9) |
Current | 6537 (41) | 2590 (32) | 3497 (50) |
Physical activity- N (%) | |||
Light | 5261 (39) | 2749 (41) | 2512 (38) |
Moderate | 6788 (51) | 3401 (50) | 3387 (51) |
Heavy | 1394 (10) | 634 (9) | 760 (11) |
Main effect of SNP/GRS on BMI
SNP | Nearest gene | Effect/other allele | β (kg/m2/allele) | SE |
P
|
---|---|---|---|---|---|
rs1000940 |
RABEP1
| G/A | −0.06 | 0.05 | 0.19 |
rs10132280 |
STXBP6
| C/A | 0.01 | 0.06 | 0.87 |
rs1016287 |
FLJ30838
| T/C | 0.12 | 0.05 | 0.02 |
rs10182181 |
ADCY3
| G/A | 0.03 | 0.04 | 0.55 |
rs10733682 |
LMX1B
| A/G | −0.06 | 0.04 | 0.18 |
rs10938397 |
GNPDA2
| G/A | 0.02 | 0.05 | 0.59 |
rs10968576 |
LINGO2
| G/A | 0.03 | 0.05 | 0.58 |
rs11030104 |
BDNF
| A/G | 0.11 | 0.05 | 0.03 |
rs11057405 |
CLIP1
| G/A | −0.10 | 0.15 | 0.48 |
rs11126666 |
KCNK3
| A/G | 0.00 | 0.05 | 0.95 |
rs11165643 |
PTBP2
| T/C | 0.04 | 0.04 | 0.37 |
rs11191560 |
NT5C2
| C/T | 0.10 | 0.06 | 0.07 |
rs11583200 |
ELAVL4
| C/T | −0.05 | 0.04 | 0.23 |
rs1167827 |
HIP1
| G/A | −0.01 | 0.04 | 0.79 |
rs11688816 |
EHBP1
| G/A | −0.09 | 0.04 | 0.04 |
rs11727676 |
HHIP
| T/C | 0.32 | 0.15 | 0.03 |
rs11847697 |
PRKD1
| T/C | 0.23 | 0.08 | 0.01 |
rs12286929 |
CADM1
| G/A | 0.01 | 0.05 | 0.85 |
rs12401738 |
FUBP1
| A/G | 0.04 | 0.05 | 0.42 |
rs12429545 |
OLFM4
| A/G | 0.10 | 0.06 | 0.07 |
rs12446632 |
GPRC5B
| G/A | 0.06 | 0.10 | 0.56 |
rs12566985 |
FPGT-TNNI3K
| G/A | 0.01 | 0.05 | 0.82 |
rs12885454 |
PRKD1
| C/A | 0.08 | 0.05 | 0.08 |
rs12940622 |
RPTOR
| G/A | 0.03 | 0.05 | 0.57 |
rs13021737 |
TMEM18
| G/A | 0.25 | 0.06 | 3.15E-05 |
rs13078960 |
CADM2
| G/T | 0.09 | 0.07 | 0.20 |
rs13191362 |
PARK2
| A/G | 0.00 | 0.07 | 0.98 |
rs13201877 |
IFNGR1
| G/A | 0.16 | 0.08 | 0.05 |
rs1441264 |
MIR548A2
| A/G | 0.03 | 0.05 | 0.50 |
rs1460676 |
FIGN
| C/T | −0.04 | 0.06 | 0.49 |
rs1516725 |
ETV5
| C/T | 0.07 | 0.06 | 0.27 |
rs1528435 |
UBE2E3
| T/C | −0.03 | 0.05 | 0.54 |
rs1558902 |
FTO
| A/T | 0.19 | 0.05 | 8.85E-05 |
rs16851483 |
RASA2
| T/G | 0.20 | 0.07 | 0.01 |
rs16907751 |
ZBTB10
| C/T | 0.02 | 0.06 | 0.69 |
rs16951275 |
MAP2K5
| T/C | 0.06 | 0.05 | 0.17 |
rs17001654 |
SCARB2
| G/C | 0.09 | 0.08 | 0.25 |
rs17094222 |
HIF1AN
| C/T | 0.02 | 0.06 | 0.75 |
rs17203016 |
CREB1
| G/A | −0.03 | 0.06 | 0.67 |
rs17405819 |
HNF4G
| T/C | 0.07 | 0.05 | 0.12 |
rs17724992 |
PGPEP1
| A/G | −0.06 | 0.04 | 0.16 |
rs1808579 |
C18orf8
| C/T | −0.02 | 0.04 | 0.58 |
rs1885988 |
MTIF3
| C/T | 0.05 | 0.08 | 0.54 |
rs1928295 |
TLR4
