Journal of Lipid Research
Research ArticlesInhibition of the central melanocortin system decreases brown adipose tissue activity[S]
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This work was supported by ‘the Netherlands CardioVascular Research Initiative: the Dutch Heart Foundation, Dutch Federation of University Medical Centers, the Netherlands Organisation for Health Research and Development, and the Royal Netherlands Academy of Sciences’ for the GENIUS project ‘Generating the best evidence-based pharmaceutical targets for atherosclerosis’ (CVON2011-19). P. C. N. Rensen is an Established Investigator of the Netherlands Heart Foundation (Grant 2009T038).
- [14C]CO
[14C]cholesteryl oleate
- [3H]TO
glycerol tri[3H]oleate
- BAT
brown adipose tissue
- CREB
cAMP response element-binding protein
- EE
energy expenditure
- FFM
fat-free mass
- gWAT
gonadal white adipose tissue
- iBAT
interscapular brown adipose tissue
- MC3/4R
melanocortin 3/4 receptor
- MC4R
melanocortin 4 receptor
- p-CREB
phosphorylated cAMP response element-binding protein
- PL
phospholipid
- RER
respiratory exchange ratio
- SR-BI
scavenger receptor class B type I
- TC
total cholesterol
- TH
tyrosine hydroxylase
- UCP-1
uncoupling protein-1
- WAT
white adipose tissue
Abbreviations:
- [S]
The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of two figures.