Knowledge, attitudes and practices of community pharmacists on generic medicines in Palestine: a cross-sectional study

The current study surveyed a set of licensed community pharmacists who are members of Palestinian Pharmacists Syndicate using self-administered questionnaire. The study was carried out in a cross-sectional design.

The study recruited practicing community pharmacists in the West Bank - Palestine. In Palestine, the majority of pharmacists work in private retail pharmacies called community pharmacies. Other forms of professional pharmacy in Palestine include pharmacists in industry, in regulatory governmental sector, and those in hospitals and other clinical settings. According to the Palestinian Pharmaceutical Syndicate, the West Bank is divided into 8 governorate sub-committees. These governorates are: East-Jerusalem, Ramallah, Bethlehem, Hebron, Jenin, Nablus, Tulkarm, and Qalqilia). A convenience sampling technique was implemented in this study. Different pharmacies located in cities, villages, and Palestinian refugee camps in West Bank were visited where practicing pharmacists were cordially invited to participate in the study. Participant pharmacists had to fill out the questionnaire in the presence of researcher and were not allowed to refer to any information resources during answering the questions. The data was collected from September 2016 to January 2017. Pharmacists affiliated with pharmacy hospitals or pharmacies affiliate with private clinical centers were excluded. Therefore, all participants were pharmacists in private community pharmacies.

The total number of licensed community pharmacies in West Bank (1027 pharmacies) was used as a guide to calculate the sample size (only one pharmacist from each pharmacy was interviewed). The estimated sample size was obtained using an automated online calculator (Raosoft sample size calculator: (http://​www.​raosoft.​com/​samplesize.​html). It was used with pre-determined margin of error of 5%, and confidence level of 95%. The minimal approximated sample size was 280 pharmacists. In order to minimize erroneous results and to increase the study reliability, the target sample size was set to be about 300 pharmacists.

A Self-administered questionnaire in the native Arabic language was conducted after the participants had agreed to participate (verbal consent form). A permission had been granted to use the data collection form as a tool which was developed and used by Awaisu and his co-authors [11]. The original questionnaire was in English. The questionnaire was translated by two colleagues who are American pharmacy graduates. The translated version was also re-checked by two different colleagues who are English Professors. The Arabic version included all statements in Arabic and in English. The questionnaire was divided into four sections (see Additional file 1). In the first section, questions on socio-demographic and professional characteristics were requested. The second part contains 10-item knowledge test statements on definition, and characteristics of generic medicines intended to examine the pharmacist’s knowledge. The respondent was given three options: “correct response,” “incorrect response” and “I do not know” to eliminate guessing. In scoring the pharmacists’ knowledge, a score of one was given to correct answers and score of zero was used for incorrect/do not know answers. The total scores range from 0 to 10 in which higher scores mean greater. The third section, pharmacists’ attitudes toward generic medicine was studied using a 15- item statements to explore their attitude toward generic medicines; regarding generic substitution policy for brand name medicines, and pharmacist s’ level of confidence. Participants had to respond on a 5- point Likert scale where, 1 indicated strong agreement and 5 indicated strong disagreement. No scoring was given to answers and all analysis was based on giving frequency for each response. In the fourth section, the influencing factors related to selection and dispensing of generic medicines was examined. With regard to validity of the tool, the face and content validity of the final questionnaire was discussed and judged by a panel of three specialist researchers/professors in pharmacy -identified as experts in generic medicine research and survey instrument development-for assessing the organization, clinical terminology, meaning of terms, completeness, appropriateness and logical sequence of the statements, and the accuracy [11]. The questionnaire was piloted among a sample of 25 pharmacists at the year of the study to test the reliability and validity of the questionnaire and to detect any defects in the methodology. The data of the pilot study were not included in the statistical analysis.

All aspects of the study protocol were authorized by the Institutional Review Board (IRB) of An-Najah National University (IRB- 11- July- 2016). Verbal consent was also obtained from the participant pharmacists prior to the commencement of the study.

