Introduction
Statistical analysis
Left ventricular dimensions and functions in the adult
CMR acquisition parameters
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Alfakih, 2003 [3] | Short axis SSFP, papillary muscle included in LV mass | 30:30 | 20-65 |
Hudsmith, 2005 [4] | Short axis SSFP, papillary muscle included in LV mass | 63:45 | 21-68 |
Maceira, 2006 [5] | Short axis SSFP, papillary muscle included in LV mass | 60:60 | 20-80 |
CMR analysis methods
Men
|
Women
| |||||
---|---|---|---|---|---|---|
mean
p
|
SD
p
|
Lower/ upper limits*
|
mean
p
|
SD
p
|
Lower/ upper limits*
| |
EDV [ml] | 160 | 27 | 106-214 | 132 | 23 | 86-178 |
EDV /BSA [ml/m2] | 81 | 12 | 57-105 | 76 | 10 | 56-96 |
ESV [ml] | 54 | 14 | 26-82 | 44 | 11 | 22-66 |
ESV/BSA [ml/m2]** | 26 | 6 | 14-38 | 24 | 5 | 14-34 |
SV [ml] | 108 | 18 | 72-144 | 87 | 15 | 57-117 |
SV/BSA [ml/m2]** | 54 | 6 | 42-66 | 52 | 7 | 38-66 |
EF [%] | 67 | 5 | 57-77 | 67 | 5 | 57-77 |
Mass [g] | 134 | 21 | 92-176 | 98 | 21 | 56-140 |
Mass/BSA [g/m2] | 67 | 9 | 49-85 | 61 | 10 | 41-81 |
Men
|
Women
| |||
---|---|---|---|---|
Parameter
|
<60 years
|
≥60 years
|
<60 years
|
≥60 years
|
EDV [ml] | 161 ± 21 (119, 203) | 148 ± 21 (106, 190) | 132 ± 21 (90, 174) | 120 ± 21 (78, 162) |
EDV /BSA [ml/m2] | 82 ± 9 (64, 100) | 76 ± 9 (58, 94) | 78 ± 8.7 (61, 95) | 69 ± 8.7 (52, 86) |
ESV [ml] | 55 ± 11 (33, 77) | 48 ± 11 (26, 70) | 44 ± 9.5 (25, 63) | 38 ± 9.5 (19, 57) |
ESV/BSA [ml/m2] | 28 ± 5.5 (17, 39) | 25 ± 5.5 (14, 36) | 26 ± 4.7 (17, 35) | 22 ± 4.7 (13, 31) |
SV [ml] | 106 ± 14 (78, 134) | 100 ± 14 (72, 128) | 88 ± 14 (60, 116) | 82 ± 14 (54, 110) |
SV/BSA [ml/m2] | 55 ± 6.1 (43, 67) | 52 ± 6.1 (40, 64) | 52 ± 6.2 (40, 64) | 47.5 ± 6.2 (35, 60) |
EF [%] | 66 ± 4.5 (57, 75) | 68 ± 4.5 (59, 77) | 67 ± 4.6 (58, 76) | 69 ± 4.6 (60, 78) |
Mass [g] | 147 ± 20 (107, 187) | 145 ± 20 (105, 185) | 106 ± 18 (70, 142) | 110 ± 18 (74, 146) |
Mass/BSA [g/m2] | 74 ± 8.5 (57, 91) | 73 ± 8.5 (56, 90) | 62 ± 7.5 (47, 77) | 63 ± 7.5 (48, 78) |
Demographic parameters
Men
|
Women
| |
---|---|---|
PFRE [ml/s] | 527 ± 140 (253, 802) | 477 ± 146 (190, 764) |
PFRE /BSA [ml/m2] | 270 ± 70 (134, 407) | 279 ± 81 (121, 437) |
PFRE/EDV [/s] | 3.4 ± 0.71 (2.0, 4.8) | 3.8 ± 0.83 (2.1, 5.4) |
PFRA [ml/s] | 373 ± 82 (212, 534) | 283 ± 69 (149, 418) |
PFRA/BSA [ml/m2] | 193 ± 44 (107, 279) | 168 ± 44 (82, 254) |
PFRA/EDV [/s] | 2.6 ± 0.57 (1.5, 3.7) | 2.3 ± 0.49 (1.4, 3.3) |
PFRE/PFRA | 1.4 ± 0.34 (0.7, 2.8) | 1.7 ± 0.29 (0.9, 3.1) |
Septal AVPD [mm] | 15 ± 3.6 (8, 22) | 14 ± 3.2 (8, 21) |
Septal AVPD /long length [%] | 15 ± 2.9 (9, 21) | 16 ± 3.5 (9, 23) |
Lateral AVPD [mm] | 18 ± 4.1 (9, 26) | 17 ± 3.2 (11, 24) |
Lateral AVPD /long length [%] | 17 ± 3.2 (11, 23) | 19 ± 3.1 (13, 24) |
Sphericity index, diastole | 0.35 ± 0.06 (0.22, 0.48) | 0.4 ± 0.07 (0.27, 0.53) |
Sphericity index, systole | 0.20 ± 0.05 (0.10, 0.29) | 0.23 ± 0.068 (0.09, 0.36) |
Studies included in this review
Additional LV function parameters
Right ventricular dimensions and functions in the adult
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Alfakih, 2003 [3] | Short axis SSFP, papillary muscles and trabeculation included in RV volume | 30:30 | 20-65 |
Hudsmith, 2005 [4] | Short axis SSFP, papillary muscles and trabeculation included in RV volume | 63:45 | 21-68 |
Maceira, 2006 [16] | Short axis SSFP, papillary muscle included in RV mass | 60:60 | 20-80 |
Men
|
Women
| |||||
---|---|---|---|---|---|---|
Parameter
|
mean
p
|
