Background
Methods
Patients and procedures
Characteristics | FTS group (n = 128) | Conventional group (n =132) | P value |
---|---|---|---|
Median age | 56.43 ± 13.28 | 55.72 ± 10.34 | 0.252 |
Gender | 0.973 | ||
Male | 103 (80.5) | 106 (80.3) | |
Female | 25 (19.5) | 26 (19.7) | |
Weight (kg) | 67.53 ± 14.37 | 66.45 ± 13.56 | 0.448 |
BMI (kg/m2) | 22.53 ± 2.85 | 22.89 ± 2.56 | 0.272 |
Operating time (min) | 168.98 ± 30.62 | 172.33 ± 24.67 | 0.438 |
Blood loss (ml) | 302.54 ± 88.48 | 312. 33 ± 76.73 | 0.727 |
Operative incision | 0.749 | ||
One | 44 (34.4) | 48 (36.4) | |
Two | 58 (45.3) | 62 (46.9) | |
Three | 26 (20.3) | 22 (16.7) | |
TNM | 0.773 | ||
I | 39 (30.5) | 36 (27.2) | |
II | 71 (55.4) | 79 (59.8) | |
III | 18 (14.1) | 17 (12.8) | |
IV | 0 (0) | 0 (0) | |
Pathology | 0.737 | ||
Adenocarcinoma | 7 (5.5) | 8 (6.1) | |
Squamous cell carcinoma | 116 (90.6) | 121 (91.6) | |
Other | 5 (3.9) | 3 (2.3) | |
Tumor location | 0.921 | ||
Upper esophagus | 12 (9.4) | 14 (10.6) | |
Mid esophagus | 73 (57.0) | 76 (57.6) | |
Distal esophagus | 43 (33.6) | 42 (31.8) | |
Neoadjuvant therapy | 0.988 | ||
Yes | 68 (53.1) | 70 (53.0) | |
No | 60 (46.9) | 62 (47.0) | |
Neoadjuvant regimen | 0.923 | ||
Neoadjuvant chemoradiotherapy | 27 (39.7) | 25 (35.7) | |
Neoadjuvant chemotherapy | 41 (60.3) | 45 (64.3) | |
pCR after Neoadjuvant therapy | 15 (22.1) | 17 (24.2) | 0.776 |
Surgical approach | 0.953 | ||
Conventional thoracotomy | 62 (48.4) | 66 (50.0) | |
Hybrid VATS | 41 (32.0) | 42 (31.8) | |
Pure VATS | 25 (19.6) | 24 (18.2) |
FTS pathway | Conventional pathway | |
---|---|---|
Preoperative education | Patients were educated systematically by the esophageal clinical nurse consultant; | Patients were educated in the standard manner |
Day before surgery | ||
Diet | Last drink 2 h and diet 6 h before operation | Last drink and diet at midnight |
Fructose and protein loading | Yes | No |
Day of surgery | ||
Nasogastric tube | No routine use of nasogastric tube | Routine use of nasogastric tube |
Pre-anesthetic medication | No | Diazepam 10 mg |
Anesthesia | General anesthesia + Epidural anesthesia; | General anesthesia; |
Maintaining normothermia | Yes | No |
Transfusion | Autologous blood transfusion or limit allogenic blood transfusion | Allogenic blood transfusion |
Abdomen tube | No routine use of drains | Routine placement; Remove at POD3 |
