Background
Methods
Ethics statement
Statistical analysis
Results
Clinicopathological differences between age groups
15-30 | 31-40 | 41-50 | 51-60 | 61-70 | 71-80 | >80 | P value | |
---|---|---|---|---|---|---|---|---|
Characteristic | (n = 1181) | (n = 5333) | (n = 18727) | (n = 39125) | (n = 53540) | (n = 64642) | (n = 43882) | |
Site | <0.001 | |||||||
Colon | 878 | 3854 | 13619 | 29335 | 42067 | 52767 | 36839 | |
% | 76.1% | 73.6% | 73.8% | 76.1% | 79.8% | 83.0% | 85.6% | |
Rectum | 276 | 1382 | 4823 | 9194 | 10625 | 10772 | 6205 | |
% | 23.9% | 26.4% | 26.2% | 23.9% | 20.2% | 17.0% | 14.4% | |
Sex | ||||||||
Male | 622 | 2881 | 10188 | 22876 | 30443 | 32157 | 16326 | <0.001 |
% | 52.7% | 54.0% | 54.4% | 58.5% | 56.9% | 49.7% | 37.2% | |
Female | 559 | 2452 | 8539 | 16249 | 23097 | 32485 | 27556 | |
% | 47.3% | 46.0% | 45.6% | 41.5% | 43.1% | 50.3% | 62.8% | |
Surgery Resection | <0.001 | |||||||
Yes | 1073 | 4874 | 17025 | 35729 | 48909 | 58248 | 36890 | |
% | 90.9% | 91.4% | 90.9% | 91.3% | 91.4% | 90.2% | 84.1% | |
No | 98 | 416 | 1594 | 3150 | 4318 | 6017 | 6647 | |
% | 8.3% | 7.8% | 8.5% | 8.1% | 8.1% | 9.3% | 15.2% | |
Unknown | 10 | 43 | 105 | 243 | 292 | 347 | 316 | |
% | 0.8% | 0.8% | 0.6% | 0.6% | 0.5% | 0.5% | 0.7% | |
Grade | <0.001 | |||||||
I/II | 687 | 3555 | 13196 | 28331 | 39003 | 46869 | 30960 | |
% | 58.2% | 66.7% | 70.5% | 72.4% | 72.8% | 72.5% | 70.6% | |
III/IV | 358 | 1232 | 3589 | 6649 | 9212 | 11727 | 8526 | |
% | 30.3% | 23.1% | 19.2% | 17.0% | 17.2% | 18.1% | 19.4% | |
Unknown | 136 | 546 | 1942 | 4145 | 5325 | 6046 | 4396 | |
% | 11.5% | 10.2% | 10.4% | 10.6% | 9.9% | 9.4% | 10.0% | |
Race | <0.001 | |||||||
Caucasian | 865 | 3943 | 14062 | 30358 | 42785 | 54227 | 38195 | |
% | 73.2% | 73.9% | 75.1% | 77.6% | 79.9% | 83.9% | 87.0% | |
African American | 158 | 726 | 2689 | 5190 | 6144 | 5550 | 3101 | |
% | 13.4% | 13.6% | 14.4% | 13.3% | 11.5% | 8.6% | 7.1% | |
Others* | 153 | 637 | 1864 | 3361 | 4358 | 4604 | 2458 | |
% | 13.0% | 11.9% | 10.0% | 8.6% | 8.1% | 7.1% | 5.6% | |
Unknown | 5 | 27 | 112 | 216 | 253 | 261 | 128 | |
% | 0.4% | 0.5% | 0.6% | 0.6% | 0.5% | 0.4% | 0.3% | |
Histological Type | <0.001 | |||||||
Adenocarcinoma | 833 | 4363 | 16225 | 34740 | 47536 | 56905 | 38431 | |
% | 72.2% | 82.5% | 86.9% | 89.0% | 88.9% | 88.1% | 87.7% | |
Mucinous/Signet-ring cancer | 320 | 927 | 2440 | 4308 | 5927 | 7655 | 5384 | |
% | 27.8% | 17.5% | 13.1% | 11.0% | 11.1% | 11.9% | 12.3% | |
AJCC stage | <0.001 | |||||||
I- II | 326 | 1857 | 6736 | 15467 | 23031 | 29743 | 19712 | |
% | 27.6% | 34.8% | 36.0% | 39.5% | 43.0% | 46.0% | 44.9% | |
III -IV | 705 | 2828 | 9432 | 17834 | 22753 | 25328 | 15786 | |
% | 59.7% | 53.0% | 50.4% | 45.6% | 42.5% | 39.2% | 36.0% | |
Unknown | 150 | 648 | 2559 | 5824 | 7756 | 9571 | 8384 | |
% | 12.7% | 12.2% | 13.7% | 14.9% | 14.5% | 14.8% | 19.1% |
Impact of age on survival outcomes in patients with CRC
15-30 | 31-40 | 41-50 | 51-60 | 61-70 | 71-80 | >80 | P value | |
---|---|---|---|---|---|---|---|---|
Total
| (n = 1181) | (n = 5333) | (n = 18727) | (n = 39125) | (n = 53540) | (n = 64642) | (n = 43882) | |
