Background
Commercially available tissue-based prognostic biomarker panels
Decipher™
First author and year | Number of cases | Study population | End point | Main results |
---|---|---|---|---|
Erho et al. [19] 2013 | 545 patients | Radical Prostatectomy | Metastases | Area Under Curve of 75 % in prediction of metastases |
Karnes et al. [22] 2013 | 219 patients | Radical Prostatectomy | Metastases | Area Under Curve of 79 % in prediction of metastases |
Den et al. [24] 2014 | 139 patients | Radical Prostatectomy and adjuvant radiation therapy | Biochemical recurrence and metastases | Area Under Curve of 78 % and 80 % in prediction of biochemical recurrence and metastases, respectively |
Ross et al. [23] 2014 | 85 patients | Radical Prostatectomy | Metastases after biochemical recurrence | Area Under Curve of 82 % in prediction of metastases in patients that have developed Biochemical recurrence |
Cooperberg et al. [28] 2015 | 185 patients | Radical Prostatectomy | Disease free survival | Predict high risk for PCa death |
Den et al. [25] 2015 | 188 patients | Radical Prostatectomy and adjuvant radiotherapy in pT3 or positive margin patients | Metastases | Predict development of clinical metastases |
Klein et al. [27] 2014 | 162 patients | Radical Prostatectomy for high risk prostate cancer in node positive patients | Metastases within 5 year after surgery | Predict development of metastases within 5 years after surgery |
Alshalalfa et al. [21] 2015 | 463 patients | Radical Prostatectomy | Differences between patients that developed Biochemical recurrence or metastasis during follow up | Patients that develop metastases after BCR can be identified |
Oncotype DX®
First author and year | Number of cases | Study population | End point | Main results |
---|---|---|---|---|
Klein et al. [30] 2014 | 608 patients | Radical prostatectomy and Prostate biopsies | Metastases after radical prostatectomy and adverse pathology in radical prostatectomy specimen | Prediction of adverse pathology at radical prostatectomy using prostate biopsies tissue. |
Cullen et al. [31] 2015 | 431 patients | Prostate biopsies in very low, low and intermediate Prostate cancer patients | Adverse radical prostatectomy pathology and biochemical recurrence | Increased BCR risk at univariable analyses and after adjusting for risk groups at multivariable using prostate biopsy tissue |
Prolaris®
First author and year | Number of cases | Study population | End point | Main results |
---|---|---|---|---|
Cuzick et al. [32] 2011 | 703 patients | Transurethral resection of prostate or radical prostatectomy | Biochemical recurrence and disease free survival | Predict biochemical recurrence and disease free survival |
Cuzick et al. [33] 2012 | 349 patients | Prostate biopsies | Disease free survival | Predict disease free survival |
Cooperberg et al. [36] 2013 | 413 patients | Radical prostatectomy | Biochemical recurrence | Predict biochemical recurrence |
Freedland et al. [35] 2013 | 141 patients | Prostate biopsies in patients treated with EBRT | Biochemical recurrence and disease free survival | Predict disease free survival |
Bishoff et al. [34] 2014 | 582 patients | Prostate biopsies | Biochemical recurrence and metastases | Predict biochemical recurrence and metastases |