Background
Methods
Subjects
Thyroid hormone measurement and evaluation of thyroid dysfunction
Neuropsychological assessment
Assessment of cognitive function
Statistical analysis
Ethics statement
Results
Study population
Characteristics | Disease status |
P value | ||
---|---|---|---|---|
NC | MCI | AD | ||
(n = 77) | (n = 64) | (n = 154) | ||
Age, years (mean ± SD) | 64.1 ± 10.4 | 64.3 ± 9.6 | 63.5 ± 9.4 | 0.822 |
Gender, No. (%) | 0.091 | |||
Male | 41 (53.2 %) | 35 (54.7 %) | 86 (55.8 %) | |
Female | 36 (46.8 %) | 29 (45.3 %) | 68 (44.2 %) | |
BMI, kg/m2(mean ± SD) | 23.8 ± 3.1 | 23.4 ± 3.2 | 23.4 ± 3.1 | 0.081 |
MMSE Score (mean ± SD) | 28.0 ± 1.4 | 26.1 ± 1.8 | 14.9 ± 5.9 | <0.017a
|
MES Score (mean ± SD) | 84.0 ± 6.2 | 63.4 ± 10.9 | 32.8 ± 18.9 | <0.017b
|
Education, years (mean ± SD) | 10.1 ± 3.5 | 9.4 ± 3.5 | 8.9 ± 4.2 | 0.094 |
fT3, pmol/L (mean ± SD) | 4.4 ± 0.5 | 4.5 ± 0.6 | 4.6 ± 0.5 | 0.032c
|
fT4, pmol/L (mean ± SD) | 15.2 ± 2.2 | 15.0 ± 1.8 | 14.8 ± 2.1 | 0.295 |
TSH, mU/L (mean ± SD) | 2.0 ± 1.0 | 2.0 ± 1.5 | 1.8 ± 1.4 | 0.359 |
Variable | Cognitive function test scores | |||||
---|---|---|---|---|---|---|
MMSE | MES | |||||
β(SE) |
P value | 95 % CI for B | β(SE) |
P value | 95 % CI for B | |
TSH | -0.20(0.34) | 0.012 | -1.52--0.19 | -0.20 (1.09) | 0.012 | -4.97--0.63 |
Variableb
| β(SE) |
P value | Exponential (B) | 95 % CI for exponential (B) |
---|---|---|---|---|
TSH(1) | 1.02(0.47) | 0.029 | 2.78 | 1.11–6.99 |
TSH(2) | 0.95(0.46) | 0.040 | 2.58 | 1.04–6.39 |
TSH(3) | 0.51(0.44) | 0.252 | 1.66 | 0.70–3.94 |
TSH(4) | 0.43(0.43) | 0.323 | 1.54 | 0.65–3.65 |
Characteristic | Hypothyroidism | Subclinical Hypothyroidism | Normal Thyroid Function | Subclinical Hyperthroidism | P value |
---|---|---|---|---|---|
(n = 14) | (n = 9) | (n = 260) | (n = 12) | ||
Cognition, No. (%) | 0.974 | ||||
NC | 4 (28.6 %) | 2 (22.2 %) | 69 (26.5 %) | 2 (16.7 %) | |
MCI | 2 (12.3 %) | 2 (22.2 %) | 54 (20.8 %) | 6 (50.0 %) | |
AD | 8 (57.1 %) | 5 (55.6 %) | 137(52.7 %) | 4 (33.3 %) | |
Age, years (Mean ± SD) | 65.9 ± 10.9 | 62.9 ± 11.7 | 63.7 ± 9.7 | 64.1 ± 6.5 | 0.855 |
Education, years (Mean ± SD) | 11.6 ± 4.8 | 7.4 ± 3.6 | 9.2 ± 3.8 | 10.2 ± 3.3 | 0.078 |
Gender, No. (%) | 0.401 | ||||
Male | 7 (50.0 %) | 3 (33.3 %) | 147 (56.5 %) | 5 (41.7 %) | |
Female | 7 (50.0 %) | 6 (66.7 %) | 113 (43.5 %) | 7 (58.3 %) | |
BMI, kg/m2(Mean ± SD) | 23.0 ± 3.2 | 23.3 ± 3.1 | 23.2 ± 3.2 | 23.3 ± 3.2 | 0.840 |
MMSE Score (Mean ± SD) | 20.3 ± 6.7 | 17.6 ± 10.2 | 20.7 ± 7.6 | 23.3 ± 5.1 | 0.400 |
MES Score (Mean ± SD) | 52.96 ± 23.3 | 41.4 ± 30.0 | 52.9 ± 27.1 | 59.1 ± 18.1 | 0.514 |
Model | Odds ratio (95 % CI) | |
---|---|---|
All hypothyroidism (n = 14) | ||
Alzheimer’s Disease (n = 145) | Crude | 1.01(0.29–3.46) |
Multivariate-adjusteda
| 1.33(0.39–4.79) | |
Mild cognitive impairment (n = 56) | Crude | 0.64(0.11–3.62) |
Multivariate-adjusteda
| 0.72(0.12–4.28) | |
All subclinical hypothyroidism (n = 9) | ||
Alzheimer’s Disease (n = 142) | Crude | 1.26(0.24–6.66) |
Multivariate-adjusteda
| 1.29(0.24–6.70) | |
Mild cognitive impairment (n = 56) | Crude | 1.28(0.17–9.37) |
Multivariate-adjusteda
| 1.06(0.14–8.00) | |
All subclinical hyperthyroidism (n = 12) | ||
Alzheimer Disease (n = 141) | Crude | 1.01(0.18–5.64) |
Multivariate-adjusteda
| 1.08(0.19–6.13) | |
Mild cognitive impairment (n = 60) | Crude | 0.26(0.05–1.34) |
Multivariate-adjusteda
| 0.25(0.05–1.30) |