CSS | <0.001 | |||||||
1-year CCS | 84.6% | 88.8% | 88.8% | 88.7% | 86.8% | 82.8% | 74.2% | |
3-year CCS | 66.4% | 72.7% | 73.3% | 75.1% | 74.1% | 70.4% | 60.0% | |
5-year CCS | 58.5% | 65.7% | 66.3% | 68.0% | 67.6% | 64.0% | 53.5% | |
OS | ||||||||
1-year OS | 83.5% | 87.9% | 87.8% | 87.2% | 83.9% | 77.3% | 63.8% | |
3-year OS | 64.8% | 71.0% | 71.6% | 72.4% | 68.9% | 60.5% | 43.0% | |
5-year OS | 56.6% | 63.6% | 63.5% | 64.0% | 60.0% | 49.9% | 30.5% | |
Operated group
| (n = 1073) | (n = 4874) | (n = 17025) | (n = 35729) | (n = 48909) | (n = 58248) | (n = 36890) | |
5-year CCS | <0.001 | |||||||
1-year CCS | 88.4% | 91.7% | 92.3% | 92.1% | 90.6% | 87.3% | 80.6% | |
3-year CCS | 70.4% | 76.5% | 77.9% | 79.5% | 78.4% | 75.2% | 67.0% | |
5-year CCS | 62.1% | 69.6% | 70.7% | 72.3% | 71.8% | 68.6% | 60.1% | |
OS | ||||||||
1-year OS | 87.4% | 90.9% | 91.6% | 90.8% | 88.0% | 82.3% | 70.7% | |
3-year OS | 69.1% | 75.1% | 76.3% | 76.8% | 73.4% | 65.5% | 49.5% | |
5-year OS | 60.4% | 67.6% | 68.3% | 68.3% | 64.2% | 54.2% | 35.3% | |
Non-operated group
| (n = 98) | (n = 416) | (n = 1594) | (n = 3150) | (n = 4318) | (n = 6017) | (n = 6647) | |
CSS | ||||||||
1-year CCS | 42.7% | 55.6% | 50.2% | 50.3% | 43.0% | 37.4% | 36.5% | |
3-year CCS | 25.2% | 27.2% | 23.4% | 25.6% | 23.3% | 20.7% | 17.0% | |
5-year CCS | 21.2% | 20.3% | 18.4% | 19.7% | 18.3% | 16.7% | 11.9% | |
OS | ||||||||
1-year OS | 41.1% | 54.0% | 48.1% | 47.6% | 38.7% | 30.7% | 26.3% | |
3-year OS | 21.6% | 25.0% | 21.8% | 23.0% | 19.2% | 14.2% | 8.4% | |
5-year OS | 18.2% | 18.0% | 16.4% | 17.0% | 14.0% | 9.8% | 4.3% |
Variable | n | 5-year CCSS (%) | Log rankχ2test | P |
---|---|---|---|---|
Years of diagnosis | 65.374 | <0.001 | ||
1996-2000 | 75517 | 67.5% | ||
2001-2005 | 127231 | 69.5% | ||
Sex | 2.520 | 0.112 | ||
Male | 103083 | 69.0% | ||
Female | 99665 | 68.5% | ||
Site | 122.381 | <0.001 | ||
Colon | 127618 | 68.2% | ||
Rectum | 35530 | 71.6% | ||
Age | 1112.554 | <0.001 | ||
15-30 | 1073 | 62.1% | ||
31-40 | 4874 | 69.6% | ||
41-50 | 17025 | 70.7% | ||
51-60 | 35729 | 72.3% | ||
61-70 | 48909 | 71.8% | ||
71-80 | 58248 | 68.6% | ||
>80 | 36890 | 60.1% | ||
Race | 0.036 | 0.850 | ||
Caucasian | 166019 | 69.2% | ||
African American | 20149 | 61.6% | ||
Others* | 16580 | 72.4% | ||
Pathological grading | 812.382 | <0.001 | ||
I- II | 150521 | 72.0% | ||
III-IV | 38018 | 52.7% | ||
Unknown | 14209 | 77.2% | ||
Histological Type | 1162.165 | <0.001 | ||
Adenocarcinoma | 177748 | 70.0% | ||
Mucinous/Signet ring cancer | 25000 | 59.7% | ||
AJCC stage | 16776.287 | <0.001 | ||
I | 37364 | 92.6% | ||
II | 59213 | 81.5% | ||
III | 54234 | 61.3% | ||
IV | 27707 | 12.6% | ||
Unknown | 24230 | 81.8% | ||
No. of LNs dissected | 337.494 | <0.001 | ||
<12 | 116783 | 69.6% | ||
≥12 | 80248 | 69.0% | ||
Unknown | 5717 | 47.7% |
Variable | n | 5-year CCSS (%) | Log rankχ2test | P |
---|---|---|---|---|
Years of diagnosis | 8.182 | 0.004 | ||
1996-2000 | 7617 | 16.6% | ||
2001-2005 | 14623 | 16.5% | ||
Sex | 19.224 | <0.001 | ||