SD
p
|
Lower/ upper limits*
|
mean
p
|
SD
p
|
Lower/ upper limits*
|
EDV [ml] | 184 | 33 | 118-250 | 139 | 31 | 77-201 |
EDV /BSA [ml/m2] | 91 | 15 | 61-121 | 80 | 16 | 48-112 |
ESV [ml] | 79 | 19 | 41-117 | 54 | 15 | 24-84 |
ESV/BSA [ml/m2]** | 39 | 10 | 19-59 | 32 | 10 | 12-52 |
SV [ml] | 106 | 19 | 68-144 | 84 | 18 | 48-120 |
SV/BSA [ml/m2]** | 57 | 8 | 41-73 | 53 | 9 | 35-71 |
EF [%] | 62 | 5 | 52-72 | 61 | 5 | 51-71 |
Mass [g]** | 41 | 8 | 25-57 | 35 | 7 | 21-49 |
Mass/BSA [g/m2]** | 21 | 4 | 13-29 | 20 | 4 | 12-28 |
Men
|
Women
| |||
---|---|---|---|---|
Parameter
|
<60 years
|
≥60 years
|
<60 years
|
≥60 years
|
EDV [ml] | 169 ± 25 (119, 219) | 153 ± 25 (103, 203) | 133 ± 22 (89, 177) | 114 ± 22 (70, 158) |
EDV /BSA [ml/m2] | 87 ± 12 (63, 111) | 77 ± 12 (53, 101) | 78 ± 9 (60, 96) | 66 ± 9 (48, 84) |
ESV [ml] | 62 ± 15 (32, 92) | 48 ± 15 (18, 78) | 49 ± 13 (23, 75) | 35 ± 13 (9, 61) |
ESV/BSA [ml/m2] | 32 ± 7 (18, 46) | 24 ± 7 (10, 38) | 28 ± 7 (14, 42) | 20 ± 7 (6, 34) |
SV [ml] | 107 ± 17 (73, 141) | 105 ± 17 (71, 139) | 85 ± 13 (59, 111) | 80 ± 13 (54, 106) |
SV/BSA [ml/m2] | 55 ± 8 (39, 71) | 53 ± 8 (37, 69) | 50 ± 6 (38, 62) | 46 ± 6 (34, 58) |
EF [%] | 64 ± 7 (50, 78) | 69 ± 7 (55, 83) | 64 ± 6 (52, 76) | 70 ± 6 (58, 82) |
Mass [g] | 68 ± 14 (40, 96) | 63 ± 14 (35, 91) | 50 ± 11 (28, 72) | 44 ± 11 (22, 66) |
Mass/BSA [g/m2] | 35 ± 7 (21, 49) | 32 ± 7 (18, 46) | 30 ± 5 (20, 40) | 25 ± 5 (15, 35) |
Additional RV function parameters
Men
|
Women
| |
---|---|---|
PFRE [ml/s] | 405 ± 137 (137, 674) | 337 ± 117 (107, 567) |
PFRE /BSA [ml/m2] | 207 ± 70 (68, 345) | 197 ± 68 (64, 330) |
PFRE/EDV [/s] | 2.4 ± 0.75 (1.0, 3.9) | 2.7 ± 0.85 (1.0, 4.3) |
PFRA [ml/s] | 489 ± 175 (146, 833) | 368 ± 153 (67, 668) |
PFRA/BSA [ml/m2] | 250 ± 94 (66, 434) | 215 ± 89 (40, 390) |
PFRA/EDV [/s] | 3.1 ± 1.0 (1.0, 5.2) | 2.9 ± 1.0 (0.9, 5.0) |
PFRE/PFRA | 0.8 ± 0.49 (−0.1, 1.8) | 0.9 ± 0.46 (0.0, 1.8) |
Septal AVPD [mm] | 15 ± 4.1 (6, 23) | 13 ± 3.0 (7, 19) |
Septal AVPD /long length [%] | 17 ± 4.5 (8, 26) | 17 ± 3.9 (9, 25) |
Lateral AVPD [mm] | 22 ± 4.4 (13, 30) | 21 ± 3.5 (14, 27) |
Lateral AVPD /long length [%] | 23 ± 4.1 (15, 31) | 24 ± 4.0 (16, 32) |
Left atrial dimensions and functions in the adult
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Sievers, 2005 [20] | 2, 3 and 4 chamber SSFP; measurement of diameters | 59:52 | 25-73 |
Hudsmith, 2005 [4] | 2 and 4 chamber SSFP; biplane area-length method; atrial appendage included, pulmonary veins excluded | 63:45 | 21-68 |
Maceira, 2010 [17] | Short axis, 2, 3 and 4 chamber SSFP; 3D modeling and measurement of area and diameters; atrial appendage included, pulmonary veins excluded (for volume analysis) | 60:60 | 20-80 |
Parameter
|
Men
|
Women
| ||||
---|---|---|---|---|---|---|
mean
|
SD
|
Lower/ upper limits*
|
mean
|
SD
|
Lower/ upper limits*
| |
Max. LA volume (ml) | 103 | 30 | 43-163 | 89 | 21 | 47-131 |
Min. LA volume (ml) | 46 | 14 | 18-74 | 41 | 11 | 19-63 |
EF (%) | 55 | 13 | 29-81 | 53 | 9 | 35-71 |
SV (ml) | 58 | 23 | 12-104 | 48 | 15 | 18-78 |
Parameter
|
Men
|
Women
| ||||
---|---|---|---|---|---|---|
mean
|
SD
|
Lower/ upper limits*
|
mean
|
SD
|
Lower/ upper limits*
| |
Max. LA volume (ml) | 77 | 14.9 | 47-107 | 68 | 14.9 | 38-98 |
Max. LA volume/BSA (ml/m2) | 39 | 6.7 | 26-52 | 40 | 6.7 | 27-53 |
Parameter
|
Men
|
Women
| ||||
---|---|---|---|---|---|---|
mean
|
SD
|
Lower/ upper limits*
|
mean
|
SD
|
Lower/ upper limits*
| |
