Introduction
Malta has been closely involved in the Libyan civil conflict on a geographical, political and humanitarian level since its inception around the year 2011, also commonly referred to as the ‘Arab Spring’. Due to our geographical proximity, as one of Libya’s closest European neighbouring countries, Malta received both civilian refugees and military casualties of war. As of the European summer of 2014, Malta has been receiving polytrauma war casualties evacuated by air and sea after initial damage control surgery and medical stabilisation of battlefield injuries in Libya. These casualties were a mixture of insurgency fighters and civilians transferred directly to our primary hospital, Mater Dei Hospital, in varying states of injury and morbidity. After being stabilised primarily by an emergency trauma surgical trauma team on the ground in Libya, they were transferred to Malta for further treatment. This involved further medical stabilisation, damage control surgery (DCS), damage control orthopaedics (DCO) and/or definite orthopaedic surgery. Our experience of being a neighbouring country to a country in civil war is paralleled to the Akkucuk et al. (2015) [
1], in their paper reporting their experience from Turkey bordering the civil war stricken Syria in which a Level 1 civilian trauma centre became a military trauma centre.
The consensus through current war trauma literature is that between 65-70 % of war wounds involve the musculoskeletal system [
2,
3]. The nature and thus prognosis of warfare injuries differ from general civilian orthopaedic practice [
1,
4,
5] due to the dangerous environment in which the injuries are sustained, the increased severity of the injuries, the increased number of body regions involved and the staged resuscitation. The current basic war surgery principles advocated worldwide, consist of aggressive resuscitation, early and thorough debridement of the wounds, short term bridging procedures to achieve stability, then rapid evacuation to centre for definitive treatment [
1,
6].
Methods
In this series, we present six cases from a total of over one hundred and fifty trauma cases with varied musculoskeletal peripheral and spinal injuries that were treated at our Trauma and Orthopaedics department at Mater Dei Hospital in Malta. The patients in this series were collected prospectively between June 2014 and January 2015. They were brought to Malta via air ambulance and transferred directly to our general hospital during the still on-going Libyan civil war. All the patients presented here were Libyan male nationals aged from 22 to 50 years.
The time of presentation of ranged from acutely (within 3 days post injury) up to a maximum of three weeks post trauma. The patients had limb and/or spinal trauma that required damage control procedures, often with external fixation in the initial phase on the Libyan battlefield itself or district hospitals performed by Libyan surgeons.
We rarely received any accompanying documentation of the surgical procedures performed. All patients arrived at Mater Dei Hospital in varying states of haemodynamic stability. The cause of their injuries were either due to improvised explosive devices (IED), gunshot wounds (GSW), rocket propelled grenades (RPG) and/or explosive blasts with shrapnel injuries. The lower limbs were involved in four of the cases, the upper limbs in one case, and the spine in two cases. Most cases presented with comminuted open fractures; four cases presented with polytrauma needing intervention by other surgical specialities concurrently (see Table
1). Table
2 shows progression from initial fixation through to final outcome.
Table 1
Table showing the six patients presented in this series. All patients were male
1 | 40 | IED, blast injury | Left subtrochanteric femoral fracture, right open ankle fracture, missing calcaneum (Gustilo-Anderson type IIIC) | Posterior parietal soft tissue contusion, right lower limb traumatic vascular dysfunction, sepsis |
2 | 50 | IED and GSW | Right open elbow fracture (Gustilo-Anderson type IIIB), left open comminuted mid-shaft humeral fracture (Gustilo-Anderson type IIIC) | Brachial and ulnar artery erosion, multiple metallic foreign bodies |
3 | 32 | GSW/RPG | Left comminuted proximal femur fracture (Gustilo-Anderson type IIIA), right open tibia/fibular fracture (Gustilo-Anderson type IIIB), right superior and inferior pubic rami fracture, T12 vertebral body fracture | Neurological compromise left leg with sciatic nerve palsy, bilateral lung contusion |
4 | 22 | Direct GSW | Right comminuted open knee complex fracture (Gustilo-Anderson type IIIB) | Neurological status right leg impaired, but vascular status leg intact |
5 | 26 | IED/Car bomb | T5 metal foreign body, right scapular and rib fracture | Paraplegia, left pneumothorax, multiple metallic foreign bodies, Deep venous thrombosis left leg |
6 | 27 | Above ground explosive blast | Right lateral four ray traumatic amputation, extensive soft tissue loss lateral aspect of leg | Loss of sensation along superficial peroneal nerve distribution. No other significant injuries |
Table 2