Male | 11622 | 16.7% | ||
Female | 10618 | 16.3% | ||
Site | 443.334 | <0.001 | ||
Colon | 15119 | 14.8% | ||
Rectum | 7121 | 20.1% | ||
Age | 257.702 | <0.001 | ||
15-30 | 98 | 21.2% | ||
31-40 | 416 | 20.3% | ||
41-50 | 1594 | 18.4% | ||
51-60 | 3150 | 19.7% | ||
61-70 | 4318 | 18.3% | ||
71-80 | 6017 | 16.7% | ||
>80 | 6647 | 11.9% | ||
Race | 26.525 | <0.001 | ||
Caucasian | 17250 | 16.5% | ||
African American | 3218 | 12.2% | ||
Others* | 1772 | 23.9% | ||
Pathological grading | 812.382 | <0.001 | ||
I- II | 11275 | 19.9% | ||
III-IV | 3113 | 9.2% | ||
Unknown | 7852 | 14.4% | ||
Histological Type | 116.240 | <0.001 | ||
Adenocarcinoma | 20362 | 17.2% | ||
Mucinous/Signet ring cancer | 1878 | 9.3% | ||
AJCC stage | 1115.463 | <0.001 | ||
I | 82 | 74.8% | ||
II | 189 | 64.7% | ||
III | 128 | 46.0% | ||
IV | 12202 | 3.5% | ||
Unknown | 9639 | 32.8% |
Variable | Hazard ratio | 95%CI | P |
---|---|---|---|
Years of diagnosis | <0.001 | ||
1996-2000 | 1.000 | Reference | |
2001-2005 | 0.944 | 0.930-0.959 | |
Site | <0.001 | ||
Colon | 1.000 | Reference | |
Rectum | 1.044 | 1.023-1.066 | |
Age | <0.001 | ||
15-30 | 1.055 | 0.955-1.165 | 0.294 |
31-40 | 0.954 | 0.906-1.005 | 0.077 |
41-50 | 0.979 | 0.948-1.011 | 0.203 |
51-60 | 1.000 | Reference | |
61-70 | 1.082 | 1.056-1.109 | <0.001 |
71-80 | 1.325 | 1.294-1.356 | <0.001 |
>80 | 1.951 | 1.902-2.002 | <0.001 |
Pathological grading | <0.001 | ||
I- II | 1.000 | Reference | |
III-IV | 1.443 | 1.418-1.468 | <0.001 |
Unknown | 0.913 | 0.880-0.948 | <0.001 |
Histological Type | <0.001 | ||
Adenocarcinoma | 1.000 | Reference | |
Mucinous/Signet ring cancer | 1.200 | 1.175-1.226 | |
AJCC stage | <0.001 | ||
I- II | 1.000 | Reference | |
III- IV | 4.880 | 4.791-4.971 | <0.001 |
Unknown | 1.170 | 1.130-1.210 | <0.001 |
No. of LNs dissected | <0.001 | ||
<12 | 1.000 | Reference | |
≥12 | 0.793 | 0.780-0.806 | <0.001 |
Unknown | 2.269 | 2.183-2.358 | <0.001 |
Variable | Hazard ratio | 95%CI | P |
---|---|---|---|
Years of diagnosis | <0.001 | ||
1996-2000 | 1.000 | Reference | |
2001-2005 | 0.869 | 0.840-0.899 | |
Sex | 0.881 | ||
Male | 1.000 | Reference | |
Female | 0.997 | 0.965-1.031 | |
Site | <0.001 | ||
Colon | 1.000 | Reference | |
Rectum | 0.842 | 0.814-0.872 | |
Age | <0.001 | ||
15-30 | 0.975 | 0.761-1.251 | 0.845 |
31-40 | 0.886 | 0.784-1.002 | 0.055 |
41-50 | 1.021 | 0.951-1.097 | 0.567 |
51-60 | 1.000 | Reference | |
61-70 | 1.185 | 1.121-1.253 | <0.001 |
71-80 | 1.463 | 1.388-1.543 | <0.001 |
>80 | 1.859 | 1.762-1.961 | <0.001 |
Race | <0.001 | ||
Caucasian | 1.000 | Reference | |
African American | 1.160 | 1.109-1.214 | <0.001 |
Others* | 0.871 | 0.818-0.927 | <0.001 |
Pathological grading | <0.001 | ||
I- II | 1.000 | Reference | |
III-IV | 1.430 | 1.365-1.498 | <0.001 |
Unknown | 1.141 | 1.100-1.184 | <0.001 |
Histological Type | 0.001 | ||
Adenocarcinoma | 1.000 | Reference | |
Mucinous/Signet ring cancer | 1.112 | 1.050-1.177 | |
AJCC stage | <0.001 | ||
I- II | 1.000 | Reference | |
III- IV | 7.808 | 6.260-9.739 | <0.001 |
Unknown | 2.735 | 2.192-3.412 | <0.001 |