Background
Methods
Identification of literature
Collection of study variables
Criteria that studies were included and excluded
Supervision of the implementation process
Quality assessment of included RCTs
Statistical methods and analysis
Results
Study selection process
Study |
N
| Male | Female | Age (average) | Sources of tumor (N) | Volume of MPE (N) | Quality of Life | End point | |||
---|---|---|---|---|---|---|---|---|---|---|---|
Lung/pleura | Breast | Digestive tract | Others | ||||||||
Liu W 2010 [15] | 96 | 51 | 45 | 40–70 | 96 | – | – | – | Unavailable | KPS | RR, DCR, SI, AEs |
Mao L 2011 [16] | 90 | 45 | 45 | 27–70 | 81 | 5 | 2 | 2 | >1000 ml | KPS | RR, DCR, SI, AEs |
Li G 2011 [17] | 60 | 30 | 30 | 41–76 | 25 | 20 | 15 | – | Large (37) Moderate (23) | KPS | RR, DCR, SI, AEs |
Ma E 2012 [18] | 56 | 32 | 24 | 35–67 | 56 | – | – | – | >1000 ml | Unavailable | RR, DCR, SI, AEs |
Yao Q 2012 [19] | 60 | 42 | 18 | 35–78 | 28 | 16 | 4 | 12 | >1000 ml | KPS | RR, DCR, SI, AEs |
Zheng Q 2013 [20] | 120 | 73 | 47 | 32–75 | 78 | 25 | 17 | – | >1000 ml | KPS | RR, DCR, SI, AEs |
Kang Y 2013 [21] | 90 | 53 | 37 | 18–72 | 90 | – | – | – | >1000 ml | KPS | RR, DCR, SI, AEs |
Wen J 2014 [22] | 60 | 34 | 26 | 35–65 (50.5) | 45 | 9 | 6 | – | Large (13) Moderate (29) Small (18) | KPS | RR, DCR, SI, AEs |
Yue G 2014 [23] | 86 | 48 | 42 | 38–69 | 86 | – | – | – | Unavailable | KPS | RR, DCR, SI, AEs |
Tu J 2014 [24] | 90 | 41 | 49 | 45–70 | 90 | – | – | – | Unavailable | KPS | RR, DCR, SI, AEs |
Xu J 2014 [25] | 70 | 43 | 27 | 44–70 | 70 | – | – | – | >1000 ml | KPS | RR, DCR, SI, AEs |
Wen X 2015 [26] | 104 | 69 | 35 | 39–76 | 104 | – | – | – | Unavailable | KPS | RR, DCR, SI, AEs |
Hu X 2015 [27] | 84 | 62 | 22 | 18–70 | 69 | 3 | 12 | – | >1000 ml | ECOG | RR, DCR, SI, AEs |
Study | Trial group (N) | Control group (N) | Interventions | Treatment cycle | Termination of treatment | |
---|---|---|---|---|---|---|
Endostar combined with chemotherapeutic agents | Chemotherapeutic agents alone | |||||
Liu W 2010 [15] | 32 | 32 | Cisplatin 40 mg/m2, 1/week Endostar 30 mg, 1/week | Cisplatin 40 mg/m2, 1/w | 3 weeks | >3 weeks, or pleural effusion disappeared |
Mao L 2011 [16] | 45 | 45 | Cisplatin 40 mg/m2, 1/week Endostar 30 mg, 2/week | Cisplatin 40 mg/m2, 1/7d | 7d/cycle, 2 cycles | >4 cycles, or pleural effusion disappeared |
Li G 2011 [17] | 30 | 30 | Bleomycin 60 mg, 1/week Endostar 30 mg, 1/week | Bleomycin 60 mg, 1/w | 3 weeks | >3 weeks, or pleural effusion disappeared |
Ma E 2012 [18] | 28 | 28 | Cisplatin 40 mg/m2, 1/week Endostar 30 mg, 1/week | Cisplatin 40 mg/m2, 1/w | 4 weeks | >4 weeks, or pleural effusion disappeared |
Yao Q 2012 [19] | 30 | 30 | Nedaplatin 40 mg, 1/week Endostar 45 mg, 1/week | Nedaplatin 40 mg, 1/w | 4 weeks | >4 weeks, or pleural effusion disappeared |
Zheng Q 2013 [20] | 60 | 60 | Cisplatin 30–40 mg, d1–3 Endostar 90 mg, d4 | Cisplatin 30–40 mg d1–3 | 21d/cycle, 1–4 cycles | >4 cycles, or pleural effusion disappeared |
Kang Y 2013 [21] | 45 | 45 | Cisplatin 40 mg, 2/week Endostar 30 mg, 2/week | Cisplatin 40 mg, 2/w | 3 weeks | >3 weeks, or pleural effusion disappeared |
Wen J 2014 [22] | 25 | 29 | Lobaplatin 30 mg/m2, d1 Endostar 30 mg, d1 | Lobaplatin 30 mg/m2, d1 | 4 cycles | >4 cycles, or pleural effusion disappeared |
Yue G 2014 [23] | 43 | 43 | Cisplatin 60 mg, 1/week Endostar 30 mg, 2/week | Cisplatin 60 mg, 1/w | 2–3 weeks | >4 weeks, or pleural effusion disappeared |
Tu J [24] | 45 | 45 | Cisplatin 40 mg/m2, 2/week Endostar 45 mg, 2/week | Cisplatin 40 mg/m2, 2/w | 3 weeks | >3 weeks, or pleural effusion disappeared |
