Background
Methods
Subjects and PET data
Kinetic models for BPND estimation
Kinetic parameters for TAC simulations
[18F]flutemetamol | [18F]florbetaben | |||
---|---|---|---|---|
Level | BPND |
k
3
| BPND |
k
3
|
BPND I | 0.380 | 0.008 | 1.000 | 0.010 |
BPND II | 0.635 | 0.013 | 1.500 | 0.015 |
BPND III | 0.890 | 0.018 | 2.000 | 0.020 |
BPND IV | 1.145 | 0.023 | 2.500 | 0.025 |
BPND V | 1.400 | 0.028 | 3.000 | 0.030 |
\( {\mathrm{BP}}_{\mathrm{ND}}^{\mathrm{NS}} \)
| k3 |
\( {\mathrm{BP}}_{\mathrm{ND}}^{\mathrm{NS}} \)
|
k
3
| |
Reference | 0.350 | 0.018 | 0.950 | 0.007 |
[18F]flutemetamol | [18F]florbetaben | |
---|---|---|
Level | BPND | BPND |
BPND I | 0.020 | 0.021 |
BPND II | 0.208 | 0.277 |
BPND III | 0.397 | 0.532 |
BPND IV | 0.585 | 0.787 |
BPND V | 0.774 | 1.042 |
TAC simulations
Plasma input-generated TACs
SRTM-generated TACs
Dual-time-window protocols
Estimating parameters of interest
Evaluation of outcome parameters
Results
Kinetic parameters for TAC simulation
TAC simulation
Estimating parameters of interest
Plasma input-generated TACs
Evaluation of outcome parameter
Outliers
FLUT | % bias DVR | % outlier | |||||
---|---|---|---|---|---|---|---|
Interval | 1% | 2% | 5% | 1% | 2% | 5% | |
BPND I | 10–90 | 0.0 | 1.9 | 2.0 | 0.0 | 0.0 | 0.0 |
20–90 | 6.4 | 6.1 | 2.4 | 0.0 | 0.0 | 0.0 | |
30–90 | 0.5 | 0.5 | 3.1 | 0.0 | 0.0 | 0.0 | |
40–90 | 1.5 | 1.6 | 1.6 | 0.0 | 0.0 | 0.0 | |
50–90 | 1.5 | 1.5 | 1.7 | 0.0 | 0.0 | 0.0 | |
60–90 | 1.5 | 1.6 | 1.9 | 0.0 | 0.0 | 0.0 | |
70–90 | 1.8 | 2.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.8 | 1.3 | 1.3 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND II | 10–90 | 1.0 | 6.2 | 8.2 | 0.0 | 2.0 | 12.0 |
20–90 | 1.5 | 0.2 | 4.0 | 0.0 | 0.0 | 2.0 | |
30–90 | 0.1 | 0.2 | 1.3 | 0.0 | 0.0 | 0.0 | |
40–90 | 0.0 | 0.3 | 0.1 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.0 | 0.3 | 0.4 | 0.0 | 0.0 | 0.0 | |
60–90 | 0.0 | 0.2 | 0.6 | 0.0 | 0.0 | 0.0 | |
70–90 | 0.0 | 0.1 | 0.6 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.1 | 0.0 | 0.3 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND III | 10–90 | 0.9 | 1.4 | 2.0 | 0.0 | 10.0 | 34.0 |
20–90 | 0.1 | 0.5 | 0.6 | 0.0 | 0.0 | 10.0 | |
30–90 | 0.1 | 0.3 | 0.3 | 0.0 | 0.0 | 4.0 | |
40–90 | 0.1 | 0.5 | 0.0 | 0.0 | 0.0 | 4.0 | |
50–90 | 0.1 | 0.5 | 0.2 | 0.0 | 0.0 | 4.0 | |
60–90 | 0.1 | 0.5 | 0.1 | 0.0 | 0.0 | 4.0 | |
70–90 | 0.1 | 0.4 | 0.3 | 0.0 | 0.0 | 4.0 | |
80–90 | 0.0 | 0.1 | 0.5 | 0.0 | 0.0 | 2.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 2.0 | |
BPND IV | 10–90 | 1.6 | 2.7 | 1.8 | 0.0 | 2.0 | 32.0 |
20–90 | 0.2 | 0.3 | 0.8 | 0.0 | 0.0 | 12.0 | |
