Earlier administration of vasopressor therapy leads to a decrease in the amount of fluids administered over the first 24 hours or more of therapy of septic shock. There is concern that the use of aggressive early fluid resuscitation in septic shock (regardless of whether it is essential for stabilization) leads to potential detrimental increased tissue edema down the road in the patient with septic shock, although this concern is not currently supported by solid evidence. It may be that this edema is associated with organ dysfunction, need for organ support, and the ability to wean organ support. This could lead to longer days on mechanical ventilation, longer days in the intensive care unit, and the potential for later-stage increases in morbidity and mortality. It is possible that aggressive fluid resuscitation saves lives on the front end but a price is paid on the back end. There likely is a fine balance between the use of vasopressors to maintain MAP versus the use of continued fluid resuscitation in the presence of capillary leak to maintain MAP. Much additional research will be required to offer guidance to the treating clinician. In the meantime, one should not err on the side of fluid restriction for the sole purpose of decreasing third spacing down the road. Patients typically autodiurese this fluid when septic shock has resolved and the patient is improving. Whether facilitating this fluid exit with diuretic therapy would be beneficial is currently unknown.