Background
Methods
Patient samples
Plasma membrane purification and protein lysis
Protein digestion and peptide tandem mass tag(TMT) labeling
SCX fractionation separation
Mass spectrometry analysis
Protein identification and quantification
Ingenuity pathway analysis
Western blot analyses
Immunohistochemistry and tissue microarray
Results
Detection of plasma membrane proteins in GC and adjacent normal tissues
Quantification of plasma membrane proteins in GC and adjacent normal tissues
Accession No.
|
Gene symbols
|
Description
|
TMT ratio
|
P value
|
Function
|
---|---|---|---|---|---|
Q12959 | DLG1 | discs, large homolog 1 (Drosophila) | -8.78 | 1.28E-05 | kinase |
G8JLH6 | CD9 | CD9 molecule | -3.723 | 7.04E-02 | other |
P30453 | HLA-A | major histocompatibility complex, class I, A | -2.903 | 7.40E-04 | other |
O95810 | SDPR | serum deprivation response | -2.623 | 1.69E-09 | other |
P48960 | CD97 | CD97 molecule | -2.615 | 3.74E-01 | G-protein coupled receptor |
Q16853 | AOC3 | amine oxidase, copper containing 3 | -2.314 | 1.11E-10 | enzyme |
E7EWP3 | MPZ | myelin protein zero | -2.266 | 2.45E-07 | other |
Q03135 | CAV1 | caveolin 1, caveolae protein, 22 kDa | -2.251 | 2.43E-10 | transmembrane receptor |
P41219 | PRPH | peripherin | -2.149 | 1.65E-08 | other |
P43121 | MCAM | melanoma cell adhesion molecule | -2.115 | 1.93E-09 | other |
Q9HAV0 | GNB4 | guanine nucleotide binding protein (G protein), beta polypeptide 4 | -1.976 | 9.69E-04 | enzyme |
Q86UP2 | KTN1 | kinectin 1 (kinesin receptor) | -1.959 | 7.69E-03 | transmembrane receptor |
P01859 | IGHG2 | immunoglobulin heavy constant gamma 2 (G2m marker) | -1.844 | 1.43E-02 | other |
B7Z2R4 | SGCE | sarcoglycan, epsilon | -1.791 | 2.91E-02 | other |
P18206 | VCL | vinculin | -1.685 | 2.01E-10 | enzyme |
A0FGR8 | ESYT2 | extended synaptotagmin-like protein 2 | -1.672 | 2.68E-03 | other |
P08133 | ANXA6 | annexin A6 | -1.668 | 1.10E-11 | ion channel |
O43491 | EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | -1.66 | 1.05E-08 | other |
Q14BN4 | SLMAP | sarcolemma associated protein | -1.645 | 6.33E-04 | other |
A6NMH8 | CD81 | CD81 molecule | -1.634 | 3.17E-04 | other |
Q96CX2 | KCTD12 | potassium channel tetramerization domain containing 12 | -1.559 | 3.59E-08 | ion channel |
Q9H223 | EHD4 | EH-domain containing 4 | -1.527 | 1.30E-03 | enzyme |
Q13418 | ILK | integrin-linked kinase | -1.526 | 1.20E-09 | kinase |
P16671 | CD36 | CD36 molecule (thrombospondin receptor) | -1.501 | 1.16E-06 | transmembrane receptor |
P38606 | ATP6V1A | ATPase, H+ transporting, lysosomal 70 kDa, V1 subunit A | 1.514 | 3.79E-05 | transporter |
Q14108 | SCARB2 | scavenger receptor class B, member 2 | 1.514 | 1.92E-08 | other |
P01903 | HLA-DRA | major histocompatibility complex, class II, DR alpha | 1.521 | 2.94E-08 | transmembrane receptor |
Q14444 | CAPRIN1 | cell cycle associated protein 1 | 1.529 | 1.30E-06 | other |
Q6IAA8 | LAMTOR1 | late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 | 1.533 | 5.18E-03 | other |
P27216 | ANXA13 | annexin A13 | 1.536 | 3.38E-09 | other |
Q9Y287 | ITM2B | integral membrane protein 2B | 1.553 | 7.16E-02 | other |
Q9Y6R1 | SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 1.558 | 2.21E-04 | transporter |
Q8WVV4 | POF1B | premature ovarian failure, 1B | 1.568 | 9.94E-09 | other |
D6RH31 | NPNT | nephronectin | 1.59 | 1.40E-05 | other |
Q9P0L0 | VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33 kDa | 1.597 | 7.50E-06 | other |
P02786 | TFRC | transferrin receptor | 1.602 | 3.53E-01 | transporter |
O00203 | AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 1.619 | 5.16E-03 | transporter |
Q00610 | CLTC | clathrin, heavy chain (Hc) | 1.623 | 6.18E-11 | other |