A total of 339 community pharmacists were asked to participate in the study, however, 302 agreed to fill out the questionnaire with a response rate of 89.1%. Of the 302 pharmacists, 158 (52.3%) were males. The highest percent of participant pharmacists 128 (42.4%) were between the ages of (20–29) year-old, whereas few were above 59 years of age 14 (4.6%). The majority of pharmacists 260 (86.1%) had a B.Sc. in pharmacy whereas the rest had Pharm D or higher pharmacy degree. Most of the participants graduated from Palestinian universities 179 (59.3%). With regard to the experience, the majority 118 (39.1%) had 5 years or less of experience. Similarly, the years of practice in Palestine, the highest percent 124 (41.1%) were practicing 5 years. Regarding the classification of pharmacy’s location weather it is in a city, village or Palestinians refugee-camp, the results showed that most of the pharmacies 193 (63.9%) were concentrated in cities. With regard to job title of the participants they were divided equally to owner pharmacists and assistant pharmacists (employee). More details regarding the demographic and professional characteristics of the community pharmacists are presented in Table 1.

Ten knowledge items were tested, the median score of knowledge on generic medicines of the participants was found to be 6.00 (inter quartile range: 5.00–7.00) (mean ± SD: 5.91 ± 1.27). The association of demographic and professional characteristics on knowledge score was analyzed using Mann-Whitney-U and Kruskal-Wallis tests. Table 2 clearly shows that there were no statistically significant differences in knowledge score between participant pharmacists according to the eight socio-demographic characteristics examined (p-values of more than 0.05). Detailed findings regarding knowledge scoring among different demographic features of the respondents are given in Table 2. The highest knowledge score value was 8 out 10 that obtained by 26 (8.6%) of respondent pharmacists, while 2 out 10 scored the lowest scale.

High percent of the respondents pharmacists 286 (94.7%) answered correctly item 4 in Table 3 which revolved about presumptuous similarity in efficacy, quality and safety aspects when bioequivalency is conquered. Similarly, 280 (92.7%) of participant pharmacists answered correct response to item 2 in Table 3 which focused on the demands of bioequivalence studies for generic registration approval. Of the 302 participant 251 (83.1%) pharmacists responded correctly to item 5 in Table 3 which questioned the consequences of bioequivalent studies and their impacts. However, item 6 which probed the FDA acceptance criteria in statistical comparative analysis of the pharmacokinetic parameter to be assessed in bioequivalence study [25], only 38 (12.6%) community pharmacists provided correct answer. Likely, item 8 that stated “when two pharmaceutical products are bioequivalent, it means that the C _max and AUC ratios estimated for each formulation can vary by -20 to +25%” [25], few of the participants 68 (22.5%) answered correctly. Detailed responses on knowledge items are provided in Table 3.

Table 4 obviously showed that the majority of participant pharmacists disagreed 3 attitudinal items out of 15. These are: item 4, 5 and 15 which illustrated the switching from brand to generic, reporting of therapeutic failure as a major problem in most generics and stopping of dispensing generics issues respectively. Detailed results are listed below and are provided in Table 4. Out of 302 respondents 188 (62.3%) agreed to attitudinal item 1 in Table 4 which explored the pharmacists’ supportiveness of generic substitution policy. In addition, 168 of the participants (55.6%) agreed item 2 that argued the lowering spending consequences on developmental research on discovering new medication that may result from using generic versions of drugs, while 76 (25.1%) of the pharmacists disagreed this point. Approximately two third of the participants (68.2%) agreed item 3 that linked reduction of governmental health-care expenditure to wider use of generics. A little more than half of participant pharmacists 157 (52.0%) disagreed item 4 that covered the issue of changing in therapeutic outcomes when a brand is switched to a generic. The majority of the pharmacists 227 (75.2%) disagreed the statement “therapeutic failure is a serious problem with most generic products”. When the pharmacists were asked when considering generic medicines as therapeutically equivalent products, the majority 219 (72.5%) agreed this item (6) in Table 4. About two third (67.6%) of pharmacists who asked about item 7 which elucidated the differences in prices between branded and generic versions as a reason for substitution. When participants were asked in item 8 about patients’ right of taking adequate clarifications why generic medicines were chosen, 246 (81.4%) pharmacists were agreed the point. Most of the pharmacists 264 (87.4%) said that community pharmacists in Palestine should be given generic substitution right. A majority of participant pharmacists (90.4%) believed that generic dispensing is significantly influenced by the intensity of promotional activities by medical representatives (item 10). Most of included pharmacists in the study 288 (95.4%) agreed item 11 in Table 4 which talked about the necessity of applying policies by health authorities like bioequivalence studies prior to marketing approval of generic product, while 7 (2.3%) disagreed the point. Item 12 which stated “community pharmacists should be allowed to perform generic substitution without consulting the prescribing physician” 69.5% agreed this attitudinal item. Almost half of participants 148 (49.0%) disagreed item 13 in Table 4 which concentrated on prescribers’ consultation by pharmacists prior of engaging in generic substitution. A large number of participant pharmacists 195 (64.5%) suggested that community pharmacists need to refer to prescriber in special cases of generic substitution such as substitution of drugs with narrow therapeutic indices (item 14). One hundred and seventy two (57.0%) of pharmacists disagreed the statement “in general, I would not dispense generic medicine to my patients” (item 15) in Table 4.

