Background
Methods
Data source and study population
Statistical analysis
Results
Baseline characteristics
Before matching | After matching | |||||
---|---|---|---|---|---|---|
No Dementia (n = 9,868) | Dementia (n = 303) |
P-value | No Dementia (n = 504) | Dementia (n = 252) |
P-value | |
Age | 71.7 ± 5.3 | 74.6 ± 5.9 | <0.001 | 74.5 ± 5.6 | 74.6 ± 5.7 | 0.729 |
Male sex | 5,346 (54.2) | 136 (44.9) | 0.002 | 243 (48.2) | 111 (44.0) | 0.315 |
Health security system | ||||||
National health insurance | 8,840 (89.6) | 261 (86.1) | 0.067 | 446 (88.5) | 214 (84.9) | 0.203 |
Medical aid | 1,028 (10.4) | 42 (13.9) | 58 (11.5) | 384 (15.1) | ||
Comorbidities | ||||||
Diabetes | 5,413 (54.9) | 175 (57.8) | 0.347 | 304 (60.3) | 142 (56.3) | 0.333 |
Cerebrovascular disease | 1,521 (15.4) | 131 (43.2) | <0.001 | 223 (44.2) | 107 (42.5) | 0.697 |
Hemiparesis | 152 (1.5) | 15 (5) | <0.001 | 29 (5.8) | 12 (4.8) | 0.691 |
Acute myocardial infarction | 459 (4.7) | 11 (3.6) | 0.487 | 14 (2.8) | 9 (3.6) | 0.708 |
Congestive heart failure | 1,829 (18.5) | 70 (23.1) | 0.053 | 115 (22.8) | 60 (23.8) | 0.831 |
Peripheral vascular disease | 792 (8) | 38 (12.5) | 0.007 | 64 (12.7) | 29 (11.5) | 0.725 |
Chronic pulmonary disease | 2,205 (22.3) | 58 (19.1) | 0.211 | 96 (19.5) | 50 (19.8) | 0.871 |
Connective tissue disease | 314 (3.2) | 7 (2.3) | 0.491 | 9 (1.8) | 4 (1.6) | 1.000 |
Peptic ulcer disease | 1,694 (17.2) | 47 (15.5) | 0.499 | 88 (17.5) | 40 (15.9) | 0.656 |
Liver disease | 885 (9) | 20 (6.6) | 0.186 | 35 (6.9) | 15 (6.0) | 0.717 |
Any cancer | 841 (8.5) | 30 (9.9) | 0.459 | 68 (13.5) | 26 (10.3) | 0.258 |
Incidence Rates and Risk Factors of MACCE in All Elderly Patients Starting Dialysis
Risks of MACCE and its components in all elderly HD patients with dementia
Before matchinga
| After matchinga
| |||||
---|---|---|---|---|---|---|
HR | (95% CI) |
P-value | HR | (95% CI) |
P-value | |
MACCE | 1.258 | 1.088–1.454 | 0.002 | 1.261 | 1.039–1.531 | 0.019 |
MACE | 1.285 | 1.101–1.499 | 0.001 | 1.204 | 0.979–1.480 | 0.078 |
All-cause mortality | 1.334 | 1.140–1.562 | <0.001 | 1.301 | 1.053–1.607 | 0.015 |
Non-fatal acute myocardial infarction | 0.994 | 0.581–1.701 | 0.982 | 0.589 | 0.264–1.314 | 0.196 |
Target vessel revascularization | 0.612 | 0.272–1.378 | 0.236 | 0.424 | 0.144–1.246 | 0.119 |
Percutaneous intervention | 0.525 | 0.216–1.275 | 0.154 | 0.319 | 0.094–1.077 | 0.066 |
Coronary artery bypass graftb
| 1.554 | 0.204–1.859 | 0.671 | – | – | – |
Non-fatal stroke | 1.134 | 0.856–1.501 | 0.382 | 1.326 | 0.923–1.904 | 0.127 |
Non-fatal hemorrhagic stroke | 0.551 | 0.204–1.492 | 0.241 | 0.556 | 0.154–2.010 | 0.371 |
Non-fatal ischemic stroke | 1.241 | 0.931–1.654 | 0.141 | 1.492 | 1.027–2.168 | 0.036 |