Journal of Lipid Research
Research Articlesα-Tocopherols modify the membrane dipole potential leading to modulation of ligand binding by P-glycoprotein
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This work was partially supported by the Engineering and Physical Sciences Research Council (EPSRC) (grant reference EP/J017566/1). The University of Exeter provided funds for consumables for some of this work. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
- Di-8-ANEPPS
1-(3-sulfonatopropyl)-4-[β[2-(di-n-octylamino)-6-naphthyl]vinyl] pyridinium betaine
- DPBS
Dulbecco's PBS
- FPE
N-(fluorescein-5-thiocarbamoyl)-1,2-dihexadecanoyl-sn-glycerol-3-phosphoethanolamine
- MDP
membrane dipole potential
- PC
phosphatidylcholine
- P-gp
P-glycoprotein
Abbreviations:
- 1
Present address of S. Davis: Immunocore Limited, 91 Park Drive, Milton Park, Abingdon OX14 4RY, Oxon, UK.
- 2
Present address of B. M. Davis: Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK.