Journal of Lipid Research
Research ArticlesA high-fat diet suppresses de novo lipogenesis and desaturation but not elongation and triglyceride synthesis in mice[S]
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Support for this work was provided by National Institutes of Health Grants DK078184 (S.C.B.), DK058398 (S.C.B.), HL020948 (J.D.H), DK087977 (J.D.B), and EB015908 (Center resources), and by the Robert A. Welch Foundation (S.C.B.). J.A.G.D and J.G.J were supported by Portuguese Foundation for Science and Technology grants SFRH/BD/44294/2008 and PTDC/SAU-MET/111398/2009.
- AMW
average molecular weight
- ANC
average number of carbons
- ANP
average number of protons
- DNL
de novo lipogenesis
- ELOVL
elongation of very long chain fatty acids
- HFD
high-fat diet
- LFD
low-fat diet
- MIDA
mass isotopomer distribution analysis
- NAFLD
nonalcoholic fatty liver disease
- PABA
para-amino benzoic acid
- SCD-1
sterol-CoA desaturase 1
- SREBP-1
sterol-regulatory element binding protein 1
- WAT
white adipose tissue
Abbreviations:
- [S]
The online version of this article (available at http://www.jlr.org) contains supplementary data in the form of eight tables and one figure.