Background
Results
Vitamin D3 supplementation induces an extensive gene dysregulation
An intriguing expression of hormone transcripts in the cortex and hippocampus
Fold change | |||||
---|---|---|---|---|---|
Hipocampus | Cortex | ||||
Gene symbol | Entrez gene name | WtVitD/Wt | TgVitD/Tg | WtVitD/Wt | TgVitD/Tg |
Ahcy
| adenosylhomocysteinase | −1,73 | −2,07 | 1,79 | 2,07 |
Atg4c
| autophagy related 4C, cysteine peptidase | −2,72 | −2,75 | 4,49 | 4,82 |
Avp
| arginine vasopressin | −1,59 | 2,21 | 1,73 | 3,96 |
C130078n14
| uncharacterized protein C130078N14 | −2,13 | −2,17 | 3,92 | 2,77 |
Cdk5rap1
| CDK5 regulatory subunit associated protein 1 | −1,78 | −2,14 | 2,66 | 2,92 |
Cpne1
| copine I | −1,56 | −1,82 | 1,6 | 1,71 |
Dnajb8
| DnaJ (Hsp40) homolog, subfamily B, member 8 | −1,85 | 1,98 | −1,92 | −1,73 |
Fam205a
| family with sequence similarity 205, member A | 2,34 | 2,78 | 1,61 | −1,55 |
Fkbp1a
| FK506 binding protein 1A, 12kDa | 1,97 | 1,62 | −1,72 | −1,52 |
Gbp6
| guanylate binding protein family, member 6 | 2,19 | 2,21 | −2,65 | −3,23 |
Gm4924
| predicted gene 4924 | 1,68 | 1,94 | 2,14 | 1,53 |
Hla-drb5
| major histocompatibility complex, class II, DR beta 5 | 1,86 | 1,53 | −2,53 | −2,34 |
Iqcf4
| IQ motif containing F4 | 2,74 | 2,22 | −1,54 | −1,73 |
Iqsec3
| IQ motif and Sec7 domain 3 | −5,23 | 4,49 | −3,3 | 1,58 |
Kcnj6
| potassium channel, inwardly rectifying subfamily J, member 6 | 1,61 | 1,93 | −1,79 | −1,67 |
Kdr
| kinase insert domain receptor | −1,6 | 1,68 | 1,53 | −1,64 |
Mirg
| miRNA containing gene | −1,91 | 1,88 | −3,41 | −1,68 |
Nanog
| Nanog homeobox | −2,91 | 1,53 | −1,52 | −1,66 |
Ocel1
| occludin/ELL domain containing 1 | −3,07 | −3,98 | 3,52 | 3,21 |
Omp
| olfactory marker protein | −1,54 | −10,41 | 3,18 | 1,66 |
Oxt
| oxytocin/neurophysin I prepropeptide | −2,75 | 4,04 | 2,03 | 4,74 |
Ppp1r16b
| protein phosphatase 1, regulatory subunit 16B | 2,29 | 2,39 | −1,78 | −1,78 |
Prkcd
| protein kinase C, delta | −2,18 | −2,52 | 1,84 | 1,65 |
Prl
| prolactin | 1,93 | −1,88 | 10,07 | 10,54 |
Rnase4
| ribonuclease, RNase A family, 4 | 1,61 | 2,12 | −2,14 | −2,07 |
Sdc4
| syndecan 4 | 2,38 | 1,95 | −1,91 | −1,81 |
Serpina3g
| serine (or cysteine) peptidase inhibitor, clade A, member 3G | 2,78 | 1,94 | −1,8 | −2,42 |
Znf669
| zinc finger protein 669 | −2,08 | −1,9 | 1,84 | 2,2 |
Annotation term | Number of genes | Genes |
---|---|---|
Hormone activity | 8 |
Avp, Igf1, Igf2, Nppa, Oxt, Pmch, Prl, Trh
|
Synaptic vesicle | 5 |
Doc2g, Slc17a6, Syn3, Sv2c, Syt10
|
Regulation of phosphorylation | 6 |
Cd4, Cd74, Cdk5rap1, Fkbp1a, Irak2, Prkcd
|
Membrane-bounded vesicle | 8 |
Capn11, Doc2g, Gpnmb, Prl, Slc17a6, Syn3, Sv2c, Syt10
|
Striated muscle tissue development | 4 |
Fkbp1a, Foxp1, Rxrg, Tnnt2
|
Blood circulation | 4 |
Acta2, Ace, Avp, Nppa
|
Lymphocyte activation | 4 |
Cd4, Cd74, Fkbp1a, Foxp1
|
C2 calcium-dependent membrane targeting | 4 |
Cpne1, Doc2g, Prkcd, Syt10
|
Immune effector process | 4 |
Cd74, C1qb, Foxp1, Prkcd
|
Synapse | 5 |
Shc4, Slc17a6, Syn3, Sv2c, Syt10
|