30–90 | 0.0 | 0.0 | 1.3 | 0.0 | 0.0 | 6.0 | |
40–90 | 0.0 | 0.1 | 0.6 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.0 | 0.1 | 0.7 | 0.0 | 0.0 | 0.0 | |
60–90 | 0.0 | 0.1 | 0.7 | 0.0 | 0.0 | 0.0 | |
70–90 | 0.1 | 0.2 | 0.7 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.0 | 0.1 | 0.9 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND V | 10–90 | 1.2 | 0.1 | 6.5 | 2.0 | 14.0 | 48.0 |
20–90 | 0.1 | 0.0 | 0.5 | 0.0 | 0.0 | 22.0 | |
30–90 | 0.0 | 0.6 | 0.8 | 0.0 | 0.0 | 18.0 | |
40–90 | 0.0 | 0.5 | 1.0 | 0.0 | 0.0 | 16.0 | |
50–90 | 0.0 | 0.6 | 0.9 | 0.0 | 0.0 | 14.0 | |
60–90 | 0.0 | 0.6 | 0.3 | 0.0 | 0.0 | 12.0 | |
70–90 | 0.0 | 0.4 | 0.5 | 0.0 | 0.0 | 14.0 | |
80–90 | 0.0 | 0.2 | 0.4 | 0.0 | 0.0 | 12.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 12.0 |
FBB | % bias DVR | % outlier | |||||
---|---|---|---|---|---|---|---|
Interval | 1% | 2% | 5% | 1% | 2% | 5% | |
BPND I | 10–90 | 2.1 | 0.9 | 3.3 | 0.0 | 0.0 | 0.0 |
20–90 | 0.9 | 0.2 | 2.3 | 0.0 | 0.0 | 0.0 | |
30–90 | 1.0 | 1.2 | 1.8 | 0.0 | 0.0 | 0.0 | |
40–90 | 0.6 | 1.9 | 0.3 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.1 | 1.1 | 1.2 | 0.0 | 0.0 | 0.0 | |
60–90 | 1.0 | 1.0 | 0.4 | 0.0 | 0.0 | 0.0 | |
70–90 | 1.0 | 1.1 | 0.7 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.5 | 0.4 | 0.4 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND II | 10–90 | 0.1 | 3.4 | 9.1 | 0.0 | 0.0 | 0.0 |
20–90 | 0.1 | 0.1 | 5.0 | 0.0 | 0.0 | 0.0 | |
30–90 | 0.1 | 0.4 | 0.2 | 0.0 | 0.0 | 0.0 | |
40–90 | 0.0 | 0.2 | 0.1 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.0 | 0.2 | 0.3 | 0.0 | 0.0 | 0.0 | |
60–90 | 0.1 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
70–90 | 0.0 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.0 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND III | 10–90 | 0.2 | 0.7 | 3.5 | 0.0 | 2.0 | 16 |
20–90 | 0.2 | 0.2 | 1.8 | 0.0 | 0.0 | 0.0 | |
30–90 | 0.3 | 0.5 | 0.6 | 0.0 | 0.0 | 0.0 | |
40–90 | 0.2 | 0.4 | 0.7 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.1 | 0.4 | 0.7 | 0.0 | 0.0 | 0.0 | |
60–90 | 0.1 | 0.4 | 0.8 | 0.0 | 0.0 | 0.0 | |
70–90 | 0.0 | 0.3 | 0.5 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.0 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND IV | 10–90 | 0.5 | 0.8 | 4.0 | 0.0 | 0.0 | 20.0 |
20–90 | 0.0 | 0.2 | 1.3 | 0.0 | 0.0 | 0.0 | |
30–90 | 0.2 | 0.3 | 0.1 | 0.0 | 0.0 | 0.0 | |
40–90 | 0.0 | 0.2 | 0.2 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.0 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
60–90 | 0.0 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
70–90 | 0.1 | 0.1 | 0.3 | 0.0 | 0.0 | 0.0 | |
