Varicella infections in patients with end stage renal disease: a systematic review

The relevant papers published were collected through a computerised search on three databases (PubMed, Embase and Cumulative Index to Nursing and Allied Health Literature, CINAHL) using the keywords: chronic kidney failure, renal replacement therapy, kidney transplantation, end stage renal disease, end stage renal failure, chicken pox, varicella, vaccine, vaccination and complication. For PubMed search, the Boolean search of (Kidney Failure, Chronic [Medical Subject Heading (MeSH) Terms]) OR Renal Replacement Therapy [MeSH Terms]) OR kidney transplantation [MeSH Terms]) OR end stage renal disease) OR end stage renal failure)) AND (“Chickenpox”[MeSH Terms]) OR “Varicella”) AND (Complicat* OR vaccin*) was used. The same search terms were used for Embase and CINAHL database searches. For CINAHL only academic journals were included, periodics and bulletins were not included. The search was conducted in April 2018. There was no time frame limitation applied for the inclusion of the studies.

Two reviewers, O.C.Y and L.S.G, independently evaluated the articles for eligibility through screening of the title and abstract first, followed by full text. Consensus on the eligibility of the articles was sought, and F.F.V was involved if there was disagreement and would act as an adjudicator.

A study is included if it is found to be relevant with regards to varicella infection in ESRD: the prevalence of seronegativity, the complications of the infection, or safety and efficacy of varicella vaccination to adult patients with ESRD or CKD. Case reports and cohort were included if measurable outcomes of death, complications, or length of stay were described. Records on herpes zoster, acyclovir, and non-renal solid organ transplants were excluded. Records on paediatric/ child populations were excluded.

Selected studies were summarised in Table 1. The data was grouped into themes of seroprevalance, impact of the disease, immunogenicity and safety of the varicella vaccination. Each article was graded for quality of study based on the Strength of Recommendation Taxonomy (SORT); which was introduced by the United States family medicine and primary care journals (i.e., American Family Physician, Family Medicine, The Journal of Family Practice, Journal of the American Board of Family Practice, and British Medical Journal-USA) and the Family Practice Inquiries Network (FPIN) [12]. The SORT was used because it can be applied to many sources of evidence and therefore suitable for our review which included studies with heterogeneous designs. Study quality was included in Tables 2, 3, 4, and 5. Risks of bias of each study were not accessed directly as most studies were of grade three in qualities based on the SORT. No statistical analysis was performed.

Out of the seven studies on the prevalence of seronegative results; four studies were on the prevalence of seronegativity among ESRD patients upon presentation of the varicella disease [9, 13‐15]. The results showed that 42 to 100% of the patients who contracted varicella had no prior immunity to varicella. Three studies examined the prevalence of seronegativity among ESRD patients before contraction of primary varicella. Of the three, the first studied on transplant recipients [16], the second on both transplant recipients and candidates on waitlist [17], and the third on haemodialysis patients [18]. The latter three studies, however, showed that prevalence of seronegativity was low (2.1 to 9.8%).

The prevalence of VZV seronegativity varies among renal transplant recipients, haemodialysis patients, and renal transplant candidates awaiting transplant (Table 2). There was no mention of whether the candidates waiting transplant was on renal replacement therapy or not. Among transplant patients (n = 935), there was a huge range of prevalence seronegativity from 2.1 to 100% [9, 13, 14, 17]. Among haemodialysis patients (n = 187), the prevalence of seronegativity was 2.1% [18]. As for candidates awaiting transplant (n = 622), 3.2 to 9.8% was seronegative to VZV [16, 17].

23 articles reported on the impact of the disease; including complications from varicella, length of stay, and mortality (Table 3). Collectively, there were nineteen deaths reported from the studies. Errasti, et al. reported four patients in which two died; both patients had significant complications (one with fulminant hepatitis, one had encephalitis) and multiorgan failure [19]. On the other hand, two other patients that had no complications survived the infection. Ishikawa, et al. reported two patients with disseminated intravascular coagulation [20]. Fehr et al. reported four cases in which all survived while their review of the literature revealed overall varicella mortality rates to be 34% [5]. Other deaths from varicella in ESRD were due to respiratory failures (one from pneumonia, one from pneumonitis), multiorgan failure (two cases), nervous system neuropathy (one case) and hepatitis (one case) [13, 21‐25]. Length of stay has been reported to vary from 2 to 40 days. Other reported complications were pancreatitis, retinal necrosis, secondary bacterial infection, acute kidney injury, myocarditis, microangiopathy, Darrier’s disease, and even Guillain-Barre syndrome.

