Background
Materials and methods
Search strategy
Selections of studies
Data extraction
Outcomes of interest
Statistical analysis
Results
Study characteristics
Study | Year | Country | Cases | Gender (M) | Age, years | NT | NOS | Hybrid | Preoperative comorbidity (MIO/OE) | TNM stage (MIO/OE) | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(MIO/OE) | (MIO/OE) | (MIO/OE) | (MIO/OE) | Cardiovascular | Pulmonary | Diabetes | 0 + I + II | III + IV | |||||
Nguyen | 2000 | USA | 18/36 | 7/29 | 64 ± 12/67 ± 8 | 9/9 | 6 | MIE | NR | NR | NR | NR | NR |
Osugi | 2003 | Japan | 77/72 | 64/57 | 63.7 ± 9 · 6/64 · ±9 · 3 | NR | 7 | TA | NR | NR | NR | NR | NR |
Kunisaki | 2004 | Japan | 15/30 | 12/21 | 62.3 ± 8.1/63 ± 6 | NR | 6 | MIE | NR | NR | NR | NR | NR |
Bernabe | 2004 | USA | 17/14 | 16/11 | 63.9 ± 13.5/64.1 ± 10.7 | NR | 6 | TA | NR | NR | NR | NR | NR |
Van den Broek | 2004 | Netherlands | 25/20 | 19/14 | 63 ± 8/64 ± 8 | 17/4 | 7 | TA | NR | NR | NR | 8/10 | 17/10 |
Braghetto | 2006 | Chile | 47/119 | NR | NR | 0/0 | 8 | MIE | NR | NR | NR | 41/80 | 6/39 |
Bresadola | 2006 | Italy | 14/14 | 8/13 | 61.9 ± 7.7/59.3 ± 10.9 | NR | 6 | MIE | NR | NR | NR | 11/6 | 3/8 |
Shiraishi | 2006 | Japan | 116/37 | 94/31 | 61.5 ± 8.1/66.5 ± 9.3 | 26/10 | 7 | Hybrid | NR | NR | NR | NR | NR |
Smithers | 2007 | Australia | 332/114 | 267/104 | 64 (27–85)/62.5 (29–81) | 136/29 | 8 | Hybrid | 76/22 | NR | 27/4 | 192/36 | 118/75 |
Benzoni | 2007 | Italy | 9/13 | 6/11 | 63.6 ± 2.6/60.2 ± 2.4 | 6/6 | 8 | TA | NR | 2/4 | NR | 9/7 | 0/6 |
Fabian | 2008 | USA | 22/43 | 16/31 | 63 (46–86)/61 (35–82) | 9/16 | 7 | MIE | NR | NR | NR | 14/25 | 7/19 |
Parameswaran | 2009 | UK | 50/30 | 45/21 | 67 (47–81)/68 (47–81) | 32/12 | 8 | MIE | NR | NR | NR | 27/17 | 23/13 |
Saha | 2009 | UK | 16/28 | 13/24 | 65 (50–80)/64 (35–78) | NR | 8 | MIE | NR | NR | NR | NR | NR |
Zingg | 2009 | Australia | 56/98 | 45/71 | 66.3 ± 1.3/67.8 ± 1.1 | 40/48 | 8 | MIE | 4/7 | 13/35 | 6/12 | 35/47 | 21/42 |
Pham | 2010 | USA | 44/46 | 41/33 | 63 ± 8.6/61 ± 10.7 | 29/23 | 6 | MIE | NR | NR | NR | 20/20 | 20/19 |
Perry | 2010 | USA | 21/21 | 18/17 | 69 ± 8/61 ± 9 | NR | 7 | MIE | NR | NR | NR | NR | NR |
Hamouda | 2010 | UK | 51/24 | 44/23 | 62/60 | 44/20 | 7 | MIE | NR | NR | NR | NR | NR |
Safranek | 2010 | UK | 75/46 | 53/38 | 60 (44–77)/64(41–74) | 71/34 | 7 | Hybrid | NR | NR | NR | 31/29 | 44/17 |
