Background
Methods
Ethical statement
Study population
Data monitoring and collection
Statistical analysis
Results
Source of infection | Number (%) |
---|---|
Appendicitis | 1553 (34.2 %) |
Cholecystitis | 837 (18.5 %) |
Post-operative | 387 (8.5 %) |
Colonic non diverticular perforation | 269 (5.9 %) |
Gastro-duodenal perforations | 498 (11 %) |
Diverticulitis | 234 (5.2 %) |
Small bowel perforation | 243 (5.4 %) |
Others | 348 (7.7 %) |
PID | 50 (1.1 %) |
Post traumatic perforation | 114 (2.5 %) |
Missing | |
Total | 4553 (100 %) |
Variable | Survided (%) n = 4117 | Died (%) n = 416 |
p value |
---|---|---|---|
Sepsis status | <0.0001 | ||
No sepsis | 1914 (46.5 %) | 23 (5.5 %) | |
Sepsis | 1725 (41.9 %) | 80 (19.2 %) | |
Severe sepsis | 404 (9.8 %) | 157 (37.7 %) | |
Septic shock | 74 (1.8 %) | 156 (37.5 %) | |
Healthcare associated infection | 433 (10.5 %) | 134 (32.2 %) | <0.0001 |
Source of infection | <0.0001 | ||
Appendicitis | 1536 (37.3 %) | 17 (4.1 %) | |
Cholecystitis | 809 (19.7 %) | 28 (6.7 %) | |
Colonic non diverticular perforation | 204 (5 %) | 65 (15.6 %) | |
Diverticulitis | 203 (4.9 %) | 31 (7.5 %) | |
Gastro-duodenal perforation | 431 (10.5 %) | 67 (16.2 %) | |
PID | 50 (1.2 %) | 0 (0) | |
Postoperative | 415 (10.1 %) | 86 (20.7 %) | |
Small bowel perforation | 174 (4.2 %) | 69 (16.6 %) | |
Post-traumatic | 104 (2.5 %) | 10 (2.4 %) | |
Others | 259 (6.3 %) | 53 (12.7 %) | |
Delay in source control | 2015 (48.9 %) | 341 (82 %) | <0.0001 |
Median age years (range) | 48 (18–97) | 79 (18–99) | <0.0001 |
Immunosuppresion | 292 (7.1) | 120 (28.8 %) | <0.0001 |
Sepsis severity score | 3 (0–17) | 10 (0–17) | <0.0001 |
Score variable | B | S.E. | Wald test |
P value | OR | OR 95 % C.I. | |
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
Sepsis status | 1.57 | 0.08 | 365.59 | <0.0001 | 4.81 | 4.09 | 5.65 |
Setting of infection acquisition | 0.6 | 0.18 | 10.49 | 0.001 | 1.81 | 1.27 | 2.6 |
Source of infectiona
| 59.38 | <0.0001 | |||||
Colonic non-diverticulical perforation | −0.26 | 0.27 | 0.97 | 0.33 | 0.77 | 0.46 | 1.3 |
Diverticulitis diffuse peritonitis | −0.26 | 0.34 | 0.51 | 0.48 | 0.78 | 0.40 | 1.54 |
Postoperative diffuse peritonitis | −0.005 | 0.29 | 0 | 0.99 | 1.00 | 0.56 | 1.76 |
Remaining sources | −1.2 | 0.21 | 32.47 | <0.0001 | 0.30 | 0.20 | 0.46 |
Delay in management | 1.47 | 0.17 | 78.53 | <0.0001 | 4.33 | 3.13 | 5.99 |
Age | 0.04 | 0.004 | 103.58 | <0.0001 | 1.04 | 1.04 | 1.05 |
Immunosuppression | 1.24 | 0.17 | 55.79 | <0.0001 | 3.46 | 2.5 | 4.79 |
Constant | −7.52 | 0.41 | 342.24 | <0.0001 | 0.001 |
Variable | B | S.E. | Wald |
P value | OR | OR 95 % C.I. | |
---|---|---|---|---|---|---|---|
Lower | Upper | ||||||
WSESSCORE | 0.58 | 0.02 | 639.59 | <0.0001 | 1.784 | 1.706 | 1.866 |
Constant | −5.79 | 0.19 | 958.74 | <0.0001 | .003 |