Most of the studies revealed that infected with primary varicella were treated with intravenous acyclovir. Standard dose of 10 mg/kg 8hourly (eight to fourteen days) were described in most cases (12 studies), renal adjusted dose were mentioned in seven reports, no dose of intravenous acyclovir was given in two reports, and in one study [9], all patients were given regimen of two weeks of intravenous acyclovir followed by three months of oral acyclovir was administered. One case was treated with three months of oral acyclovir. One case was treated with intravenous valaciclovir [26]. Intravenous ganciclovir was given in two cases [5, 9]. Cessation and reduction of immunosuppressant d rugs were described in four cases [5, 21, 25, 27, 28] and two studies [5, 9] respectively. Adjunctive antibiotics were initiated in five cases [5, 25, 27, 29, 30]. Foscarnet was given in one case following failure of initial treatment [23]. Immunoglobulins were administered in eight cases [13, 20, 31].

Three studies examined the seroconversion rate or post vaccination after administration of two doses of varicella vaccine. All three studies have limited number of patients. Crespo, et al. [16] reported a highly encouraging response rate of 94% while Geel, et al. [17] and Kho, et al. [32] found that the response rate to be around 64–77%. Table 4 summarises the seroconversion rates of selected studies.

As far as safety is concerned, Crespo, et al. and Geel, et al. found no secondary effect of vaccination [16, 32]. None of their vaccinated patients developed the varicella-zoster disease. Kho, et al. followed up 52 patients post-vaccination for complications and found one to have primary varicella and two to have herpes zoster [32]. Only one reported pain at injection site, no cellulitis or skin infection was reported. Interestingly, Scanlon-Kohlroser, et al. reported a case where transmission of varicella took place from two infants that were vaccinated to a post-renal transplant patient [28]. Table 5 summarises the complications of the vaccine.

In this review, the prevalence of seronegativity among varicella-infected ESRD adults was found to be significantly alarming at 42 to 100% [9, 13‐15]. Nineteen deaths were reported in 23 studies that reported the varicella infections. At least 52 patients were reported to have complications from varicella infections. Efficacy of vaccination (measured by seroconversion rate after two doses of VZV vaccine) was found to be around 64–74%. Safety of vaccines showed that adverse effects or complications from vaccinations were zero in a cohort of fewer than twenty persons [16, 17]. Four adverse effects from vaccinations were reported in a study of 52 patients [32].

Varicella has been recognised as a potentially fatal disease among adults even though it has been largely regarded as a benign disease of childhood [33]. Although accounting for only 5% of reported cases of varicella, adults in general population contributed to 35% of all varicella deaths [34]. Furthermore, varicella is a more severe threat to adult patients with ESRD the myriad of organ and system-complications described. This dismisses the general perception of acute varicella being a self-limiting disease.

In the general population (adults and paediatrics), mortality rates were around 0.41 deaths per 1 million through 1990–1994. This decreased drastically to 0.14 deaths per 1 million during 1999 through 2001 [35, 36]. Compared to general population, mortality rates of varicella among adult patients with ESRD is much higher; suggesting the vulnerability of this group of patients to varicella infection.

Varicella-related complications derived from the review were no different from known complications of varicella infection [34]. Pneumonia, hepatitis, and encephalitis were found to be the leading complications. These complications may progress to multi-organ failure with high mortality.

Based on this review, seroconversion rates of 64–94% are encouraging and reflecting high immunogenicity when administered. This is in keeping with findings of live-attenuated varicella vaccinations being immunogenic, efficacious and safe in preventing varicella infections [35, 37]. Besides that, there are no major adverse effects in the cohort studies of vaccinated adult patients. This could suggest the positive role of vaccinating VZV seronegative patients with ESRD in preventing varicella infection.