Area (cm2) 4ch | 22 | 3.7 | 15-29 | 20 | 3.7 | 13-27 |
Area/BSA (cm2/ m2) 4ch | 11 | 1.8 | 7-15 | 12 | 1.8 | 8-16 |
Area (cm2) 2ch | 21 | 4.7 | 12-30 | 19 | 4.7 | 10-28 |
Area/BSA (cm2/ m2) 2ch | 11 | 2.4 | 6-16 | 11 | 2.4 | 6-16 |
Area (cm2) 3ch | 19 | 3.6 | 12-26 | 17 | 3.6 | 10-24 |
Area/BSA (cm2/ m2) 3ch | 10 | 1.8 | 6-14 | 10 | 1.8 | 6-14 |
Parameter
|
Men
|
Women
| ||||
---|---|---|---|---|---|---|
mean
|
SD
|
Lower/ upper limits*
|
mean
|
SD
|
Lower/ upper limits*
| |
Longitudinal diameter (cm) 4ch | 5.9 | 0.7 | 4.5-7.3 | 5.5 | 0.7 | 4.1-6.9 |
Longitudinal diameter/BSA (cm/m2) 4ch | 3.0 | 0.4 | 2.2-3.8 | 3.2 | 0.4 | 2.4-4.0 |
Transverse diameter (cm) 4ch | 4.1 | 0.5 | 3.1-5.1 | 4.1 | 0.5 | 3.1-5.1 |
Transverse diameter/BSA (cm/m2) 4ch | 2.1 | 0.3 | 1.5-2.7 | 2.4 | 0.3 | 1.8-3.0 |
Longitudinal diameter (cm) 2ch | 5.0 | 0.7 | 3.6-6.4 | 4.6 | 0.7 | 3.2-6.0 |
Longitudinal diameter/BSA (cm/m2) 2ch | 2.5 | 0.4 | 1.7-3.3 | 2.7 | 0.4 | 1.9-3.5 |
Transverse diameter (cm) 2ch | 4.6 | 0.5 | 3.6-5.6 | 4.4 | 0.5 | 3.4-5.4 |
Transverse diameter/BSA (cm/m2) 2ch | 2.3 | 0.2 | 1.9-2.7 | 2.6 | 0.2 | 2.2-3.0 |
AP diameter (cm) 3ch | 3.3 | 0.5 | 2.3-4.3 | 3.1 | 0.5 | 2.1-4.1 |
AP diameter/BSA (cm/m2) 3ch | 1.7 | 0.3 | 1.1-2.3 | 1.8 | 0.3 | 1.2-2.4 |
Right atrial dimensions and functions in the adult
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Sievers, 2007 [21] | Short axis SSFP and 4 chamber SSFP; Simpsons method and biplane area length method; atrial appendage included, pulmonary veins excluded | 38:32 | 25-73 |
Maceira, 2013 [22] | Short axis SSFP; 3D modeling; atrial appendage included, pulmonary veins excluded | 60:60 | 20-80 |
Parameter
|
mean
|
SD
|
Lower/ upper limits*
|
---|---|---|---|
Max. RA volume (ml) | 101 | 30 | 41-161 |
Max. RA volume/BSA (ml/ m2) | 53 | 16 | 21-85 |
Min. RA volume (ml) | 50 | 19 | 12-88 |
Min. RA volume/BSA (ml/m2) | 27 | 10 | 7-47 |
SV (ml) | 50 | 16 | 18-82 |
SV/BSA (ml/m2) | 26 | 9 | 8-44 |
EF (%) | 47 | 8 | 31-63 |
Parameter
|
mean
|
SD
|
Lower/ upper limits*
|
---|---|---|---|
Max. RA volume (ml) | 103 | 33 | 37-169 |
Max. RA volume/BSA (ml/ m2) | 54 | 18 | 18-90 |
Min. RA volume (ml) | 51 | 20 | 11-91 |
Min. RA volume/BSA (ml/m2) | 27 | 11 | 5-49 |
SV (ml) | 52 | 17 | 18-86 |
SV/BSA (ml/m2) | 27 | 9 | 9-45 |
EF (%) | 51 | 9 | 33-69 |
Parameter
|
mean
|
SD
|
Lower/ upper limits*
|
---|---|---|---|
Max. RA volume (ml) | 100 | 20 | 60-140 |
Max. RA volume/BSA (ml/ m2) | 54 | 10 | 34-74 |
Parameter
|
mean
|
SD
|
Lower/ upper limits*
|
---|---|---|---|
Area (cm2) 4ch | 22 | 3.8 | 14-30 |
Area/BSA (cm2/ m2) 4ch | 12 | 1.8 | 8-16 |
Area (cm2) 2ch | 22 | 3.95 | 14-30 |
Area/BSA (cm2/ m2) 2ch | 12 | 2.27 | 7-17 |
Parameter
|
mean
|
SD
|
Lower/ upper limits*
|
---|---|---|---|
Longitudinal diameter (cm) 4ch | 5.5 | 0.58 | 4.3-6.7 |
Longitudinal diameter/BSA (cm/m2) 4ch | 3.0 | 0.32 | 2.4-3.6 |
Transverse diameter (cm) 4ch | 4.7 | 0.55 | 3.6-5.8 |
Transverse diameter/BSA (cm/m2) 4ch | 2.6 | 0.3 | 2.0-3.2 |
Longitudinal diameter (cm) 2ch | 5.4 | 0.5 | 4.4-6.4 |
Longitudinal diameter/BSA (cm/m2) 2ch | 2.9 | 0.3 | 2.3-3.5 |
Transverse diameter (cm) 2ch | 4.3 | 0.7 | 2.9-5.7 |
Transverse diameter/BSA (cm/m2) 2ch | 2.4 | 0.4 | 1.6-3.2 |
Left and right ventricular dimensions and function in children
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Robbers-Visser, 2009 [23] | Short axis SSFP, papillary muscle/ trabeculation excluded from volumes | 30:30* | 8-17 |