Summary of the interventions performed and outcomes achieved
1 | Left subtrochanteric femoral fracture, Right open ankle fracture, missing calcaneum | Left femoral external fixator, right tibio-metatarsal external fixator | Left Intramedullary femoral nail, right below knee amputation | Transferred to rehabilitation hospital |
2 | Right open elbow fracture, left comminuted mid-shaft humeral fracture | Right humero-ulnar external fixator and multiple Kirsches wire fixation, left non-spanning humeral external fixator | Repeated soft tissue debridements and necrectomies, removal of infected metalwork | Inpatient mortality due to sepsis |
3 | Left comminuted proximal femur fracture, right open tibia/fibular fracture, right superior and inferior pubic rami fracture, T12 vertebral body fracture | Left femoral external fixator, right tibio-calcaneal external fixator | Left Intramedullary femoral nail, right conversion to ring external fixator | Transferred to rehabilitation hospital |
4 | Right comminuted open distal femur and tibial fracture | Right femoro-tibial external fixator | Repeated soft tissue debridements and necrectomies, Planned knee fusion | Discharge against medical advise |
5 | T5 metal foreign body, Right scapular and rib fracture | Nil | Observations, Acute rehabilitation | Transferred to rehabilitation hospital |
6 | Traumatic amputation of lateral four metatarsals of right foot | Right tibio-metatarsal external fixator | Repeated soft tissue debridements then eventual right below knee amputation as foot deemed unsalvageable | Transferred to rehabilitation hospital |
In terms of classification systems in war trauma we used the Gustilo-Anderson’s classification for open fractures which is widely used mainly due to its simplicity and reproducibility (Table
3) [
7], but is perhaps insufficient as sometimes the severity of closed cutaneofascial injury is belied by the extent of the open wound. Alternatives in injury classification include the AO foundation classification of soft tissue injury in open fractures [
8,
9] and Red Cross Classification of War Wounds, the latter of which classifies the wound itself [
4,
10].
Discussion
Our hospital received in excess of one hundred and fifty Libyan civil war casualties between June 2014 and January 2015, most of whom were treated by our orthopaedic department at Mater Dei Hospital, Malta. Our hospital has a bed capacity for 925 patients. We perform an average of 1800 civilian orthopaedic trauma operations per annum.
We received patients from a wide range of Libyan cities and outskirt towns from both public and private hospitals. They presented with extensive bony and soft tissue injuries, soft tissue infection and necrosis, as well as haemodynamically unstable patients largely due to combination of the severity of their injuries and prolonged evacuation and transit. Our case series echoes current anatomical trauma patterns seen with injuries caused by war, especially those caused by IEDs which are designed to destroy and incapacitate personnel and vehicles [
3].
Our role as a civilian tertiary hospital turned to that of a Level 1 Trauma hospital was our first experience as a hospital and unit in dealing with an influx of war trauma casualties on a daily basis. It not only put a strain on the National Health Service, but also on individual departments including intensive care, operating theatres, surgery and orthopaedics/trauma. As an orthopaedic department we aimed to treat the injuries definitively, converting to internal fixation when permissible in line with DCO, restoring functional mobility and curtailing soft tissue and joint infections.
The usage of the term ‘damage control surgery’ has gained popularity since the mid 1990’s [
11], however its principles have been alluded to in various literature from the Napoleonic campaigns in 18th century, through to major world wars in the 19th and 20th century.
The phrase “damage control” is traditionally a navy term. It refers to keeping a badly damaged ship afloat after major penetrating injury to the hull. Procedures for temporary righting and stabilising the ship, which keep the ship afloat, permit assessment of other damage and time to establish a sensible plan for definitive repair. The analogy to care of the seriously injured trauma patient is likened to this concept [
5,
12].
Damage control surgery was initially practised by general surgeons by packing the abdominal cavity to control diffuse bleeding from solid organs and other structures [
12], thus preventing the lethal triad of coagulopathy, acidosis and hypothermia [
13]. Damage control surgery consists of three phases: first, the control of haemorrhage and contamination; secondly, rewarming and correction of coagulopathy; and thirdly, surgical re-exploration and definitive repair [
13]. DCO is an extension of damage control surgery [
2]. It comprises early marginal and meticulous wound debridement, temporary fracture stabilisation typically through the use of an external fixator, minimal blood and heat loss, physiological stabilisation, and then secondary definitive orthopaedic management after medical evacuation [
2,
14‐
16].