80–90 | 0.0 | 0.0 | 0.5 | 0.0 | 0.0 | 0.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | |
BPND V | 10–90 | 0.4 | 1.4 | 2.7 | 0.0 | 0.0 | 32 |
20–90 | 0.3 | 0.5 | 0.9 | 0.0 | 0.0 | 10 | |
30–90 | 0.3 | 0.8 | 0.7 | 0.0 | 0.0 | 2.0 | |
40–90 | 0.0 | 0.6 | 0.4 | 0.0 | 0.0 | 0.0 | |
50–90 | 0.0 | 0.6 | 0.8 | 0.0 | 0.0 | 2.0 | |
60–90 | 0.0 | 0.6 | 0.6 | 0.0 | 0.0 | 2.0 | |
70–90 | 0.0 | 0.4 | 0.2 | 0.0 | 0.0 | 2.0 | |
80–90 | 0.0 | 0.2 | 0.0 | 0.0 | 0.0 | 2.0 | |
90–90 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
FLUT | Absolute mean bias BPND (SD) | AUC | |||||||
---|---|---|---|---|---|---|---|---|---|
Interval | 0% | 1% | 2% | 5% | 0% | 1% | 2% | 5% | |
BPND I | 10–90 | 0.001 (0.000) | 0.017 (0.058) | 0.042 (0.079) | 0.093 (0.154) | 0.993 | 0.971 | 0.943 | 0.894 |
20–90 | 0.001 (0.000) | 0.084 (0.283) | 0.086 (0.276) | 0.098 (0.211) | 0.993 | 0.908 | 0.902 | 0.887 | |
30–90 | 0.001 (0.000) | 0.012 (0.079) | 0.017 (0.074) | 0.105 (0.222) | 0.993 | 0.969 | 0.961 | 0.878 | |
40–90 | 0.001 (0.000) | 0.002 (0.011) | 0.006 (0.022) | 0.055 (0.113) | 0.993 | 0.986 | 0.977 | 0.929 | |
50–90 | 0.000 (0.000) | 0.002 (0.011) | 0.007 (0.025) | 0.053 (0.116) | 0.993 | 0.986 | 0.976 | 0.929 | |
60–90 | 0.000 (0.000) | 0.002 (0.029) | 0.006 (0.045) | 0.051 (0.115) | 0.993 | 0.981 | 0.974 | 0.932 | |
70–90 | 0.000 (0.000) | 0.036 (0.119) | 0.000 (0.020) | 0.075 (0.147) | 0.993 | 0.948 | 0.978 | 0.909 | |
80–90 | 0.000 (0.000) | 0.026 (0.174) | 0.035 (0.181) | 0.058 (0.133) | 1.000 | 0.955 | 0.946 | 0.923 | |
90–90 | 0.000 (0.000) | 0.018 (0.162) | 0.022 (0.162) | 0.072 (0.202) | 1.000 | 0.962 | 0.958 | 0.910 | |
BPND II | 10–90 | 0.002 (0.000) | 0.014 (0.046) | 0.081 (0.217) | 0.128 (0.271) | 0.993 | 0.970 | 0.895 | 0.838 |
20–90 | 0.001 (0.000) | 0.021 (0.135) | 0.009 (0.040) | 0.076 (0.200) | 0.993 | 0.963 | 0.965 | 0.881 | |
30–90 | 0.001 (0.000) | 0.002 (0.015) | 0.003 (0.030) | 0.043 (0.159) | 0.993 | 0.982 | 0.971 | 0.906 | |
40–90 | 0.000 (0.000) | 0.002 (0.015) | 0.003 (0.029) | 0.029 (0.112) | 0.993 | 0.982 | 0.971 | 0.919 | |
50–90 | 0.000 (0.000) | 0.002 (0.015) | 0.002 (0.029) | 0.022 (0.097) | 0.993 | 0.982 | 0.972 | 0.923 | |
60–90 | 0.000 (0.000) | 0.003 (0.014) | 0.004 (0.029) | 0.020 (0.095) | 0.993 | 0.983 | 0.972 | 0.922 | |
70–90 | 0.000 (0.000) | 0.002 (0.014) | 0.005 (0.029) | 0.020 (0.096) | 0.993 | 0.984 | 0.972 | 0.924 | |
80–90 | 0.000 (0.000) | 0.002 (0.013) | 0.007 (0.027) | 0.023 (0.098) | 1.000 | 0.985 | 0.973 | 0.924 | |
90–90 | 0.000 (0.000) | 0.003 (0.013) | 0.006 (0.024) | 0.027 (0.098) | 1.000 | 0.985 | 0.975 | 0.925 | |
