Background
Methods
Screening of patients and sample collection
Detection of k13 mutation
Analysis of pfmdr1 copy number variation
Statistical analysis
Results
K13 sequence
Ann | Homemalin | Myit Kyi Nar | Kyauk Me | Phruso | Total | |
---|---|---|---|---|---|---|
Total n | 64 | 91 | 32 | 13 | 6 | 206 |
Wild type | 61**
| 59**
| 6 | 0 | 4 | 126 |
Non-propeller mutations | ||||||
R254L*
| 1 | 1 | ||||
R255K | 2 | 2 | ||||
E294G*
| 1 | 1 | ||||
I352T | 2 | 2 | ||||
R411K*
| 1 | 1 | ||||
Total | 0 | 6 | 1 | 0 | 0 | 7 |
% | 0 | 6.6 | 3.2 | 0 | 0 | 3.4 |
(95 % CI) | (0.0–5.7) | (3.0–13.6) | (0.56–15.8) | (0–22.8) | (0–39.0) | (1.7–6.8) |
Propeller mutations | ||||||
P441L | 1 | 1 | ||||
P443S | 3 | 3 | ||||
F446I | 13 | 18 | 1 | 32 | ||
G449A | 1 | 1 | 2 | |||
S485N | 1 | 1 | ||||
Y511H*
| 1 | 1 | ||||
A529T*
| 1 | 1 | ||||
N554L*
| 1 | 1 | ||||
P574L | 1 | 2 | 12 | 15 | ||
R561H | 1 | 1 | ||||
R575K | 1 | 1 | ||||
A675V | 2 | 2 | ||||
A676D | 4 | 3 | 7 | |||
H719N | 1 | 1 | ||||
Total | 3 | 26 | 25 | 13 | 2 | 69 |
% | 4.7 | 28.6 | 78.1 | 100 | 33.3 | 33.5 |
(95 % CI) | (1.6–12.9) | (20.3–38.6) | (61.2–89.0) | (77.2–100) | (9.7–70.0) | (27.4–40.2) |
pfmdr1 copy number variation
Single | Multiple | % multiple | (95 % CI) | |
---|---|---|---|---|
Ann | 63 | 2 | 3.1 | (0.8–10.6) |
Homemalin | 94 | 4 | 4.1 | (1.6–10.0) |
Myit Kyi Nar | 35 | 1 | 2.8 | (0.5–14.2) |
Kyauk Me | 9 | 4 | 30.8 | (12.7–57.6) |
Phruso | 5 | 1 | 16.7 | (3.0–56.4) |
Total | 206 | 12 | 5.5 | (3.2–9.4) |