Buechel, 2009 [25] | Short axis SSFP, papillary muscle/trabeculation included in volumes, separate analysis of papillary muscle mass | 23:27** | 7 mo – 18 |
Sarikouch, 2010 [24] | Axial SSFP (in 29 children additional short axis stack), papillary muscle/ trabeculation excluded from volumes | Total: 55:59* Percentiles: 51:48 | Total: 4–20 Percentiles: 8-20 |
Parameter
|
Male
|
Female
| ||||
---|---|---|---|---|---|---|
mean
p
|
SD
p
|
Lower/ upper limits*
|
mean
p
|
SD
p
|
Lower/ upper limits*
| |
EDV/BSA [ml/m2] | 80 | 12 | 56-104 | 75 | 10 | 55-95 |
ESV/BSA [ml/m2] | 28 | 6 | 16-40 | 25 | 5 | 15-35 |
SV/BSA [ml/m2]** | 54 | 9 | 36-72 | 50 | 8 | 34-66 |
EF [%]** | 66 | 5 | 56-76 | 63 | 6 | 51-75 |
CI [l/min/ m2]** | 4.4 | 0.85 | 2.7-6.1 | 3.9 | 0.62 | 2.7-5.1 |
Mass/BSA [g/m2] | 62 | 12 | 38-86 | 53 | 9 | 35-71 |
Parameter
|
Male
|
Female
| ||||
---|---|---|---|---|---|---|
mean
p
|
SD
p
|
Lower/ upper limits*
|
mean
p
|
SD
p
|
Lower/ upper limits*
| |
EDV/BSA [ml/m2] | 84 | 12 | 60-108 | 76 | 9 | 58-94 |
ESV/BSA [ml/m2] | 32 | 7 | 18-46 | 27 | 5 | 17-37 |
SV/BSA [ml/m2]** | 52 | 8 | 36-68 | 49 | 7 | 35-63 |
EF [%]** | 62 | 4 | 54-70 | 63 | 4 | 55-71 |
Mass/BSA [g/m2] | 21 | 5 | 11-31 | 18 | 4 | 10-26 |
Left and right atrial dimensions and function in children
CMR acquisition parameters
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Sarikouch, 2011 [18] | Axial SSFP; pulmonary veins, SVC, IVC and coronary sinus excluded, atrial appendages included from/in the left and right atrial volume, respectively | 56:59 | 4.4-20.3 |
CMR analysis methods
Demographic parameters
Studies included in this review
Male
|
Female
| |||
---|---|---|---|---|
Parameter
|
mean
|
SD
|
mean
|
SD
|
Vol. max. [ml] | 71 | 30 | 59 | 20 |
Vol. max./BSA [ml/m2] | 47 | 10 | 44 | 9 |
Vol. min. [ml] | 33 | 15 | 26 | 9 |
Vol. min./BSA [ml/m2] | 22 | 5 | 19 | 4 |
SV [ml] | 38 | 16 | 33 | 12 |
EF [%] | 54 | 6 | 56 | 6 |
Male
|
Female
| |||
---|---|---|---|---|
Parameter
|
mean
|
SD
|
mean
|
SD
|
Vol. max. [ml] | 89 | 43 | 71 | 25 |
Vol. max./BSA [ml/m2] | 58 | 16 | 53 | 12 |
Vol. min. [ml] | 42 | 21 | 31 | 13 |
Vol. min./BSA [ml/m2] | 27 | 8 | 23 | 6 |
SV [ml] | 47 | 24 | 40 | 15 |
EF [%] | 53 | 7 | 56 | 8 |
Normal left ventricular myocardial thickness
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Dawson, 2011 [30] | Short axis SSFP, papillary muscle/ trabeculation excluded from LVMT | 60:60 | 20-80 |
Kawel, 2012 [29] | Short and long axis SSFP, papillary muscle/ trabeculation excluded from LVMT | 131:169 | 54-91 |
Men
|
Women
| ||||||
---|---|---|---|---|---|---|---|
Level
|
Region
|
mean
|
SD
|
Lower/upper limits*
|
mean
|
SD
|
Lower/upper limits*
|
basal | anterior | 8.2 | 1.3 | 5.6-10.8 | 7.0 | 1.1 | 4.8-9.2 |
inferior | 8.2 | 1.3 | 5.6-10.8 | 6.7 | 1.1 | 4.5-8.9 | |
septal | 9.1 | 1.3 | 6.5-11.7 | 7.3 | 1.1 | 5.1-9.5 | |
lateral | 7.6 | 1.3 | 5.0-10.2 | 6.0 | 1.1 | 3.8-8.2 | |
mean
| 8.3 | 1.0 | 6.3-10.3 | 6.8 | 0.9 | 5.0-8.6 | |
mid-cavity | anterior | 6.0 | 1.3 | 3.4-8.6 | 4.9 | 1.1 | 2.7-7.1 |
inferior | 7.7 | 1.3 | 5.1-10.3 | 6.5 | 1.1 | 4.3-8.7 | |
septal | 8.3 | 1.3 | 5.7-10.9 | 6.8 | 1.1 | 4.6-9.0 | |
lateral | 6.6 | 1.3 | 4.0-9.2 | 5.3 | 1.1 | 3.1-7.5 | |
mean
| 7.2 | 1.0 | 5.2-9.2 | 5.9 | 0.9 | 4.1-7.7 | |
apical | anterior | 5.1 | 1.3 | 2.5-7.7 | 4.2 | 1.1 | 2.0-6.4 |
inferior | 5.8 | 1.3 | 3.2-8.4 | 5.0 | 1.1 | 2.8-7.2 | |
septal | 5.8 | 1.3 | 3.2-8.4 | 5.0 | 1.1 | 2.8-7.2 | |
lateral | 5.5 | 1.3 | 2.9-8.1 | 4.6 | 1.1 | 2.4-6.8 | |
mean
| 5.6 | 1.0 | 3.6-7.6 | 4.7 | 0.9 | 2.9-6.5 |