Xu J 2014 [25] | 35 | 35 | Nedaplatin 60 mg, 1/week Endostar 60 mg, 1/week | Nedaplatin 60 mg, 1/w | 4 weeks | >4 weeks, or pleural effusion disappeared |
Wen X 2015 [26] | 68 | 36 | Bleomycin 45 mg, w1 Endostar 45 mg, w2 | Bleomycin 45 mg, 1/7d | 7d/cycle, 2–4 cycles | >2 weeks, or pleural effusion disappeared |
Hu X 2015 [27] | 43 | 41 | Cisplatin 40 mg, 2/week Endostar 60 mg, 2/week | Cisplatin 40 mg, 2/week | 2 weeks | >2 weeks, or pleural effusion disappeared |
Quality of study design
Quality of study characteristics
Studies | Region | Sequence generation | Allocation concealment | Blind | Outcome data | Selective outcome reporting | Other sources of bias | ITT | Risk of bias |
---|---|---|---|---|---|---|---|---|---|
Liu W 2010 [15] | Single center | Random number table (SPSS) | Clear | Clear | Yes | No | Clear | No | Unclear risk of bias |
Mao L 2011 [16] | Single center | Random number table (SAS) | Unclear | Unclear | Yes | No | Clear | Yes | Unclear risk of bias |
Li G 2011 [17] | Single center | Random number table (SAS) | sufficient | Unclear | Yes | No | Clear | Yes | Low risk of bias |
Ma E 2012 [18] | Single center | Random number table (SPSS) | Unclear | Unclear | Yes | No | Clear | No | Unclear risk of bias |
Yao Q 2012 [19] | Single center | Random number table (SPSS) | Unclear | Unclear | Yes | No | Clear | No | Unclear risk of bias |
Zheng Q 2013 [20] | Single center | Random number table (SAS) | sufficient | Unclear | Yes | No | Clear | Yes | Low risk of bias |
Kang Y 2013 [21] | Single center | Random number table (SAS) | Unclear | Unclear | Yes | N0 | Clear | Yes | Unclear risk of bias |
Wen J 2014 [22] | Single center | unclear | Unclear | Unclear | Yes | N0 | Clear | Yes | Unclear risk of bias |
Yue G 2014 [23] | Single center | Random number table (SAS) | Unclear | Unclear | Yes | No | Clear | Yes | Unclear risk of bias |
Tu J 2014 [24] | Single center | Random number table (SPSS) | Insufficient | Unclear | Yes | No | Unclear | Yes | Low risk of bias |
Xu J 2014 [25] | Single center | Random number table (SPSS) | Unclear | Clear | Yes | No | Unclear | No | Unclear risk of bias |
Wen X 2015 [26] | Single center | Random number table (SPSS) | Unclear | Unclear | Yes | No | Clear | No | Unclear risk of bias |
Hu X 2015 [27] | Single center | unclear | Insufficient | Unclear | Yes | No | Clear | No | Low risk of bias |
Comparison of ORR
Comparison of DCR
Comparison of QOL after treatment
Adverse reactions comparison of two projects
Study | Myelotoxicity (%) | Nausea/vomiting (%) | Liver and renal injury (%) | Arrhythmia (%) | Fever (%) | |||||
---|---|---|---|---|---|---|---|---|---|---|
Group 1 | Group 2 | Group 1 | Group 2 | Group 1 | Group 2 | Group 1 | Group 2 | Group 1 | Group 2 | |
Li G 2011 [17] | 4 (13.3) | 4 (13.3) | 4 (13.3) | 3 (10) | – | – | 1 (3.3) | 0 (0) | 7 (23.3) | 6 (20) |
Yao Q 2012 [19] | 12 (40) | 10 (30) | 5 (16.7) | 5 (16.7) | – | – | – | – | – | – |
Zheng Q 2013 [20] | 17 (28.3) | 16 (26.6) | 10 (16.7) | 5 (8.3) | – | – | – | – | – | – |
Kang Y 2013 [21] | 11 (24.4) | 10 (22.2) | 15 (25) | 15 (25) | 4 (8.8) | 3 (6.6) | 2 (3.3) | 0 (0) | 7 (15.5) | 5 (11.1) |
Wen J 2014 [22] | 22 (73.3) | 20 (66.6) | 6 (20) | 4 (13.3) | – | – | 5 (16.6) | 1 (3.3) | – | – |
Yue G 2014 [23] | 10 (23.3) | 8 (18.6) | 7 (16.3) | 6 (14) | – | – | – | – | – | – |
Tu J 2014 [24] | 7 (15.5) | 9 (20) | 9 (20) | 9 (20) | 2 (4.4) | 2 (4.4) | 2 (4.4) | 1 (2.2) | – | – |
Xu J 2014 [25] | 14 (40) | 9 (25.7) | 4 (11.4) | 2 (5.7) | 2 (5.7) | 1 (2.8) | 1 (2.8) | 1 (2.8) | 1 (2.8) | 0 (0) |
Hu X 2015 [27] | 7 (16.3) | 5 (12.2) | 26 (60.4) | 20 (48.7) | 5 (11.6) | 5 (12.1) | 3 (6.9) | 3 (7.3) | 5 (11.6) | 5 (12.1) |
P > 0.05 | P > 0.05 | P > 0.05 | P > 0.05 | P > 0.05 |