Background
Methods
Assays
Insulin-like growth factor-1 (IGF-1) method
Growth hormone method
Statistics
Results
All patients n = 62 | GH deficient n = 29 | Non-GH deficient n = 18 | |
---|---|---|---|
Age (median, IQR) | 43 (21.8) | 46 (17) | 39 (18) p = 0.216 |
Gender | M: n = 29 | M: n = 15 | M: n = 7 |
F: n = 33 | F: n = 14 | F: n = 11 | |
Weight (median, IQR) | 78.1 kg (32.3) | 83 kg (34.0) | 74.2 kg (23.6) p = 0.220 |
#months to endo referral (median, IQR) | 20 (16) | 24 (13) | 15 (20) p = 0.317 |
TBI Severity | Mild n = 48 | Mild n = 22 | Mild n = 17 |
Mod n = 6 | Mod n = 1 | Mod n = 1 | |
Severe n = 8 | Severe n = 6 | ||
Documented Sport Concussion | n = 15 | n = 7 | n = 5 |
Hockey n = 4 | Hockey n = 3 | Basketball n = 1 | |
Cycling n = 2 | Cycling n = 2 | Dirt biking n = 1 | |
Basketball n = 2 | Basketball n = 1 | Football n = 1 | |
Soccer n = 2 | Football n = 1 | Equestrian n = 1 | |
Football n = 2 | Soccer n = 1 | ||
Dirt biking n = 1 | |||
Wrestling n = 1 | |||
Equestrian n = 1 | |||
Documented pituitary deficits | n = 4 | n = 2 | n = 1 |
n = 1 secondary hypothyroidism | n = 1 secondary hypothyroidism | n = 1 secondary hypogonadism and hypothyroidism | |
n = 2 secondary hypogonadism | n = 1 secondary hypogonadism | ||
n = 1 secondary hypothyroidism and secondary hypogonadism | |||
IGF-1 Z score (median, IQR) | −0.193 (2.07) | −0.214 (1.52) | −0.060 (1.24) p = 0.979 |
Peak GH during stim test (median, IQR) | 3.8 μg/L (6.9) | 1.3 μg/L (2.6) | 9.7 μg/L (4.3) p = < 0.001 |
GH deficient | Non-GH deficient | |
---|---|---|
IGF-1 low | 0 | 1 |
IGF-1 normal | 25 | 15 |
Median z-score | −0.214 | − 0.060 p = 0.979 |