| T/C | 0.04 | 0.05 | 0.41 |
rs2033529 |
TDRG1
| G/A | 0.08 | 0.06 | 0.14 |
rs2033732 |
RALYL
| C/T | 0.07 | 0.05 | 0.16 |
rs205262 |
C6orf106
| G/A | 0.06 | 0.05 | 0.31 |
rs2075650 |
TOMM40
| A/G | −0.01 | 0.07 | 0.90 |
rs2080454 |
CBLN1
| C/A | 0.12 | 0.05 | 0.02 |
rs2112347 |
POC5
| T/G | −0.04 | 0.04 | 0.39 |
rs2121279 |
LRP1B
| T/C | 0.10 | 0.10 | 0.32 |
rs2176040 |
LOC646736
| A/G | 0.11 | 0.05 | 0.03 |
rs2176598 |
HSD17B12
| T/C | 0.06 | 0.06 | 0.31 |
rs2207139 |
TFAP2B
| G/A | 0.10 | 0.05 | 0.07 |
rs2245368 |
PMS2L11
| C/T | 0.07 | 0.05 | 0.16 |
rs2287019 |
QPCTL
| C/T | −0.03 | 0.06 | 0.61 |
rs2365389 |
FHIT
| C/T | −0.02 | 0.04 | 0.71 |
rs2650492 |
SBK1
| A/G | 0.03 | 0.06 | 0.56 |
rs2820292 |
NAV1
| C/A | 0.09 | 0.04 | 0.06 |
rs2836754 |
ETS2
| C/T | 0.16 | 0.05 | 7.45E-04 |
rs29941 |
KCTD15
| G/A | 0.10 | 0.05 | 0.02 |
rs3101336 |
NEGR1
| C/T | 0.10 | 0.05 | 0.03 |
rs3736485 |
DMXL2
| A/G | 0.04 | 0.04 | 0.41 |
rs3810291 |
ZC3H4
| A/G | 0.04 | 0.04 | 0.36 |
rs3817334 |
MTCH2
| T/C | 0.00 | 0.05 | 0.95 |
rs3849570 |
GBE1
| A/C | 0.01 | 0.05 | 0.83 |
rs3888190 |
ATP2A1
| A/C | 0.04 | 0.05 | 0.45 |
rs4256980 |
TRIM66
| G/C | 0.07 | 0.04 | 0.11 |
rs4740619 |
C9orf93
| T/C | −0.09 | 0.04 | 0.04 |
rs4787491 |
INO80E
| G/A | −0.01 | 0.04 | 0.81 |
rs492400 |
USP37
| C/T | 0.03 | 0.05 | 0.54 |
rs543874 |
SEC16B
| G/A | 0.13 | 0.06 | 0.04 |
rs6091540 |
ZFP64
| C/T | 0.10 | 0.05 | 0.04 |
rs6465468 |
ASB4
| T/G | −0.14 | 0.06 | 0.02 |
rs6477694 |
EPB41L4B
| C/T | 0.06 | 0.04 | 0.18 |
rs6567160 |
MC4R
| C/T | 0.24 | 0.05 | 1.15E-07 |
rs657452 |
AGBL4
| A/G | −0.04 | 0.04 | 0.40 |
rs6804842 |
RARB
| G/A | 0.00 | 0.04 | 0.98 |
rs7138803 |
BCDIN3D
| A/G | 0.06 | 0.05 | 0.16 |
rs7141420 |
NRXN3
| T/C | 0.03 | 0.04 | 0.56 |
rs7164727 |
LOC100287559
| T/C | 0.06 | 0.05 | 0.20 |
rs7239883 |
LOC284260
| G/A | 0.07 | 0.05 | 0.17 |
rs7243357 |
GRP
| T/G | 0.07 | 0.05 | 0.21 |
rs758747 |
NLRC3
| T/C | 0.15 | 0.05 | 1.29E-03 |
rs7599312 |
ERBB4
| G/A | −0.03 | 0.06 | 0.66 |
rs7715256 |
GALNT10
| G/T | 0.00 | 0.04 | 0.91 |
rs7899106 |
GRID1
| G/A | 0.34 | 0.14 | 0.01 |
rs7903146 |
TCF7L2
| C/T | 0.13 | 0.05 | 0.01 |
rs9374842 |
LOC285762
| T/C | 0.02 | 0.05 | 0.65 |
rs9400239 |
FOXO3
| C/T | 0.00 | 0.04 | 1.00 |
rs9540493 |
MIR548X2
| A/G | 0.06 | 0.04 | 0.17 |
rs9641123 |
CALCR
| C/G | 0.10 | 0.05 | 0.02 |
rs977747 |
TAL1
| T/G | −0.07 | 0.04 | 0.13 |
rs9914578 |
SMG6
| G/C | 0.00 | 0.05 | 0.92 |
rs9925964 |
KAT8
| A/G | −0.05 | 0.06 | 0.41 |