If we consider, from a physiological point of view, the aetiology of the war injuries as the patient's “first hit”, the purpose of DCO is to avoid worsening the patient’s condition by the “second hit” of a major orthopaedic procedure and to delay definitive fracture repair until the patient's general physiological condition is optimised. The second hit phenomenon has added systemic physiological effects affecting morbidity and mortality by exhausting a patient's biological reserve [
11]. Definitive open reduction and repair is delayed until the inflammatory response and tissue oedema has decreased and the patients are clinically stable [
13]. The incidence of multiple organ failure decreased significantly from the times of early trauma care to the DCO period regardless of the type of treatment of the femoral fracture thus proving of effectiveness of the current practise of DCO [
14,
16].
In conjunction with DCO comes the current challenge of infection prevention. Injuries from IEDs differ markedly from GSWs. The contamination and soft tissue injury require more aggressive treatment [
4,
6]. IEDs come in forms of buried artillery rounds, above ground explosives, and car bombs amongst others [
6]. Other forms include mortars, rockets, and RPGs [
2]. Wounds should not be closed primarily but rather debrided thoroughly and covered temporarily. Splinting and external fixation are mainstays of bony stabilisation [
2].
Our experience as a tertiary centre and Level 1 care hospital was an extension of the DCO strategy. Our efforts to convert external fixators to definitive internal fixation within a timeframe of two weeks were greatly hampered and at times deemed impossible by high levels of systemic sepsis, local soft tissue infection and osteomyelitis. The majority of cases had open fractures which are known risk factors for bony non-union and prosthesis failure [
10,
11].
Scoring systems such as the Gustilo-Anderson classification (Table
3) correlates the severity of the fracture and soft tissue injury to the rate of infection and thus has prognostic value [
7]. Gustilo et al. [
17] presented their own experience with Type III injuries showing wound sepsis in the three subtypes were: Type IIIA, 4 %, IIIB, 52 %; and IIIC, 42 %; while amputation rates were, respectively, 0 %, 16 %, and 42 %. Our experience mirrored their results with the majority of fractures in this case series being most severe in the Gustilo-Anderson classification, scoring Type IIIB and Type IIIC.
Table 3
Gustilo and Anderson classification of open fractures [
7]
Type I | Open fracture with laceration <1 cm and clean |
Type II | Open fracture with laceration >1 cm without extensive soft tissue damage, flaps of avulsions |
Type III | Open segmental fracture with >10 cm laceration with extensive soft tissue injury or traumatic amputation. Any gunshot injury or farm machinery injury falls into this category. Type III are further subdivided into three categories (A, B and C). |
IIIA | Adequate soft tissue overage |
IIIB | Significant soft tissue loss with exposed bone that requires tissue transfer to achieve bony coverage |
IIIC | Associated vascular injury that requires repair for limb preservation |
We underline the difficulties of repeated planned limb reconstruction procedures required in order to attain satisfactory functional results. There was difficulty persuading victims of war zones for followup procedures as shown in our case 4 in this series.
The types of original fixation we encountered by and large stayed true to the principles of DCO by being monoplane and evolutive, with small number of pins placed distant to the fracture site with the aim of reducing the incidence of fracture site infection that could compromise later definitive treatment [
5].
Secondary internal fixation remains a controversial issue in management of battlefield injuries. Both Murray et al. in 2008 [
3] and Mody et al. in 2011 [
18] reported a 40 % infection rate, with up to 17 % osteomyelitis. Infections occurred secondary to blast injuries in 91 % of cases. Furthermore, Murray [
3] reported that intramedullary nailing is indicated in initially closed fractures as well as open femoral fractures when soft tissue management has allowed proper bone coverage without early infection, and interestingly Mody [
18] reported good long term functional results from secondary femoral and tibial nailing despite high rate of infectious complications.
Late conversion from an external fixator to internal fixation is associated with a high risk of infection, with a timeframe of two weeks being the benchmark [
19]. This is supported by Mathieu [
5] who showed that early conversion to internal fixation for closed diaphyseal fractures yield better results.
The mainstay of secondary definitive treatment carried out by our centre was based on the principles of adequate soft tissue debridement, definitive fracture stabilisation often employing the principle of relative stability by bridging the often comminuted fractures, and then soft tissue cover.
Competing interests
The author(s) declare that they have no competing interests.
Authors contributions
CN, MM and CM participated in case study design, data collection, summary of patients along with drafting the manuscript. JB participated in its design and coordination and helped to draft the manuscript. All authors read and approved the final manuscript.