Cervical tube | No routine use of drains | Routine placement; Remove at POD2 |
Early postoperative care | Patient sent to floor | Patient sent to ICU |
Analgesia | Epidural PCA | Analgesia by morphine or vein PCA |
Enteral nutrition | Jejunostomy tube feeding | Nasojejunal tube feeding |
Day | FTS pathway | Conventional pathway |
---|---|---|
POD1 | Jejunostomy tube feeding 500 mL (starting at 20 mL/h) Early postoperative mobilization program (>2 h out of bed) Physical therapy and nebulizers Remove urine catheter Head of bed put at 30° Supply albumin Chest tube to suction Promoted to lung recruitment | Total parenteral nutrition Bed rest Gastrointestinal decompression Closed thoracic drainage |
POD2 | Jejunostomy tube feeding 1000 mL (40 mL/h) Chest tube to suction Expand mobilization (>4 h out of bed) Continue physical therapy and nebulizers Continue supply albumin | Nasojejunal tube feeding 500 mL (starting at 20 mL/h) Remove urine catheter With help, sit in the chair 2 times during the day for at least 30 min each time Gastrointestinal decompression Closed thoracic drainage |
POD3 | Jejunostomy tube feeding 1500 mL (60–80 mL/h) Remove chest tube Remove epidural catheter Expand mobilization (>6 h out of bed) Continue physical therapy and nebulizers Continue supply albumin | Nasojejunal tube feeding 1000 mL (40 mL/h) Sit in the chair 3 times for at least 30–60 min each time. With help, walk twice in the hallway. Do deep breathing exercise Remove nasogastric tube Closed thoracic drainage |
POD4 | Gastrograffin opacification of upper gastrointestine If swallow shows no leak, advance patient to oral drink Jejunostomy tube feeding 1500 mL (60–80 mL/h) Continue physical therapy and nebulizers Education on aspiration precaution Education on chewing and swallowing | Nasojejunal tube feeding 1000 mL (40 mL/h) Sit in the chair 3 times today for at least 30–60 min each time. Walk the length of the hallway 3 times Continue to do breathing exercises Closed thoracic drainage |
POD5 | Jejunostomy tube feeding 1500 mL (60–80 mL/h) Advance patient to a full liquid diet Continue aspiration precautions Continue physical therapy and nebulizers | Nasojejunal tube feeding 1500 mL (60–80 mL/h) Walk the length of the hallway 4–5 times. Sit in the chair 3 times today for at least 30–60 min Continue to do breathing exercises |