BPND III | 10–90 | 0.003 (0.000) | 0.014 (0.063) | 0.031 (0.099) | 0.023 (0.128) | 0.993 | 0.956 | 0.924 | 0.898 |
20–90 | 0.002 (0.000) | 0.001 (0.026) | 0.019 (0.080) | 0.060 (0.145) | 0.993 | 0.975 | 0.946 | 0.876 | |
30–90 | 0.001 (0.000) | 0.001 (0.023) | 0.007 (0.054) | 0.056 (0.158) | 0.993 | 0.977 | 0.956 | 0.881 | |
40–90 | 0.001 (0.000) | 0.001 (0.023) | 0.004 (0.049) | 0.051 (0.146) | 0.993 | 0.978 | 0.958 | 0.885 | |
50–90 | 0.001 (0.000) | 0.001 (0.023) | 0.005 (0.048) | 0.049 (0.147) | 0.993 | 0.978 | 0.959 | 0.886 | |
60–90 | 0.001 (0.000) | 0.001 (0.022) | 0.005 (0.048) | 0.050 (0.147) | 0.993 | 0.978 | 0.959 | 0.887 | |
70–90 | 0.001 (0.000) | 0.000 (0.021) | 0.006 (0.047) | 0.047 (0.144) | 0.993 | 0.979 | 0.960 | 0.888 | |
80–90 | 0.000 (0.000) | 0.001 (0.022) | 0.010 (0.046) | 0.059 (0.164) | 1.000 | 0.979 | 0.961 | 0.883 | |
90–90 | 0.000 (0.000) | 0.001 (0.021) | 0.012 (0.043) | 0.051 (0.142) | 1.000 | 0.979 | 0.963 | 0.894 | |
BPND IV | 10–90 | 0.005 (0.000) | 0.034 (0.082) | 0.041 (0.147) | 0.027 (0.192) | 0.993 | 0.932 | 0.892 | 0.854 |
20–90 | 0.003 (0.000) | 0.012 (0.038) | 0.004 (0.067) | 0.043 (0.183) | 0.993 | 0.963 | 0.942 | 0.859 | |
30–90 | 0.002 (0.000) | 0.008 (0.032) | 0.002 (0.055) | 0.036 (0.168) | 0.993 | 0.968 | 0.949 | 0.866 | |
40–90 | 0.001 (0.000) | 0.008 (0.030) | 0.003 (0.054) | 0.048 (0.173) | 0.993 | 0.970 | 0.950 | 0.858 | |
50–90 | 0.001 (0.000) | 0.007 (0.031) | 0.003 (0.054) | 0.045 (0.174) | 0.993 | 0.970 | 0.949 | 0.858 | |
60–90 | 0.001 (0.000) | 0.008 (0.030) | 0.003 (0.053) | 0.046 (0.169) | 0.993 | 0.969 | 0.951 | 0.863 | |
70–90 | 0.001 (0.000) | 0.007 (0.031) | 0.004 (0.051) | 0.045 (0.165) | 0.993 | 0.969 | 0.953 | 0.868 | |
80–90 | 0.000 (0.000) | 0.008 (0.030) | 0.000 (0.050) | 0.043 (0.163) | 1.000 | 0.969 | 0.954 | 0.867 | |
90–90 | 0.000 (0.000) | 0.008 (0.028) | 0.001 (0.045) | 0.057 (0.179) | 1.000 | 0.970 | 0.959 | 0.861 | |
BPND V | 10–90 | 0.006 (0.000) | 0.023 (0.082) | 0.005 (0.145) | 0.117 (0.111) | 0.988 | 0.929 | 0.885 | 0.852 |
20–90 | 0.004 (0.000) | 0.001 (0.042) | 0.004 (0.090) | 0.011 (0.179) | 0.993 | 0.960 | 0.925 | 0.850 | |
30–90 | 0.002 (0.000) | 0.000 (0.037) | 0.014 (0.074) | 0.015 (0.179) | 0.993 | 0.965 | 0.938 | 0.851 | |
40–90 | 0.001 (0.000) | 0.001 (0.034) | 0.014 (0.072) | 0.019 (0.168) | 0.993 | 0.968 | 0.940 | 0.853 | |
50–90 | 0.001 (0.000) | 0.001 (0.034) | 0.015 (0.071) | 0.018 (0.164) | 0.993 | 0.968 | 0.940 | 0.855 | |
60–90 | 0.001 (0.000) | 0.001 (0.034) | 0.015 (0.071) | 0.008 (0.173) | 0.993 | 0.968 | 0.940 | 0.849 | |
70–90 | 0.001 (0.000) | 0.001 (0.033) | 0.012 (0.072) | 0.010 (0.163) | 0.993 | 0.968 | 0.939 | 0.856 | |