Schoppmann | 2010 | Australia | 31/31 | 25/21 | 61.5 (36–75)/58.6 (34–77) | 15/7 | 8 | MIE | 6/8 | 10/8 | 1/1 | 18/19 | 13/12 |
Schröder | 2010 | Germany | 238/181 | 198/151 | 61.1 (60–62)/57.8 (56–59) | 144/66 | 6 | TA | NR | NR | NR | NR | NR |
Mehran | 2011 | USA | 44/44 | 43/40 | 61.0 (42–79)/62.5 (38–83) | 31/30 | 7 | MIE | NR | NR | NR | 23/21 | 16/20 |
Berger | 2011 | USA | 65/53 | 51/38 | 61 (41–78)/62 (40–86) | 28/43 | 6 | MIE | NR | NR | NR | 52/41 | 13/12 |
Lee | 2011 | Japan | 74/64 | 73/61 | 59.7 ± 10.3/56.6 ± 11.6 | 47/52 | 8 | Hybrid | NR | NR | NR | 54/49 | 20/15 |
Nafteux | 2011 | Belgium | 65/101 | 52/81 | 63 (41–82)/64 (29–82) | NR | 8 | MIE | 11/24 | 6/13 | 6/12 | NR | NR |
Yamasaki | 2011 | Japan | 109/107 | 87/95 | 64.6 ± 8.5/64.7 ± 8.0 | 85/68 | 8 | TA | 20/20 | 11/13 | 10/6 | NR | NR |
Biere | 2012 | Netherlands | 59/56 | 43/46 | 62 (34–75)/62 (42–75) | 59/56 | 8 | MIE | NR | NR | NR | 31/26 | 15/19 |
Maas | 2012 | Netherlands | 50/50 | 41/33 | 62.5 (57–69)/65 (57–69) | 23/13 | 8 | MIE | NR | NR | NR | 19/19 | 31/31 |
Briez | 2012 | France | 140/140 | 110/117 | NR | 67/69 | 8 | TA | NR | NR | NR | 92/89 | 48/51 |
Kinjo | 2012 | Japan | 106/79 | 87/70 | 62.7 ± 7.4/63.3 ± 8.6 | 54/11 | 7 | MIE | NR | NR | NR | 65/45 | 41/34 |
Mamidanna | 2012 | UK | 1155/6347 | 892/4870 | NR | NR | 7 | MIE | 400/2234 | 141/782 | 90/598 | NR | NR |
Sihag | 2012 | USA | 38/76 | 29/61 | 61.4 ± 8.1/63.3 ± 9.3 | 25/46 | 7 | MIE | 6/16 | 8/13 | NR | 29/53 | 9/23 |
Sundaram | 2012 | USA | 47/57 | 38/52 | 67.3 (42–79)/61.7 (34–84) | 35/40 | 8 | MIE | 33/42 | NR | 11/14 | NR | NR |
Tsujimoto | 2012 | Japan | 22/27 | 21/21 | 70 ± 5.4/67 ± 10.1 | 8/16 | 6 | TA | NR | NR | NR | 12/14 | 10/13 |
Javidfar | 2012 | USA | 92/165 | 71/122 | 65 (56–74)/68 (60–74) | 51/96 | 7 | MIE | 9/23 | 9/23 | 22/35 | 65/96 | 27/69 |
Bailey | 2013 | UK | 39/31 | 32/27 | 65 (37–78)/62 (38–78) | 33/31 | 7 | TA | NR | NR | NR | NR | NR |
Ichikawa | 2013 | Japan | 152/163 | 129/145 | 63.8 ± 8.5/64.6 ± 8.6 | 54/64 | 8 | TA | 23/35 | 21/24 | 26/37 | 101/81 | 51/79 |
Kitagawa | 2013 | Japan | 45/47 | 35/40 | 63 (47–77)/64 (39–83) | 8/11 | 7 | MIE | NR | NR | 8/8 | NR | NR |
Noble | 2013 | UK | 53/53 | 43/45 | 66 (45–85)/64 (36–81) | 13/11 | 8 | MIE | NR | NR | NR | NR | NR |
Parameswaran | 2013 | UK | 67/19 | 47/15 | 64 (45–84)/64 (51–77) | 50/17 | 7 | Hybrid | NR | NR | NR | 43/8 | 23/11 |