POD6 | Increase liquid diet Decrease jejunostomy tube feeding (500 ml or 1000 ml) Continue aspiration precautions Continue physical therapy and nebulizers | Nasojejunal tube feeding 1500 mL (60–80 mL/h) Remove chest tube Walk the length of the hallway 4–5 times. Sit in the chair 3 times today for at least 30–60 min Continue to do breathing exercises |
POD7 | Remove jejunostomy tube Full liquid diet Discharge home on soft diet and liquid diet Continue aspiration precautions | Gastrograffin opacification of upper gastrointestine If swallow shows no leak, advance patient to oral drink Nasojejunal tube feeding 1500 mL (60–80 mL/h) Expand mobilization (>4 h out of bed) Continue to do breathing exercises |
POD8 | Increase liquid diet Decrease jejunostomy tube feeding (500 ml or 1000 ml) Expand mobilization (>6 h out of bed) Continue to do breathing exercises | |
POD9 | Remove nasojejunal tube Full liquid diet Expand mobilization (>6 h out of bed) Continue to do breathing exercises | |
POD10-11 | Soft diet and liquid diet Nearly out of bed Observe whether there is delayed anastomotic leakage | |
POD12 | Discharge home on soft diet and liquid diet |
Clinical parameters
Protocol for esophageal cancer
Pro-inflammatory parameters
Immunological parameters
Lymphocyte subpopulation parameters
Discharge and follow-up
Statistical analysis
Results
Clinical parameters
Outcomes | FTS group (n = 128) | Conventional group (n =132) | P value |
---|---|---|---|
Postoperative hospital stay (d) | 7.62 ± 1.38 | 12.56 ± 1.92 | 0.000 |
Hospitalization expenditure (RMB) | 35823.62 ± 3598.81 | 41032.73 ± 4013.32 | 0.000 |
Incision pain scale (NRS) | 4.72 ± 1.94 | 7.66 ± 1.59 | 0.000 |
Morbidity | 11 (8.6) | 16 (12.1) | 0.351 |
Atrial arrhythmia | 2 | 3 | |
Ileus | 0 | 1 | |
Pneumonia | 3 | 4 | |
Anastomotic leak | 2 | 3 | |
Incision infection | 2 | 2 | |
ARDS | 2 | 3 | |
Mortality | 2 (1.6) | 2 (1.5) | 1.000 |
30-day readmission rate | 3 (2.3) | 3 (2.3) | 1.000 |
Pro-inflammatory parameters
Factor and time | FTS group (n = 128) | Conventional group (n = 132) | P value |
---|---|---|---|
IL-6 (ng/L) | |||
Before surgery | 53.83 ± 21.66 | 55.73 ± 20.37 | 0.585 |
POD1 | 121.74 ± 22.57 | 138.77 ± 21.53* | 0.000 |
POD3 | 142.37 ± 25.09 | 154.90 ± 24.33* | 0.035 |
POD7 | 116.70 ± 22.39 | 122.79 ± 25.64 | 0.412 |
CRP (μg/L) | |||
Before surgery | 4.97 ± 1.33 | 4.85 ± 1.43 | 1.000 |
POD1 | 65.57 ± 13.37 | 74.61 ± 14.71* | 0.034 |
POD3 | 136.79 ± 23.34 | 155.38 ± 28.75* | 0.012 |