80–90 | 0.000 (0.000) | 0.001 (0.031) | 0.008 (0.067) | 0.006 (0.172) | 1.000 | 0.969 | 0.943 | 0.849 | |
90–90 | 0.000 (0.000) | 0.001 (0.029) | 0.004 (0.061) | 0.002 (0.150) | 1.000 | 0.971 | 0.949 | 0.867 |
SRTM-generated [18F]flutemetamol interval TACs
SRTM-generated [18F]florbetaben interval TACs
FBB | Absolute mean bias BPND (SD) | AUC | |||||||
---|---|---|---|---|---|---|---|---|---|
Interval | 0% | 1% | 2% | 5% | 0% | 1% | 2% | 5% | |
BPND I | 10–90 | 0.000 (0.000) | 0.012 (0.026) | 0.021 (0.043) | 0.059 (0.080) | 0.993 | 0.979 | 0.966 | 0.929 |
20–90 | 0.000 (0.000) | 0.000 (0.011) | 0.013 (0.040) | 0.048 (0.076) | 0.993 | 0.986 | 0.971 | 0.937 | |
30–90 | 0.000 (0.000) | 0.000 (0.008) | 0.001 (0.028) | 0.006 (0.046) | 0.993 | 0.988 | 0.979 | 0.968 | |
40–90 | 0.000 (0.000) | 0.003 (0.032) | 0.008 (0.014) | 0.021 (0.063) | 0.993 | 0.978 | 0.981 | 0.956 | |
50–90 | 0.000 (0.000) | 0.009 (0.012) | 0.000 (0.037) | 0.012 (0.056) | 0.993 | 0.983 | 0.978 | 0.962 | |
60–90 | 0.000 (0.000) | 0.000 (0.007) | 0.001 (0.015) | 0.029 (0.063) | 0.993 | 0.989 | 0.983 | 0.956 | |
70–90 | 0.000 (0.000) | 0.001 (0.006) | 0.000 (0.013) | 0.032 (0.069) | 0.993 | 0.990 | 0.984 | 0.953 | |
80–90 | 0.000 (0.000) | 0.005 (0.036) | 0.007 (0.066) | 0.029 (0.081) | 1.000 | 0.978 | 0.963 | 0.948 | |
90–90 | 0.000 (0.000) | 0.010 (0.011) | 0.011 (0.064) | 0.024 (0.067) | 1.000 | 0.983 | 0.962 | 0.956 | |
BPND II | 10–90 | 0.001 (0.000) | 0.003 (0.013) | 0.045 (0.167) | 0.131 (0.307) | 0.993 | 0.984 | 0.935 | 0.861 |
20–90 | 0.001 (0.000) | 0.000 (0.012) | 0.000 (0.023) | 0.079 (0.207) | 0.993 | 0.985 | 0.976 | 0.891 | |
30–90 | 0.002 (0.000) | 0.000 (0.012) | 0.003 (0.023) | 0.016 (0.063) | 0.993 | 0.985 | 0.975 | 0.946 | |
40–90 | 0.000 (0.000) | 0.001 (0.012) | 0.001 (0.023) | 0.012 (0.062) | 0.993 | 0.985 | 0.976 | 0.946 | |
50–90 | 0.000 (0.000) | 0.001 (0.011) | 0.001 (0.022) | 0.010 (0.060) | 0.993 | 0.986 | 0.977 | 0.948 | |
60–90 | 0.000 (0.000) | 0.002 (0.010) | 0.000 (0.021) | 0.009 (0.056) | 0.993 | 0.987 | 0.978 | 0.948 | |
70–90 | 0.000 (0.000) | 0.001 (0.009) | 0.001 (0.020) | 0.010 (0.055) | 0.993 | 0.988 | 0.979 | 0.950 | |
80–90 | 0.000 (0.000) | 0.001 (0.007) | 0.002 (0.017) | 0.011 (0.053) | 1.000 | 0.989 | 0.981 | 0.954 | |
90–90 | 0.000 (0.000) | 0.001 (0.008) | 0.002 (0.015) | 0.014 (0.053) | 1.000 | 0.989 | 0.983 | 0.954 | |
BPND III | 10–90 | 0.002 (0.000) | 0.002 (0.022) | 0.014 (0.066) | 0.084 (0.159) | 0.993 | 0.978 | 0.955 | 0.875 |
20–90 | 0.002 (0.000) | 0.003 (0.016) | 0.000 (0.041) | 0.058 (0.117) | 0.993 | 0.982 | 0.964 | 0.898 | |