In addition to the database search, we also searched specifically for guidelines on varicella vaccinations. As for recommendations for varicella vaccination in this group of patients; only a handful recommendations from published guidelines were found. The Advisory Committee on Immunization Practices (ACIP); Centres for Disease Control and Prevention (CDC) have recommended varicella vaccine for ESRD patients, who meet age criteria and who do not have contraindications to vaccine [38].

The American Society of Transplantation and the American Society of Transplant Surgeons recommended pre-transplantation VZV serology checking. Seronegative adults should receive one dose of varicella vaccine with serologic testing post vaccination. If seroconversion does not occur, the dose may be repeated once if time permits [39].

Similarly, the Korean Vaccination Society has recommended varicella vaccination for the seronegative adults; and this should be completed at least one month before transplantation [40]. The 2013 Infectious Disease Society of America (IDSA) Clinical Practice Guideline (CPG) for vaccination of the immunocompromised host advocated that varicella vaccine (VAR) should be given to immunocompetent patients without evidence of varicella immunity if it can be administered at least four weeks before initiating immunosuppressive therapy [41].

Both the US Department of Veterans Affairs and Department of Defence (2014) on their Clinical Practice Guideline for the Management of Chronic Kidney Disease in Primary Care (strong recommendation); and Public Health Agency of Canada (in their Canadian Immunisation Guide 2016) have extended the recommendation to include patients with chronic kidney disease or chronic renal disease [42, 43]. The Kidney Disease: Improving Global Outcomes (KDIGO) and the National Kidney Foundation’s Kidney Disease Outcome: Quality Improvement (KDOQI) have not specifically advocated for varicella vaccination post-transplant, the reason being varicella vaccine is a live-attenuated vaccine [44, 45]. At present, there is yet to be any recommendation by both KDIGO and KDOQI on pre-transplant vaccinations in general. While post-exposure prophylaxis with varicella immunoglobulin, and primary varicella treatment with acyclovir or valaciclovir has been recommended; they are still silent with regards to VZV immunisation as a preventive method [43, 45].

There is a lack of guidelines in the Asia Pacific Region on varicella vaccination in patients with ESRD. Since most patients with ESRD or advanced CKD are managed by renal physicians and family physicians; it is critical to advocate, initiate planning, followed by implementing policies on varicella vaccination among these susceptible patients. This is of increasing importance considering the increasing number of patients developing ESRD in Asia.

The first limitation is the heterogeneity of the population in the studies that were included. The aim of this review is to review the available literature of adult populations with ESRD comprehensively. However, most studies included only subset populations of ESRD; namely renal transplant recipients or patients on haemodialysis and therefore findings may not be fully representative of the overall population of ESRD. Therefore, there is a real need for study varicella among patients with ESRD without renal transplantation. To date, guidelines by the US Veterans’ Affairs and Canadian Public Health Agency are the only two available ones to advocate vaccination even, among chronic kidney disease, while most of the published guidelines advocate vaccination among ESRD. Studies on varicella among CKD patients (before progressing into ESRD) may help to give insight whether vaccinating patients once they are diagnosed with CKD of certain stages (before their progression to ESRD) may prevent this vulnerable group of patients from contracting varicella.

There is some heterogeneity in the reports of prevalence of varicella immunity among patients in ESRD. Three described the prevalence among ESRD patients who yet to contract varicella [16‐18]; while four described the prevalence in already infected ESRD patients [9, 13‐15]. Despite the comprehensive search, the number of available studies in the literature is low, they were summarised together in Table 2.

Another limitation is the design of the selected articles. As varicella in adult patients with ESRD has not been widely studied, there are no large-scale observational studies to date to give an impactful insight on the burden of the disease in this group of population. Most available studies are case reports and retrospective data collection and therefore are prone to selective bias (reporting bias).

Finally, future research on the cost-effectiveness on vaccinating all patients with ESRD compared to screening patients with ESRD for seronegativity before vaccinating them and monitoring will be helpful to guide national guidelines on varicella vaccination in adult patients with ESRD. This can be challenging and varies between countries depending on the robustness of national healthcare surveillance data on patients with ESRD and cost of delivering and administrating vaccines and serological tests.