Takeno | 2013 | Japan | 91/166 | 77/147 | 63.7/64.2 | NR | 8 | TA | NR | NR | NR | NR | NR |
Kubo | 2014 | Japan | 135/74 | 111/60 | 64.1 ± 8.2/62.2 ± 7.2 | 22/4 | 7 | Hybrid | 12/3 | 9/7 | NR | 112/41 | 23/33 |
Schneider | 2014 | UK | 19/61 | 46/15 | 62.3 (35–74)/66.7 (45–79) | 7/45 | 6 | MIE | NR | NR | NR | 16/36 | 2/24 |
Daiko | 2015 | Japan | 31/33 | 28/28 | 66 (49–78)/65 (49–76) | NR | 7 | MIE | NR | NR | NR | 23/32 | 8/1 |
Kauppi | 2015 | Finland | 74/79 | 59/68 | 66 (51–85)/63 (39–82) | 61/62 | 8 | MIE | 14/17 | 12/14 | 17/13 | 28/25 | 46/54 |
Law | 1997 | China | 18/63 | 13/55 | 66 (43–80)/63 (36–84) | NR | 7 | MIE | NR | NR | NR | 5/15 | 13/45 |
Chen | 2010 | China | 67/38 | 45/25 | 61 ± 7/66 ± 6 | NR | 7 | MIE | 15/4 | 10/3 | 9/2 | 42/15 | 25/23 |
Gao | 2011 | China | 96/78 | 89/70 | 58.5 ± 7.3/59.1 ± 6.4 | NR | 6 | MIE | NR | NR | NR | 54/40 | 42/38 |
Shen | 2012 | China | 76/71 | 52/50 | 60.9 ± 9/62.6 ± 8.7 | NR | 6 | MIE | NR | NR | NR | 41/44 | 35/27 |
Liu | 2012 | China | 98/105 | 67/71 | 62.3 ± 10.1/65.8 ± 7.6 | NR | 6 | MIE | 13/18 | 40/37 | 6/8 | 51/43 | 47/62 |
Mao | 2012 | China | 34/38 | 28/26 | 62/60 | NR | 6 | TA | NR | NR | NR | 27/21 | 7/17 |
Wang | 2012 | China | 260/322 | 194/232 | 61.6 ± 8.761.2 ± 8.8 | 37/44 | 6 | MIE | NR | NR | NR | 201/234 | 59/88 |
MU | 2014 | China | 176/142 | 116/106 | 60 (55–66)/59 (54–62) | NR | 6 | MIE | NR | NR | NR | 120/109 | 56/33 |
Meng | 2014 | China | 94/89 | 65/63 | 59.7 ± 9.3/61.1 ± 6.7 | NR | 7 | MIE | 11/14 | 27/31 | 12/10 | 56/50 | 38/39 |
Zhang | 2014 | China | 60/61 | 48/47 | 62.4 ± 8/61.8 ± 8.4 | NR | 6 | MIE | NR | NR | NR | 41/42 | 19/19 |
Chen | 2015 | China | 59/59 | 42/40 | 57 (41–72)/56 (48–71) | NR | 7 | MIE | 4/2 | 1/0 | 2/3 | 56/55 | 3/4 |
Yang | 2015 | China | 62/62 | 45/45 | 62 ± 9/62 ± 8 | NR | 7 | MIE | NR | NR | NR | 44/43 | 18/19 |
Li | 2015 | China | 89/318 | 66/227 | 73 (70–83)/73 (70–85) | NR | 7 | MIE | NR | NR | NR | 64/188 | 25/126 |
Preoperative clinical data
Postoperative data
Complications
MIO and total complications
Study | Total | Pulmonary | Circulatory system | Digestive system | AL | RLNP | STR | Mortality |
---|---|---|---|---|---|---|---|---|
MIO/OE | MIO/OE | MIO/OE | MIO/OE | MIO/OE | MIO/OE | MIO/OE | MIO/OE | MIO/OE |
Nguyen | NR | 2/6 | 1/1 | 1/2 | 3/4 | 0/4 | 0/1 | 0/1 |
Osugi | 25/27 | 12/14 | 3/2 | NR | 2/1 | 11/9 | 4/4 | NR |
Kunisaki | NR | 0/1 | NR | NR | 2/1 | 3/3 | NR | NR |