30–90 | 0.003 (0.000) | 0.004 (0.016) | 0.004 (0.035) | 0.038 (0.112) | 0.993 | 0.982 | 0.966 | 0.910 | |
40–90 | 0.001 (0.000) | 0.002 (0.016) | 0.003 (0.036) | 0.041 (0.116) | 0.993 | 0.982 | 0.966 | 0.909 | |
50–90 | 0.001 (0.000) | 0.002 (0.016) | 0.002 (0.035) | 0.041 (0.117) | 0.993 | 0.982 | 0.967 | 0.908 | |
60–90 | 0.001 (0.000) | 0.001 (0.015) | 0.002 (0.034) | 0.041 (0.114) | 0.993 | 0.983 | 0.968 | 0.909 | |
70–90 | 0.001 (0.000) | 0.001 (0.014) | 0.001 (0.031) | 0.037 (0.108) | 0.993 | 0.984 | 0.971 | 0.911 | |
80–90 | 0.000 (0.000) | 0.000 (0.014) | 0.002 (0.030) | 0.033 (0.092) | 1.000 | 0.985 | 0.972 | 0.926 | |
90–90 | 0.000 (0.000) | 0.000 (0.013) | 0.003 (0.027) | 0.029 (0.083) | 1.000 | 0.985 | 0.974 | 0.933 | |
BPND IV | 10–90 | 0.003 (0.000) | 0.014 (0.035) | 0.014 (0.074) | 0.085 (0.184) | 0.993 | 0.964 | 0.943 | 0.848 |
20–90 | 0.004 (0.000) | 0.004 (0.024) | 0.003 (0.047) | 0.036 (0.148) | 0.993 | 0.975 | 0.956 | 0.891 | |
30–90 | 0.005 (0.000) | 0.001 (0.023) | 0.006 (0.046) | 0.011 (0.115) | 0.993 | 0.976 | 0.958 | 0.904 | |
40–90 | 0.001 (0.000) | 0.004 (0.023) | 0.003 (0.046) | 0.008 (0.108) | 0.993 | 0.976 | 0.958 | 0.907 | |
50–90 | 0.001 (0.000) | 0.004 (0.024) | 0.002 (0.045) | 0.006 (0.107) | 0.993 | 0.975 | 0.959 | 0.909 | |
60–90 | 0.001 (0.000) | 0.005 (0.022) | 0.002 (0.043) | 0.007 (0.099) | 0.993 | 0.976 | 0.961 | 0.917 | |
70–90 | 0.001 (0.000) | 0.004 (0.022) | 0.003 (0.040) | 0.006 (0.092) | 0.993 | 0.977 | 0.964 | 0.924 | |
80–90 | 0.000 (0.000) | 0.005 (0.021) | 0.000 (0.037) | 0.003 (0.089) | 1.000 | 0.977 | 0.966 | 0.926 | |
90–90 | 0.000 (0.000) | 0.005 (0.019) | 0.000 (0.034) | 0.012 (0.091) | 1.000 | 0.978 | 0.970 | 0.925 | |
BPND V | 10–90 | 0.005 (0.000) | 0.005 (0.044) | 0.024 (0.122) | 0.029 (0.111) | 0.993 | 0.960 | 0.911 | 0.903 |
20–90 | 0.006 (0.000) | 0.008 (0.027) | 0.015 (0.056) | 0.008 (0.147) | 0.988 | 0.971 | 0.950 | 0.882 | |
30–90 | 0.007 (0.000) | 0.008 (0.027) | 0.021 (0.051) | 0.011 (0.165) | 0.988 | 0.972 | 0.954 | 0.870 | |
40–90 | 0.002 (0.000) | 0.002 (0.026) | 0.016 (0.052) | 0.018 (0.172) | 0.993 | 0.973 | 0.955 | 0.868 | |
50–90 | 0.002 (0.000) | 0.002 (0.026) | 0.016 (0.052) | 0.010 (0.156) | 0.993 | 0.973 | 0.955 | 0.878 | |
60–90 | 0.001 (0.000) | 0.002 (0.025) | 0.016 (0.051) | 0.015 (0.156) | 0.993 | 0.974 | 0.955 | 0.875 | |
70–90 | 0.001 (0.000) | 0.002 (0.024) | 0.012 (0.050) | 0.022 (0.153) | 0.993 | 0.976 | 0.955 | 0.876 | |
80–90 | 0.000 (0.000) | 0.002 (0.022) | 0.008 (0.045) | 0.027 (0.147) | 0.993 | 0.978 | 0.959 | 0.876 | |
90–90 | 0.000 (0.000) | 0.002 (0.020) | 0.005 (0.041) | 0.026 (0.135) | 0.993 | 0.979 | 0.963 | 0.888 |