Table 5 illustrates possible influencing factors related to selection and dispensing of generic medicines among the community pharmacist. The majority of pharmacists reported that the two main factors affecting their selections and dispensing generic medicines are personal faith in the product and cost effectiveness of generic medicines 260 (86.1%) and 254 (84.1%) respectively.

In general, participant pharmacists had relatively low knowledge score on generic medicines. However, our data showed that the majority of participant pharmacists had enough information about the definition of generics. Similarly, almost two thirds of pharmacists in Poland correctly answered the term assessing the definition of generic medicines [23]. These results are harmonic with former studies that have been recorded from other improving nations, such as Pakistan and Malaysia [6, 15].

Although the mean knowledge score of the respondents about generic medicines were lower than Qatar’s survey findings, our data were similar to those reported by Awaisu et al. in the following aspects; (i) poor knowledge of pharmacists included in both countries in the area of bioequivalence notions, the pharmacokinetic parameters (i.e., AUC, C_max) and the technical determination of bioequivalent products. (ii) no significant association between knowledge score on generic medicines and the socio-demographic and professional characteristics. However, the obtained results assessing the therapeutic equivalency were higher compared to results reported by Awaisu and his colleagues [11]. These feedbacks suggest a demand for interventions to develop pharmacists’ awareness on these important matters underlining the safety, quality and efficacy of generic medicines.

Similarly, In Saudi Arabia, Wajid et al. [18] revealed that community health practitioners own doubts on curative efficacy and integrity profiles of generic medicine products. This outcome could be linked to their poor awareness about the notion of bioequivalence, the FDA acceptance criteria and the statistical comparative analysis of the pharmacokinetic parameter to be assessed in bioequivalence study.

Drozdowska and Hermanows [23] clarified that characteristics like: sex, age, pharmacy case (series pharmacy vs. separate pharmacy), and site of pharmacy did not distinguish the pharmacists answers to a statistically considerable level in referring to repetition that made patients aware that they have a choice of generic substitution (p > 0.05), and this outcome is similar to our study in Palestine. However, a survey conducted in New Zealand reported a significant variation in pharmacists’ awareness of generic medicines based on the length of time in expertise; the participants with less than 5 years in expertise had a better perception of generic drugs than those with larger than or similar to 5 years in expertise [24].

The current study showed that among factors affecting the pharmacists’ generic drug exchange experiences according to the participants contain the cheaper price to the customer, faith in the product, having no other options and cost-efficiency of the generic drugs. These findings were similar to previous studies that reported these agents as substantial influencing agents [11, 18, 23, 24]. In addition, the majority of the respondents agreed that the patient should have right of having adequate information on the use of generic medicines. In Poland, less than half of the participants introduced consumers about generic product [23].

The overall pharmacists’ attitudes on generic medicines in our survey in Palestine was similar to former study in Saudi Arabia accomplished by Wajid et al. [18], where participants were positively directing to generic exchange as they see it as definition of their function as drug treatment experts [18].

Our data announced that the plurality of the participants united in opinion on that the community pharmacist should have the right to perform generic substitution without consulting the prescribing physician. This was similar to results reported in Qatar [11]. But, O’Leary et al. [20] reported that the matters mostly concentrated on medications with limited therapeutic indices i.e. antiepileptic medications, digoxin, warfarin and thyroxine in addition to sustained-released and multi-constituent forms. In some civilized counties such as Canada and New Zealand, there are a finite number of drugs that are believed non-interchangeable drugs, and these drugs are exempt from generic exchange.

Since the method recruit a self-administered questionnaire, response bias is likely. The use of self-evaluation and limited questions for evaluation of knowledge are limitation of this research. Normally, the best way for practice evaluation is achieved through observation. In addition, the generalization of the results is limited as the sample of pharmacists was taken from West Bank alone which may not be representative of all Palestinian pharmacists. Besides, the study did not include biosilmalr products since they are not available in the Palestinian market.