Men
|
Women
| ||||||
---|---|---|---|---|---|---|---|
Level
|
Segment
|
mean
p
|
SD
p
|
Lower/upper limits*
|
mean
p
|
SD
p
|
Lower/upper limits*
|
basal | 1 | 8.2 | 1.1 | 6.0-10.4 | 6.7 | 1.0 | 4.7-8.7 |
2 | 9.6 | 1.1 | 7.4-11.8 | 7.9 | 1.0 | 5.9-9.9 | |
3 | 9.2 | 1.1 | 7.0-11.4 | 7.5 | 1.0 | 5.5-9.5 | |
4 | 8.1 | 1.1 | 5.9-10.3 | 6.6 | 1.0 | 4.6-8.6 | |
5 | 7.3 | 1.1 | 5.1-9.5 | 6.0 | 1.0 | 4.0-8.0 | |
6 | 7.4 | 1.1 | 5.2-9.6 | 6.1 | 0.9 | 4.3-7.9 | |
mid-cavity | 7 | 6.7 | 1.1 | 4.5-8.9 | 5.7 | 1.0 | 3.7-7.7 |
8 | 7.7 | 1.1 | 5.5-9.9 | 6.4 | 1.0 | 4.4-8.4 | |
9 | 8.2 | 1.1 | 6.0-10.4 | 6.9 | 1.0 | 4.9-8.9 | |
10 | 7.0 | 1.1 | 4.8-9.2 | 5.9 | 1.0 | 3.9-7.9 | |
11 | 6.2 | 1.1 | 4.0-8.4 | 5.2 | 0.9 | 3.4-7.0 | |
12 | 6.4 | 1.1 | 4.2-8.6 | 5.4 | 1.0 | 3.4-7.4 | |
apical | 13 | 6.7 | 1.1 | 4.5-8.9 | 6.4 | 1.0 | 4.4-8.4 |
14 | 7.3 | 1.1 | 5.1-9.5 | 6.3 | 1.0 | 4.3-8.3 | |
15 | 6.2 | 1.1 | 4.0-8.4 | 5.4 | 1.0 | 3.4-7.4 | |
16 | 6.3 | 1.1 | 4.1-8.5 | 5.9 | 1.0 | 3.9-7.9 |
Cardiac valves and quantification of flow
CMR acquisition parameters
Flow encoding velocity (Venc)
CMR analysis methods
Demographic parameters
Studies included in this review
Valve disease
|
Indicator
|
Mild
|
Moderate
|
Severe
|
---|---|---|---|---|
Aortic stenosis | Peak velocity [m/s] | <3 | 3-4 | >4 |
Orifice area [cm2] | >1.5 | 1.0-1.5 | <1.0 | |
Orifice area /BSA [cm2/m2] | <0.6 | |||
Aortic regurgitation | Regurgitant volume [ml/beat] | <30 | 30-59 | ≥60 |
Regurgitant fraction [%] | <30 | 30-49 | ≥50 | |
Regurgitant orifice area [cm2] | <0.10 | 0.10-0.29 | ≥0.30 | |
Mitral stenosis | Peak velocity [m/s] | <1.2 | 1.2-2.2 | >2.2 |
Orifice area [cm2] | >1.5 | 1.0-1.5 | <1.0 | |
Mitral regurgitation | Regurgitant volume [ml/beat] | <30 | 30-59 | ≥60 |
Regurgitant fraction [%] | <30 | 30-49 | ≥50 | |
Regurgitant orifice area [cm2] | <0.20 | 0.20-0.39 | ≥0.40 | |
Pulmonary stenosis | Peak velocity [m/s] | <3 | 3-4 | >4 |
Orifice area [cm2] | <1 | |||
Pulmonary regurgitation | Regurgitant volume [ml/beat] | <30 | 30-40 | >40 |
Regurgitant fraction [%] | <25 | 20-35 | >35 | |
Tricuspid stenosis | Orifice area [cm2] | <1.0 |
Parameter
|
Normal
|
Type 1 (Impaired relaxation)
|
Type 2 (Pseudonormal)
|
Type 3 (Restrictive, partially reversible)
|
Type 3 (Restrictive, fixed)
|
---|---|---|---|---|---|
MDT (ms) | 150-220 | Increased | Normal | Decreased | Decreased |
E/A ratio | 1-2 | <1 | 1-2 | >2 | >2 |
Normal aortic dimensions in the adult
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Davis, 2014 [46] | SSFP; luminal diameter of thoracic and abdominal aorta | 208: 239 | 19-70 |
Turkbey, 2013 [45] | Phase contrast (magnitude image); luminal diameter of ascending thoracic aorta | 770:842 | 45-84 |
Burman, 2008 [47] | SSFP; luminal diameter of aortic root | 60:60 | 20-80 |
Men
|
Women
| |||||
---|---|---|---|---|---|---|
Level
|
Normal weight
|
Overweight
|
Obese
|
Normal weight
|
Overweight
|
Obese
|
Aortic annulus
| 23.9 (18.6-29.2) | 24.3 (18.9-29.7) | 25.6 (20.4-30.8) | 20.6 (17.4-23.8) | 21.7 (18.4-25.0) | 21.5 (17.2-25.8) |
Aortic sinus
| 31.9 (24.3-39.5) | 32.8 (25.2-40.4) | 33.3 (24.3-42.3) | 27.5 (21.9-33.1) | 28.0 (21.8-34.2) | 27.5 (21.3-33.7) |
Sinotubular junction
| 24.4 (18.2- 30.6) | 25.7 (16.7- 34.7) | 26.2 (18.9- 33.5) | 21.6 (16.6- 26.6) | 22.3 (17.0- 27.6) | 22.1 (15.9- 28.3) |
Ascending aorta
| 26.0 (18.7-33.3) | 27.4 (18.9-35.9) | 28.5 (23.1-33.9) | 24.7 (17.8-31.6) | 26.5 (19.3-33.7) | 26.6 (18.8-34.4) |
Prox. desc. aorta