P26006 | ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 1.645 | 3.24E-08 | other |
O95292 | VAPB | VAMP (vesicle-associated membrane protein)-associated protein B and C | 1.652 | 4.17E-05 | other |
B4DNJ6 | STRAP | serine/threonine kinase receptor associated protein | 1.654 | 4.56E-03 | other |
B5MCA4 | EPCAM | epithelial cell adhesion molecule | 1.655 | 4.47E-03 | other |
Q14247 | CTTN | cortactin | 1.664 | 2.58E-06 | other |
C9JME2 | FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 1.667 | 4.07E-10 | other |
P15144 | ANPEP | alanyl (membrane) aminopeptidase | 1.693 | 7.85E-10 | peptidase |
G5EA09 | SDCBP | syndecan binding protein (syntenin) | 1.71 | 1.01E-06 | enzyme |
O75955 | FLOT1 | flotillin 1 | 1.727 | 2.09E-02 | other |
Q86XK7 | VSIG1 | V-set and immunoglobulin domain containing 1 | 1.727 | 1.27E-04 | other |
P00533 | EGFR | epidermal growth factor receptor | 1.755 | 2.27E-01 | kinase |
P17301 | ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 1.786 | 1.19E-08 | transmembrane receptor |
P29992 | GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | 1.786 | 7.56E-02 | enzyme |
C9J6P4 | ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 1.835 | 3.35E-09 | other |
P27105 | STOM | stomatin | 1.844 | 1.31E-04 | other |
P46977 | STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 1.895 | 5.89E-05 | enzyme |
Q9BX66 | SORBS1 | sorbin and SH3 domain containing 1 | 1.895 | 1.62E-08 | other |
O95563 | MPC2 | mitochondrial pyruvate carrier 2 | 1.917 | 2.32E-08 | other |
P09496 | CLTA | clathrin, light chain A | 1.926 | 1.13E-12 | other |
Q13155 | AIMP2 | aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 | 1.928 | 1.03E-07 | other |
P09497 | CLTB | clathrin, light chain B | 1.954 | 1.00E-10 | other |
H9KV28 | DIAPH1 | diaphanous-related formin 1 | 1.958 | 8.62E-04 | other |
Q99720 | SIGMAR1 | sigma non-opioid intracellular receptor 1 | 1.961 | 3.62E-04 | G-protein coupled receptor |
P13473 | LAMP2 | lysosomal-associated membrane protein 2 | 1.999 | 5.05E-10 | enzyme |
F5H7K4 | NCEH1 | neutral cholesterol ester hydrolase 1 | 2.006 | 5.68E-04 | enzyme |
P11215 | ITGAM | integrin, alpha M (complement component 3 receptor 3 subunit) | 2.012 | 2.29E-10 | transmembrane receptor |
P15924 | DSP | desmoplakin | 2.031 | 8.86E-13 | other |
Q9UGM3 | DMBT1 | deleted in malignant brain tumors 1 | 2.079 | 2.59E-06 | transmembrane receptor |
Q93008 | USP9X | ubiquitin specific peptidase 9, X-linked | 2.19 | 1.22E-01 | peptidase |
O15400 | STX7 | syntaxin 7 | 2.208 | 1.94E-07 | transporter |
Q9BXJ0 | C1QTNF5 | C1q and tumor necrosis factor related protein 5 | 2.223 | 2.33E-04 | transmembrane receptor |
Q9UJZ1 | STOML2 | stomatin (EPB72)-like 2 | 2.228 | 1.06E-04 | other |
P55011 | SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 2.332 | 5.91E-11 | transporter |
O00182 | LGALS9 | lectin, galactoside-binding, soluble, 9 | 2.45 | 1.39E-05 | other |
Q08380 | LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 2.469 | 4.66E-06 | transmembrane receptor |
Q9UGI8 | TES | testis derived transcript (3 LIM domains) | 2.577 | 1.55E-06 | other |
Q9NZ01 | TECR | trans-2,3-enoyl-CoA reductase | 2.83 | 1.45E-07 | enzyme |
G3V1K3 | PON2 | paraoxonase 2 | 2.932 | 3.93E-06 | enzyme |
O95841 | ANGPTL1 | angiopoietin-like 1 | 3.109 | 4.33E-04 | other |
Q92542 | NCSTN | nicastrin | 3.634 | 3.58E-02 | peptidase |
O95497 | VNN1 | vanin 1 | 3.718 | 1.00E-08 | enzyme |
P16144 | ITGB4 | integrin, beta 4 | 3.792 | 2.40E-01 | transmembrane receptor |
Q96HR9 | REEP6 | receptor accessory protein 6 | 3.797 | 2.70E-08 | other |
P48230 | TM4SF4 | transmembrane 4 L six family member 4 | 4.71 | 1.42E-04 | other |