POD7 | 51.83 ± 17.66 | 62.36 ± 18.37* | 0.042 |
Immunological parameters
Factor and time | FTS group (n = 128) | Conventional group (n = 132) | P value |
---|---|---|---|
Globulin (g/l) | |||
Before surgery | 28.37 ± 3.93 | 27.32 ± 4.33 | 0.943 |
POD1 | 22.74 ± 3.93 | 22.39 ± 3.82 | 1.000 |
POD3 | 25.66 ± 2.94 | 22.21 ± 2.99* | 0.038 |
POD7 | 29.95 ± 3.85 | 27.97 ± 4.41 | 0.537 |
IgG (g/l) | |||
Before surgery | 14.38 ± 2.78 | 15.33 ± 3.79 | 0.573 |
POD1 | 8.97 ± 1.79 | 6.11 ± 1.38* | 0.033 |
POD3 | 11.02 ± 3.53 | 8.17 ± 2.94* | 0.002 |
POD7 | 14.53 ± 3.81 | 13.02 ± 3.73 | 0.741 |
IgA (g/l) | |||
Before surgery | 2.79 ± 0.52 | 2.98 ± 0.35 | 0.757 |
POD1 | 1.81 ± 0.43 | 1.65 ± 0.17* | 0.012 |
POD3 | 2.08 ± 0.54 | 1.76 ± 0.47* | 0.003 |
POD7 | 2.58 ± 0.47 | 2.62 ± 0.39 | 0.637 |
IgM (g/l) | |||
Before surgery | 1.21 ± 0.35 | 1.24 ± 0.44 | 1.000 |
POD1 | 0.82 ± 0.39 | 0.89 ± 0.43 | 0.964 |
POD3 | 0.75 ± 0.22 | 0.77 ± 0.31 | 0.543 |
POD7 | 1.18 ± 0.59 | 1.23 ± 0.48 | 0.424 |
CD3 | |||
Before surgery | 55.99 ± 2.72 | 57.83 ± 2.64 | 0.813 |
POD1 | 49.92 ± 2.75 | 46.01 ± 2.83* | 0.042 |
POD3 | 51.83 ± 2.42 | 48.02 ± 2.51* | 0.019 |
POD7 | 55.05 ± 2.69 | 53.83 ± 2.71 | 0.737 |
CD4 | |||
Before surgery | 45.58 ± 3.92 | 44.97 ± 4.32 | 0.958 |
POD1 | 33.26 ± 4.72 | 30.37 ± 5.21* | 0.039 |
POD3 | 39.39 ± 4.81 | 34.34 ± 5.72* | 0.012 |
POD7 | 43.76 ± 4.38 | 42.87 ± 3.98 | 0.887 |
CD8 | |||
Before surgery | 26.73 ± 4.85 | 26.08 ± 3.97 | 1.000 |
POD1 | 23.72 ± 4.33 | 24.42 ± 4.74 | 0.958 |
POD3 | 23.76 ± 3.83 | 22.73 ± 4.65 | 0.832 |
POD7 | 28.73 ± 4.38 | 27.62 ± 3.83 | 0.732 |
CD4/CD8 | |||
Before surgery | 1.53 ± 0.33 | 1.48 ± 0.42 | 0.739 |
POD1 | 1.45 ± 0.31 | 1.22 ± 0.45* | 0.042 |
POD3 | 1.52 ± 0.45 | 1.39 ± 0.30* | 0.023 |
POD7 | 1.58 ± 0.32 | 1.53 ± 0.54 | 0.865 |
Factor and time | FTS group (n = 60) | Conventional group (n = 62) | P value |
---|---|---|---|
IL-6 (ng/L) | |||
Before surgery | 52.13 ± 25.54 | 54.67 ± 22.36 | 0.651 |
POD1 | 123.43 ± 20.73 | 139.26 ± 22.92* | 0.007 |
POD3 | 144.05 ± 26.39 | 156.25 ± 25.38* | 0.032 |
POD7 | 117.23 ± 21.29 | 123.36 ± 25.56 | 0.321 |
CRP (mg/L) | |||
Before surgery | 4.92 ± 1.53 | 4.83 ± 1.72 | 0.953 |
POD1 | 66.37 ± 12.93 | 75.52 ± 14.88* | 0.023 |
POD3 | 138.84 ± 22.04 | 156.58 ± 29.21* | 0.019 |
POD7 | 53.84 ± 16.95 | 64.06 ± 16.74* | 0.031 |
Globulin (g/l) | |||
Before surgery | 28.82 ± 3.93 | 27.97 ± 5.21 | 0.643 |