| 20.1 (14.7-25.5) | 20.9 (15.6-26.2) | 22.2 (16.3-28.1) | 18.5 (14.6-22.4) | 19.2 (14.8-23.6) | 19.6 (16.5-23.2) |
Abdominal aorta *
| 17.1 (12.0-22.2) | 17.9 (12.8-23.0) | 18.8 (14.4-23.2) | 16.0 (12.1-19.9) | 16.3 (12.3-20.3) | 17.4 (13.9-20.9) |
Age (years)
|
Men
|
Women
|
---|---|---|
Absolute values (mm)
| ||
45-54
| 31.6 (27.2-37.3) | 28.8 (24.6-34.4) |
55-64
| 32.8 (28.1-40.7) | 30.1 (25.7-36.4) |
65-74
| 34.2 (28.7-41.0) | 30.6 (26.1-36.3) |
75-84
| 34.7 (28.6-40.8) | 31.1 (26.8-37.1) |
Values indexed to BSA (mm/m
2
)
| ||
45-54
| 15.9 (13.3-19.5) | 16.7 (13.5-20.7) |
55-64
| 16.8 (13.6-21.1) | 17.6 (14.8-22.1) |
65-74
| 17.8 (14.2-21.8) | 18.1 (14.5-22.1) |
75-84
| 18.6 (15.2-22.6) | 19.7 (15.3-28.2) |
Men
|
Women
| |||
---|---|---|---|---|
Age (years)
|
systolic
|
diastolic
|
systolic
|
diastolic
|
Absolute values (mm)
| ||||
20-29
| 32.6 ± 3.5 (26–40) | 30.4 ± 3.3 (24–37) | 28.6 ± 3.9 (21–36) | 26.3 ± 3.9 (19–34) |
30-39
| 32.0 ± 3.3 (25–39) | 29.7 ± 3.5 (23–37) | 28.5 ± 2.8 (23–34) | 26.8 ± 2.8 (21–32) |
40-49
| 33.3 ± 2.1 (29–38) | 31.6 ± 1.6 (28–35) | 31.7 ± 2.8 (26–37) | 30.0 ± 2.1 (26–34) |
50-59
| 33.9 ± 5.1 (24–44) | 32.7 ± 4.8 (23–42) | 29.5 ± 2.0 (26–34) | 28.4 ± 1.8 (25–32) |
60-69
| 34.6 ± 2.5 (30–40) | 33.5 ± 2.3 (29–38) | 30.5 ± 1.9 (27–34) | 29.5 ± 2.0 (26–34) |
70-79
| 35.1 ± 3.1 (29–41) | 33.9 ± 3.0 (28–40) | 30.7 ± 1.3 (28–33) | 29.6 ± 1.4 (27–32) |
all
| 33.6 ± 3.4 (27–40) | 32.0 ± 3.5 (25–39) | 29.9 ± 2.7 (25–35) | 28.4 ± 2.8 (23–34) |
Values indexed to BSA (mm/m
2
)
| ||||
20-29
| 16.8 ± 1.6 (14–20) | 15.6 ± 1.7 (12–19) | 16.7 ± 1.9 (13–21) | 15.3 ± 2.0 (11–19) |
30-39
| 16.3 ± 1.6 (13–20) | 15.1 ± 1.6 (12–18) | 17.5 ± 1.3 (15–20) | 16.4 ± 1.3 (14–19) |
40-49
| 16.1 ± 1.1 (14–18) | 15.3 ± 1.0 (13–17) | 17.8 ± 2.6 (13–23) | 16.8 ± 2.3 (12–21) |
50-59
| 17.2 ± 2.1 (13–21) | 16.6 ± 1.9 (13–20) | 17.8 ± 1.4 (15–21) | 17.2 ± 1.4 (14–20) |
60-69
| 17.7 ± 1.8 (14–21) | 17.2 ± 1.7 (14–21) | 17.7 ± 1.5 (15–21) | 17.1 ± 1.4 (14–20) |
70-79
| 18.0 ± 1.2 (16–20) | 17.4 ± 1.2 (15–20) | 18.5 ± 0.9 (17–20) | 17.8 ± 0.9 (16–20) |
all
| 17.0 ± 1.7 (14–20) | 16.2 ± 1.8 (13–20) | 17.7 ± 1.7 (14–21) | 16.8 ± 1.7 (13–20) |
Men
|
Women
| |||
---|---|---|---|---|
Age (years)
|
systolic
|
diastolic
|
systolic
|
diastolic
|
Absolute values (mm)
| ||||
20-29
| 34.4 ± 4.2 (26–43) | 32.8 ± 3.8 (25–40) | 30.2 ± 4.7 (21–40) | 28.4 ± 4.7 (19–38) |
30-39
| 33.8 ± 3.8 (26–41) | 32.0 ± 3.9 (24–40) | 30.0 ± 3.1 (24–36) | 28.7 ± 3.0 (23–35) |
40-49
| 36.0 ± 2.7 (31–41) | 34.1 ± 2.3 (30–39) | 33.9 ± 2.5 (29–39) | 32.8 ± 2.5 (28–38) |
50-59
| 36.3 ± 5.9 (25–48) | 35.2 ± 5.7 (24–47) | 31.4 ± 2.5 (26–36) | 30.6 ± 2.6 (25–36) |
60-69
| 37.4 ± 2.9 (32–43) | 36.2 ± 2.5 (31–41) | 32.8 ± 2.3 (28–37) | 32.0 ± 2.2 (28–36) |
70-79
| 37.8 ± 3.9 (30–46) | 37.0 ± 3.5 (30–44) | 32.9 ± 1.7 (30–36) | 32.0 ± 1.6 (29–35) |
all
| 36.0 ± 4.1 (28–44) | 34.6 ± 4.0 (27–43) | 31.9 ± 3.2 (26–38) | 30.7 ± 3.3 (24–37) |
Values indexed to BSA (mm/m
2
)
| ||||
20-29
| 17.7 ± 1.9 (14–22) | 16.9 ± 1.9 (13–21) | 17.6 ± 2.3 (13–22) | 16.6 ± 2.3 (12–21) |
30-39
| 17.2 ± 2.0 (13–21) | 16.2 ± 1.9 (12–20) | 18.4 ± 1.4 (16–21) | 17.6 ± 1.3 (15–20) |
40-49
| 17.4 ± 1.4 (15–20) | 16.5 ± 1.3 (14–19) | 19.0 ± 2.7 (14–24) | 18.4 ± 2.5 (13–23) |
50-59
| 18.5 ± 2.4 (14–23) | 17.9 ± 2.3 (13–23) | 18.9 ± 1.7 (16–22) | 18.5 ± 1.8 (15–22) |
60-69
| 19.2 ± 2.2 (15–24) | 18.6 ± 2.0 (15–23) | 19.0 ± 1.8 (15–23) | 18.6 ± 1.6 (15–22) |
70-79
