Background
Materials and methods
Study design, settings, and patients
Clinical variables and data sources
Statistical methods
Results
Clinical characteristics of patients with LD
Clinical characteristics | 18 patients with LD | 129 patients without LD | P values, patients with LD vs patients without LD |
---|---|---|---|
Age, mean ± SD | 53.6 ± 14.7 years | 44.0 ± 16.1 years | 0.017 |
Gender, n (%) | 9 (50.0) male | 80 (62.0) male | 0.441 |
Fever, n (%) | 18 (100.0) | 129 (100.0) | / |
Arthritis, n (%) | 16 (88.9) | 114 (88.4) | 0.654 |
Skin Rash, n (%) | 13 (72.2) | 97 (75.2) | 0.492 |
Myalgia, n (%) | 16 (88.9) | 79 (61.2) | 0.033 |
Splenomegaly, n (%) | 14 (77.8) | 84 (65.1) | 0.215 |
Lymph node involvement, n (%) | 14 (77.8) | 66 (51.2) | 0.028 |
Sore throat, n (%) | 12 (66.7) | 71 (55.0) | 0.450 |
Liver Involvement, n (%) | 11 (61.1) | 80 (62.0) | 0.567 |
Pleuritis, n (%) | 10 (55.5) | 19 (14.7) | < 0.001 |
Pericarditis, n (%) | 7 (38.9) | 24 (18.6) | 0.064 |
Abdominal Pain, n (%) | 8 (44.4) | 12 (9.3) | 0.001 |
Systemic score, mean ± SD | 8.4 ± 2.1 | 5.7 ± 1.8 | < 0.001 |
MAS, n (%) | 5 (27.8) | 21 (16.3) | 0.071 |
Leucocytosis > 15,000/mm3, n (%) | 11 (61.1) | 67 (51.9) | 0.318 |
ESR, mean ± SD | 70.7 ± 24.7 mm/hr | 69.2 ± 27.7 mm/hr | 0.821 |
CRP, median (interquartile range) | 113.1 (99.2) mg/L | 77.0 (79.6) mg/L | 0.080 |
Ferritin, median (interquartile range) | 3370.5 (3051.8) ng/mL | 2841.5 (3545.1) ng/mL | 0.010 |
Low dosage GCs (≤ 0.5 mg/kg/day), n (%) | 4 (22.2) | 57 (44.2) | 0.062 |
High dosage GCs (> 0.5 mg/kg/day), n (%) | 14 (77.8) | 72 (55.8) | 0.789 |
Synthetic DMARDs, n (%) | 11 (61.1) | 84 (65.1) | 0.464 |
Biologic DMARDs, n (%) | 5 (27.8) | 39 (30.2) | 0.536 |
Monocyclic disease pattern, n (%) | 4 (22.2) | 47 (36.4) | 0.510 |
Polycyclic disease pattern, n (%) | 3 (16.7) | 46 (35.6) | 0.044 |
Chronic disease pattern, n (%) | 4 (22.2) | 34 (26.3) | 0.479 |
Mortality, n (%) | 7 (38.9) | 13 (10.1) | 0.004 |
Time of follow-up, median (interquartile range) | 2.8 (3.4) years | 3.9 (3.4) years | 0.199 |
Predictive factors of LD
Clinical variables | OR | 95%CI | p |
---|---|---|---|
Univariate analyses | |||
Age | 1.04 | 1.01–1.07 | 0.021 |
Male gender | 0.61 | 0.23–1.65 | 0.332 |
Arthritis | 1.05 | 0.22–5.04 | 0.95 |
Skin Rash | 0.86 | 0.28–2.59 | 0.786 |
Myalgia | 5.06 | 1.12–22.97 | 0.036 |
Splenomegaly | 1.87 | 0.58–6.03 | 0.290 |
Lymph node involvement | 3.34 | 1.04–10.69 | 0.042 |
Sore throat | 1.63 | 0.58–4.62 | 0.355 |
Liver Involvement | 0.96 | 0.35–2.65 | 0.941 |
Pleuritis | 7.34 | 2.53–20.67 | < 0.001 |
Pericarditis | 2.78 | 0.98–7.92 | 0.060 |
Abdominal pain | 7.80 | 2.59–23.51 | < 0.001 |
Systemic score | 2.14 | 1.54–2.97 | < 0.001 |
Systemic score ≥ 7 | 19.16 | 4.20–87.41 | < 0.001 |
MAS | 1.39 | 0.42–4.62 | 0.592 |
Leucocytosis > 15,000/mm3 | 1.45 | 0.53–3.99 | 0.467 |
ESR | 1.01 | 0.98–1.02 | 0.819 |
CRP | 1.32 | 0.85–2.06 | 0.214 |
Ferritin | 1.48 | 0.95–2.31 | 0.083 |
Low dosage of GCs | 0.36 | 0.11–1.16 | 0.086 |
Synthetic DMARDs | 0.84 | 0.30–2.32 | 0.739 |
Biologic DMARDs | 0.88 | 0.29–2.66 | 0.831 |
Monocyclic Pattern | 0.87 | 0.31–2.48 | 0.798 |
Polycyclic disease pattern | 0.23 | 0.05–1.02 | 0.064 |
Chronic disease pattern | 0.80 | 0.25–2.59 | 0.708 |
Multivariate analyses | |||
Age | 1.04 | 1.01–1.08 | 0.044 |
Systemic score | 2.08 | 1.50–2.88 | < 0.001 |
X2 = 28.72, p < 0.001 | |||
Age | 1.05 | 1.01–1.09 | 0.011 |
Systemic score ≥ 7 | 23.31 | 4.85–42.08 | < 0.001 |
X2 = 23.06, p < 0.001 |