POD1 | 22.25 ± 3.83 | 21.09 ± 3.90 | 0.231 |
POD3 | 25.72 ± 3.08 | 22.68 ± 2.89* | 0.026 |
POD7 | 28.56 ± 2.25 | 27.74 ± 4.04 | 0.447 |
IgG (g/l) | |||
Before surgery | 15.82 ± 2.98 | 14.18 ± 3.69 | 0.585 |
POD1 | 8.87 ± 1.65 | 6.32 ± 1.19* | 0.025 |
POD3 | 10.88 ± 3.37 | 7.94 ± 2.87* | 0.000 |
POD7 | 14.51 ± 2.83 | 13.97 ± 3.63 | 0.231 |
IgA (g/l) | |||
Before surgery | 2.76 ± 0.33 | 2.85 ± 0.27 | 0.654 |
POD1 | 1.71 ± 0.54 | 1.45 ± 0.14* | 0.013 |
POD3 | 1.98 ± 0.47 | 1.67 ± 0.52* | 0.002 |
POD7 | 2.53 ± 0.33 | 2.42 ± 0.38 | 0.585 |
IgM (g/l) | |||
Before surgery | 1.24 ± 0.33 | 1.19 ± 0.46 | 0.841 |
POD1 | 0.85 ± 0.49 | 0.81 ± 0.32 | 0.432 |
POD3 | 0.77 ± 0.17 | 0.71 ± 0.26 | 0.233 |
POD7 | 1.15 ± 0.53 | 1.21 ± 0.50 | 0.190 |
CD3+ | |||
Before surgery | 57.92 ± 2.63 | 58.23 ± 2.48 | 0.764 |
POD1 | 48.87 ± 2.51 | 46.13 ± 2.78* | 0.047 |
POD3 | 51.17 ± 2.20 | 48.19 ± 2.31* | 0.013 |
POD7 | 55.59 ± 2.28 | 53.07 ± 2.84 | 0.230 |
CD4+ | |||
Before surgery | 44.28 ± 3.48 | 44.73 ± 4.52 | 0.864 |
POD1 | 34.95 ± 4.72 | 31.07 ± 5.09* | 0.020 |
POD3 | 38.52 ± 3.61 | 34.54 ± 5.22* | 0.016 |
POD7 | 43.38 ± 5.86 | 42.48 ± 3.84 | 0.382 |
CD4+/CD8+ | |||
Before surgery | 1.64 ± 0.32 | 1.55 ± 0.49 | 0.872 |
POD1 | 1.43 ± 0.21 | 1.20 ± 0.51* | 0.036 |
POD3 | 1.54 ± 0.55 | 1.41 ± 0.34* | 0.018 |
POD7 | 1.57 ± 0.24 | 1.51 ± 0.28 | 0.341 |
Factor and time | FTS group (n = 68) | Conventional group (n = 70) | P value |
---|---|---|---|
IL-6 (ng/L) | |||
Before surgery | 50.57 ± 21.45 | 51.42 ± 19.83 | 0.979 |
POD1 | 119.54 ± 18.62 | 131.42 ± 21.58* | 0.004 |
POD3 | 138.42 ± 22.73 | 150.48 ± 21.97* | 0.043 |
POD7 | 112.52 ± 19.43 | 116.43 ± 22.57 | 0.573 |
CRP (mg/L) | |||
Before surgery | 4.53 ± 1.24 | 4.45 ± 1.29 | 0.942 |
POD1 | 61.32 ± 13.77 | 70.52 ± 11.56* | 0.032 |
POD3 | 132.73 ± 21.56 | 150.49 ± 25.72* | 0.013 |
POD7 | 49.78 ± 15.84 | 60.43 ± 16.38* | 0.035 |
Globulin (g/l) | |||
Before surgery | 25.67 ± 3.34 | 25.82 ± 4.39 | 1.000 |
POD1 | 21.43 ± 3.63 | 20.21 ± 3.45 | 0.760 |
POD3 | 24.76 ± 3.82 | 21.64 ± 2.94* | 0.023 |
POD7 | 25.73 ± 3.35 | 25.87 ± 4.09 | 0.848 |
IgG (g/l) | |||
Before surgery | 13.76 ± 3.13 | 13.62 ± 3.42 | 0.858 |
POD1 | 7.42 ± 1.42 | 5.23 ± 1.35* | 0.031 |
POD3 | 9.42 ± 3.53 | 6.44 ± 2.95* | 0.001 |
POD7 | 12.56 ± 2.67 | 11.94 ± 3.83 | 0.656 |
IgA (g/l) | |||
Before surgery | 2.19 ± 0.29 | 2.21 ± 0.25 | 0.769 |
POD1 | 1.61 ± 0.37 | 1.34 ± 0.25* | 0.017 |
