Background
Methods
Study participants and data collection
Diagnosis criteria
Statistical analysis
Results
Baseline clinical characteristics and pathological features
Total | IgAN | non-IgAN | p-value | |
---|---|---|---|---|
n = 1070 | n = 429 | n = 641 | ||
Age (years) | 38 ± 15 | 34 ± 12 | 40 ± 16 | <0.001 |
Male (n, %) | 516 (48.2%) | 171 (39.9%) | 345 (53.8%) | <0.001 |
Cr (μmol/L) | 84.2 ± 50.1 | 90.3 ± 50.8 | 80.1 ± 50.4 | 0.004 |
eGFR (ml/min/1.73m2) | 98.1 ± 31.3 | 93.0 ± 32.9 | 101.6 ± 29.8 | <0.001 |
Urea (mmol/L) | 6.5 ± 3.7 | 6.8 ± 3.7 | 6.3 ± 3.7 | 0.03 |
Alb (g/L) | 33.2 ± 9.5 | 38.0 ± 6.7 | 30.0 ± 9.7 | <0.001 |
UA (μmol/L) | 372.7 ± 104.1 | 382.4 ± 105.2 | 366.2 ± 102.8 | 0.01 |
HUA (n,%) | 415 (38.8%) | 188 (43.8%) | 277 (35.4%) | 0.84 |
24 h-u-pro (g/d) | 1.6 (0.5,4.0) | 1.2 (0.5,2.3) | 2.2 (0.5,5.1) | <0.001 |
SBP | 126.74 ± 17.87 | 126.13 ± 17.52 | 127.13 ± 18.09 | 0.40 |
DBP | 78.01 ± 12.32 | 77.72 ± 17.16 | 78.19 ± 12.43 | 0.57 |
hypertension(n,%) | 230 (21.5%) | 85 (19.8%) | 145 (22.6%) | 0.60 |
Histopathological changes | ||||
S0 (n,%) | 812 (75.9%) | 237 (55.2%) | 575 (89.7%) | <0.001 |
S1 (n,%) | 258 (24.1%) | 192 (44.8%) | 66 (10.3%) | |
T1 (n,%) | 989 (92.4%) | 369 (86.0%) | 620 (96.7%) | <0.001 |
T2 (n,%) | 68 (6.4%) | 51 (11.9%) | 17 (2.7%) | |
T3 (n,%) | 13 (1.2%) | 9 (2.1%) | 4 (0.6%) |
Uric acid and renal pathological features
Total | S0 | S1 | p-value | T1 | T2 | T3 | p-value |
---|---|---|---|---|---|---|---|
(n = 1070) | (n = 812) | (n = 258) | (n = 989) | (n = 68) | (n = 13) | ||
age | 38.67 ± 15.51 | 34.87 ± 11.53 | <0.001 | 37.64 ± 14.99 | 38.91 ± 11.54 | 41.15 ± 9.54 | 0.55 |
SBP | 126.42 ± 17.55 | 127.74 ± 18.84 | 0.33 | 126.24 ± 17.79 | 131.18 ± 15.83△ | 142.17 ± 24.07# | 0.001 |
DBP | 77.62 ± 11.98 | 79.23 ± 13.29 | 0.09 | 77.67 ± 12.29 | 81.05 ± 10.00△ | 88.08 ± 18.46 | 0.002 |
UA | 365.8 ± 102.2 | 394.3 ± 107.1 | <0.001 | 367.0 ± 101.3 | 436.6 ± 114.1△ | 469.1 ± 103.0# | <0.001 |
Cr | 81.5 ± 52.7 | 92.7 ± 43.2 | 0.002 | 78.1 ± 40.7 | 146.2 ± 78.0△ | 221.8 ± 117.4# | <0.001 |
eGFR | 101.0 ± 30.4 | 89.2 ± 32.7 | <0.001 | 102.0 ± 28.7 | 54.5 ± 23.5△ | 35.3 ± 18.1#ο | <0.001 |
Urea | 6.3 ± 3.7 | 7.2 ± 3.6 | <0.001 | 6.2 ± 3.3 | 9.9 ± 5.6△ | 14.0 ± 5.5# | <0.001 |
Alb | 32.0 ± 9.8 | 37.1 ± 7.3 | <0.001 | 33.0 ± 9.7 | 35.2 ± 7.4 | 35.6 ± 6.1 | 0.12 |
24 h-u-pro | 1.7 (0.4, 4.3) | 1.5 (0.7, 2.8) | <0.001 | 1.6 (0.5, 4.0) | 1.9 (1.0, 3.6) | 3.7 (1.9, 4.6) | 0.89 |
IgAN(n = 429) | (n = 237) | (n = 192) | (n = 369) | (n = 51) | (n = 9) | ||
age | 35.23 ± 12.30 | 33.22 ± 10.25 | 0.07 | 34.09 ± 11.77 | 35.73 ± 9.73 | 36.78 ± 6.03 | 0.51 |