Bernabe | NR | NR | NR | 7/8 | NR | NR | NR | NR |
Van den Broek | 14/18 | 2/2 | NR | 3/5 | 2/3 | 2/3 | 2/4 | NR |
Braghetto | 18/72 | 7/22 | 0/3 | 4/6 | 3/17 | 0/2 | 1/0 | 3/13 |
Bresadola | NR | 1/2 | 1/0 | NR | 1/2 | 3/1 | NR | NR |
Shiraishi | NR | 25/12 | 13/9 | NR | 12/9 | 42/10 | NR | 6/5 |
Smithers | 207/76 | 106/44 | 60/24 | 83/9 | 17/11 | 8/0 | 25/14 | 7/3 |
Benzoni | NR | 0/2 | NR | 0/1 | 1/1 | 1/1 | NR | 0/1 |
Fabian | 15/31 | 1/18 | 5/8 | 1/0 | 3/3 | 1/2 | 0/3 | 1/4 |
Parameswaran | 24/15 | 4/2 | 0/3 | 3/1 | 4/1 | 6/0 | 5/4 | NR |
Saha | 3/6 | NR | NR | NR | 2/3 | NR | NR | 0/2 |
Zingg | 19/20 | 17/33 | NR | NR | 11/11 | NR | 2/2 | 2/6 |
Pham | 34/27 | 13/9 | 18/16 | 3/1 | 4/5 | 6/0 | 3/10 | 3/2 |
Perry | 13/17 | 2/3 | 5/8 | 5/4 | 4/6 | 1/2 | 2/5 | NR |
Hamouda | NR | 15/5 | 5/3 | 3/1 | 4/2 | NR | 3/0 | NR |
Safranek | NR | 19/13 | NR | 17/4 | 11/1 | 10/1 | 5/5 | 3/1 |
Schoppmann | NR | 5/17 | NR | 0/1 | 1/8 | 4/13 | 3/4 | NR |
Schröder | NR | NR | NR | NR | 18/17 | NR | NR | 7/11 |
Mehran | NR | 14/15 | 9/9 | 18/8 | 11/6 | NR | NR | NR |
Berger | 31/32 | 10/22 | 1/6 | NR | 9/6 | NR | NR | 5/4 |
Lee | NR | 11/20 | NR | NR | 10/18 | NR | NR | 4/8 |
Nafteux | 44/61 | 17/47 | 11/13 | 13/6 | 5/10 | NR | 6/9 | 2/2 |
Yamasaki | 26/38 | 7/15 | 3/6 | 0/2 | 6/4 | 17/20 | 3/5 | 0/2 |
Biere | NR | 14/35 | 1/1 | 1/0 | 7/4 | 1/8 | 1/1 | 3/1 |
Maas | 21/33 | 9/13 | 3/6 | NR | 4/3 | 3/5 | 2/5 | 0/1 |
Briez | 50/83 | 22/60 | NR | 6/4 | 8/6 | NR | NR | 2/10 |
Kinjo | 54/54 | 22/31 | 10/5 | 8/9 | 11/13 | 21/10 | 4/10 | NR |
Mamidanna | NR | 276/1419 | 165/1035 | NR | NR | NR | NR | 46/274 |
Sihag | NR | 1/33 | 5/19 | NR | 0/2 | NR | 3/5 | 0/2 |
Sundaram | 28/41 | 5/19 | 9/19 | 26/10 | 4/4 | 1/1 | 10/11 | 2/1 |
Tsujimoto | 13/16 | 2/10 | NR | 1/1 | 7/3 | 2/2 | 1/4 | 1/5 |
Javidfar | NR | 9/26 | 29/56 | 19/33 | 5/7 | 3/0 | 22/38 | 3/7 |
Bailey | NR | 15/18 | 4/9 | 1/0 | 1/0 | NR | 6/15 | 2/2 |
Ichikawa | 94/117 | 20/33 | 17/38 | 4/5 | 14/27 | 60/77 | 2/2 | 0/8 |
Kitagawa | NR | 6/14 | NR | NR | NR | NR | 13/20 | 2/1 |
Noble | NR | 14/18 | 10/7 | NR | 5/2 | NR | 2/2 | 1/1 |
Parameswaran | 42/12 | 7/2 | 2/1 | 14/2 | NR | 2/1 | 6/3 | 3/1 |
Takeno | 39/69 | NR | NR | NR | NR | NR | NR | 4/15 |
Kubo | 57/35 | 13/16 | NR | 2/0 | 10/7 | 37/14 | 18/19 | 2/2 |
Schneider | 7/13 | NR | NR | NR | NR | NR | NR | 0/2 |
Daiko | 10/12 | NR | NR | NR | 6/4 | 3/6 | 2/6 | NR |