POD3 | 1.85 ± 0.42 | 1.51 ± 0.51* | 0.004 |
POD7 | 2.04 ± 0.37 | 2.15 ± 0.42 | 0.753 |
IgM (g/l) | |||
Before surgery | 1.14 ± 0.31 | 1.11 ± 0.41 | 0.893 |
POD1 | 0.71 ± 0.39 | 0.72 ± 0.33 | 0.957 |
POD3 | 0.67 ± 0.22 | 0.64 ± 0.32 | 0.873 |
POD7 | 1.09 ± 0.43 | 1.10 ± 0.42 | 0.673 |
CD3+ | |||
Before surgery | 55.62 ± 2.43 | 56.82 ± 2.58 | 0.875 |
POD1 | 46.73 ± 2.52 | 44.09 ± 2.03* | 0.043 |
POD3 | 49.82 ± 2.43 | 46.17 ± 2.35* | 0.033 |
POD7 | 53.85 ± 2.05 | 54.04 ± 2.73 | 0.482 |
CD4+ | |||
Before surgery | 42.43 ± 3.57 | 42.48 ± 4.92 | 0.803 |
POD1 | 32.52 ± 4.13 | 29.12 ± 5.02* | 0.025 |
POD3 | 35.32 ± 3.90 | 32.55 ± 5.02* | 0.013 |
POD7 | 41.42 ± 5.24 | 40.98 ± 4.27 | 0.484 |
CD4+/CD8+ | |||
Before surgery | 1.52 ± 0.41 | 1.55 ± 0.45 | 0.842 |
POD1 | 1.33 ± 0.36 | 1.11 ± 0.41* | 0.027 |
POD3 | 1.47 ± 0.56 | 1.32 ± 0.37* | 0.025 |
POD7 | 1.50 ± 0.36 | 1.52 ± 0.29 | 0.562 |
Factor and time | FTS group (n = 63) | Conventional group (n = 65) | P value |
---|---|---|---|
IL-6 (ng/L) | |||
Before surgery | 53.26 ± 24.18 | 53.58 ± 23.14 | 0.842 |
POD1 | 123.73 ± 22.69 | 139.42 ± 24.78* | 0.006 |
POD3 | 143.31 ± 25.42 | 155.79 ± 24.42* | 0.043 |
POD7 | 117.73 ± 22.45 | 123.57 ± 23.84 | 0.571 |
CRP (mg/L) | |||
Before surgery | 4.94 ± 1.48 | 4.86 ± 1.32 | 0.943 |
POD1 | 66.42 ± 13.73 | 75.75 ± 13.57* | 0.032 |
POD3 | 137.76 ± 24.73 | 156.79 ± 27.42* | 0.015 |
POD7 | 52.75 ± 15.79 | 63.73 ± 15.2* | 0.042 |
Globulin (g/l) | |||
Before surgery | 27.82 ± 3.59 | 28.71 ± 5.33 | 0.875 |
POD1 | 21.63 ± 3.54 | 21.79 ± 3.82 | 0.941 |
POD3 | 25.59 ± 3.14 | 22.79 ± 2.98* | 0.043 |
POD7 | 28.73 ± 3.08 | 27.95 ± 4.24 | 0.545 |
IgG (g/l) | |||
Before surgery | 14.59 ± 3.28 | 13.97 ± 3.82 | 0.833 |
POD1 | 8.93 ± 1.59 | 6.47 ± 1.25* | 0.034 |
POD3 | 10.51 ± 3.56 | 7.82 ± 2.96* | 0.000 |
POD7 | 13.75 ± 2.97 | 13.66 ± 3.32 | 0.741 |
IgA (g/l) | |||
Before surgery | 2.65 ± 0.41 | 2.75 ± 0.32 | 1.000 |
POD1 | 1.78 ± 0.49 | 1.41 ± 0.25* | 0.009 |
POD3 | 1.94 ± 0.46 | 1.65 ± 0.43* | 0.004 |
POD7 | 2.43 ± 0.35 | 2.49 ± 0.41 | 0.842 |
IgM (g/l) | |||
Before surgery | 1.26 ± 0.41 | 1.21 ± 0.33 | 0.892 |
POD1 | 0.83 ± 0.38 | 0.85 ± 0.36 | 0.731 |
POD3 | 0.72 ± 0.19 | 0.71 ± 0.22 | 1.000 |
POD7 | 1.19 ± 0.49 | 1.24 ± 0.42 | 0.766 |
CD3+ | |||
Before surgery | 58.03 ± 2.52 | 57.43 ± 2.67 | 0.852 |
POD1 | 48.93 ± 2.47 | 45.89 ± 2.49* | 0.048 |
POD3 | 51.67 ± 2.33 | 47.87 ± 2.52* | 0.011 |