| 19.4 ± 1.4 (17–22) | 19.0 ± 1.3 (16–22) | 19.8 ± 1.0 (18–22) | 19.3 ± 1.0 (17–21) |
all
| 17.6 ± 2.0 (14–22) | 17.5 ± 2.0 (14–22) | 18.8 ± 1.9 (15–23) | 18.1 ± 2.0 (14–22) |
Normal aortic dimensions in children
CMR acquisition parameters
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Kaiser, 2008 [52] | Contrast enhanced 3D MR angiography; shortest diameter | 30:23 | 2-20 |
Voges, 2012 [53] | Cine GRE; measurements obtained at maximal distension of the aorta | 30:41 | 2.3-28.3 |
Kutty, 2012 [54] | Cine phase contrast CMR; measurements obtained at systole | 55:50 | 4.4-20.4 |
CMR analysis methods
Demographic parameters
Studies included in this review
Site
|
Predicted diameter
|
SD of residuals
|
---|---|---|
Aortic sinus | 0.57 + 19.37*BSA0.5
| 2.38 |
Sinotubular junction | −0.03 + 16.91*BSA0.5
| 1.92 |
Ascending aorta | −1.33 + 18.6*BSA0.5
| 1.99 |
Proximal to the origin of the brachiocephalic artery | −3.38 + 20.07*BSA0.5
| 1.69 |
First transverse segment | −3.52 + 18.66*BSA0.5
| 1.63 |
Second transverse segment | −2.63 + 16.5*BSA0.5
| 1.31 |
Isthmic region | −3.37 + 16.52*BSA0.5
| 1.46 |
Descending aorta | −1.12 + 14.42*BSA0.5
| 1.64 |
Thoracoabdominal aorta at the level of the diaphragm | 1.27 + 9.89*BSA0.5
| 1.34 |
Site
|
Predicted diameter
|
---|---|
Ascending aorta | −0.0386 + 2.913*BSA |
Normal aortic distensibility/ pulse wave velocity in adults
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Redheuil, 2010 [51] | Phase contrast CMR and gradient echo cine | 54:57 | 20-84 |
Rose, 2010 [58] | SSFP | 13:13 | 23-61 |
Age categories (years)
| ||||||
---|---|---|---|---|---|---|
20-29
|
30-39
|
40-49
|
50-59
|
60-69
|
≥70
| |
Ascending aortic distensibility (kPa
−1
. 10
−3
)
| 74 ± 23 | 61 ± 23 | 31 ± 18 | 18 ± 7 | 12 ± 7 | 10 ± 6 |
Descending aortic distensibility (kPa
−1
. 10
−3
)
| 72 ± 18 | 70 ± 24 | 38 ± 17 | 29 ± 13 | 18 ± 8 | 17 ± 6 |
Aortic arch PWV (m/s)
| 3.5 ± 0.5 | 3.9 ± 1.1 | 5.6 ± 1.4 | 7.2 ± 2.3 | 9.7 ± 2.9 | 11.1 ± 4.6 |
Men
|
Women
| |
---|---|---|
Ascending Aorta
| 6.1 ± 2.5 | 8.6 ± 2.7 |
Descending Aorta
| 5.1 ± 2.4 | 7.2 ± 1.6 |
Normal aortic distensibility/ pulse wave velocity in children
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
---|---|---|---|
Voges, 2012 [53] | Cine GRE; phase-contrast cine CMR | 30:41 | 2.3-28.3 |
Normal values of myocardial T1 relaxation time and the extracellular volume (ECV)
CMR acquisition parameters
Factors affecting T1 and ECV
CMR analysis methods
Demographic parameters
Studies included in this review
Author
|
n
|
Age (yrs)
|
Male (%)
|
Sequence
|
Gd type & dose (mmol/kg)
|
Time p.c. (min)
|
T1 native (ms)
|
T1 p.c. (ms)
|
ECV
|
Slice(s), % thickness
|
---|---|---|---|---|---|---|---|---|---|---|
1.5 Tesla
| ||||||||||
Iles (2008) [77] | 20 | 38 ± 3 | 50 | GE, VAST 3–4 BH | 0.2 Magnevist | 15 | 975 ± 62 | 564 ± 23 | n/a | 3x SAX & 4Ch full thickness |
Ugander (2012) [68] | 60 | 49 ± 17 | 52 | MOLLI | 0.15-0.2 Magnevist | 15-20 | Not reported | Not reported | 27 ± 3 | 1x SAX & 4Ch full thickness |
Kellman (2012) [78] | 62 | 44 ± 17 | 48 | MOLLI | 0.15 Magnevist | 15-20 | 965 ± 35 | Not reported | 25 ± 3** | 1x SAX & 4Ch midwall |
Flett (2012) [69] | 30 | 64 ± 13 | 67 | FLASH, multi-BH | 0.1 Dotarem | 45-80 EQCMR | 698 ± 86 | 408 ± 33 | n/a | 2x SAX septum |
Fontana (2012) [76] | 50 | 47 ± 7 | 53 | ShMOLLI* | 0.1 Dotarem | 45-80 EQCMR | Not reported | Not reported | 26 ± 3 | 2x SAX septum |
Sado (2012) [70] | 81 | 44 ± 17 | 52 | FLASH, multi-BH | 0.1 Dotarem | 45-80 EQCMR | Not reported | Not reported | 25 ± 4 | 2x SAX septum |