Kauppi | 37/48 | 13/15 | 17/27 | 5/14 | 5/5 | 0/4 | 12/11 | NR |
Law | NR | 4/15 | 3/16 | NR | 0/2 | 4/8 | NR | NR |
Chen | NR | 7/10 | NR | 2/0 | 1/0 | NR | 2/1 | NR |
Gao | 31/36 | 13/11 | NR | 7/12 | 7/6 | 2/4 | 1/2 | 2/3 |
Shen | 32/28 | 5/6 | 9/8 | 1/1 | 16/14 | 7/2 | 2/3 | 0/1 |
Liu | 22/38 | 5/21 | 4/13 | 3/5 | 2/4 | 3/4 | 3/5 | 1/3 |
Mao | 14/16 | 0/2 | 1/6 | 0/1 | 8/1 | 5/3 | NR | NR |
Wang | 90/145 | 12/23 | 21/36 | 11/13 | 26/32 | 6/7 | 8/16 | 2/11 |
MU | 28/22 | 6/4 | NR | NR | 12/4 | NR | NR | 1/1 |
Meng | 24/41 | 9/24 | 4/11 | 2/2 | 6/7 | 4/4 | 3/4 | 1/4 |
Zhang | NR | 4/7 | 3/5 | 3/2 | 3/2 | 2/1 | 2/7 | NR |
Chen | 14/19 | 2/4 | 3/5 | NR | 2/3 | 4/5 | 1/1 | NR |
Yang | 19/31 | NR | NR | NR | NR | NR | NR | NR |
Li | 32/137 | 8/51 | 9/34 | 2/5 | 19/45 | 18/49 | 4/19 | 3/16 |
Variables | No. studies | WMD/OR (95%CI) |
P
V
|
P
Q
|
I
2 (%) |
P
E
|
---|---|---|---|---|---|---|
Age, years | 57 (n = 15790) | −0.343 (−1.200, 0.514) | 0.433 | <0.05 | 68.1 | 0.059 |
NT | 34 (n = 5138) | 1.364 (1.042,1.785) | 0.024 | <0.05 | 73.0 | 0.362 |
Comorbidity | ||||||
Cardiovascular | 16 (n = 10337) | 0.913 (0.815,1.022) | 0.112 | 0.030 | 44.2 | 0.930 |
Pulmonary | 15 (n = 9779) | 0.949 (0.819,1.099) | 0.485 | 0.881 | 0 | 0.722 |
Diabetes | 15 (n = 9983) | 0.942 (0.798,1.111) | 0.476 | 0.457 | 0 | 0.082 |
Operating time, min | 46 (n = 6260) | 24.427 (10.912,37.943) | <0.05 | <0.05 | 96.1 | 0.155 |
Blood loss, ml | 40 (n = 5285) | −196.060 (−255.195,-136.926) | <0.05 | <0.05 | 98.9 | 0.592 |
LN harvest | 46 (n = 6390) | −1.275 (−5.851,3.301) | 0.585 | <0.05 | 99.8 | 0.786 |
LOS, day | 45 (n = 13899) | −3.660 (−4.891,-2.428) | <0.05 | <0.05 | 86.0 | 0.175 |
ICU stay, day | 27 (n = 10761) | −1.599 (−2.680, −0.518) | 0.004 | <0.05 | 98.2 | 0.078 |
Complication | ||||||
Total complication | 35 (n = 5991) | 0.700 (0.626,0.781) | <0.05 | 0.012 | 38.5 | 0.178 |
Pulmonary | 50 (n = 14781) | 0.527 (0.431, 0.645) | <0.05 | <0.05 | 60.3 | <0.05 |
Circulatory system | 36 (n = 12883) | 0.770 (0.681,0.872) | <0.05 | 0.427 | 2.4 | 0.386 |
Digestive system | 21 (n = 4081) | 1.097 (0.835,1.442) | 0.507 | 0.083 | 31.7 | 0.664 |
AL | 50 (n = 7528) | 1.023 (0.870,1.202) | 0.785 | 0.304 | 8.5 | 0.018 |
RLNP | 37 (n = 5429) | 1.108 (0.917,1.339) | 0.289 | 0.089 | 24.8 | 0.014 |
STR | 39 (n = 5991) | 0.639 (0.522,0.781) | <0.05 | 0.918 | 0 | 0.206 |
Mortality | 38 (n = 14132) | 0.668 (0.539,0.827) | <0.05 | 0.944 | 0 | 0.508 |