SBP | 126.73 ± 16.64 | 125.43 ± 18.53 | 0.48 | 125.21 ± 17.48 | 130.74 ± 15.12 | 136.88 ± 24.86 | 0.03 |
DBP | 77.35 ± 11.30 | 78.16 ± 13.13 | 0.53 | 76.95 ± 12.06 | 81.53 ± 10.09△ | 87.00 ± 19.03 | 0.006 |
UA | 374.6 ± 101.2 | 392.0 ± 109.5 | 0.09 | 373.1 ± 101.1 | 435.3 ± 115.3△ | 464.9 ± 97.2# | <0.001 |
Cr | 89.7 ± 56.6 | 91.0 ± 42.8 | 0.79 | 79.6 ± 33.0 | 152.4 ± 86.2△ | 177.6 ± 57.4# | <0.001 |
eGFR | 94.9 ± 33.0 | 90.7 ± 32.6 | 0.19 | 99.6 ± 29.2 | 53.9 ± 24.4△ | 42.2 ± 16.4# | <0.001 |
Urea | 6.6 ± 3.7 | 7.1 ± 3.7 | 0.11 | 6.2 ± 2.8 | 10.1 ± 6.0△ | 13.6 ± 4.5# | <0.001 |
Alb | 37.7 ± 7.5 | 38.6 ± 5.6 | 0.17 | 38.4 ± 6.7 | 36.1 ± 6.9△ | 34.9 ± 4.5 | 0.02 |
24 h-u-pro | 1.0 (0.4, 2.0) | 1.4 (0.7, 2.5) | 0.52 | 1.0 (0.5, 2.1) | 2.0 (0.9, 4.0)△ | 3.7 (2.0, 4.8) | <0.001 |
non-IgAN (n = 641) | (n = 575) | (n = 66) | (n = 620) | (n = 17) | (n = 4) | ||
age | 40.09 ± 16.45 | 39.73 ± 13.60 | 0.84 | 39.75 ± 16.25 | 48.47 ± 11.49△ | 51.00 ± 8.98 | 0.03 |
SBP | 126.31 ± 17.90 | 133.89 ± 18.40 | 0.002 | 126.81 ± 17.94 | 132.50 ± 18.40 | 152.75 ± 21.42#ο | 0.009 |
DBP | 77.72 ± 12.24 | 82.08 ± 13.38 | 0.009 | 78.07 ± 12.41 | 79.57 ± 9.95 | 90.25 ± 19.87 | 0.13 |
UA | 362.2 ± 102.4 | 401. ± 100.3 | 0.003 | 363.4 ± 101.4 | 440.4 ± 113.6△ | 478.6 ± 130.7# | <0.001 |
Cr | 78.1 ± 50.6 | 97.7 ± 44.5 | 0.003 | 77.3 ± 44.7 | 127.3 ± 41.5△ | 321.3 ± 165.3 | <0.001 |
eGFR | 103.5 ± 28.9 | 84.7 ± 32.6 | <0.001 | 103.4 ± 28.3 | 56.4 ± 20.9△ | 19.8 ± 11.3#ο | <0.001 |
Urea | 6.2 ± 3.7 | 7.3 ± 3.4 | 0.02 | 6.2 ± 3.6 | 9.5 ± 3.9△ | 14.7 ± 8.0 | <0.001 |
Alb | 29.6 ± 9.7 | 32.6 ± 9.5 | 0.02 | 29.8 ± 9.7 | 32.6 ± 8.4 | 37.1 ± 9.6 | 0.17 |
24 h-u-pro | 2.3 (0.4, 5.1) | 1.8 (1.0, 4.5) | 0.44 | 2.3 (0.4, 5.1) | 1.6 (1.1, 4.8) | 3.3 (1.8, 3.3) | 0.86 |
Hyperuricemia and renal pathological changes
OR1 (95% CI) | OR2 (95% CI) | OR3 (95% CI) | OR4 (95% CI) | OR 5 (95% CI) | |
---|---|---|---|---|---|
HUA | 1.800△ (1.309–2.477) | 1.771△ (1.250–2.509) | 1.812△ (1.297–2.533) | 1.400 (0.975–2.011) | 1.422△ (1.003–2.016) |
Model 1 | Model 2 | Model 3 | Model 4 | |||||
---|---|---|---|---|---|---|---|---|
HUA | HUA | HUA | HUA | HUA | HUA | HUA | HUA | |
absent | present | absent | present | absent | present | absent | present | |
Sensitivity | 0.758 | 0.815 | 0.711 | 0.773 | 0.837 | 0.774 | 0.828 | 0.819 |
Specificity | 0.493 | 0.429 | 0.531 | 0.466 | 0.535 | 0.571 | 0.559 | 0.573 |
AUC (SE) | 0.617 (0.020) | 0.6433 (0.020) | 0.629 (0.021) | 0.652 (0.021) | 0.700 (0.019) | 0.716 (0.019) | 0.738 (0.019) | 0.741 (0.019) |