Kawel (2012) [62] | 23 | 28 ± 6 | 36 | MOLLI | 0.15 Magnevist | 12 | 1003 ± 46 | 522 ± 34 | 28 ± 3 | 1x SAX full thickness |
Piechnik (2013) [74] | 342 | 38 ± 15 | 49 | ShMOLLI* | No contrast given | n/a | 962 ± 25 | n/a | n/a | 3x SAX full thickness |
Bull (2013) [75] | 33 | 62 ± 7 | 64 | ShMOLLI | No contrast given | n/a | 944 ± 16 | n/a | n/a | 1x SAX septal midwall |
3 Tesla
| ||||||||||
Kawel (2012) [65] | 23 | 28 ± 6 | 31 | MOLLI | 0.15 Magnevist | 12 | 1286 ± 59 | 538 ± 34 | 28 ± 3 | 1x SAX full thickness |
Kawel (2012) [65] | 23 | 28 ± 6 | 33 | MOLLI | 0.1 Multihance | 12 | As above | 555 ± 33 | 27 ± 3 | 1x SAX full thickness |
Puntmann (2013) [67] | 21 | 38 ± 6 | 23 | MOLLI* | 0.2 Gadobutrol | 15 | 1056 ± 27 | 454 ± 53 | 26 ± 5 | 1x SAX septal midwall |
Puntmann (2013) [79] | 30 | 43 ± 9 | 63 | MOLLI* | 0.2 Gadobutrol | 10 | 1070 ± 55 | 402 ± 58 | 27 ± 5 | 1x SA septal midwall |
Liu (2012) [80] | 24 | 29 ± 6 | 33 | MOLLI | 0.15 Magnevist | 12 | 1159 ± 39 | Not reported | 27 ± 3 | 1x SAX full thickness |
Liu (2012) [80] | 24 | 29 ± 6 | 33 | MOLLI | 0.1 Multihance | 12 | 1159 ± 39 | Not reported | 26 ± 3 | 1x SAX full thickness |
Normal values of myocardial T2* relaxation time
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
First author, year
|
CMR technique
|
N, male: female
|
Age range (yrs)
|
Mean ± SD (ms)
|
---|---|---|---|---|
Kirk, 2010 [85] | GRE, 8 echo times (2.6-16.74 ms) | 38:25 | 18-77 | 36.3* |
Pepe 2006 [86] | GRE, 9 echo times (2.2-20.3) | 14:6 | (33 ± 9**) | 36.4 ± 6.7 |
Anderson, 2001 [82] | GRE, 8 echo times (2.2-20.1 ms) | 9:6 | 26-39 | 52 ± 16 |
Regional Measurements and Cardiac Strain
CMR acquisition parameters
CMR analysis methods
Demographic parameters
Studies included in this review
Author
|
n
|
Age (yrs)
|
Acquis. method
|
Estimation method
|
Tagged resol.
|
FS (T)
|
base
|
mid
|
ap
|
sept
|
ant
|
lat
|
inf
|
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Circumferential Strain
| |||||||||||||
Moore (2000) [98] | 31 | 37 ± 11 | SPAMM | FindTags | 6 mm | 1.5 | −0.19±0.04 | −0.19±0.05 | −0.22±0.05 | −0.17±0.03 | −0.22±0.05 | −0.22±0.04 | −0.18±0.05 |
Cupps (2010) [89] | 50 | 32.8±10.6 | SPAMM | finite element model | 7 mm | 1.5 | −0.19±0.04 | −0.21±0.04 | −0.20±0.04 | −0.18±0.03 | −0.20±0.04 | −0.23±0.04 | −0.19±0.04 |
Del-Canto (2013) [90] | 36 | 58.8 ± 11.6 | SPAMM | SinMod | 7 mm | 1.5 | −0.17 ± 0.03 | −0.20 ± 0.03 | −0.20 ± 0.03 | −0.16 ± 0.04 | −0.20 ± 0.04 | −0.22 ±0.04 | −0.18 ± 0.04 |
Venkatesh (2014) [103] | 129 | 58.8 ± 9.3 | SPAMM | HARP | 7 mm | 1.5 | −15.1 ± 3.2 | −18.0 ± 2.2 | −17.9 ± 2.5 | ||||
Longitudinal Strain
| |||||||||||||
Moore (2000) [98] | 31 | 37 ± 11 | SPAMM | FindTags | 6 mm | 1.5 | −0.15±0.03 | −0.15±0.03 | −0.19±0.04 | −0.16±0.04 | −0.16±0.04 | −0.16±0.04 | −0.16±0.04 |
Cupps (2010) [89] | 50 | 32.8±10.6 | SPAMM | finite element model | 7 mm | 1.5 | −0.13±0.04 | −0.15±0.03 | −0.18±0.05 | −0.16±0.04 | 0.15±0.04 | −0.15±0.04 | −0.15±0.05 |
Radial Strain
| |||||||||||||
Moore (2000) [98] | 31 | 37 ± 11 | SPAMM | FindTags | 6 mm | 1.5 | 0.45±0.26 | 0.42±0.26 | 0.48±0.33 | 0.41±0.19 | 0.54±0.28 | 0.46±0.23 | 0.38±0.38 |
Del-Canto (2013) [90] | 36 | 58.8 ± 11.6 | SPAMM | SinMod | 7 mm | 1.5 | 0.13 ± 0.04 | 0.09 ± 0.04 | 0.12 ± 0.04 | 0.09 ±0.05 | 0.10 ±0.05 | 0.12 ±0.07 | 0.14±0.07 |
Venkatesh (2014) [103] | 129 | 58.8 ± 9.3 | SPAMM | HARP | 7 mm | 1.5 | 27.4 ± 5.6 | 24.8 ± 5.3 | 23.4 ± 6.7 |