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Cardiac Vagal Tone in Generalised Anxiety Disorder

Published online by Cambridge University Press:  02 January 2018

Mark Kollai  and
Balazs Kollai
Mark Kollai*
Affiliation:
Department of Physiology, Semmelweis Medical University, Ulloi ut 78/A, Budapest 1082, Hungary
Balazs Kollai
Affiliation:
Department of Internal Medicine, Balassa Janos Hospital, Vas u. 17, Budapest, 1088, Hungary
*
∗Correspondence
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Abstract

The aim of the present study was twofold: firstly, to determine cardiac vagal tone in subjects with generalised anxiety disorder directly, using an invasive pharmacological method; and secondly, to test whether the non-invasive method of measuring the amplitude of respiratory sinus arrhythmia (RSA) gives a reliable estimate of cardiac vagal tone in this form of anxiety disorder. Comparison of baseline physiological measures of anxious and control subjects revealed that cardiac vagal tone and heart rate were not different in the two groups of subjects, whereas length of the respiratory cycle and amplitude of respiratory sinus arrhythmia were reduced in the former group. Because of the higher respiratory rates of anxious subjects, the RSA method was found to underestimate cardiac vagal tone in generalised anxiety disorder.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 6 , December 1992 , pp. 831 - 835
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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References

Ackner, B. (1956) The relationship between anxiety and the level of peripheral vasomotor activity. Journal of Psychosomatic Research, 1, 21–48.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.Google Scholar
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.Google Scholar
Berne, R. M. & Levy, M. N. (1988) Physiology. St Louis: Mosby.Google Scholar
Charney, D. S., Heninger, G. R. & Breier, A. (1984) Noradrenergic function in panic anxiety. Archives of General Psychiatry, 41, 751–763.Google Scholar
Eckberg, D. L. (1983) Human sinus arrhythmia as an index of vagal outflow. Journal of Applied Physiology, 54, 961–966.CrossRefGoogle Scholar
Eysenck, S. B. G. & Eysenck, H. J. (1975) Manual of the Eysenck Personality Questionnaire. Sevenoaks: Hodder and St ought on.Google Scholar
Freedman, R. R., Ianni, P., Ettedgui, E., et al (1984) Psychophysiological factors in panic disorder. Psychopathology, 17 (suppl. 1): 66–73.Google Scholar
Freedman, R. R., Ianni, P., Ettedgui, E., et al (1985) Ambulatory monitoring of panic disorder. Archives of General Psychiatry, 42, 244–248.Google Scholar
Goldstein, I. B. (1964) Physiological responses in anxious women patients. Archives of General Psychiatry, 10, 382–388.Google Scholar
Gorman, J. M. & Uy, J. (1987) Respiratory physiology and pathological anxiety. General Hospital Psychiatry, 9, 410–419.Google Scholar
Gorman, J. M., Fyer, M. R., Goetz, R., et at (1988) Ventilatory physiology of patients with panic disorder. Archives of General Psychiatry, 45, 31–39.Google Scholar
Grossman, P. (1983) Respiration, stress and cardiovascular function. Psychophysiology, 20, 284–300.Google Scholar
Hamilton, M. (1959) The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50–55.CrossRefGoogle ScholarPubMed
Hoehn-Saric, R., McLeod, D. R. & Zimmerli, W. D. (1989a) Somatic manifestations in women with generalized anxiety disorder. Archives of General Psychiatry, 46, 1113–1119.Google Scholar
Hoehn-Saric, R., McLeod, D. R. & Zimmerli, W. D. (1989b) Symptoms and treatment responses of generalized anxiety disorder patients with high versus low levels of cardiovascular complaints. American Journal of Psychiatry, 146, 854–859.Google ScholarPubMed
Jurko, M., Jost, H. & Hill, T. S. (1952) Pathology of the energy system: an experimental clinical study of physiological adaptive capacity in a non-patient, a psychoneurotic, and an early period schizophrenic group. Journal of Psychology, 33, 183–198.Google Scholar
Katona, P. G. & Jih, F. (1975) Respiratory sinus arrhythmia: noninvasive measure of parasympathetic cardiac control. Journal of Applied Physiology, 39, 801–805.CrossRefGoogle ScholarPubMed
Kelly, D. (1980) Anxiety and Emotions. Springfield: Thomas.Google Scholar
Kelly, D., Brown, C. C. & Shaffer, W. (1970) A comparison of physiological and psychological measurements on anxious patients and normal controls. Psychophysiology, 6, 429–441.Google Scholar
Koizumi, K. & Kollai, M. (1981) Control of reciprocal and non-reciprocal action of vagal and sympathetic efferents: study of centrally induced reactions. Journal of the Autonomic Nervous System, 3, 483–501.Google Scholar
Kollai, M. & Mizsei, G. (1990) Respiratory sinus arrhythmia is a limited measure of cardiac parasympathetic control in man. Journal of Physiology, 424, 329–342.Google Scholar
Lader, M. H. (1980) The psychophysiology of anxiety. In Handbook of Biological Psychiatry, Part II: Brain Mechanisms and Abnormal Behavior–Psychophysiology (ed. A. M. Van Praag). New York: Marcel Dekker.Google Scholar
Liebowitz, M. R., Gorman, J. M., Fyer, A. J., et al (1985) Lactate provocation of panic attacks. Archives of General Psychiatry, 42, 709–719.CrossRefGoogle ScholarPubMed
Lum, L. C. (1976) The syndrome of habitual chronic hyperventilation. In Modern Trends in Psychosomatic Medicine, vol. 3 (ed. O. W. Hill). London: Butterworths.Google Scholar
Marks, I. & Lader, M. H. (1973) Anxiety states (anxiety neurosis): a review. Journal of Nervous and Mental Disorders, 150, 3–18.CrossRefGoogle Scholar
Mathew, R. J., Ho, B. T., Francis, D. J., et al (1982) Catecholamines and anxiety. Acta Psychiatrica Scandinavica, 65, 142–147.CrossRefGoogle ScholarPubMed
Nesse, R. M., Cameron, O. G., Curtis, G. C., et al (1984) Adrenergic function in patients with panic anxiety. Archives of General Psychiatry, 41, 771–776.Google Scholar
Peronnet, F., Blier, P., Brisson, G., et al (1986) Plasma catecholamines at rest and exercise in subjects with high- and low-trait anxiety. Psychosomatic Medicine, 48, 52–58.Google Scholar
Shear, M. K., Kligfield, P., Harshfield, G., et al (1987) Cardiac rate and rhythm in panic patients. American Journal of Psychiatry, 144, 633–637.Google Scholar
Spielberger, C. S., Gorsuch, R. L. & Lushene, R. E. (1970) Manual for the State-Trait Anxiety Inventory. Palo Alto: Consulting Psychologists Press.Google Scholar
Spyer, K. M. (1982) Central nervous integration of cardiovascular control. Journal of Experimental Biology, 100, 109–128.CrossRefGoogle ScholarPubMed
Taylor, C. B., Sheikh, J., Agras, W. S., et al (1986) Ambulatory heart rate changes in patients with panic attacks. American Journal of Psychiatry, 143, 478–482.Google Scholar
Winer, B. J. (1971) Statistical Principles in Experimental Design (2nd edn). New York: McGraw-Hill.Google Scholar
Wishner, J. (1953) Neurosis and tension: an exploratory study of the relation of physiological and Rorschach measures. Journal of Abnormal Psychology, 2, 253–260.CrossRefGoogle Scholar
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