POD7 | 54.68 ± 2.32 | 53.25 ± 2.93 | 0.473 |
CD4+ | |||
Before surgery | 44.37 ± 3.52 | 44.52 ± 4.31 | 0.768 |
POD1 | 36.43 ± 4.28 | 32.66 ± 5.14* | 0.028 |
POD3 | 39.13 ± 4.52 | 33.95 ± 5.38* | 0.004 |
POD7 | 42.57 ± 4.38 | 42.64 ± 3.95 | 1.000 |
CD4+/CD8+ | |||
Before surgery | 1.59 ± 0.41 | 1.54 ± 0.43 | 0.892 |
POD1 | 1.47 ± 0.23 | 1.22 ± 0.41* | 0.032 |
POD3 | 1.51 ± 0.45 | 1.40 ± 0.51* | 0.012 |
POD7 | 1.54 ± 0.29 | 1.57 ± 0.21 | 0.842 |
Factor and time | FTS group (n = 65) | Conventional group (n = 67) | P value |
---|---|---|---|
IL-6 (ng/L) | |||
Before surgery | 52.33 ± 24.37 | 53.42 ± 22.73 | 0.764 |
POD1 | 119.34 ± 21.57 | 134.42 ± 22.53* | 0.005 |
POD3 | 140.05 ± 25.63 | 151.67 ± 24.52* | 0.035 |
POD7 | 113.72 ± 22.42 | 117.66 ± 25.74 | 0.152 |
CRP (mg/L) | |||
Before surgery | 4.62 ± 1.63 | 4.53 ± 1.57 | 0.842 |
POD1 | 62.42 ± 13.83 | 71.42 ± 14.32* | 0.027 |
POD3 | 134.73 ± 22.57 | 153.82 ± 25.62* | 0.017 |
POD7 | 50.46 ± 15.73 | 61.43 ± 15.66* | 0.012 |
Globulin (g/l) | |||
Before surgery | 27.72 ± 3.55 | 27.58 ± 5.14 | 0.942 |
POD1 | 23.57 ± 3.73 | 22.64 ± 3.73 | 0.543 |
POD3 | 25.42 ± 3.95 | 23.31 ± 3.52* | 0.021 |
POD7 | 28.04 ± 2.76 | 27.87 ± 4.13 | 0.735 |
IgG (g/l) | |||
Before surgery | 14.63 ± 2.57 | 14.03 ± 3.1 | 0.872 |
POD1 | 9.43 ± 1.25 | 7.62 ± 1.17* | 0.028 |
POD3 | 11.82 ± 3.52 | 8.73 ± 2.94* | 0.002 |
POD7 | 14.42 ± 2.76 | 13.52 ± 3.33 | 0.542 |
IgA (g/l) | |||
Before surgery | 2.57 ± 0.31 | 2.77 ± 0.29 | 0.767 |
POD1 | 1.83 ± 0.41 | 1.54 ± 0.22* | 0.015 |
POD3 | 1.99 ± 0.35 | 1.69 ± 0.42* | 0.000 |
POD7 | 2.55 ± 0.32 | 2.52 ± 0.32 | 0.652 |
IgM (g/l) | |||
Before surgery | 1.28 ± 0.31 | 1.21 ± 0.36 | 0.853 |
POD1 | 0.94 ± 0.43 | 0.92 ± 0.35 | 0.482 |
POD3 | 0.87 ± 0.21 | 0.81 ± 0.32 | 0.353 |
POD7 | 1.25 ± 0.46 | 1.22 ± 0.52 | 0.320 |
CD3+ | |||
Before surgery | 57.43 ± 2.82 | 58.12 ± 2.73 | 0.873 |
POD1 | 49.69 ± 2.43 | 47.02 ± 2.57* | 0.044 |
POD3 | 53.38 ± 2.57 | 49.93 ± 2.65* | 0.017 |
POD7 | 56.73 ± 2.52 | 56.48 ± 2.49 | 1.000 |
CD4+ | |||
Before surgery | 44.52 ± 3.46 | 44.37 ± 4.41 | 1.000 |
POD1 | 35.87 ± 4.15 | 32.35 ± 4.89* | 0.022 |
POD3 | 39.98 ± 3.73 | 35.43 ± 4.64* | 0.013 |
POD7 | 44.73 ± 5.02 | 43.76 ± 3.92 | 0.859 |
CD4+/CD8+ | |||
Before surgery | 1.58 ± 0.30 | 1.52 ± 0.42 | 0.973 |
POD1 | 1.49 ± 0.24 | 1.26 ± 0.43* | 0.031 |
POD3 | 1.64 ± 0.45 | 1.45 ± 0.28* | 0.015 |
POD7 | 1.56 ± 0.32 | 1.50 ± 0.37 | 0.458 |